Ligand ID: TP0


Drugbank ID:
DB00321
(Amitriptyline)


Indication:
- Indicated for the treatment of major depressive disorder in adults

Get human targets for TP0 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TP0' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE B 112
GLU B 290
SER D   1
SER B 139
TYR B 126
1.78A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE A 112
GLU A 290
SER C   1
SER A 139
TYR A 126
1.77A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 435
PHE A 419
PHE A 859
HIS A 439
TYR A 884
1.52A11.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 435
PHE A 419
PHE A 859
HIS A 439
TYR A 884
1.54A11.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 321
LEU A 282
GLU A 278
ARG A 285
ALA A 253
1.76A11.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.61A11.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.63A11.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR B 789
VAL A 705
GLU A1072
ALA B 890
SER B 884
1.53A9.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A  55
PHE C 562
ARG A  44
ALA A 222
TYR A 204
1.69A9.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w02 NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
VAL B  77
PHE B 116
LEU B  93
ALA B  50
1.74A17.89
APR  B 201 (-3.5A)
None
None
None
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w4b NSP9
(SARS-CoV-2)		5 / 12
PHE A  57
VAL A  42
PHE A  76
LEU A 107
ALA A  29
1.59A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.14A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 132
VAL B  77
PHE B 116
LEU B  93
ALA B  50
1.73A
MES  B 201 ( 3.4A)
None
None
None
MES  B 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.15A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6842
LEU C6893
ALA D4324
SER D4325
TYR D4349
1.13A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
TYR A 113
VAL A 151
LEU A  53
ALA A 129
SER A 139
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
PHE A 132
VAL A  77
PHE A 116
LEU A  93
ALA A  50
1.70A
MES  A 201 (-2.5A)
None
None
None
MES  A 201 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
TYR A 113
VAL A 151
LEU A  53
ALA A 129
SER A 139
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR B 149
PHE B  92
LEU B  95
ALA B 110
SER A  61
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR B 149
PHE B  92
LEU B  95
ALA B 110
SER A  61
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE E 274
VAL E 270
LEU E 352
ALA E 308
SER F 312
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL C6842
LEU C6893
ALA D4324
SER D4325
TYR D4349
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
HIS A 145
SER A  78
ASN A  75
ILE A 146
TYR D 172
1.71A16.67
 ZN  A 201 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
HIS C 145
SER C  78
ASN C  75
ILE C 146
TYR B 172
1.73A16.67
 ZN  C 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6842
LEU C6893
ALA D4324
SER D4325
TYR D4349
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE B 132
VAL B  77
PHE B 116
LEU B  93
ALA B  50
1.70A
APR  B 201 (-3.6A)
None
None
None
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE D 132
VAL D  77
PHE D 116
LEU D  93
ALA D  50
1.73A
APR  D 201 (-3.5A)
None
None
None
APR  D 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 132
VAL A  77
PHE A 116
LEU A  93
ALA A  50
1.74A
APR  A 201 (-3.1A)
None
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE C 132
VAL C  77
PHE C 116
LEU C  93
ALA C  50
1.73A
APR  C 201 (-3.5A)
None
None
None
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6842
LEU A6893
ALA B4324
SER B4325
TYR B4349
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
TYR B 149
PHE B  92
LEU B  95
ALA B 110
SER A  61
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
TYR B 149
PHE B  92
LEU B  95
ALA B 110
SER A  61
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
VAL B 115
PHE E 456
LEU E 455
GLU B  16
SER B  89
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
VAL H 115
PHE A 456
LEU A 455
GLU H  16
SER H  89
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
VAL E  77
PHE E 116
LEU E  93
ALA E  50
1.77A
EPE  E 202 (-3.2A)
None
None
None
EPE  E 202 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
VAL A  77
PHE A 116
LEU A  93
ALA A  50
1.77A
EDO  A 202 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR C 113
VAL C 151
LEU C  53
ALA C 129
SER C 139
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
VAL A  77
PHE A 116
LEU A  93
ALA A  50
1.73A
APR  A 201 (-3.7A)
None
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE E 132
VAL E  77
PHE E 116
LEU E  93
ALA E  50
1.74A
APR  E 201 (-3.5A)
None
None
None
APR  E 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
VAL B  77
PHE B 116
LEU B  93
ALA B  50
1.74A
APR  B 201 (-3.5A)
None
None
None
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE D 132
VAL D  77
PHE D 116
LEU D  93
ALA D  50
1.76A
APR  D 201 (-3.3A)
None
None
None
APR  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
VAL C  77
PHE C 116
LEU C  93
ALA C  50
1.77A
APR  C 201 (-3.5A)
None
None
None
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE C 132
VAL C  77
PHE C 116
LEU C  93
ALA C  50
1.77A
MES  C 201 (-3.6A)
None
None
None
MES  C 201 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE A 132
VAL A  77
PHE A 116
LEU A  93
ALA A  50
1.73A
MES  A 201 (-3.5A)
None
None
None
MES  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
TYR B 113
VAL B 151
LEU B  53
ALA B 129
SER B 139
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
PHE B 132
VAL B  77
PHE B 116
LEU B  93
ALA B  50
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 435
PHE A 419
PHE A 859
HIS A 439
TYR A 884
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 435
PHE A 419
PHE A 859
HIS A 439
TYR A 884
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
TYR D 149
PHE D  92
LEU D  95
ALA D 110
SER C  61
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		6 / 12
TYR A 788
PHE A 471
PHE A 745
LEU A 727
HIS A 133
ALA A 702
1.64A
None