Ligand ID: TMI


Drugbank ID:
DB04794
(Bifonazole)


Indication:
Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).

Get human targets for TMI in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TMI' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.17A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.11A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5r83 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
LEU A 220
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.59A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.73A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 287
LEU A 271
THR A 280
LEU A 282
SER A 284
1.62A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A 104
VAL A  86
VAL A  35
1.71A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  42
VAL A  18
VAL A  91
1.76A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 205
ILE A 200
ASN A 231
THR A 243
1.77A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A 148
VAL A  18
VAL A  35
1.53A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  30
VAL A  86
LEU A  89
VAL A  68
1.77A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.33A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  86
VAL A 104
VAL A 157
1.75A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLN A  19
LEU A  67
VAL A  18
VAL A  77
1.66A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 205
LEU A 250
ILE A 259
THR A 225
1.64A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  27
VAL A  36
LEU A  30
VAL A 148
1.47A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLN A 244
LEU A 262
VAL A 261
VAL A 202
1.73A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  18
LEU A  27
VAL A  42
1.48A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 220
ILE A 281
LEU A 271
LEU A 268
SER A 267
1.57A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 205
ASN A 228
LEU A 227
THR A 226
1.61A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 177
VAL A  13
VAL A  36
VAL A  86
1.59A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.60A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  91
VAL A  86
VAL A 148
1.56A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 272
LEU A 271
LEU A 208
THR A 280
LEU A 286
1.80A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		6 / 12
LEU D 977
LEU D 981
LEU D 984
ILE D 980
ILE F 980
LEU E 981
1.33A13.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.38A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  18
LEU A  27
VAL A  42
1.46A21.37
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A21.37
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.47A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.75A21.37
ELL  D   3 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.27A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 208
LEU A 287
ASN A 274
SER A 267
1.48A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.75A21.32
ELL  D   3 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.39A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
LEU A 220
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.63A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A21.32
None
DMS  A 401 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.17A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU B  32
VAL B  18
VAL B 148
VAL B 157
1.17A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER D  62
PHE D  66
GLY D  23
THR D  24
1.40A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU C  67
LEU C  27
VAL C  42
VAL C  77
1.37A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D  89
VAL D  18
LEU D  27
VAL D  42
1.43A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  45
1.72A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.29A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D  67
LEU D  27
VAL D  42
VAL D  77
1.43A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER C  62
PHE C  66
GLY C  23
THR C  24
1.28A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 205
ASN C 228
LEU C 227
THR C 226
LEU C 262
1.48A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 205
ASN B 228
LEU B 227
THR B 226
LEU B 262
1.41A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER B  62
PHE B  66
GLY B  23
THR B  24
1.35A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 220
ILE B 281
ASN B 274
LEU B 271
LEU B 268
1.40A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU C  27
VAL C  36
LEU C  30
VAL C 148
1.46A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER D 139
LEU D 141
PHE D 140
GLY D 143
1.23A21.22
None
None
None
3WL  D 401 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER A 139
LEU A 141
PHE A 140
GLY A 143
1.20A21.22
None
None
None
3WL  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 281
ASN B 274
LEU B 271
LEU B 268
SER B 267
1.31A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
ASN A 228
LEU A 227
THR A 226
LEU A 262
1.31A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU B 272
VAL B 204
LEU B 205
VAL B 233
1.44A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
LEU D  67
PHE D  66
GLY D  23
ILE A 152
1.60A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 205
LEU B 208
LEU B 287
ASN B 274
SER B 267
1.50A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D  32
VAL D  18
VAL D 148
VAL D 157
1.15A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER B 139
LEU B 141
PHE B 140
GLY B 143
1.22A21.22
None
None
None
3WL  B 401 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.35A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  18
LEU A  27
VAL A  42
1.46A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU C  32
VAL C  18
VAL C 148
VAL C 157
1.14A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.34A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.13A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.38A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.73A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 754
GLY A 584
THR A 582
ILE A 579
1.25A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
MET A 666
GLY A 345
THR A 344
ILE A 333
1.73A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 578
LEU A 575
GLY A 486
THR A 644
1.34A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 671
ILE B 185
1.50A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m71 NSP7
(SARS-CoV-2)		4 / 8
LEU C  13
VAL C  22
LEU C  20
VAL C  66
1.36A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 122
ILE C  39
LEU C  55
LEU C  56
SER C  57
1.48A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 103
ILE B 120
ILE B 119
ASN B 109
LEU A 271
1.41A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		4 / 7
LEU A 351
PHE A 348
GLY A 352
THR A 276
1.49A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  56
ILE D 107
ILE C  68
LEU C  71
THR D  89
1.49A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
ILE B 119
ILE B 120
ASN B 104
LEU B 103
1.44A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  60
LEU D  91
VAL C  16
VAL C  58
1.41A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
LEU A 241
ILE A 244
LEU A 212
THR A 123
1.41A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
LEU A 142
LEU A 247
THR A 248
LEU A 172
1.40A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 8
ARG A 555
VAL C  11
LEU C  14
VAL C  33
1.37A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 164
LEU A 160
LEU A 127
SER A 139
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 164
LEU B 160
LEU B 127
SER B 139
1.32A
None
None
SO4  B 204 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		4 / 7
SER A  65
MET A  61
GLY A  46
ILE A 131
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		4 / 7
SER B  65
MET B  61
GLY B  46
ILE B 131
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.38A
None
None
SO4  A 203 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.42A
None
None
SO4  B 204 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
LEU A  73
LEU A  76
ILE A  72
ASN A 178
THR A 145
PHE A 123
1.58A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
PHE C 338
LEU C 513
ILE C 358
THR C 393
PHE C 515
1.56A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ARG C 466
VAL C 395
LEU C 513
VAL C 511
1.77A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
LEU C 390
LEU C 387
ILE L  28
THR H 100
SER C 383
1.74A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
SER C 383
LEU C 390
GLY C 526
ILE C 358
1.43A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w4h NSP16
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.49A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A7010
ILE A7079
THR A6856
LEU A6857
1.74A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
LEU A6893
ILE A6926
THR A6846
LEU A6848
1.62A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6961
ILE A7080
ILE A7069
LEU A7070
SER A7074
1.73A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6857
LEU A6887
VAL A6865
VAL A6965
1.64A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6857
LEU A6883
VAL A6865
VAL A6965
1.69A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6978
ILE A7017
THR A6989
PHE A6985
1.76A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
LEU A6834
ILE A6838
ASN A6996
THR A6993
1.63A14.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7072
ILE A7069
ILE A7065
LEU A6961
LEU A7010
1.65A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLN A6850
LEU A7042
VAL A6882
VAL A6995
1.71A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6959
ILE A6955
ILE A6951
LEU A7004
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6855
LEU A6924
ILE A7005
LEU A6848
THR A6846
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
MET A6863
LEU A6857
GLY A6963
ILE A6951
1.78A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
MET A6863
LEU A6857
GLY A6963
ILE A6967
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6857
LEU A6924
ILE A7005
LEU A6848
THR A6846
1.60A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6852
LEU A6883
VAL A6865
VAL A6965
1.66A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7004
ILE A6967
ILE A6951
LEU A6981
PHE A6985
1.51A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6887
LEU A6893
THR A6846
LEU A6848
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6893
LEU A6883
ASN A6853
LEU A7050
LEU A7052
1.76A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET A6982
ARG A7014
LEU A6959
VAL A6965
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  18
LEU A  27
VAL A  42
1.45A
None
None
X77  A 401 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 139
LEU A 141
PHE A 140
GLY A 143
1.31A
None
None
None
X77  A 401 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.35A
None
X77  A 401 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 7
SER B  65
MET B  61
GLY B  46
ILE B 131
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 153
VAL A 144
VAL A 165
VAL A 155
1.75A17.16
None
None
None
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  53
ILE B  23
ASN B   4
THR B  33
LEU B 122
1.63A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
ILE A  23
ASN A   4
THR A  33
LEU A 122
1.63A17.16
None
AMP  A 201 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 126
VAL B 151
LEU B  12
VAL B 165
1.66A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
LEU A 126
LEU A 140
ASN A  15
LEU A 122
1.63A17.16
None
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  10
VAL B 155
LEU B 140
VAL B 144
1.60A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
VAL A 151
LEU A  12
VAL A 165
1.55A17.16
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
LEU A  12
ILE A  18
LEU A 169
SER A 167
1.65A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 127
VAL B  35
LEU B 122
VAL B 147
1.65A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.21A
None
None
AMP  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 127
VAL B 147
LEU B 122
VAL B  49
1.67A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  53
LEU B  88
ASN B   4
THR B  33
LEU B 122
1.76A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLN A 118
LEU A  93
VAL A  95
VAL A 147
1.65A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
LEU A  88
ASN A   4
THR A  33
LEU A 122
1.75A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
VAL A  16
LEU A  12
VAL A 165
1.45A
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 164
LEU B 140
LEU B  12
ILE B  18
LEU B 169
1.78A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 126
VAL B  16
LEU B  12
VAL B 165
1.51A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
LEU B 126
LEU B 140
ASN B  15
LEU B 122
1.63A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 123
LEU B 153
ASN B 117
THR B 149
PHE B   6
1.79A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  12
LEU B 153
LEU B 126
ILE B 137
LEU B 160
1.70A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 127
VAL A  35
LEU A 122
VAL A 147
1.65A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 153
VAL B 144
VAL B 165
VAL B 155
1.78A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 127
VAL A 147
LEU A 122
VAL A  49
1.67A17.16
None
None
None
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7004
ILE A6967
ILE A6951
LEU A6981
PHE A6985
1.49A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
LEU C6978
ILE C7017
THR C6989
PHE C6985
1.80A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6852
LEU A6883
VAL A6865
VAL A6965
1.70A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C6857
LEU C6924
ILE C7005
LEU C6848
1.43A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C7010
ILE C7079
THR C6856
LEU C6857
1.72A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6852
LEU C6883
VAL C6865
VAL C6965
1.68A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
MET A6982
ARG A7014
LEU A6959
VAL A6965
1.16A14.78
None
FMT  A7111 ( 2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C6924
ILE C7005
LEU C6848
THR C6846
1.48A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6852
LEU A6848
ILE A6926
ILE A6967
THR A6989
1.51A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6887
LEU C6893
THR C6846
LEU C6848
1.36A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6893
LEU C6883
ASN C6853
LEU C7050
LEU C7052
1.77A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6852
LEU C6848
ILE C6926
ILE C6967
THR C6989
1.50A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7072
ILE C7069
ILE C7065
LEU C6961
LEU C7010
1.68A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6866
ILE C7088
ASN C6862
LEU C6892
THR C6891
1.71A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
LEU C6959
ILE C6955
ILE C6951
LEU C7004
1.19A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6909
VAL C7092
LEU A6909
VAL C7087
1.79A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU C6857
LEU C7050
LEU C6887
ILE C6926
THR C6846
LEU C6848
1.49A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.48A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6978
ILE A7017
THR A6989
PHE A6985
1.78A14.78
None
None
FMT  A7111 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6857
LEU A6924
ILE A7005
LEU A6848
THR A6846
1.61A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6848
ILE C6926
ILE C6967
THR C6989
1.56A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
MET C6982
ARG C7014
LEU C6959
VAL C6965
1.23A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6893
LEU A6883
ASN A6853
LEU A7050
LEU A7052
1.78A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
LEU A6834
ILE A6838
ASN A6996
THR A6993
1.66A13.70
None
None
None
FMT  A7104 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6887
LEU A6893
THR A6846
LEU A6848
1.36A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
LEU C6893
ILE C6926
THR C6846
LEU C6848
1.64A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6985
LEU C6959
ILE C6925
LEU C6852
LEU C6857
1.79A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7078
LEU C6961
ILE C7080
ILE C7069
SER C7074
1.80A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		6 / 12
PHE A6985
ILE A6925
ILE A6955
ASN A6975
LEU A6978
LEU A7004
1.79A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6954
LEU C6893
LEU C6883
ILE C6925
LEU C6924
1.66A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6848
ILE A6926
ILE A6967
THR A6989
1.55A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7072
ILE A7069
ILE A7065
LEU A6961
LEU A7010
1.66A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A7010
ILE A7079
THR A6856
LEU A6857
1.73A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6857
LEU C6924
ILE C7005
LEU C6848
THR C6846
1.60A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
VAL B4274
LEU D4328
VAL D4361
VAL C6902
1.60A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6857
LEU A6887
VAL A6865
VAL A6965
1.65A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
LEU C6834
ILE C6838
ASN C6996
THR C6993
1.62A13.70
None
None
None
FMT  C7108 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6954
LEU A6893
LEU A6883
ILE A6925
LEU A6924
1.68A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6857
LEU C6887
VAL C6865
VAL C6965
1.65A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6959
ILE A6955
ILE A6951
LEU A7004
1.29A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 7
SER A6907
LEU A6909
GLY A6911
ILE A6951
1.70A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6857
LEU A6883
VAL A6865
VAL A6965
1.72A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6857
LEU C6883
VAL C6865
VAL C6965
1.72A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
LEU A6893
ILE A6926
THR A6846
LEU A6848
1.63A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
VAL D4274
LEU B4328
VAL B4361
VAL A6902
1.67A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
MET C 243
LEU C 172
PHE C 173
ILE C 104
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 113
LEU C 117
LEU C 120
LEU C 132
LEU C 150
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 113
LEU A 117
LEU A 120
LEU A 132
LEU A 150
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
MET A 101
ARG A  99
LEU A 103
VAL A 110
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
SER A  46
LEU A  51
THR A  67
ILE A  65
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wcf NSP3
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wcf NSP3
(SARS-CoV-2)		4 / 7
SER A  65
MET A  61
GLY A  46
ILE A 131
1.60A
None
None
MES  A 202 (-4.7A)
MES  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 164
LEU A 160
LEU A 127
SER A 139
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wen NSP3
(SARS-CoV-2)		4 / 7
SER A  80
LEU A  75
GLY A  73
THR A  71
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wen NSP3
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wen NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
VAL A  16
LEU A  12
VAL A 165
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 164
LEU A 160
LEU A 127
SER A 139
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wey NSP3
(SARS-CoV-2)		4 / 8
LEU A 344
VAL A 355
VAL A 359
VAL A 369
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 357
LEU A 368
LEU A 364
LEU A 331
SER A 343
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
VAL A  22
LEU A  20
VAL A  66
VAL B 115
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  95
LEU B 103
ILE A  39
LEU A  55
LEU A  14
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
GLN B  88
LEU B  91
LEU A  20
VAL A  66
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
ILE A  39
LEU A  55
LEU A  56
SER A  57
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 128
ILE B 120
ILE B 106
LEU A  60
SER A  61
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER D 310
PHE C 274
GLY C 284
ILE C 357
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER A 310
PHE B 274
GLY B 284
ILE B 357
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE A 286
LEU B 331
LEU A 339
ILE A 304
LEU A 352
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE B 286
LEU A 331
LEU B 339
ILE B 304
LEU B 352
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER E 310
PHE F 274
GLY F 284
ILE F 357
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER B 310
PHE A 274
GLY A 284
ILE A 357
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE C 286
LEU D 331
LEU C 339
ILE C 304
LEU C 352
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE D 286
LEU C 331
LEU D 339
ILE D 304
LEU D 352
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE F 286
LEU E 331
LEU F 339
ILE F 304
LEU F 352
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER F 310
PHE E 274
GLY E 284
ILE E 357
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER C 310
PHE D 274
GLY D 284
ILE D 357
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE E 286
LEU F 331
LEU E 339
ILE E 304
LEU E 352
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6887
LEU A6893
THR A6846
LEU A6848
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6887
LEU C6893
THR C6846
LEU C6848
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER C6907
LEU C6892
GLY C6890
THR C6889
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.49A
None
FMT  A7107 (-4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU C6857
LEU C7050
LEU C6887
ILE C6926
THR C6846
LEU C6848
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET C6982
ARG C7014
LEU C6959
VAL C6965
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET A6982
ARG A7014
LEU A6959
VAL A6965
1.12A
None
FMT  A7105 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6981
LEU C6959
ILE C6955
ILE C6951
LEU C7004
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
PHE C6985
ILE C6925
ILE C6955
ASN C6975
LEU C6978
LEU C7004
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6959
ILE A6955
ILE A6951
LEU A7004
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7004
ILE A6967
ILE A6951
LEU A6981
PHE A6985
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER C  51
PHE C 110
GLY C  71
THR C 165
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER B  51
PHE B 110
GLY B  71
THR B 165
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER A6907
LEU A6909
GLY A6911
ILE A6951
1.68A
None
None
NA  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER C6907
LEU C6892
GLY C6890
THR C6889
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		4 / 8
MET A6982
ARG A7014
LEU A6959
VAL A6965
1.16A
None
FMT  A7107 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		6 / 12
PHE A6985
ILE A6925
ILE A6955
ASN A6975
LEU A6978
LEU A7004
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6959
ILE A6955
ILE A6951
LEU A7004
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		6 / 12
PHE C6985
ILE C6925
ILE C6955
ASN C6975
LEU C6978
LEU C7004
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		6 / 12
LEU C6857
LEU C7050
LEU C6887
ILE C6926
THR C6846
LEU C6848
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
LEU C6959
ILE C6955
ILE C6951
LEU C7004
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A7004
ILE A6967
ILE A6951
LEU A6981
PHE A6985
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		4 / 8
MET C6982
ARG C7014
LEU C6959
VAL C6965
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6887
LEU A6893
THR A6846
LEU A6848
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6924
LEU C6887
LEU C6893
THR C6846
LEU C6848
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C6924
ILE C7005
LEU C6848
THR C6846
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C6857
LEU C6924
LEU C6848
THR C6846
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU A 249
GLY A 248
THR A 341
ILE A 307
1.32A
None
U5P  A 401 ( 4.5A)
U5P  A 401 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU A 143
GLY A 141
THR A 121
ILE A  80
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU B 143
GLY B 141
THR B 121
ILE B  80
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU B 249
GLY B 248
THR B 341
ILE B 307
1.38A
None
U5P  B 401 ( 4.4A)
U5P  B 401 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
LEU A  73
LEU A  76
ILE A  72
ASN A 178
THR A 145
PHE A 123
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.75A
U5G  A 401 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
LEU A 220
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU C 140
VAL C 151
VAL C 155
VAL C 165
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 164
LEU B 160
LEU B 127
SER B 139
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU D 126
VAL D  16
LEU D  12
VAL D 165
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU D 140
VAL D 151
VAL D 155
VAL D 165
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 164
LEU C 160
LEU C 127
SER C 139
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 164
LEU A 160
LEU A 127
SER A 139
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET A6982
ARG A7014
LEU A6959
VAL A6965
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU A6857
LEU A7050
LEU A6887
ILE A6926
THR A6846
LEU A6848
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
PHE A6985
ILE A6925
ILE A6955
ASN A6975
LEU A6978
LEU A7004
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6907
LEU A6892
GLY A6890
THR A6889
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
LEU A6959
ILE A6955
ILE A6951
LEU A7004
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6855
LEU A6924
ILE A7005
LEU A6848
THR A6846
1.47A
8NK  A7103 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
LEU A6887
LEU A6893
THR A6846
LEU A6848
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
VAL C  22
LEU C  20
VAL C  66
VAL D 115
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 128
ILE D 120
ILE D 106
LEU C  60
SER C  61
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
(SARS-CoV-2)		4 / 8
ARG A  21
VAL A  58
LEU A  59
VAL A  66
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU C  13
VAL C  22
LEU C  20
VAL C  66
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 128
ILE B 120
ILE B 106
LEU A  60
SER A  61
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
GLN B  88
LEU B  91
LEU A  20
VAL A  66
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
VAL A  22
LEU A  20
VAL A  66
VAL B 115
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  95
LEU D 103
ILE C  39
LEU C  55
LEU C  14
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
GLN C  19
VAL C  66
VAL D  83
VAL A  11
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU A  13
VAL A  66
LEU A  71
VAL A  53
1.39A
None
None
None
EDO  B 302 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
GLN D  88
LEU D  91
LEU C  20
VAL C  66
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 122
ILE C  39
LEU C  55
LEU C  56
SER C  57
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
MET C  62
LEU C  60
LEU D  91
VAL C  16
VAL C  58
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
ILE A  39
LEU A  55
LEU A  56
SER A  57
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  95
LEU B 103
ILE A  39
LEU A  55
LEU A  14
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
MET A  62
LEU A  60
LEU B  91
VAL A  16
VAL A  58
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 113
LEU A 117
LEU A 120
LEU A 132
LEU A 150
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.62A15.78
DMS  A 402 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  27
VAL A  36
LEU A  30
VAL A 148
1.50A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  91
VAL A  86
VAL A 148
1.56A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 220
ILE A 281
LEU A 271
LEU A 268
SER A 267
1.57A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.75A15.78
DMS  A 405 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  18
LEU A  27
VAL A  42
1.49A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLN A  19
LEU A  67
VAL A  18
VAL A  77
1.65A15.78
None
DMS  A 402 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 205
ASN A 228
LEU A 227
THR A 226
1.62A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  30
VAL A  86
LEU A  89
VAL A  68
1.76A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  89
VAL A  42
VAL A  18
VAL A  91
1.76A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A 148
VAL A  18
VAL A  35
1.53A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
LEU A 205
ILE A 200
ASN A 231
THR A 243
1.76A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 205
LEU A 250
ILE A 259
THR A 225
1.64A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLN A 244
LEU A 262
VAL A 261
VAL A 202
1.70A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 177
VAL A  13
VAL A  36
VAL A  86
1.59A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 122
ILE C  39
LEU C  55
LEU C  56
SER C  57
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU C  60
LEU D  91
VAL C  16
VAL C  58
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
GLN D  88
LEU D  91
LEU C  20
VAL C  66
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B  95
LEU B 103
ILE A  39
LEU A  55
LEU A  14
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 128
ILE B 120
ILE B 106
LEU A  60
SER A  61
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
MET C  62
LEU C  60
LEU D  91
VAL C  16
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
VAL A  22
LEU A  20
VAL A  66
VAL B 115
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
VAL C  22
LEU C  20
VAL C  66
VAL D 115
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D  95
LEU D 103
ILE C  39
LEU C  55
LEU C  14
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 122
ILE A  39
LEU A  55
LEU A  56
SER A  57
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 128
ILE D 120
ILE D 106
LEU C  60
SER C  61
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU A  60
LEU B  91
VAL A  16
VAL A  58
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 140
GLY A 135
THR A  14
ILE A 117
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER E 514
PHE E 429
GLY E 381
THR H 104
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
GLY E 431
THR E 430
ILE L  34
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER A 514
PHE A 429
GLY A 381
THR B 104
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER E 514
PHE E 429
GLY E 381
THR H 104
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
GLY E 431
THR E 430
ILE L  34
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A 139
LEU A 141
PHE A 140
GLY A 143
1.24A
None
None
None
P6N  A 502 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE A 377
GLY A 431
THR A 430
ILE C  34
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER A 514
PHE A 429
GLY A 381
THR B 104
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
PHE E 377
GLY E 431
THR E 430
ILE L  34
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER E 514
PHE E 429
GLY E 381
THR H 104
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.73A
DMS  A 403 ( 2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 140
VAL C 151
VAL C 155
VAL C 165
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E 140
VAL E 151
VAL E 155
VAL E 165
1.28A
None
None
EDO  E 205 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
SER D  65
MET D  61
GLY D  46
ILE D 131
1.62A
None
None
EDO  D 206 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
VAL E 155
LEU E 153
VAL E  16
VAL E 142
1.46A
EDO  E 205 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E 109
LEU E 153
VAL E 151
VAL E  95
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 164
LEU C 160
LEU C 127
SER C 139
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 153
LEU E 164
LEU E 160
LEU E 127
SER E 139
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 164
LEU B 160
LEU B 127
SER B 139
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU D 140
VAL D 151
VAL D 155
VAL D 165
1.25A
None
None
EDO  D 208 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 164
LEU A 160
LEU A 127
SER A 139
1.36A
None
None
None
EDO  A 202 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
LEU D 164
LEU D 160
LEU D 127
SER D 139
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 140
VAL C 151
VAL C 155
VAL C 165
1.27A
None
None
APR  C 201 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 164
LEU B 160
LEU B 127
SER B 139
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E 140
VAL E 151
VAL E 155
VAL E 165
1.31A
None
None
APR  E 201 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU D 140
VAL D 151
VAL D 155
VAL D 165
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 126
VAL B  16
LEU B  12
VAL B 165
1.46A
APR  B 201 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.25A
None
None
APR  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ARG C 141
LEU C 140
VAL C 155
VAL C 151
1.45A
None
None
APR  C 201 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 126
VAL C  16
LEU C  12
VAL C 165
1.45A
APR  C 201 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E 109
LEU E 153
VAL E 151
VAL E  95
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A 140
VAL A 151
VAL A 155
VAL A 165
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 164
LEU C 160
LEU C 127
SER C 139
1.38A
None
None
EDO  C 203 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 140
VAL C 151
VAL C 155
VAL C 165
1.28A
None
None
EDO  C 206 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
SER B  65
MET B  61
GLY B  46
ILE B 131
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 164
LEU B 160
LEU B 127
SER B 139
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 140
VAL B 151
VAL B 155
VAL B 165
1.22A
None
None
EDO  B 202 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		6 / 12
LEU A 220
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
SER A 144
PHE A 140
GLY A 170
THR A 169
1.74A
PJE  C   5 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 208
LEU A 287
ASN A 274
SER A 267
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		4 / 7
SER A 518
MET A 519
PHE A 368
ILE A 539
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A   8
PHE A   7
GLY A  23
THR A  28
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  60
LEU D  91
VAL C  16
VAL C  58
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		4 / 7
SER A 754
GLY A 584
THR A 582
ILE A 579
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 671
ILE B 185
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
LEU A 142
LEU A 247
THR A 248
LEU A 172
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
LEU A 241
ILE A 244
LEU A 212
THR A 123
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLN A 789
LEU A 469
VAL A 472
VAL A 693
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 128
ILE D 120
ILE D 106
LEU C  60
SER C  61
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		4 / 7
SER A 607
GLY A 584
THR A 582
ILE A 579
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  95
LEU D 103
ILE C  39
LEU C  55
LEU C  14
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 186
ILE A 244
LEU A 127
THR A 123
LEU A 207
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  67
LEU A  27
VAL A  42
VAL A  77
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		6 / 12
LEU A 220
ILE A 281
ASN A 274
LEU A 271
LEU A 268
SER A 267
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
SER A  46
MET A  49
GLY A  23
THR A  21
1.54A
None
JRY  A 401 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
SER A  62
PHE A  66
GLY A  23
THR A  24
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  32
VAL A  18
VAL A 148
VAL A 157
1.12A
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 8
MET C  62
LEU C  60
LEU D  91
VAL C  16
VAL C  58
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLN A 210
LEU A 207
VAL A 182
LEU A 186
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
LEU A 142
LEU A 247
THR A 248
LEU A 172
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
ILE B 119
ILE B 120
ASN B 104
LEU B 103
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
LEU A 241
ILE A 244
LEU A 212
THR A 123
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 518
MET A 519
PHE A 368
ILE A 539
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 754
GLY A 584
THR A 582
ILE A 579
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 607
GLY A 584
THR A 582
ILE A 579
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLN A 789
LEU A 469
VAL A 472
VAL A 693
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 670
ILE B 185
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 671
ILE B 185
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 670
ILE B 185
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 891
ILE A 856
ASN A 911
THR A 908
LEU A 885
1.41A
None
None
U  T  17 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 673
PHE A 504
GLY A 671
ILE B 185
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 607
GLY A 584
THR A 582
ILE A 579
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
LEU A 241
ILE A 244
LEU A 212
THR A 123
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 754
GLY A 584
THR A 582
ILE A 579
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
GLN A 789
LEU A 469
VAL A 472
VAL A 693
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 891
GLY A 852
THR A 850
ILE A 847
1.71A
None
None
None
U  P  17 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 146
LEU A 142
LEU A 247
THR A 248
LEU A 172
1.26A
None