Ligand ID: TKT


Drugbank ID:
DB11699
(Tropisetron)


Indication:
For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.

Get human targets for TKT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TKT' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP B 467
ILE B 468
ARG B 454
ASN B 354
1.51A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 8
ASP F 467
ILE F 468
ARG F 454
ASN F 354
1.47A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B  83
ILE B 147
TRP B  53
ASN B 155
1.32A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.61A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.61A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.61A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.61A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASN A 791
TYR A 458
ASP A 170
ILE A 171
1.61A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP C 994
ILE C 997
ARG B 995
TYR A 756
1.55A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.43A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.55A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP D  82
ILE D 146
TRP D  52
ASN D 154
1.19A13.23
 ZN  D 201 ( 2.4A)
MES  C 204 ( 4.7A)
MES  C 204 (-3.6A)
MES  C 204 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ASN C 354
ASP C 467
ILE C 468
ARG C 454
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
ASP C 467
ILE C 468
ARG C 454
ASN C 354
1.54A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASN B 154
ASP B  82
ILE B 146
TRP B  52
1.25A13.23
MES  B 201 (-3.2A)
ZN  B 202 (-2.3A)
MES  B 201 ( 4.6A)
MES  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP D  82
ILE D 146
TRP D  52
ASN D 154
1.33A13.23
 ZN  D 202 (-2.7A)
MES  D 201 ( 4.4A)
MES  D 201 (-3.5A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP D  82
ILE D 146
TRP D  52
ASN D 154
1.34A13.23
 ZN  D 202 (-2.7A)
MES  D 201 ( 4.4A)
MES  D 201 (-3.5A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASN D 154
ASP D  82
ILE D 146
TRP D  52
1.34A13.23
MES  D 201 (-3.8A)
ZN  D 202 (-2.7A)
MES  D 201 ( 4.4A)
MES  D 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP D  82
ILE D 146
TRP D  52
ASN D 154
1.33A13.23
 ZN  D 202 (-2.7A)
MES  D 201 ( 4.4A)
MES  D 201 (-3.5A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B  82
ILE B 146
TRP B  52
ASN B 154
1.23A13.23
 ZN  B 202 (-2.3A)
MES  B 201 ( 4.6A)
MES  B 201 (-3.6A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B  82
ILE B 146
TRP B  52
ASN B 154
1.24A13.23
 ZN  B 202 (-2.3A)
MES  B 201 ( 4.6A)
MES  B 201 (-3.6A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP D  82
ILE D 146
TRP D  52
ASN D 154
1.32A13.23
 ZN  D 202 (-2.7A)
MES  D 201 ( 4.4A)
MES  D 201 (-3.5A)
MES  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B  82
ILE B 146
TRP B  52
ASN B 154
1.25A13.23
 ZN  B 202 (-2.3A)
MES  B 201 ( 4.6A)
MES  B 201 (-3.6A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
ASP B  82
ILE B 146
TRP B  52
ASN B 154
1.25A13.23
 ZN  B 202 (-2.3A)
MES  B 201 ( 4.6A)
MES  B 201 (-3.6A)
MES  B 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A  23
ILE A  91
ARG A  49
TYR A  69
1.58A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A  23
ILE A  91
ARG A  49
TYR A  69
1.57A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A  42
ILE A 106
TRP A  12
ASN A 114
1.78A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A  23
ILE A  91
ARG A  49
TYR A  69
1.58A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A  69
ASP A  23
ILE A  91
ARG A  49
1.58A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A  23
ILE A  91
ARG A  49
TYR A  69
1.58A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.56A16.11
None
None
None
DMS  E 905 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.56A16.11
None
None
None
DMS  E 905 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.52A16.11
None
None
None
PG0  A 902 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.52A16.11
None
None
None
PG0  A 902 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.56A16.11
None
None
None
DMS  E 905 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.56A16.11
None
None
None
DMS  E 905 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN E 354
ASP E 467
ILE E 468
ARG E 454
1.56A16.11
DMS  E 905 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.52A16.11
None
None
None
PG0  A 902 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A 354
ASP A 467
ILE A 468
ARG A 454
1.52A16.11
PG0  A 902 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.52A16.11
None
None
None
PG0  A 902 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN E 354
ASP E 467
ILE E 468
ARG E 454
1.57A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.55A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.56A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN E 354
ASP E 467
ILE E 468
ARG E 454
1.56A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.56A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.56A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 467
ILE A 468
ARG A 454
ASN A 354
1.55A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASN A 354
ASP A 467
ILE A 468
ARG A 454
1.56A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP E 467
ILE E 468
ARG E 454
ASN E 354
1.57A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASN A 791
TYR A 458
ASP A 170
ILE A 171
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.70A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASN A 791
TYR A 458
ASP A 170
ILE A 171
1.70A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.70A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.70A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.71A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.70A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.71A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.71A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASN A 791
TYR A 458
ASP A 170
ILE A 171
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ASN A 791
TYR A 458
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ARG A 173
TRP A 162
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TRP A 162
ASP A 170
ILE A 171
ARG A 173
1.71A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
ARG A 173
TRP A 162
1.72A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 170
ILE A 171
TRP A 162
ARG A 173
1.73A17.60
None