Ligand ID: SRE


Drugbank ID:
DB01104
(Sertraline)


Indication:
For the management of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD) with or without agoraphobia, premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD) [FDA Label].

Get human targets for SRE in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SRE' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.67A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.62A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.60A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.60A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 242
PHE A 230
LEU A 272
THR A 198
1.63A16.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.69A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.64A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 9
ALA C 972
ILE C 973
PHE A 970
PHE C 970
GLY C 971
1.68A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 9
ALA C 972
ILE C 973
PHE A 970
PHE C 970
GLY C 971
1.68A12.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.74A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.69A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 263
VAL A 212
ALA A 210
TYR A 209
PHE A 219
1.78A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 176
PRO A 132
ALA A 129
GLY A 183
PHE A 134
1.77A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA B 435
ILE B 434
PHE B 338
PHE B 342
SER B 371
1.60A17.15
None
None
None
NAG  B 601 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA B 435
ILE B 434
PHE B 338
PHE B 342
SER B 371
1.61A17.15
None
None
None
NAG  B 601 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.66A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.72A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR B 161
ASP B 176
ILE B 106
PHE B 134
GLY B 149
1.78A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR A 161
ASP A 176
ILE A 106
PHE A 134
GLY A 149
1.76A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
ASP C 289
PRO C 241
ALA C 234
TYR C 239
GLY C 109
1.78A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR A 161
ASP A 176
ILE A 106
PHE A 134
GLY A 149
1.76A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR B 161
ASP B 176
ILE B 106
PHE B 134
GLY B 149
1.78A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 9
ASP D 289
PRO D 241
ALA D 234
TYR D 239
GLY D 109
1.80A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.68A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.73A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR A 161
ASP A 176
ILE A 106
PHE A 134
GLY A 149
1.68A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 9
TYR A 161
ASP A 176
ILE A 106
PHE A 134
GLY A 149
1.68A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.26A17.41

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.53A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 250
LEU A 186
MET A 463
LEU A 241
1.45A15.59

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.51A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 207
LEU A 241
ALA A 185
LEU A 212
ASP A 211
1.70A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE C  68
VAL C  53
LEU C  56
LEU C  60
LEU D 103
1.66A17.41

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ILE A 145
LEU A 131
LEU A 142
LEU A 178
LEU A 247
1.59A15.59

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.46A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 107
VAL C  16
LEU C  71
LEU C  60
LEU C  59
1.53A17.96

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 185
LEU A 178
LEU A 127
LEU A 247
1.68A15.59

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.55A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
LEU A 575
TYR A 689
PHE A 480
THR A 591
1.71A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ILE A 562
ALA B  81
LEU A 514
MET B  87
LEU A 372
1.62A15.59

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
VAL A 472
LEU A 469
LEU A 630
LEU A 636
1.50A15.59

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.65A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
LEU A 371
PHE B  92
ALA A 375
THR B  93
1.79A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 178
ARG A 183
GLN A 184
ALA A 185
LEU A 241
1.75A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ASP B  53
VAL B  36
ALA B 222
TYR B  37
PHE B 275
1.50A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 922
GLN B 920
TYR B1067
PHE B 906
ALA B 924
1.42A17.46
NAG  B1307 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 371
1.64A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ASP B  53
VAL B  36
ALA B 222
TYR B  37
PHE B 275
1.41A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 371
1.64A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE A 742
ALA A 989
LEU A 977
LEU A 996
LEU A 753
1.33A12.97
9.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vxs NSP3
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.68A
None
SO4  A 203 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL A  16
LEU A 140
LEU A 126
TYR A   9
LEU A  12
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.48A
SO4  B 204 (-3.7A)
None
None
None
SO4  B 204 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B  16
LEU B 140
LEU B 126
TYR B   9
LEU B  12
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA C 575
ILE C 584
GLY A 283
PHE A  43
GLY C 566
1.63A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA C 575
ILE C 584
GLY A 283
PHE A  43
GLY C 566
1.63A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 922
GLN C 920
TYR C1067
PHE C 906
ALA C 924
1.35A17.95
NAG  C1313 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE C 742
ALA C 989
LEU C 977
LEU C 996
LEU C 753
1.28A13.81
9.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ILE C 742
ALA C 989
LEU C 977
LEU C 996
LEU C 753
1.24A13.81
9.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA B 575
ILE B 584
GLY C 283
PHE C  43
GLY B 566
1.58A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA B 575
ILE B 584
GLY C 283
PHE C  43
GLY B 566
1.58A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 922
GLN C 920
TYR C1067
PHE C 906
ALA C 924
1.38A17.95
NAG  C1311 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ASP C  40
VAL C  47
TYR C 279
GLY B 566
GLY C 283
1.38A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6w02 NSP3
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.64A15.64
None
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w02 NSP3
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.67A21.92
21.99
None
APR  B 201 ( 4.8A)
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6w02 NSP3
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.67A15.45
None
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 9
ALA C 435
ILE C 434
PHE C 338
PHE C 342
SER C 371
1.45A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 9
ILE C 434
PHE C 338
GLY C 339
PHE C 342
SER C 371
1.48A15.85
None
None
NAG  C 601 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 9
ALA C 435
ILE C 434
PHE C 338
PHE C 342
SER C 371
1.46A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 9
ILE C 434
PHE C 338
GLY C 339
PHE C 342
SER C 371
1.49A15.85
None
None
NAG  C 601 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w4b NSP9
(SARS-CoV-2)		5 / 12
LEU A  89
LEU A  46
ALA A  31
LEU A  43
THR A  68
1.56A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6859
ALA A6858
LEU A7050
LEU A6852
LEU A6883
1.67A17.88
22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
VAL A6965
ALA A6966
LEU A6857
LEU A6959
1.55A17.88
22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7065
ALA A7056
LEU A7060
LEU A7070
LEU A7072
1.62A17.88
22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6881
LEU A6893
TYR A6845
LEU A6924
LEU A6887
1.74A17.88
22.22
None
None
SAM  A7104 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
ALA A6966
LEU A6924
LEU A6959
LEU A6857
1.61A17.88
22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6858
LEU A7050
LEU A6852
LEU A6883
LEU A6887
1.79A17.88
22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w6y NSP3
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.67A19.03
21.35
None
AMP  A 201 ( 4.4A)
AMP  A 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.56A
None
None
None
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.55A
None
None
None
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w6y NSP3
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.76A19.03
21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
VAL C6859
ALA C6858
LEU C7050
LEU C6852
LEU C6883
1.66A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE A7079
VAL A6965
ALA A6966
LEU A6857
LEU A6959
1.54A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
VAL A6859
ALA A6858
LEU A7050
LEU A6852
LEU A6883
1.66A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE C7079
ALA C6966
LEU C6924
LEU C6959
LEU C6857
1.62A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA A6858
LEU A7050
LEU A6852
LEU A6883
LEU A6887
1.78A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA C6881
LEU C6893
TYR C6845
LEU C6924
LEU C6887
1.73A19.37
24.18
None
None
SAM  C7105 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE C7079
VAL C6965
ALA C6966
LEU C6857
LEU C6959
1.53A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE A7065
ARG A7077
LEU A7078
LEU A7072
LEU A7060
1.69A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA A6881
LEU A6893
TYR A6845
LEU A6924
LEU A6887
1.74A19.37
24.18
None
None
SAM  A7102 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ARG C6884
VAL C6894
ALA C6905
LEU C6892
LEU A7093
1.51A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ARG A6884
VAL A6894
ALA A6905
LEU A6892
LEU C7093
1.52A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE A7065
ALA A7056
LEU A7060
LEU A7070
LEU A7072
1.73A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA C6858
LEU C7050
LEU C6852
LEU C6883
LEU C6887
1.79A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ILE A7079
ALA A6966
LEU A6924
LEU A6959
LEU A6857
1.62A19.37
24.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 120
LEU A 172
PHE A 173
ASP A 302
THR A 301
1.79A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 132
GLN C 174
ALA C 176
PHE C 127
LEU C 120
1.67A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 150
TYR A  71
ALA A 153
LEU A  80
THR A  75
1.74A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 132
GLN A 174
ALA A 176
PHE A 127
LEU A 120
1.71A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 150
TYR B  71
ALA B 153
LEU B  80
THR B  75
1.72A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 132
LEU A 150
ALA A 149
LEU A 113
THR A 102
1.69A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA A 135
LEU A 120
LEU A 172
LEU A 113
LEU A 117
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 132
LEU A 150
ALA A 139
PHE A 147
LEU A 120
1.79A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 120
LEU B 172
PHE B 173
ASP B 302
THR B 301
1.76A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  88
LEU A  45
ALA A  30
LEU A  42
THR A  67
1.66A13.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  42
ALA A  43
PHE A  90
LEU A 103
THR A 109
1.77A13.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.58A
None
None
None
MES  A 201 (-3.2A)
MES  A 201 (-2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.59A
None
None
None
MES  A 201 (-3.2A)
MES  A 201 (-2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wcf NSP3
(SARS-CoV-2)		5 / 10
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wen NSP3
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wey NSP3
(SARS-CoV-2)		6 / 10
ILE A 341
VAL A 359
ALA A 358
LEU A 368
LEU A 344
LEU A 364
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 107
VAL A  16
LEU A  71
LEU A  60
LEU A  59
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL A  16
LEU A  13
LEU B  95
LEU A  60
LEU A  59
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 106
VAL A  16
LEU B  95
LEU A  60
LEU A  59
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wiq NSP7
(SARS-CoV-2)		5 / 10
VAL A  58
LEU A  55
LEU A  35
LEU A  14
LEU A  17
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
ALA A6966
LEU A6924
LEU A6959
LEU A6857
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL C6859
ALA C6858
LEU C7050
LEU C6852
LEU C6883
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
VAL A6965
ALA A6966
LEU A6857
LEU A6959
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6859
ALA A6858
LEU A7050
LEU A6852
LEU A6883
1.65A
None
None
FMT  A7107 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE C7079
ALA C6966
LEU C6924
LEU C6959
LEU C6857
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE C7079
VAL C6965
ALA C6966
LEU C6857
LEU C6959
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE A7079
ALA A6966
LEU A6924
LEU A6959
LEU A6857
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE A7079
VAL A6965
ALA A6966
LEU A6857
LEU A6959
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE C7079
VAL C6965
ALA C6966
LEU C6857
LEU C6959
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ILE C7079
ALA C6966
LEU C6924
LEU C6959
LEU C6857
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
VAL C6859
ALA C6858
LEU C7050
LEU C6852
LEU C6883
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wkq NSP16
(SARS-CoV-2)		5 / 10
VAL A6859
ALA A6858
LEU A7050
LEU A6852
LEU A6883
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 176
PRO A 132
ALA A 129
GLY A 183
PHE A 134
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.69A
None
None
None
APR  B 201 (-3.3A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.67A
None
None
None
APR  B 201 (-3.3A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.66A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 10
ILE C 137
VAL C 155
ALA C 154
LEU C 164
LEU C 140
LEU C 160
1.63A
None
None
APR  C 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.63A
None
None
None
APR  C 201 (-3.0A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO D  98
VAL D  96
ALA D 112
GLY D 130
PHE D 132
1.68A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO D  98
VAL D  96
ALA D 112
GLY D 130
PHE D 132
1.66A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.66A
None
None
APR  A 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.66A
None
None
APR  B 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.67A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 10
ILE D 137
VAL D 155
ALA D 154
LEU D 164
LEU D 140
LEU D 160
1.67A
None
None
APR  D 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  16
LEU D 140
LEU D 126
TYR D   9
LEU D  12
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.66A
None
None
None
APR  C 201 (-3.0A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
ALA A6966
LEU A6924
LEU A6959
LEU A6857
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ILE A7079
VAL A6965
ALA A6966
LEU A6857
LEU A6959
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6859
ALA A6858
LEU A7050
LEU A6852
LEU A6883
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL A  16
LEU A  13
LEU B  95
LEU A  60
LEU A  59
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 106
VAL C  66
ALA C  65
LEU C  71
LEU C  56
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL C  66
ALA C  65
LEU C  71
LEU C  60
LEU D  95
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 106
VAL A  66
LEU A  60
LEU A  56
LEU A  71
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 107
LEU B  91
MET A  52
LEU B 103
LEU B  98
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 106
VAL A  16
LEU B  95
LEU A  60
LEU A  59
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 106
VAL C  16
LEU D  95
LEU C  60
LEU C  59
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
(SARS-CoV-2)		5 / 10
VAL C  58
LEU C  55
LEU C  35
LEU C  14
LEU C  17
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
(SARS-CoV-2)		5 / 10
VAL A  58
LEU A  55
LEU A  35
LEU A  14
LEU A  17
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE B 106
VAL A  66
ALA A  65
LEU A  71
LEU A  56
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 9
ASP A  37
PRO A  33
VAL A  57
TYR A  56
GLY A  81
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 125
LEU A 120
GLN A 122
PHE A 241
ASP A 302
1.73A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 150
GLN A 174
ALA A 176
PHE A 127
LEU A 120
1.33A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.72A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.67A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL A  66
LEU B  91
LEU B  95
LEU A  55
LEU A  59
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
ILE B 106
VAL A  16
LEU B  95
LEU A  60
LEU A  59
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
ILE D 106
VAL C  16
LEU D  95
LEU C  60
LEU C  59
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL A  58
LEU A  55
LEU A  35
LEU A  14
LEU A  17
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL A  16
LEU A  13
LEU B  95
LEU A  60
LEU A  59
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL C  66
ALA C  65
LEU C  71
LEU C  60
LEU D  95
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 10
VAL C  58
LEU C  55
LEU C  35
LEU C  14
LEU C  17
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA E 435
ILE E 434
PHE E 338
GLY E 339
PHE E 342
SER E 371
1.79A16.70
None
None
None
NAG  E 907 ( 4.0A)
None
DMS  E 901 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 371
1.67A16.70
None
None
None
None
DMS  A 901 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 373
1.79A16.70
None
None
None
None
DMS  A 901 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.77A16.70
None
None
None
None
DMS  E 901 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 371
1.66A16.70
None
None
None
None
DMS  A 901 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA E 435
ILE E 434
PHE E 338
GLY E 339
PHE E 342
SER E 371
1.79A16.70
None
None
None
NAG  E 907 ( 4.0A)
None
DMS  E 901 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.76A16.70
None
None
None
None
DMS  E 901 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ILE A 434
PHE A 338
GLY A 339
PHE A 342
SER A 371
1.73A16.70
None
None
NAG  A 904 ( 3.7A)
None
DMS  A 901 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 373
1.78A16.70
None
None
None
None
DMS  A 901 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ILE A 434
PHE A 338
GLY A 339
PHE A 342
SER A 371
1.74A16.70
None
None
NAG  A 904 ( 3.7A)
None
DMS  A 901 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.77A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.78A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA E 435
ILE E 434
PHE E 338
GLY E 339
PHE E 342
SER E 371
1.80A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 205
LEU A 242
PHE A 230
LEU A 272
THR A 198
1.64A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.77A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 373
1.75A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA A 435
ILE A 434
PHE A 338
PHE A 342
SER A 373
1.76A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
ALA E 435
ILE E 434
PHE E 338
PHE E 342
SER E 373
1.77A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA A 435
ILE A 434
PHE A 338
GLY A 339
PHE A 342
SER A 371
1.78A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA A 435
ILE A 434
PHE A 338
GLY A 339
PHE A 342
SER A 371
1.79A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 9
ALA E 435
ILE E 434
PHE E 338
GLY E 339
PHE E 342
SER E 371
1.79A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.46A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.74A
None
None
None
PEG  A 404 (-3.8A)
PEG  A 405 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.46A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.70A
None
None
None
PEG  A 404 (-3.8A)
PEG  A 405 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE E 137
VAL E 155
ALA E 154
LEU E 164
LEU E 140
LEU E 160
1.70A
None
EDO  E 205 ( 4.2A)
EDO  E 205 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE D 137
VAL D 155
ALA D 154
LEU D 164
LEU D 140
LEU D 160
1.66A
None
EDO  D 208 ( 4.2A)
EDO  D 208 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE C 137
VAL C 155
ALA C 154
LEU C 164
LEU C 140
LEU C 160
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.68A
None
None
None
APR  B 201 (-3.2A)
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.67A
None
None
APR  B 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.67A
None
APR  A 201 ( 4.8A)
APR  A 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO B  98
VAL B  96
ALA B 112
GLY B 130
PHE B 132
1.71A
None
None
None
APR  B 201 (-3.2A)
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO E  98
VAL E  96
ALA E 112
GLY E 130
PHE E 132
1.64A
None
None
None
APR  E 201 (-3.2A)
APR  E 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE E 137
VAL E 155
ALA E 154
LEU E 164
LEU E 140
LEU E 160
1.71A
None
APR  E 201 ( 4.9A)
APR  E 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.70A
None
None
None
APR  A 201 ( 3.2A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.66A
None
None
None
APR  C 201 (-3.2A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE D 137
VAL D 155
ALA D 154
LEU D 164
LEU D 140
LEU D 160
1.70A
None
None
APR  D 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.67A
None
None
None
APR  A 201 ( 3.2A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO D  98
VAL D  96
ALA D 112
GLY D 130
PHE D 132
1.68A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.69A
None
None
None
APR  C 201 (-3.2A)
APR  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE C 137
VAL C 155
ALA C 154
LEU C 164
LEU C 140
LEU C 160
1.69A
None
APR  C 201 ( 4.9A)
APR  C 201 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO D  98
VAL D  96
ALA D 112
GLY D 130
PHE D 132
1.66A
None
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO E  98
VAL E  96
ALA E 112
GLY E 130
PHE E 132
1.67A
None
None
None
APR  E 201 (-3.2A)
APR  E 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.59A
None
None
None
MES  A 201 (-3.1A)
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE C 137
VAL C 155
ALA C 154
LEU C 164
LEU C 140
LEU C 160
1.68A
None
EDO  C 206 ( 4.2A)
EDO  C 206 (-4.4A)
None
None
EDO  C 203 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE B 137
VAL B 155
ALA B 154
LEU B 164
LEU B 140
LEU B 160
1.66A
None
EDO  B 202 (-4.0A)
EDO  B 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 10
ILE A 137
VAL A 155
ALA A 154
LEU A 164
LEU A 140
LEU A 160
1.66A
EDO  A 206 (-4.6A)
None
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO A  98
VAL A  96
ALA A 112
GLY A 130
PHE A 132
1.58A
None
None
None
MES  A 201 (-3.1A)
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.61A
None
None
None
MES  C 201 (-3.3A)
MES  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PRO C  98
VAL C  96
ALA C 112
GLY C 130
PHE C 132
1.63A
None
None
None
MES  C 201 (-3.3A)
MES  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
LEU A 371
PHE B  92
ALA A 375
THR B  93
1.75A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 244
LEU A 241
LEU A 245
LEU A 127
LEU A 207
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 145
LEU A 131
LEU A 142
LEU A 178
LEU A 247
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
VAL A 472
LEU A 469
LEU A 630
LEU A 636
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
ILE A 562
ALA B  81
LEU A 514
MET B  87
LEU A 372
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 661
TYR A 374
PHE A 506
LEU A 372
THR A 531
1.77A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
LEU A 575
TYR A 689
PHE A 480
THR A 591
1.69A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ILE A 145
LEU A 142
LEU A 146
LEU A 127
LEU A 131
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 207
LEU A 241
ALA A 185
LEU A 212
ASP A 211
1.65A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 250
LEU A 127
LEU A 131
LEU A 146
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP7
(SARS-CoV-2)		5 / 10
VAL C  58
LEU C  55
LEU C  35
LEU C  14
LEU C  17
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 106
VAL C  16
LEU D  95
LEU C  60
LEU C  59
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 638
LEU A 575
GLN A 573
ASP A 684
THR A 565
1.69A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.63A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 9
ASP A 176
PRO A 132
ALA A 129
GLY A 183
PHE A 134
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
VAL A 472
LEU A 469
LEU A 630
LEU A 636
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 119
ALA A 443
LEU C  35
LEU C  55
LEU C  28
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 9
ASP C   5
VAL A 424
ALA A 423
TYR A 420
SER C   4
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 10
ILE D 119
ALA C  48
LEU C  35
LEU D 122
LEU C  55
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
ALA A  34
PHE A  45
LEU A 207
ASP A 208
1.67A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.60A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 250
LEU A 127
LEU A 131
LEU A 146
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ILE A 562
ALA B  81
LEU A 514
MET B  87
LEU A 372
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 661
TYR A 374
PHE A 506
LEU A 372
THR A 531
1.72A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 250
LEU A 186
MET A 463
LEU A 241
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
LEU A 575
TYR A 689
PHE A 480
THR A 591
1.69A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ILE A 562
ALA B  81
LEU A 514
MET B  87
LEU A 372
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
VAL A 704
ALA A 702
LEU A 749
LEU A 723
LEU A 727
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 122
LEU A 387
PHE A 396
ALA A 399
LEU B 117
1.60A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ILE A 145
LEU A 131
LEU A 142
LEU A 178
LEU A 247
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASP A 274
PRO A 328
TYR A 273
GLY A 352
GLY A 345
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ILE A 632
VAL A 472
LEU A 469
LEU A 630
LEU A 636
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP7
(SARS-CoV-2)		5 / 10
VAL C  58
LEU C  55
LEU C  35
LEU C  14
LEU C  17
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
ALA A 250
LEU A 127
LEU A 131
LEU A 146
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 707
LEU A 727
GLN A 468
PHE A 745
LEU A 749
1.67A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
LEU A 575
TYR A 689
PHE A 480
THR A 591
1.68A20.33
None
None
U  T  12 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 661
TYR A 374
PHE A 506
LEU A 372
THR A 531
1.76A20.33
None