Ligand ID: SC2


Drugbank ID:
DB06151
(Acetylcysteine)


Indication:
Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.

Get human targets for SC2 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SC2' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.32A23.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.38A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.72A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  87
SER A  81
LEU A  58
GLU A  55
1.56A23.32
None
K1Y  A 404 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
LEU A 984
SER A 982
ASP A 979
GLU C 988
1.25A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6lxt SPIKE PROTEIN S2,
SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
LEU C 984
SER C 982
ASP C 979
GLU B 988
1.46A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
LEU D 984
SER D 982
ASP D 979
GLU F 988
1.27A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.58A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.39A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D 205
SER D 267
LEU D 208
ASP D 263
1.69A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER B 267
LEU B 271
LEU B 208
ASP B 263
1.61A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER C 267
LEU C 271
LEU C 208
ASP C 263
1.55A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER B 267
LEU B 268
LEU B 205
ASP B 263
1.64A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D 268
SER D 267
LEU D 208
ASP D 263
1.26A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.58A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 268
LEU A 205
ASP A 263
1.66A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.40A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.74A23.15

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 6
ASP B  64
ARG B  90
ASP B 104
THR B  92
ASP B 129
1.71A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 241
SER A 236
LEU A 207
ASP A 235
1.64A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 187
ASP A 260
ARG A 285
GLU A 254
1.32A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 236
LEU A 207
SER A 239
ASP A 465
1.71A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 575
LEU A 638
ASP A 477
ASP A 481
1.67A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 236
LEU A 207
SER A 239
ASP A 465
1.70A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
SER A 236
LEU A 207
ASP A 235
1.68A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  25
LEU C  28
SER C  26
ASP B 161
1.54A19.90

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 576
SER A 578
LEU A 575
ASP A 484
1.71A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 207
SER A 239
LEU A 240
ASP A 235
1.71A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 470
ASP A 736
ASP A 738
ARG A 305
1.65A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 885
LEU A 907
ASP A 910
ARG A 889
1.72A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 673
SER A 672
LEU A 401
ASP A 390
1.36A13.52

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 221
ASP A  36
THR A 206
ASP A 218
1.63A13.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLY B 744
LEU B 977
SER B 746
LEU B 981
ASP B 745
1.71A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 8
LEU B 977
SER B 975
LEU B 996
ASP A 571
ARG B1000
1.76A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ARG B 995
ASP B 994
THR B 998
ASP C 994
1.38A11.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 258
SER A 242
LEU A 249
GLY A 247
1.55A19.78
 MG  A 403 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6vxs NSP3
(SARS-CoV-2)		4 / 6
SER B  65
LEU B  83
ASP B  67
ASP B  66
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6vxs NSP3
(SARS-CoV-2)		4 / 8
SER B  65
LEU B  83
ASP B  67
ASP B  66
1.40A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
LEU C 977
SER C 975
LEU C 996
ASP B 571
1.37A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER B 813
ASP B 820
ASP B 808
GLU B 819
1.49A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER B 974
SER B 975
LEU B 996
ASP A 571
THR A 572
1.67A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 8
LEU A 977
SER A 975
LEU A 996
ASP C 571
ARG A1000
1.66A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER A 813
ASP A 820
ASP A 808
GLU A 819
1.57A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER A 974
SER A 975
LEU A 996
ASP C 571
THR C 572
1.77A10.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
ASP A  63
ARG A  89
ASP A 103
ASP A 128
1.30A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
SER A 242
LEU A 249
GLY A 247
ARG A 258
1.74A19.78
None
None
CIT  A 412 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER C 383
SER H  96
ASP H 101
GLU L  55
1.35A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 6
SER C 383
SER H  96
ASP H 101
GLU L  55
1.43A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w4h NSP16
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.98A20.83
6.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w4h NSP16
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.37A21.24
SAM  A7102 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w4h NSP16
(SARS-CoV-2)		4 / 6
SER A7074
LEU A7073
SER A7071
ASP A7067
1.47A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.98A19.12
7.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.76A19.33
None
None
SAM  A7104 (-4.4A)
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w61 NSP10
(SARS-CoV-2)		3 / 3
VAL B4372
GLN B4385
CYH B4381
1.46A19.91
6.40
 ZN  B4402 ( 4.8A)
None
ZN  B4402 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.80A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.41A19.33
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.44A19.33
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7074
LEU A7073
SER A7071
ASP A7067
1.40A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A7010
SER A7071
LEU A7073
ASP A7067
1.65A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
1.05A19.12
7.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w6y NSP3
(SARS-CoV-2)		4 / 6
SER B 128
SER B 111
LEU B 108
GLY B  78
1.62A21.00
MES  B 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.40A19.48
SAM  C7105 ( 3.5A)
None
None
NA  C7104 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A7071
LEU A7072
SER A7074
ARG A7077
1.69A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.59A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A7090
LEU A6909
SER A7089
ASP C7091
1.70A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.71A19.48
None
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.71A19.48
None
None
SAM  C7105 ( 4.4A)
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.42A19.48
SAM  A7102 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
0.98A19.81
7.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A7090
LEU A6909
SER A7089
ASP C7091
1.75A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP10
(SARS-CoV-2)		3 / 3
VAL B4372
GLN B4385
CYH B4381
1.38A19.72
6.30
 ZN  B4402 ( 4.8A)
None
ZN  B4402 ( 2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.45A19.48
SAM  A7102 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		5 / 10
SER A7090
LEU A6909
SER A7089
ASP C7091
THR C6915
1.57A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.74A19.48
None
None
SAM  A7102 ( 4.6A)
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
1.07A19.81
7.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.99A19.81
7.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.43A19.48
SAM  C7105 ( 3.5A)
None
None
NA  C7104 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.49A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
1.07A19.81
7.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.63A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w75 NSP10
(SARS-CoV-2)		3 / 3
VAL D4372
GLN D4385
CYH D4381
1.51A19.72
6.30
 ZN  D4402 ( 4.9A)
None
ZN  D4402 ( 2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.50A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.75A19.48
None
None
SAM  C7105 ( 4.4A)
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
VAL C 187
GLN C 229
CYH C 224
1.06A
None
None
ZN  C 401 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU B 113
LEU B 152
ASP B 164
GLU B 161
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 293
LEU A 282
SER A 294
GLU A 252
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER B 293
LEU B 282
SER B 294
GLU B 252
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 293
LEU A 282
SER A 294
GLU A 252
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
SER B 293
LEU B 282
SER B 294
GLU B 252
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
VAL A 187
GLN A 229
CYH A 224
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU C 113
LEU C 152
ASP C 164
GLU C 161
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wey NSP3
(SARS-CoV-2)		4 / 6
SER A 332
SER A 315
LEU A 312
GLY A 282
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wey NSP3
(SARS-CoV-2)		4 / 6
SER A 332
SER A 315
LEU A 312
GLY A 282
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wiq NSP7
(SARS-CoV-2)		4 / 8
LEU A  17
SER A  15
LEU A  14
GLU A  23
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7090
LEU A6909
SER A7089
ASP C7091
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.47A
SAH  C7102 (-3.3A)
None
None
FMT  C7107 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.43A
SAH  A7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.69A
None
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6904
ARG A6884
THR A6889
ASP A6906
1.54A21.24
None
None
NA  A7101 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.45A
SAH  C7102 (-3.3A)
None
None
FMT  C7107 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt NSP10
(SARS-CoV-2)		3 / 3
VAL B4372
GLN B4385
CYH B4381
1.38A
 ZN  B4402 ( 4.8A)
None
ZN  B4402 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
SER A7090
LEU A6909
SER A7089
ASP C7091
THR C6915
1.58A21.24
None
None
None
None
FMT  C7107 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt NSP10
(SARS-CoV-2)		3 / 3
VAL D4372
GLN D4385
CYH D4381
1.43A
 ZN  D4402 ( 4.9A)
None
ZN  D4402 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.45A
SAH  A7102 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7090
LEU A6909
SER A7089
ASP C7091
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.67A
None
None
SAH  C7102 (-4.7A)
SAH  C7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.99A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7090
SER C7089
LEU C6909
ASP A7091
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.71A
None
None
SAH  C7102 (-4.7A)
SAH  C7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.73A
None
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP B  63
ARG B  89
ASP B 103
THR B  91
1.52A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER B 105
LEU B 104
ASP C  82
ASP C  81
1.49A
None
None
ZN  C 201 (-2.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER D 105
LEU D 104
ASP A  82
ASP A  81
1.53A
None
None
ZN  A 201 (-2.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 6
ASP D  63
ARG D  89
ASP D 103
THR D  91
ASP D 128
1.63A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP C  63
ARG C  89
THR C  91
ASP C 128
1.41A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ASP C  63
ASP C 103
THR C  91
ASP C 128
1.48A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A7071
LEU A7072
SER A7074
ARG A7077
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A7090
SER C7089
LEU C6909
ASP A7091
1.74A
 NA  A7102 ( 3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		5 / 10
SER A7090
LEU A6909
SER A7089
ASP C7091
THR C6915
1.57A21.24
 NA  A7102 ( 3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.43A
SFG  A7103 ( 3.3A)
None
None
NA  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.69A
None
None
SFG  A7103 ( 4.5A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.47A
SFG  C7103 ( 3.4A)
None
None
NA  C7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A7090
LEU A6909
SER A7089
ASP C7091
1.72A
 NA  A7102 ( 3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.74A
None
None
SFG  C7103 ( 4.5A)
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
SER C6903
SER C6872
GLY C6871
1.70A
None
None
SFG  C7103 ( 4.5A)
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP C6912
SER C6896
LEU C6909
GLY C6911
1.45A
SFG  C7103 ( 3.4A)
None
None
NA  C7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A7090
LEU A6909
SER A7089
ASP C7091
1.68A
 NA  A7102 ( 3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.46A
SFG  A7103 ( 3.3A)
None
None
NA  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP10
(SARS-CoV-2)		3 / 3
VAL D4372
GLN D4385
CYH D4381
1.50A
 ZN  D4402 ( 4.8A)
None
ZN  D4402 ( 2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.51A
None
NA  A7102 ( 3.2A)
None
NA  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.73A
None
None
SFG  A7103 ( 4.5A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6900
SER A7090
LEU A6909
GLY A6911
1.52A
None
NA  A7102 ( 3.2A)
None
NA  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
VAL C6882
GLN C6847
CYH C6849
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wkq NSP10
(SARS-CoV-2)		3 / 3
VAL B4372
GLN B4385
CYH B4381
1.37A
 ZN  B4402 ( 4.7A)
None
ZN  B4402 ( 2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
SER A 242
LEU A 249
GLY A 247
ARG A 258
1.73A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
LEU B 251
LEU B 298
ASP B 302
ASP B 301
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 258
SER B 242
LEU B 249
GLY B 247
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 258
SER A 242
LEU A 249
GLY A 247
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 258
SER B 242
LEU B 249
GLY B 247
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
SER B 242
LEU B 249
GLY B 247
ARG B 258
1.74A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
LEU A 251
LEU A 298
ASP A 302
ASP A 301
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 258
SER A 242
LEU A 249
GLY A 247
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER C 128
SER C 111
LEU C 108
GLY C  78
1.70A
APR  C 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.44A
SAH  A7101 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7074
LEU A7073
SER A7071
ASP A7067
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A7010
SER A7071
LEU A7073
ASP A7067
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7074
LEU A7073
SER A7071
ASP A7067
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.71A
None
None
SO4  A7109 (-4.5A)
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
VAL A6882
GLN A6847
CYH A6849
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
SER A6903
SER A6872
GLY A6871
1.68A
None
None
SO4  A7109 (-4.5A)
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6912
SER A6896
LEU A6909
GLY A6911
1.42A
SAH  A7101 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7053
SER A7074
SER A6964
GLY A6962
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU C  17
SER C  15
LEU C  14
GLU C  23
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL D 130
GLN C  63
CYH D 114
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP7
(SARS-CoV-2)		4 / 8
LEU A  17
SER A  15
LEU A  14
GLU A  23
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP8
(SARS-CoV-2)		4 / 8
SER D 177
LEU D 180
LEU D 184
ASP D 134
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP8
(SARS-CoV-2)		4 / 8
LEU B 103
LEU B  98
ASP B  99
ASP B 101
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
VAL B 130
GLN A  63
CYH B 114
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP8
(SARS-CoV-2)		4 / 8
SER B 177
LEU B 180
LEU B 184
ASP B 134
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqd NSP8
(SARS-CoV-2)		4 / 8
LEU D 103
LEU D  98
ASP D  99
ASP D 101
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		3 / 3
VAL A 187
GLN A 229
CYH A 224
1.34A
None
None
ZN  A 501 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
SER A 293
LEU A 282
SER A 294
GLU A 252
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
SER A 293
LEU A 282
SER A 294
GLU A 252
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.41A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.74A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
SER D 177
LEU D 180
LEU D 184
ASP D 134
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU B 103
LEU B  98
ASP B  99
ASP B 101
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU C  17
SER C  15
LEU C  14
GLU C  23
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU A  17
SER A  15
LEU A  14
GLU A  23
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER L  32
LEU L  30
SER L  33
ASP E 428
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
SER L  32
LEU L  30
SER L  33
ASP E 428
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
LEU B  18
SER B  17
LEU B  86
ASP E 405
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
LEU H  18
SER H  17
LEU H  86
ASP A 405
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.37A
None
None
None
IMD  A 402 ( 2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  87
SER A  81
LEU A  58
GLU A  55
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER E  65
LEU E  83
ASP E  67
ASP E  66
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER B 128
SER B 111
LEU B 108
GLY B  78
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C 128
SER C 111
LEU C 108
GLY C  78
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER E 128
SER E 111
LEU E 108
GLY E  78
1.71A
EPE  E 202 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER D  65
LEU D  83
ASP D  67
ASP D  66
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER D  65
LEU D  83
ASP D  67
ASP D  66
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER E  65
LEU E  83
ASP E  67
ASP E  66
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER B 128
SER B 111
LEU B 108
GLY B  78
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER B  65
LEU B  83
ASP B  67
ASP B  66
1.67A
None
None
EDO  B 203 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER D  65
LEU D  83
ASP D  67
ASP D  66
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER E 128
SER E 111
LEU E 108
GLY E  78
1.74A
APR  E 201 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER E  65
LEU E  83
ASP E  67
ASP E  66
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER B 167
LEU B 164
LEU B 140
ASP A  22
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C 128
SER C 111
LEU C 108
GLY C  78
1.62A
MES  C 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER C  65
LEU C  83
ASP C  67
ASP C  66
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER A  65
LEU A  83
ASP A  67
ASP A  66
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER B  65
LEU B  83
ASP B  67
ASP B  66
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 140
SER B 167
LEU B  12
ASP A  22
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER A  65
LEU A  83
ASP A  67
ASP A  66
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER B 128
SER B 111
LEU B 108
GLY B  78
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
SER B  65
LEU B  83
ASP B  67
ASP B  66
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
SER A 267
LEU A 271
LEU A 208
ASP A 263
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 6
SER A 236
LEU A 207
SER A 239
ASP A 465
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 236
LEU A 207
SER A 239
ASP A 465
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 673
SER A 672
LEU A 401
ASP A 390
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP8
(SARS-CoV-2)		4 / 8
SER B 177
LEU B 180
LEU B 184
ASP B 134
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 575
LEU A 638
ASP A 477
ASP A 481
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 241
SER A 236
LEU A 207
ASP A 235
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 241
SER A 239
LEU A 207
ASP A 235
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 187
ASP A 260
ARG A 285
GLU A 254
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 207
SER A 239
LEU A 240
ASP A 235
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP8
(SARS-CoV-2)		4 / 8
SER D 173
SER D 177
LEU D 180
ASP D 175
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 681
LEU A 663
ASP A 623
ARG A 631
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 268
SER A 267
LEU A 208
ASP A 263
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
LEU A 663
ASP A 623
ARG A 631
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
SER A 236
LEU A 207
SER A 239
ASP A 465
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER C  25
LEU C  28
SER C  26
ASP B 163
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 241
SER A 236
LEU A 207
ASP A 235
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 576
SER A 578
LEU A 575
ASP A 484
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  25
LEU C  28
SER C  26
ASP B 163
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		7bv1 NSP7
(SARS-CoV-2)		3 / 3
VAL C  58
GLN C  34
CYH C  32
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 187
ASP A 260
ARG A 285
GLU A 254
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 261
ASP A 258
ARG A 183
GLU A 254
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 673
SER A 672
LEU A 401
ASP A 390
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER C  25
LEU C  28
SER C  26
ASP B 163
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 236
LEU A 207
SER A 239
ASP A 465
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
SER B 177
LEU B 180
LEU B 184
ASP B 134
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 187
ASP A 258
ARG A 285
GLU A 254
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 236
LEU A 207
SER A 239
ASP A 465
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 673
SER A 672
LEU A 401
ASP A 390
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 576
SER A 578
LEU A 575
ASP A 484
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 187
ASP A 260
ARG A 285
GLU A 254
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		7bv2 NSP7
(SARS-CoV-2)		3 / 3
VAL C  58
GLN C  34
CYH C  32
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		7bv2 NSP7
(SARS-CoV-2)		3 / 3
VAL C  58
GLN C  34
CYH C  32
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 241
SER A 236
LEU A 207
ASP A 235
1.75A
None