Ligand ID: RIV


Drugbank ID:
DB06228
(Rivaroxaban)


Indication:
Rivaroxaban is indicated for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hips replacements and total knee replacement surgery; prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); to reduce risk of recurrent DVT and/or PE. Due to a lack of safety studies, it is not recommended for use in those under 18 years old. Its use is also not recommended in those with severe renal impairment (<30mL/min).

Get human targets for RIV in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RIV' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
PHE D 294
ALA B 116
SER B 139
GLY D 302
GLY B 124
1.70A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 812
TRP A 598
CYH A 765
GLY A 808
TYR A 828
1.78A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ALA C 890
GLN C 784
VAL B1040
GLY B1044
GLY B1046
1.51A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 890
SER C1030
VAL B1040
GLY B1044
GLY B1046
1.49A10.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
TYR B  42
ALA A  60
SER A  65
VAL A  63
GLY A  85
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A 389
SER A 530
VAL A 327
GLY A 526
GLY A 545
1.26A10.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR B1067
ASP B1041
GLY B1046
GLY B1044
GLY C 889
1.52A10.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
TYR B1067
ASP B1041
GLY B1046
GLY B1044
GLY C 889
1.54A10.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 11
ALA A6881
VAL B4295
GLY B4323
GLY B4347
GLY B4322
1.51A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6895
SER B4325
VAL A6902
GLY A6879
GLY A6871
1.74A
None
None
None
SAM  A7104 (-3.6A)
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ASP A6904
ALA A6881
GLY B4323
GLY B4347
TYR B4349
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6895
SER B4325
VAL A6902
GLY A6879
GLY A6871
1.64A20.34
None
None
None
SAM  A7102 ( 3.4A)
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
ASP A6904
ALA A6881
GLY B4323
GLY B4347
TYR B4349
1.66A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6895
SER D4325
VAL C6902
GLY C6879
GLY C6871
1.63A20.34
None
None
None
SAM  C7105 ( 3.4A)
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
ALA C6881
VAL D4295
GLY D4323
GLY D4347
GLY D4322
1.50A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 11
ALA A6881
VAL B4295
GLY B4323
GLY B4347
GLY B4322
1.52A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP C6895
SER D4325
VAL C6902
GLY C6879
GLY C6871
1.66A
None
None
None
SAH  C7102 (-3.5A)
SAH  C7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6895
SER B4325
VAL A6902
GLY A6879
GLY A6871
1.65A
None
None
None
SAH  A7102 (-3.5A)
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ALA A6881
VAL B4295
GLY B4323
GLY B4347
GLY B4322
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ALA C6881
VAL D4295
GLY D4323
GLY D4347
GLY D4322
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ASP A6904
ALA A6881
GLY B4323
GLY B4347
TYR B4349
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ASP C6904
ALA C6881
GLY D4323
GLY D4347
TYR D4349
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP A6895
SER B4325
VAL A6902
GLY A6879
GLY A6871
1.65A
None
None
None
SFG  A7103 ( 3.5A)
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
ASP C6904
ALA C6881
GLY D4323
GLY D4347
TYR D4349
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
ALA C6881
VAL D4295
GLY D4323
GLY D4347
GLY D4322
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 11
ALA A6881
VAL B4295
GLY B4323
GLY B4347
GLY B4322
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ASP C6895
SER D4325
VAL C6902
GLY C6879
GLY C6871
1.63A
None
None
None
SFG  C7103 ( 3.5A)
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6895
SER B4325
VAL A6902
GLY A6879
GLY A6871
1.69A
None
None
None
SAH  A7101 (-3.5A)
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ASP A6904
ALA A6881
GLY B4323
GLY B4347
TYR B4349
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 11
ALA A6881
VAL B4295
GLY B4323
GLY B4347
GLY B4322
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
TYR B  52
PHE A 377
GLY B 101
GLY A 381
GLY B  99
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
TYR H  52
PHE E 377
GLY H 101
GLY E 381
GLY H  99
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
TYR H  52
PHE E 377
GLY H 101
GLY E 381
GLY H  99
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  52
GLN B  62
VAL B  49
GLY B  47
GLY E 133
1.72A
APR  B 201 ( 4.0A)
EDO  B 202 (-4.2A)
APR  B 201 (-3.7A)
APR  B 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  52
GLN B  62
GLY B  46
GLY E 133
GLY B  48
1.67A
APR  B 201 ( 4.0A)
EDO  B 202 (-4.2A)
EDO  B 202 (-3.9A)
None
APR  B 201 (-3.5A)