Ligand ID: RIM


Drugbank ID:
DB00478
(Rimantadine)


Indication:
For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.

Get human targets for RIM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RIM' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.71A14.02
None
None
None
None
DMS  A 403 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.46A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 121
ALA A 116
SER A 123
SER A 147
1.58A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
SER D 937
ALA D 944
SER D 940
ALA F 942
1.38A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 9
SER B 937
ALA B 944
SER B 940
ALA A 942
VAL A1189
1.67A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 10
VAL C 952
VAL B 952
ALA B 956
ALA A1174
VAL A 952
1.37A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.72A6.67

None
None
None
None
DMS  A 403 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE B 358
ARG B 355
LEU B 513
ASP B 398
1.37A14.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.72A7.02

None
None
None
None
DMS  A 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.38A7.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ILE C  43
ARG C  40
LEU C  57
ASP C 187
1.67A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER C 301
ALA A 116
SER A 123
SER A 139
1.72A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.75A6.27

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER D 301
ALA B 116
SER B 123
SER B 139
1.71A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER C 147
SER C 121
ALA C 116
SER C 123
1.73A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER D 121
ALA D 116
SER D 123
SER D 147
1.60A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER C 121
ALA C 116
SER C 123
SER C 147
1.72A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER B 139
SER D 301
ALA B 116
SER B 123
1.71A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER D 147
SER D 121
ALA D 116
SER D 123
1.60A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
SER A 139
SER C 301
ALA A 116
SER A 123
1.71A6.71

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ILE C  43
ARG C  40
LEU C  87
LEU C  57
1.30A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 10
VAL D  36
VAL D  91
ALA D  94
VAL D  68
ALA D  70
1.70A6.27

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.45A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ILE A 466
ARG A 735
LEU A 470
ASP A 235
1.71A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 10
ALA A 383
VAL A 341
ALA A 379
SER A 343
VAL B 115
1.64A3.56

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
ASP A 303
ILE A 307
ARG A 305
1.66A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 120
LEU B  98
LEU B 117
ASP A 377
1.71A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 308
LEU A 469
ILE A 307
ARG A 305
1.75A4.04

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ALA A 777
VAL A 704
ALA A 706
VAL A 785
SER A 784
1.68A3.56

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ILE A 244
ARG A 132
LEU A 131
LEU A 207
1.71A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 10
SER A 343
VAL B 115
ALA A 383
VAL A 341
ALA A 379
1.70A3.56

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		5 / 9
GLY A 584
ALA A 581
SER A 578
VAL A 587
ALA A 585
1.61A2.46

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 709
ALA A 771
ALA A 777
SER A 778
1.73A2.46

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 132
ARG A 392
LEU A 389
ASP A 390
1.30A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ILE A 171
ARG A 173
LEU A 172
LEU A 146
1.36A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 10
VAL A 637
ALA A 634
ALA A 690
SER A 692
VAL A 476
1.43A3.56

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 585
LEU A 533
ASP A 578
ILE A 584
1.31A3.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
LEU A  12
ILE A 137
ARG A 141
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B  41
ALA B  39
ALA B  38
ALA B 112
VAL B  77
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU C 242
LEU C 244
ILE C 101
ARG C 102
1.68A2.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLY A 652
SER A 691
ALA A 672
SER A 673
ALA A 609
1.71A2.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER B 937
SER B 940
ALA B 944
SER B 943
1.32A2.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLY C 652
SER C 691
ALA C 672
SER C 673
ALA C 609
1.69A2.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 298
LEU A 299
ASP A 302
ILE A 323
1.38A10.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 6
ILE C 358
ARG C 355
LEU C 513
ASP C 398
1.51A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w4b NSP9
(SARS-CoV-2)		5 / 9
GLY B 101
ALA A   9
ALA B 109
VAL A 103
SER A 106
1.41A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w4h NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.72A6.69
SAM  A7102 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w4h NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.58A6.69
SAM  A7102 (-4.1A)
None
SAM  A7102 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
ALA A6905
VAL A6894
1.72A12.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.67A9.38
SAM  A7104 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
VAL A6902
ALA B4324
SER A6903
1.72A11.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6877
ALA A6870
SER A6896
SER A6907
1.45A12.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6905
ALA A6881
VAL A6876
ALA A6877
1.62A12.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6877
ALA A6870
SER A6896
ALA A6905
SER A6907
1.69A12.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7039
ALA A6997
1.75A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6896
ALA A6905
ALA A6877
SER A6903
1.37A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
ALA A6870
GLY A6871
ALA A6881
GLY A6879
ALA B4324
1.62A9.38
None
SAM  A7104 (-4.4A)
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.50A9.38
SAM  A7104 (-4.4A)
None
SAM  A7104 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
ALA A6870
SER A6896
ALA A6877
GLY A6871
SER A6903
1.75A9.38
None
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.55A11.25
None
None
AMP  A 201 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL B  41
ALA B  39
ALA B  38
ALA B 112
VAL B  77
1.55A11.25
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL B  16
VAL B 151
ALA B 124
VAL B 144
SER B 139
1.75A11.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.75A11.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
GLY D4322
ALA C6905
GLY D4347
ALA C6877
SER C6903
1.77A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 10
VAL C6902
ALA D4324
SER C6903
VAL C6876
ALA C6877
1.78A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		5 / 9
GLY C6871
ALA C6905
VAL C6902
ALA C6877
SER C6903
1.71A9.38
SAM  C7105 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7038
ALA C6843
1.73A9.38
None
FMT  C7111 ( 3.6A)
FMT  C7111 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C6884
LEU C6883
LEU C6892
ASP C6906
1.44A13.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
ALA C6870
GLY C6871
ALA C6881
GLY C6879
ALA D4324
1.62A9.38
None
SAM  C7105 ( 4.2A)
None
SAM  C7105 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
ALA C6881
GLY D4322
ALA C6905
GLY D4347
SER C6903
1.78A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA C6870
SER C6896
ALA C6877
SER C6903
VAL C6894
1.67A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA A6877
ALA A6870
SER A6896
ALA A6905
SER A6907
1.70A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
SER A6903
VAL A6894
1.66A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7039
ALA A6997
1.67A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
ALA C6877
ALA C6870
SER C6896
ALA C6905
SER C6907
1.79A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A7038
SER A7041
ALA A6843
ALA A6832
1.36A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A6896
ALA A6905
ALA A6877
SER A6903
1.49A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
GLY B4347
ALA A6877
SER A6903
1.78A11.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 9
ALA A6870
GLY A6871
ALA A6881
GLY A6879
ALA B4324
1.64A9.38
None
SAM  A7102 ( 4.2A)
None
SAM  A7102 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		5 / 9
GLY C6871
SER C6896
GLY C6869
ALA C6905
SER C6903
1.62A9.38
SAM  C7105 ( 4.2A)
None
SAM  C7105 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
VAL C6902
ALA C6905
ALA C6881
VAL C6876
ALA C6877
1.67A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C6896
ALA C6905
ALA C6877
SER C6903
1.50A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C7038
SER C7041
ALA C6843
ALA C6832
1.31A9.38
FMT  C7111 ( 4.8A)
None
None
FMT  C7111 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6905
ALA A6881
VAL A6876
ALA A6877
1.68A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 10
VAL A6902
ALA B4324
SER A6903
VAL A6876
ALA A6877
1.79A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.62A9.38
SAM  A7102 ( 4.2A)
None
SAM  A7102 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.68A9.38
SAM  A7102 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7039
ALA C6997
1.69A9.38
None
FMT  C7111 ( 3.6A)
FMT  C7111 ( 3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7038
ALA A6843
1.73A9.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA C 246
SER C 245
ALA C 249
VAL C 303
SER C 262
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 120
LEU C 117
ILE C 123
ARG C 140
1.67A9.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 120
LEU B 117
ILE B 123
ARG B 140
1.70A9.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 10
ALA A 246
SER A 245
ALA A 249
VAL A 303
SER A 262
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 120
LEU B 117
ILE B 123
ARG B 140
1.77A9.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 120
LEU C 117
ILE C 123
ARG C 140
1.72A9.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wcf NSP3
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.53A
None
MES  A 201 ( 4.7A)
MES  A 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 344
LEU A 216
ILE A 341
ARG A 345
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
GLY C 284
ALA C 273
GLY C 275
ALA D 313
SER D 312
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA F 313
SER F 312
GLY F 316
SER F 310
ALA E 308
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA C 313
SER C 312
GLY C 316
SER C 310
ALA D 308
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA D 313
SER D 312
GLY D 316
SER D 310
ALA C 308
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER E 310
ALA F 264
ALA E 311
SER E 312
1.61A
None
None
CL  F 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER A 310
ALA B 264
ALA A 311
SER A 312
1.62A
None
None
CL  B 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER B 310
ALA A 264
ALA B 311
SER B 312
1.61A
None
None
CL  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA B 273
ALA A 313
GLY A 316
ALA A 311
SER A 310
1.80A
None
None
None
CL  B 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE F 304
LEU F 353
LEU F 291
ASP F 288
1.44A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE D 304
LEU D 353
LEU D 291
ASP D 288
1.48A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE C 304
LEU C 353
LEU C 291
ASP C 288
1.43A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA C 264
GLY C 295
ALA D 313
GLY D 316
ALA D 311
SER D 310
1.73A
None
None
None
None
CL  C 401 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA F 273
ALA E 313
GLY E 316
ALA E 311
SER E 310
1.78A
None
None
None
CL  F 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE B 304
LEU B 353
LEU B 291
ASP B 288
1.41A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA A 273
ALA B 313
GLY B 316
ALA B 311
SER B 310
1.77A
None
None
None
CL  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE E 304
LEU E 353
LEU E 291
ASP E 288
1.42A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
GLY B 284
ALA B 273
GLY B 275
ALA A 313
SER A 312
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA E 313
SER E 312
GLY E 316
SER E 310
ALA F 308
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
GLY F 284
ALA F 273
GLY F 275
ALA E 313
SER E 312
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
GLY A 284
ALA A 273
GLY A 275
ALA B 313
SER B 312
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA B 313
SER B 312
GLY B 316
SER B 310
ALA A 308
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ILE A 304
LEU A 353
LEU A 291
ASP A 288
1.44A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER D 310
ALA C 264
ALA D 311
SER D 312
1.61A
None
None
CL  C 401 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER F 310
ALA E 264
ALA F 311
SER F 312
1.65A
None
None
CL  E 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA F 264
GLY F 295
ALA E 313
GLY E 316
ALA E 311
SER E 310
1.72A
None
None
None
None
CL  F 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA A 264
GLY A 295
ALA B 313
GLY B 316
ALA B 311
SER B 310
1.72A
None
None
None
None
CL  A 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
GLY D 284
ALA D 273
GLY D 275
ALA C 313
SER C 312
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA D 264
GLY D 295
ALA C 313
GLY C 316
ALA C 311
SER C 310
1.73A
None
None
None
None
CL  D 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER C 310
ALA D 264
ALA C 311
SER C 312
1.65A
None
None
CL  D 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA D 273
ALA C 313
GLY C 316
ALA C 311
SER C 310
1.78A
None
None
None
CL  D 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA E 264
GLY E 295
ALA F 313
GLY F 316
ALA F 311
SER F 310
1.73A
None
None
None
None
CL  E 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		6 / 9
ALA B 264
GLY B 295
ALA A 313
GLY A 316
ALA A 311
SER A 310
1.75A
None
None
None
None
CL  B 401 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
ALA A 313
SER A 312
GLY A 316
SER A 310
ALA B 308
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6877
ALA A6870
SER A6896
SER A6907
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
SER C6872
ALA D4324
SER D4325
ALA C6877
1.72A
SAH  C7102 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7038
ALA A6843
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.68A
SAH  A7102 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
GLY B4347
ALA A6877
SER A6903
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7038
SER A7041
ALA A6843
ALA A6832
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7039
ALA A6997
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6905
ALA A6881
VAL A6876
ALA A6877
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6877
ALA A6870
SER A6896
ALA A6905
SER A6907
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL C6902
ALA C6905
ALA C6881
VAL C6876
ALA C6877
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
SER A6872
ALA B4324
SER B4325
ALA A6877
1.77A
SAH  A7102 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA C6870
SER C6896
ALA C6877
SER C6903
VAL C6894
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
GLY D4322
ALA C6905
GLY D4347
ALA C6877
SER C6903
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.64A
SAH  A7102 (-4.4A)
None
SAH  A7102 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
ALA A6870
GLY A6871
ALA A6881
GLY A6879
ALA B4324
1.64A
None
SAH  A7102 (-4.4A)
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA C6870
SER C6896
ALA C6877
ALA C6905
VAL C6894
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY C6871
SER C6896
GLY C6869
ALA C6905
SER C6903
1.65A
SAH  C7102 (-4.4A)
None
SAH  C7102 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C6896
ALA C6905
ALA C6877
SER C6903
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6896
ALA A6905
ALA A6877
SER A6903
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C7038
SER C7041
ALA C6843
ALA C6832
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY C6871
ALA C6905
VAL C6902
ALA C6877
SER C6903
1.70A
SAH  C7102 (-4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA C6997
SER C6998
ALA C6832
SER C7038
SER C6831
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7038
ALA C6843
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7039
ALA C6997
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA C6877
ALA C6870
SER C6896
ALA C6905
SER C6907
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
ALA C6870
GLY C6871
ALA C6881
GLY C6879
ALA D4324
1.63A
None
SAH  C7102 (-4.4A)
None
SAH  C7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ALA C6870
SER C6896
ALA C6877
SER C6903
VAL C6894
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6905
ALA A6881
VAL A6876
ALA A6877
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7038
ALA C6843
1.74A
None
FMT  C7111 ( 3.5A)
FMT  C7111 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
GLY C6871
SER C6896
GLY C6869
ALA C6905
SER C6903
1.65A
SFG  C7103 ( 4.1A)
None
SFG  C7103 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7038
ALA A6843
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ALA A6877
ALA A6870
SER A6896
ALA A6905
SER A6907
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A7041
ALA A6832
SER A7039
ALA A6997
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.68A
SFG  A7103 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
GLY C6871
ALA C6905
VAL C6902
ALA C6877
SER C6903
1.71A
SFG  C7103 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.63A
SFG  A7103 ( 4.2A)
None
SFG  A7103 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A7038
SER A7041
ALA A6843
ALA A6832
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C7038
SER C7041
ALA C6843
ALA C6832
1.30A
FMT  C7111 ( 4.9A)
None
None
FMT  C7111 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
ALA A6905
VAL A6894
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
ALA A6870
GLY A6871
ALA A6881
GLY A6879
ALA B4324
1.63A
None
SFG  A7103 ( 4.2A)
None
SFG  A7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
VAL C6902
ALA C6905
ALA C6881
VAL C6876
ALA C6877
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
ALA C6870
GLY C6871
ALA C6881
GLY C6879
ALA D4324
1.62A
None
SFG  C7103 ( 4.1A)
None
SFG  C7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
GLY B4347
ALA A6877
SER A6903
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 9
GLY D4322
ALA C6905
GLY D4347
ALA C6877
SER C6903
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
SER A6903
VAL A6894
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C6896
ALA C6905
ALA C6877
SER C6903
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
ALA C6870
SER C6896
ALA C6877
GLY C6871
SER C6903
1.75A
None
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C7041
ALA C6832
SER C7039
ALA C6997
1.68A
None
FMT  C7111 ( 3.5A)
FMT  C7111 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A6896
ALA A6905
ALA A6877
SER A6903
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ILE A 281
ARG A 258
LEU A 246
LEU A 255
1.73A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
VAL B  85
ALA B  81
VAL B 102
SER B  98
ALA B  95
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 298
LEU A 299
ASP A 302
ILE A 323
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ILE B 281
ARG B 258
LEU B 246
LEU B 255
1.76A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 258
LEU B 255
LEU B 246
ASP B 283
1.59A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 298
LEU B 299
ASP B 302
ILE B 323
1.50A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 266
LEU A 201
ILE A 281
ARG A 258
1.64A11.54
None
EDO  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 258
LEU A 255
LEU A 246
ASP A 283
1.57A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 298
LEU B 299
ASP B 302
ILE B 323
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 298
LEU A 299
ASP A 302
ILE A 323
1.42A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 10
VAL A  85
ALA A  81
VAL A 102
SER A  98
ALA A  95
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 298
LEU B 299
ASP B 302
ILE B 323
1.41A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 266
LEU A 201
ILE A 281
ARG A 258
1.65A11.54
None
EDO  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 298
LEU A 299
ASP A 302
ILE A 323
1.51A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.39A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 9
SER A 254
GLY A 258
SER A 267
VAL A 261
ALA A 260
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER D 128
SER D 139
ALA D 124
ALA D  38
1.37A
APR  D 201 (-4.3A)
None
None
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.52A
None
None
APR  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
SER D 139
ALA D 124
ALA D  38
ALA D 129
SER D 128
1.56A
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.7A)
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ALA A 112
GLY A  78
ALA A  39
GLY A  97
SER A  80
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER D 139
ALA D  38
ALA D 129
SER D 128
1.41A
None
APR  D 201 (-3.2A)
APR  D 201 (-3.7A)
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B  41
ALA B  39
ALA B  38
ALA B 112
VAL B  77
1.55A
None
None
APR  B 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL C  41
ALA C  39
ALA C  38
ALA C 112
VAL C  77
1.53A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  41
ALA D  39
ALA D  38
ALA D 112
VAL D  77
1.54A
None
None
APR  D 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6896
ALA A6905
ALA A6877
SER A6903
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 6
SER A6872
ALA B4324
SER B4325
ALA A6877
1.79A
SO4  A7109 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
ALA A6870
GLY A6871
ALA A6881
GLY A6879
ALA B4324
1.65A
None
SAH  A7101 (-4.3A)
None
SAH  A7101 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
SER A6903
VAL A6894
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
ALA A6905
VAL A6902
ALA A6877
SER A6903
1.71A
SAH  A7101 (-4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
ALA A6870
SER A6896
ALA A6877
ALA A6905
VAL A6894
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 10
VAL A6902
ALA B4324
SER A6903
VAL A6876
ALA A6877
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
GLY A6871
SER A6896
GLY A6869
ALA A6905
SER A6903
1.64A
SAH  A7101 (-4.3A)
None
SAH  A7101 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 10
VAL A6902
ALA A6905
ALA A6881
VAL A6876
ALA A6877
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
VAL A6902
ALA B4324
SER A6903
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 9
GLY B4322
ALA A6905
GLY B4347
ALA A6877
SER A6903
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.45A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
SER A 147
SER A 121
ALA A 116
SER A 123
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ILE B  43
ARG B  40
LEU B  87
LEU B  57
1.39A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
SER A 121
ALA A 116
SER A 123
GLY A 124
SER A 147
1.80A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
ALA A 116
SER A 123
GLY A 124
SER A 147
SER A 121
1.76A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.72A14.02
None
None
None
None
DMS  A 406 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A 147
SER A 121
ALA A 116
SER A 123
1.59A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
SER A 121
ALA A 116
SER A 123
SER A 147
1.60A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.45A14.05
None
DMS  A 408 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU D 184
LEU D 180
ASP D 161
ILE D 185
1.79A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
LEU B 184
LEU B 180
ASP B 161
ILE B 185
1.78A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 119
TRP A  12
ILE A 106
ARG A 109
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 119
TRP A  12
ILE A 106
ARG A 109
1.75A12.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE E 358
ARG E 355
LEU E 513
ASP E 398
1.35A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE A 358
ARG A 355
LEU A 513
ASP A 398
1.38A16.94
None
PG0  A 902 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE E 358
ARG E 355
LEU E 513
ASP E 398
1.43A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.43A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE A 358
ARG A 355
LEU A 513
ASP A 398
1.34A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE E 358
ARG E 355
LEU E 513
ASP E 398
1.35A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.45A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C   5
SER E 166
ALA B  70
SER C   7
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  41
ALA D  39
ALA D  38
ALA D 112
VAL D  77
1.55A
None
None
EDO  D 205 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
LEU A  12
ILE A 137
ARG A 141
1.65A13.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 140
LEU D  12
ILE D 137
ARG D 141
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  41
ALA B  39
ALA B  38
ALA B 112
VAL B  77
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  41
ALA C  39
ALA C  38
ALA C 112
VAL C  77
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C   7
SER C   5
SER E 166
ALA B  70
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  41
ALA E  39
ALA E  38
ALA E 112
VAL E  77
1.52A
None
None
EPE  E 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.51A
None
None
EDO  A 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  16
VAL E 151
ALA E 124
VAL E 144
SER E 139
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 140
LEU D  12
ILE D 137
ARG D 141
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL E  41
ALA E  39
ALA E  38
ALA E 112
VAL E  77
1.55A
None
None
APR  E 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C   5
SER E 166
ALA B  70
SER C   7
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  41
ALA C  39
ALA C  38
ALA C 112
VAL C  77
1.54A
None
None
APR  C 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  41
ALA D  39
ALA D  38
ALA D 112
VAL D  77
1.56A
None
None
APR  D 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.55A
None
None
APR  A 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
LEU A  12
ILE A 137
ARG A 141
1.74A13.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  16
VAL D 151
ALA D 124
VAL D 144
SER D 139
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER C   7
SER C   5
SER E 166
ALA B  70
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  16
VAL B 151
ALA B 124
VAL B 144
SER B 139
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
LEU A  12
ILE A 137
ARG A 141
1.68A13.87
None
None
EDO  A 206 (-4.6A)
EDO  A 206 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  41
ALA C  39
ALA C  38
ALA C 112
VAL C  77
1.54A
None
None
MES  C 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
LEU A  12
ILE A 137
ARG A 141
1.69A13.87
None
None
EDO  A 206 (-4.6A)
EDO  A 206 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 140
LEU C  12
ILE C 137
ARG C 141
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  16
VAL A 151
ALA A 124
VAL A 144
SER A 139
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  16
VAL C 151
ALA C 124
VAL C 144
SER C 139
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  41
ALA A  39
ALA A  38
ALA A 112
VAL A  77
1.53A
None
None
MES  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  16
VAL B 151
ALA B 124
VAL B 144
SER B 139
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 140
LEU C  12
ILE C 137
ARG C 141
1.61A13.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  41
ALA B  39
ALA B  38
ALA B 112
VAL B  77
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		4 / 6
LEU C   4
ASP A 187
ILE A  43
ARG A  40
1.78A
PJE  C   5 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		4 / 6
ARG A  40
LEU A  57
LEU C   4
ASP A 187
1.47A9.02
None
None
PJE  C   5 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A 147
SER A 121
ALA A 116
SER A 123
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A 121
ALA A 116
SER A 123
SER A 147
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 10
VAL A 171
ALA A 194
ALA A 193
ALA C   2
ALA A 173
1.51A
None
None
None
02J  C   1 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
ILE A 244
ARG A 132
LEU A 131
LEU A 207
1.73A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 308
LEU A 469
ILE A 307
ARG A 305
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
ILE A 171
ARG A 173
LEU A 172
LEU A 146
1.36A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
ILE A 466
ARG A 735
LEU A 470
ASP A 235
1.79A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D  95
LEU D  98
ILE D 107
ARG D  96
1.55A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 132
ARG A 392
LEU A 389
ASP A 390
1.25A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		5 / 9
GLY A 584
ALA A 581
SER A 578
VAL A 587
ALA A 585
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_F_RIMF101_0
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		5 / 9
ALA A 558
SER A 681
GLY A 683
GLY A 559
SER A 561
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
SER A 709
ALA A 771
ALA A 777
SER A 778
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 10
ALA A 777
VAL A 704
ALA A 706
VAL A 785
SER A 784
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU B 184
LEU B 180
ASP B 161
ILE B 185
1.77A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
LEU A 648
ASP A 303
ARG A 305
1.78A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
ALA A 383
VAL A 341
ALA A 379
SER A 343
VAL B 115
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 535
ALA A 656
VAL A 354
ALA A 660
SER A 664
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
ASP A 303
ILE A 307
ARG A 305
1.55A4.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 185
ARG A 392
LEU A 388
ASP A 390
1.75A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 10
SER A 343
VAL B 115
ALA A 383
VAL A 341
ALA A 379
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D  95
LEU D  98
ILE D 107
ARG D  96
1.64A10.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D  95
LEU D  98
ILE D 107
ARG D  96
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ILE A  43
ARG A  40
LEU A  87
LEU A  57
1.40A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 10
VAL A  36
VAL A  91
ALA A  94
VAL A  68
ALA A  70
1.70A
None
None
None
None
DMS  A 403 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
SER A 121
ALA A 116
SER A 123
SER A 147
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
ASP A 303
ILE A 307
ARG A 305
1.53A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ALA A 777
VAL A 704
ALA A 706
VAL A 785
SER A 784
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 632
LEU A 351
LEU A 636
ASP A 304
1.79A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 241
LEU A 207
ILE A 244
ARG A 132
1.57A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 244
ARG A 132
LEU A 131
LEU A 207
1.74A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
SER A 681
GLY A 679
ALA A 690
SER A 635
VAL A 662
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7bv1 NSP8
(SARS-CoV-2)		4 / 6
LEU B 184
LEU B 180
ASP B 161
ILE B 185
1.80A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
LEU A 648
ASP A 303
ARG A 305
1.62A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 466
ARG A 735
LEU A 470
ASP A 235
1.63A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  54
ALA D 102
ALA D 152
SER D 151
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 132
ARG A 392
LEU A 389
ASP A 390
1.25A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 171
ARG A 173
LEU A 172
LEU A 146
1.47A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 119
LEU B 122
LEU A 271
ASP A 269
1.77A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 308
LEU A 469
ILE A 307
ARG A 305
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
LEU A 648
ASP A 303
ARG A 305
1.72A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 119
LEU B 122
LEU A 271
ASP A 269
1.63A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		7bv2 NSP8
(SARS-CoV-2)		4 / 6
LEU B 184
LEU B 180
ASP B 161
ILE B 185
1.77A10.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_C_RIMC101_0
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 709
ALA A 771
ALA A 777
SER A 778
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 171
ARG A 173
LEU A 172
LEU A 146
1.44A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_D_RIMD101_0
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
GLY A 584
ALA A 581
SER A 578
VAL A 587
ALA A 585
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LJC_A_RIMA1_1
(M2 PROTEIN, BM2
PROTEIN CHIMERA)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ALA A 777
VAL A 704
ALA A 706
VAL A 785
SER A 784
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 302
ASP A 303
ILE A 307
ARG A 305
1.54A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 244
ARG A 132
LEU A 131
LEU A 207
1.62A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 308
LEU A 469
ILE A 307
ARG A 305
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 466
ARG A 735
LEU A 470
ASP A 235
1.64A3.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ILE B 132
ARG A 392
LEU A 389
ASP A 390
1.22A10.14
None