Ligand ID: RGZ


Drugbank ID:
DB00412
(Rosiglitazone)


Indication:
Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Get human targets for RGZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RGZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PRO A 627
LEU A 247
GLN A 468
TYR A 788
TYR A 732
1.74A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 636
LEU A 308
LEU A 469
GLN A 789
ILE A 632
1.78A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 655
LEU A 351
CYH A 310
ILE A 632
TYR A 294
1.77A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 146
LEU A 178
ILE A 244
ILE A 145
1.70A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B 977
LEU B 966
GLN B 965
ILE B 742
TYR B 741
1.55A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 600
LEU C 650
ILE C 664
ILE C 692
PHE C 643
1.33A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
LEU C 945
LEU C 822
ILE C 934
GLN C1054
ILE C 726
PHE C 823
1.80A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU C 977
LEU C 966
GLN C 965
ILE C 742
TYR C 741
1.57A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 600
LEU C 650
ILE C 312
ILE C 692
PHE C 643
1.29A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B 977
LEU B 966
GLN B 965
ILE B 742
TYR B 741
1.55A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO A 344
LEU A 251
ILE A 306
ILE A 296
PHE A 195
1.48A19.58
None
None
None
None
EDO  A 414 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 11
LEU C 425
LEU C 513
PHE C 338
TYR C 365
TYR C 369
1.71A15.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 425
LEU C 513
PHE C 338
TYR C 365
TYR C 369
1.72A15.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w6y NSP3
(SARS-CoV-2)		5 / 11
TYR B   9
LEU A 140
LEU A 169
ILE A  18
TYR B 161
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO A 344
LEU A 251
ILE A 306
ILE A 296
PHE A 195
1.45A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO A  68
LEU A  76
LEU A 190
ILE A  72
TYR A 325
1.65A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO B 344
LEU B 251
LEU B 298
ILE B 296
PHE B 195
1.78A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
PRO B  68
LEU B  73
LEU B  76
LEU B 190
ILE B  72
TYR B 325
1.79A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO B 344
LEU B 251
ILE B 306
ILE B 296
PHE B 195
1.45A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A  73
LEU A  76
ILE A 144
ILE A  72
TYR A 325
1.63A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO A 344
LEU A 251
LEU A 298
ILE A 296
PHE A 195
1.80A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B  73
LEU B  76
ILE B 144
ILE B  72
TYR B 325
1.61A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PRO A  68
LEU A  73
LEU A  76
ILE A  72
TYR A 325
1.59A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 655
LEU A 351
CYH A 310
ILE A 632
TYR A 294
1.76A18.55
None
None
ZN  A1001 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		5 / 12
PRO A 832
LEU A 838
LEU A 883
ILE A 837
PHE A 422
1.78A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 636
LEU A 308
LEU A 469
GLN A 789
ILE A 632
1.76A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 142
LEU A 146
LEU A 178
ILE A 244
ILE A 145
1.76A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 636
LEU A 308
LEU A 469
GLN A 789
ILE A 632
1.76A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PRO A 627
LEU A 247
GLN A 468
TYR A 788
TYR A 732
1.62A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 655
LEU A 351
CYH A 310
ILE A 632
TYR A 294
1.69A18.85
None
None
ZN  A1001 (-2.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 121
LEU B 103
LEU B  98
ILE B 120
PHE A 340
1.56A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 655
LEU A 351
CYH A 310
ILE A 632
TYR A 294
1.67A18.85
None
None
ZN  A1001 (-2.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PRO A 627
LEU A 247
GLN A 468
TYR A 788
TYR A 732
1.72A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
PRO B 121
LEU B 103
LEU B  98
ILE B 120
PHE A 340
1.63A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 636
LEU A 308
LEU A 469
GLN A 789
ILE A 632
1.75A18.85
None