Ligand ID: RCX


Drugbank ID:
DB00533
(Rofecoxib)


Indication:
For the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras.

Get human targets for RCX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RCX' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.47A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
ARG A 217
ILE A 281
PHE A 219
1.67A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.73A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.63A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.42A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.63A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.60A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.33A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.60A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.32A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 125
LEU C 115
VAL C  13
GLY C  11
SER A  10
1.38A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
LEU A 115
VAL A  13
GLY A  11
SER C  10
1.37A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C 125
SER C 113
VAL C  13
GLY C  11
SER A  10
1.68A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.33A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 125
SER D 113
VAL D  13
GLY D  11
SER B  10
1.70A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER D  10
1.37A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A 125
SER A 113
VAL A  13
GLY A  11
SER C  10
1.67A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ARG D 279
ILE D 281
PHE D 219
1.28A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D 125
LEU D 115
VAL D  13
GLY D  11
SER B  10
1.41A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ARG B 279
ILE B 281
PHE B 219
1.38A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B 125
SER B 113
VAL B  13
GLY B  11
SER D  10
1.64A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 561
ALA A 512
GLY A 683
ALA A 558
SER A 681
1.67A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 557
SER A 682
ALA A 685
VAL A 560
GLY A 503
1.32A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLN A 210
VAL A 182
GLY A 179
ALA A 250
LEU A 251
1.35A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 705
ALA B 701
GLY C 891
ALA C 892
LEU C 894
1.44A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG B 509
ILE B 434
PHE B 374
1.20A17.84
None
None
NAG  B1315 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLN B  62
VAL B  41
LEU B  43
TYR A  68
GLY B  73
1.60A
None
None
None
None
NHE  A 202 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.59A
None
None
SO4  A 201 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  96
GLY B  79
SER B 111
LEU B 108
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.58A
None
None
None
SO4  A 201 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG C 509
ILE C 434
PHE C 342
1.12A18.22
None
None
NAG  C1307 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 705
ALA A 701
GLY B 891
ALA B 892
LEU B 894
1.44A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 705
ALA B 701
GLY C 891
ALA C 892
LEU C 894
1.39A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG A 509
ILE A 434
PHE A 342
1.09A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 511
TYR C 423
ALA C 352
ALA C 397
LEU C 513
1.75A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 511
TYR C 423
ALA C 352
ALA C 397
LEU C 513
1.74A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		3 / 3
ARG C 509
ILE C 434
PHE C 342
1.18A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6851
ALA A7002
GLY A7006
SER A6964
LEU A6857
1.78A13.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A6851
ALA A7002
GLY A7006
SER A6964
LEU A6857
1.72A13.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.65A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  78
ALA B 112
SER B 111
LEU B 109
1.71A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  24
ALA A 124
VAL A  49
GLY A  48
ALA A  52
1.75A14.37
None
None
AMP  A 201 ( 3.7A)
AMP  A 201 ( 3.6A)
AMP  A 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.53A
None
MES  B 201 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.60A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
HIS B  45
VAL B  36
LEU B  93
GLY B  79
LEU B 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  24
ALA B 124
VAL B  49
GLY B  48
ALA B  52
1.73A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  78
ALA B 112
SER B 111
LEU B 109
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLN A 118
VAL A 147
VAL A  36
ALA A 124
LEU A 153
1.80A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.59A
None
None
AMP  A 201 ( 3.7A)
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.58A
None
None
None
MES  B 201 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.57A
None
None
AMP  A 201 ( 3.7A)
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLN A 118
VAL A 147
VAL A  36
ALA A 124
LEU A 153
1.79A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 128
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.76A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.60A
None
None
None
MES  B 201 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
HIS B  86
SER B  65
ALA B  60
GLY B  51
ALA B  50
1.56A
None
None
None
None
MES  B 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.57A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
HIS A  86
SER A  65
ALA A  60
GLY A  51
ALA A  50
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLN C6847
VAL C6992
ALA C6843
SER C7000
LEU C6825
1.61A13.07
None
None
None
FMT  C7110 ( 2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		6 / 12
HIS A6917
SER A7090
ALA A6914
VAL C7087
SER C6907
LEU C6909
1.63A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		6 / 12
HIS C6917
SER C7090
ALA C6914
VAL A7087
SER A6907
LEU A6909
1.77A13.07
FMT  C7113 ( 4.9A)
NA  C7104 ( 2.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C7092
LEU C7093
VAL A7086
SER A6907
LEU A6909
1.71A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C6851
ALA C7002
GLY C7006
SER C6964
LEU C6857
1.75A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A6851
ALA A7002
GLY A7006
SER A6964
LEU A6857
1.74A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.61A13.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.58A
None
None
None
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.51A
None
MES  A 201 ( 3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		6 / 12
SER A 128
ALA A  50
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.79A
MES  A 201 (-4.4A)
MES  A 201 ( 3.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  96
GLY A  79
SER A 111
LEU A 108
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.53A
None
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
HIS A  86
SER A  65
ALA A  60
GLY A  51
ALA A  50
1.58A
None
None
None
MES  A 202 (-3.3A)
MES  A 201 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.54A
None
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.60A
None
None
None
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLN A 118
VAL A 147
VAL A  36
ALA A 124
LEU A 153
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 240
ALA A 260
VAL A 253
ALA A 242
LEU A 331
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 299
GLY A 282
ALA A 316
SER A 315
LEU A 313
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 299
GLY A 282
ALA A 316
SER A 315
LEU A 313
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 304
VAL A 281
GLY A 301
SER A 332
LEU A 313
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 240
ALA A 260
VAL A 253
ALA A 242
LEU A 331
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
HIS A 249
VAL A 240
LEU A 297
GLY A 283
LEU A 331
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
ALA A 254
VAL A 300
GLY A 283
LEU A 312
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
VAL A 300
GLY A 283
SER A 315
LEU A 312
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG A 277
ILE B 320
PHE A 286
1.48A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG E 277
ILE F 320
PHE E 286
1.48A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG F 277
ILE E 320
PHE F 286
1.50A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN A 294
LEU A 291
TRP A 301
VAL A 270
GLY B 316
1.63A
None
None
CL  A 401 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG C 277
ILE D 320
PHE C 286
1.50A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN C 294
LEU C 291
TRP C 301
VAL C 270
GLY D 316
1.63A
None
None
CL  C 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ARG D 277
ILE C 320
PHE D 286
1.51A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN D 294
LEU D 291
TRP D 301
VAL D 270
GLY C 316
1.61A
None
None
CL  D 401 ( 4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
HIS A6917
SER A7090
ALA A6914
VAL C7087
SER C6907
LEU C6909
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C7090
ALA C6914
VAL A7087
SER A6907
LEU A6909
1.70A
FMT  C7107 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A7092
LEU A7093
VAL C7086
SER C6907
LEU C6909
1.59A
 NA  A7102 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN A6847
VAL A6992
ALA A6843
SER A7000
LEU A6825
1.64A
None
None
None
FMT  A7106 ( 2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN C6847
VAL C6992
ALA C6843
SER C7000
LEU C6825
1.62A
None
None
None
FMT  C7110 ( 3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		6 / 12
HIS A6917
SER A7090
ALA A6914
VAL C7087
SER C6907
LEU C6909
1.60A
None
NA  A7102 ( 3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wkq NSP16
(SARS-CoV-2)		6 / 12
HIS C6917
SER C7090
ALA C6914
VAL A7087
SER A6907
LEU A6909
1.77A
FMT  C7108 ( 4.7A)
NA  C7102 ( 2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.30A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  95
GLY C  78
ALA C 112
SER C 111
LEU C 109
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  36
ALA D  56
VAL D  49
ALA D  38
LEU D 127
1.62A
None
None
APR  D 201 (-3.6A)
APR  D 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS B  45
VAL B  36
LEU B  93
GLY B  79
LEU B 127
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS D  45
VAL D  36
LEU D  93
GLY D  79
LEU D 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.61A
None
None
APR  C 201 (-3.8A)
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.60A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.62A
None
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER A 128
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.72A
APR  A 201 (-4.4A)
APR  A 201 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.63A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.47A
None
APR  B 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  36
ALA D  56
VAL D  49
ALA D  38
LEU D 127
1.59A
None
None
APR  D 201 (-3.6A)
APR  D 201 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS C  45
VAL C  36
LEU C  93
GLY C  79
LEU C 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C 100
VAL C  77
GLY C  97
SER C 128
LEU C 109
1.64A
None
None
None
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.62A
None
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.61A
None
None
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 127
ALA D  50
VAL D  96
GLY D  79
LEU D 108
1.50A
None
APR  D 201 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.62A
None
None
APR  A 201 (-3.8A)
APR  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER B 128
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.73A
APR  B 201 (-4.5A)
APR  B 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.47A
None
APR  A 201 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  78
ALA B 112
SER B 111
LEU B 109
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 100
VAL D  77
GLY D  97
SER D 128
LEU D 109
1.61A
None
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.62A
None
None
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 100
VAL D  77
GLY D  97
SER D 128
LEU D 109
1.62A
None
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
ALA C  50
VAL C  96
GLY C  79
LEU C 108
1.52A
None
APR  C 201 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  61
VAL D 115
GLY D 113
ALA D 110
LEU C  71
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER A  61
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
SER A 262
GLY A 287
ALA A 114
SER A 103
LEU A 117
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
0.95A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 125
LEU B 115
VAL B  13
GLY B  11
SER A  10
1.28A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.63A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.40A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER C  61
VAL D 115
GLY D 113
ALA D 110
LEU C  71
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  66
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER A  61
VAL B 115
GLY B 113
ALA B 110
LEU A  71
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
TYR A 423
ALA A 352
ALA A 397
LEU A 513
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN B   1
VAL A 367
SER A 366
ALA A 363
LEU A 335
1.68A
None
NAG  A 904 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 509
ILE E 434
PHE E 342
1.15A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.71A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  36
ALA E  56
VAL E  49
ALA E  38
LEU E 127
1.61A
None
None
None
EPE  E 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
ALA D  56
VAL D  49
ALA D  38
LEU D 127
1.56A
None
None
EDO  D 209 (-4.6A)
EDO  D 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
VAL D  77
GLY D  97
SER D 128
LEU D 109
1.66A
None
None
None
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 100
VAL E  77
GLY E  97
SER E 128
LEU E 109
1.66A
None
None
None
EPE  E 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
ALA E  50
VAL E  96
GLY E  79
LEU E 108
1.55A
None
EPE  E 202 (-3.1A)
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  86
SER C  65
ALA C  60
GLY C  51
ALA C  50
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  95
GLY D  78
ALA D 112
SER D 111
LEU D 109
1.70A
None
None
None
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  95
GLY E  78
ALA E 112
SER E 111
LEU E 109
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.66A
None
None
EDO  A 202 ( 4.9A)
EDO  A 202 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  78
ALA B 112
SER B 111
LEU B 109
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  36
ALA E  56
VAL E  49
ALA E  38
LEU E 127
1.57A
None
None
None
EPE  E 202 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 127
ALA D  50
VAL D  96
GLY D  79
LEU D 108
1.59A
None
EDO  D 206 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
GLY C  78
ALA C 112
SER C 111
LEU C 109
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  86
SER B  65
ALA B  60
GLY B  51
ALA B  50
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS D  86
SER D  65
ALA D  60
GLY D  51
ALA D  50
1.51A
None
None
None
None
EDO  D 206 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS E  45
VAL E  36
LEU E  93
GLY E  79
LEU E 127
1.63A
None
None
None
EPE  E 203 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
ALA D  56
VAL D  49
ALA D  38
LEU D 127
1.59A
None
None
EDO  D 209 (-4.6A)
EDO  D 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.54A
EDO  A 202 ( 4.8A)
None
None
None
EDO  D 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  86
SER A  65
ALA A  60
GLY A  51
ALA A  50
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS E  86
SER E  65
ALA E  60
GLY E  51
ALA E  50
1.53A
None
None
None
None
EPE  E 202 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.63A
None
None
None
None
EDO  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS D  45
VAL D  36
LEU D  93
GLY D  79
LEU D 127
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.61A
None
None
None
EDO  A 202 (-3.3A)
EDO  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  45
VAL B  36
LEU B  93
GLY B  79
LEU B 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
ALA C  50
VAL C  96
GLY C  79
LEU C 108
1.57A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  45
VAL C  36
LEU C  93
GLY C  79
LEU C 127
1.61A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  36
ALA E  56
VAL E  49
ALA E  38
LEU E 127
1.61A
None
None
APR  E 201 (-3.7A)
APR  E 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.62A
None
None
APR  B 201 (-3.7A)
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  86
SER B  65
ALA B  60
GLY B  51
ALA B  50
1.54A
None
None
None
None
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 127
ALA D  50
VAL D  96
GLY D  79
LEU D 108
1.56A
None
APR  D 201 (-3.6A)
None
EDO  D 203 (-3.1A)
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  36
ALA D  56
VAL D  49
ALA D  38
LEU D 127
1.61A
None
None
APR  D 201 (-3.7A)
APR  D 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.62A
None
None
APR  A 201 (-3.7A)
APR  A 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
ALA E  50
VAL E  96
GLY E  79
LEU E 108
1.53A
None
APR  E 201 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.62A
None
None
APR  C 201 (-3.6A)
APR  C 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS D  45
VAL D  36
LEU D  93
GLY D  79
LEU D 127
1.63A
None
None
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
ALA C  50
VAL C  96
GLY C  79
LEU C 108
1.57A
None
APR  C 201 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.54A
None
APR  A 201 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.54A
None
APR  B 201 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
GLY C  78
ALA C 112
SER C 111
LEU C 109
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  86
SER B  65
ALA B  60
GLY B  51
ALA B  50
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  78
ALA B 112
SER B 111
LEU B 109
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
VAL C  77
GLY C  97
SER C 128
LEU C 109
1.61A
None
None
None
MES  C 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  95
GLY A  78
ALA A 112
SER A 111
LEU A 109
1.71A
None
None
None
EDO  C 205 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
VAL C  77
GLY C  97
SER C 128
LEU C 109
1.62A
None
None
None
MES  C 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
ALA A  50
VAL A  96
GLY A  79
LEU A 108
1.53A
None
MES  A 201 ( 3.7A)
None
EDO  A 204 (-3.6A)
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.55A
None
None
None
MES  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  45
VAL C  36
LEU C  93
GLY C  79
LEU C 127
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS B  45
VAL B  36
LEU B  93
GLY B  79
LEU B 127
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  36
ALA B  56
VAL B  49
ALA B  38
LEU B 127
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
ALA C  50
VAL C  96
GLY C  79
LEU C 108
1.59A
None
MES  C 201 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.58A
None
None
None
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  86
SER C  65
ALA C  60
GLY C  51
ALA C  50
1.55A
None
None
None
None
MES  C 201 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS A  45
VAL A  36
LEU A  93
GLY A  79
LEU A 127
1.64A
None
None
None
EDO  A 204 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.64A
None
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
ALA B  50
VAL B  96
GLY B  79
LEU B 108
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  36
ALA C  56
VAL C  49
ALA C  38
LEU C 127
1.55A
None
None
None
MES  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  36
ALA A  56
VAL A  49
ALA A  38
LEU A 127
1.58A
None
None
None
MES  A 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
VAL B  77
GLY B  97
SER B 128
LEU B 109
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
VAL A  77
GLY A  97
SER A 128
LEU A 109
1.65A
None
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.42A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  86
LEU A  87
VAL A  36
GLY A  29
LEU A 177
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.61A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 561
ALA A 512
GLY A 683
ALA A 558
SER A 681
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 187
VAL A 182
GLY A 179
ALA A 250
LEU A 251
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 557
SER A 682
ALA A 685
VAL A 560
GLY A 503
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 4
LEU A 208
ARG A 217
ILE A 281
PHE A 219
1.62A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  68
LEU A  67
VAL A  73
GLY A  71
ALA A  70
1.49A
None
None
None
DMS  A 403 (-4.0A)
DMS  A 403 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
ARG A 279
ILE A 281
PHE A 219
1.34A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 561
ALA A 512
GLY A 683
ALA A 558
SER A 681
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 557
SER A 682
ALA A 685
VAL A 560
GLY A 503
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 398
SER A 397
TYR A 674
ALA A 400
LEU A 401
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 371
TYR A 515
ALA A 376
ALA B  86
SER B  85
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 210
VAL A 182
GLY A 179
ALA A 250
LEU A 251
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 561
ALA A 512
GLY A 683
ALA A 558
SER A 681
1.63A
None
None
U  T  10 ( 3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 371
TYR A 515
ALA A 376
ALA B  86
SER B  85
1.59A
None