Ligand ID: PFN


Drugbank ID:
DB00573
(Fenoprofen)


Indication:
For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.

Get human targets for PFN in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'PFN' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A 167
HIS A  41
MET A  49
THR A 175
PRO A  39
1.72A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
VAL B1189
SER B 937
ALA B 930
PHE B 927
1.73A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6m03 MAIN PROTEASE
(SARS-CoV-2)		5 / 11
LEU A 167
HIS A  41
MET A  49
THR A 175
PRO A  39
1.71A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A 167
HIS A  41
MET A  49
THR A 175
PRO A  39
1.74A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU C 162
LEU C 168
LEU C 160
THR B 166
PRO B  68
1.77A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 208
SER A 236
ALA A  46
PHE A  48
1.71A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
VAL A 373
SER A 561
ALA A 660
PHE A 348
1.50A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
VAL A 315
SER A 664
ALA A 656
PHE A 652
1.36A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6m71 NSP12
(SARS-CoV-2)		5 / 11
TYR A 175
LEU A 178
LEU A 127
LEU A 146
LYS A 143
1.72A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
TYR B  91
LEU B 223
LYS B 206
THR B  95
PRO B 217
1.73A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
VAL C1061
SER C 937
ALA C 930
PHE C 927
1.44A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
VAL B1061
SER B 937
ALA B 930
PHE B 927
1.33A14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
VAL C1061
SER C 937
ALA C 930
PHE C 927
1.35A14.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6w4h NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.54A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6w4h NSP16
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.71A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.58A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
VAL C6865
ALA C6877
PHE C6901
1.55A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 4
TYR C7009
LEU C7073
LEU C7010
HIS C6984
1.72A20.17
 NA  C7103 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6w75 NSP16
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.71A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP C6895
VAL C6865
ALA C6877
PHE C6901
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
TYR C7009
LEU C7073
LEU C7010
HIS C6984
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6897
ASP A6928
ALA A6877
PHE A6901
1.70A
SAH  A7102 (-2.6A)
SAH  A7102 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wkq NSP16
(SARS-CoV-2)		4 / 4
TYR C7009
LEU C7073
LEU C7010
HIS C6984
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP C6895
VAL C6865
ALA C6877
PHE C6901
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
TYR A7009
LEU A7073
LEU A7010
HIS A6984
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6895
VAL A6865
ALA A6877
PHE A6901
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A6897
ASP A6928
ALA A6877
PHE A6901
1.68A
SAH  A7101 (-2.7A)
SAH  A7101 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A 167
HIS A  41
MET A  49
THR A 175
PRO A  39
1.78A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A 167
HIS A  41
MET A  49
THR A 175
PRO A  39
1.72A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.78A21.01
None
None
DMS  L1601 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.78A21.01
None
None
DMS  L1601 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.65A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.65A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.77A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER A 514
PHE A 429
VAL A 382
TYR A 396
1.78A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER A 514
PHE A 429
VAL A 382
TYR A 396
1.78A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
SER E 514
PHE E 429
VAL E 382
TYR E 396
1.77A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 11
LEU C  56
LEU C  59
LEU C  55
HIS C  36
PRO A 412
1.75A13.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
VAL A 315
SER A 664
ALA A 656
PHE A 652
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 208
SER A 236
ALA A  46
PHE A  48
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
ASP B 112
VAL A 353
SER A 325
ALA B 110
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU C  56
LEU D 103
LEU C  55
LYS C  51
PRO D 121
1.79A13.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
VAL A 373
ASP A 377
SER A 561
ALA A 660
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
VAL A 373
SER A 561
ALA A 660
PHE A 348
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 373
SER A 561
ALA A 660
PHE A 348
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 315
SER A 664
ALA A 656
PHE A 652
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 662
ASP A 684
SER A 635
ALA A 688
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A 208
SER A 236
ALA A  46
PHE A  48
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ASP B 112
VAL A 353
SER A 325
ALA B 110
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
VAL A 315
SER A 664
ALA A 656
PHE A 652
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 11
TYR A 515
LEU A 372
MET B  87
THR A 538
PRO A 505
1.77A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 11
LEU C  56
LEU C  59
LEU C  55
HIS C  36
PRO A 412
1.78A13.24
None