Ligand ID: NMY


Drugbank ID:
DB00452
(Framycetin)
DB00994
(Neomycin)


Indication:
For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal;Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic E. coli (EPEC).

Get human targets for NMY in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'NMY' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASN A  76
TYR A 112
ASP A  83
GLY A 148
ASP A 145
1.68A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.79A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
TYR A 238
ASP A 208
THR A 206
GLY A 214
ASP A 211
1.63A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.78A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 329
TYR A 273
ASN A 300
LEU A 282
PHE A 321
1.59A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.79A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
TYR A 238
ASP A 208
THR A 206
GLY A 214
ASP A 211
1.68A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
TYR A 238
ASP A 208
THR A 206
GLY A 214
ASP A 211
1.69A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ASP A 833
TYR A 831
HIS A 872
ASP A 879
GLU A 876
1.76A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 10
TYR A 238
ASP A 208
THR A 206
GLY A 214
ASP A 211
1.69A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 187
PRO A  94
ASP A 211
ASN A 215
PHE A 192
1.72A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR C1110
HIS C1101
ASN C1135
PHE C1095
ILE C1115
1.56A14.13
None
NAG  C1303 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
TYR B 917
ASN B 914
THR B 912
GLY A1093
GLU A1092
1.63A13.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
TYR A 365
ASP B 985
THR A 385
GLY A 381
GLU B 988
1.47A13.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A 279
ASN A 969
ASP C 571
LEU C 546
PHE C 565
1.76A15.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
TYR A 365
ASP B 985
THR A 385
GLY A 381
GLU B 988
1.46A13.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
ASN C  75
TYR C 111
ASP C  82
THR C 148
GLY C 147
1.75A19.56
MES  B 203 ( 3.3A)
None
ZN  C 201 ( 2.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A  69
GLU A 146
SER A 162
ARG A 127
ASP A 125
1.57A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6w4b NSP9
(SARS-CoV-2)		5 / 11
TYR A  67
THR A  68
THR A  20
GLY A  18
ASP A  51
1.74A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		6w4b NSP9
(SARS-CoV-2)		5 / 10
TYR A  67
THR A  68
THR A  20
GLY A  18
ASP A  51
1.77A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  76
ASN B 108
LEU A  60
PHE B  92
ILE B 107
1.61A15.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASN C  75
TYR C 111
ASP C  82
GLY C 147
ASP C 144
1.71A19.93
None
None
ZN  C 201 (-2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ASN D  75
TYR D 111
ASP D  82
THR D 148
GLY D 147
1.75A19.93
MES  D 201 (-3.0A)
None
ZN  D 202 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU A  69
GLU A 146
SER A 162
ARG A 127
ASP A 125
1.55A23.14
EDO  A 408 (-3.8A)
None
EDO  A 408 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLU B  69
GLU B 146
SER B 162
ARG B 127
ASP B 125
1.54A23.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
ASN A  37
TYR A  71
ASP A  42
THR A  75
ASP A 104
1.61A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.67A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 187
PRO A  94
ASP A 211
ASN A 215
PHE A 192
1.67A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.66A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.74A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.66A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.69A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.62A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU B 103
ASN A 356
ASP A 377
LEU A 366
PHE A 340
1.68A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.60A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.66A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.62A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 318
ASN A 314
ASP A 274
GLU A 350
TYR A 346
1.73A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.58A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.64A14.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 318
ASN A 314
ASP A 274
GLU A 350
TYR A 346
1.72A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASP A 452
THR A 556
THR A 409
GLY A 446
ASP A 445
1.61A14.56
None