Ligand ID: MYT


Drugbank ID:
DB01011
(Metyrapone)


Indication:
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.

Get human targets for MYT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MYT' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.72A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.78A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
VAL A 296
LEU A 250
ALA A 210
THR A 257
1.75A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
VAL A 296
LEU A 205
ALA A 210
THR A 257
1.73A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 287
ILE A 281
ALA A 211
ALA A 206
1.47A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 271
ILE A 281
ALA A 211
ALA A 206
1.65A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.65A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.53A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.53A20.47
DMS  A 403 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.68A20.47
None
DMS  A 403 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.34A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.54A21.60
DMS  A 401 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.40A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
THR A 257
LEU A 282
VAL A 212
GLY A 215
VAL A 303
1.70A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.68A21.60
None
DMS  A 401 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU C  30
VAL C  18
GLY C  29
ASP C  33
VAL C  91
1.64A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
VAL C  18
GLY C  29
VAL C  35
ASP C  33
VAL C  91
1.49A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
PHE C 181
THR C 175
GLY C 146
ASP C 187
VAL C  86
1.72A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.48A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU B  30
VAL B  18
GLY B  29
ASP B  33
VAL B  91
1.66A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.40A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU D  30
VAL D  18
GLY D  29
ASP D  33
VAL D  91
1.67A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
PHE A 181
THR A 175
GLY A 146
ASP A 187
VAL A  86
1.70A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
VAL D  18
GLY D  29
VAL D  35
ASP D  33
VAL D  91
1.57A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.64A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
VAL B  18
GLY B  29
VAL B  35
ASP B  33
VAL B  91
1.54A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 220
ILE B 259
ALA B 260
THR B 224
1.42A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
PHE A 181
THR A 175
GLY A 146
ASP A 187
VAL A  86
1.66A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.51A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.66A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER C  52
ALA C  56
THR C  58
ALA C  91
1.31A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER C  52
ALA C  56
THR C  58
ALA C  91
1.14A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
VAL A 667
ALA A 558
THR A 556
ALA A 449
1.30A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 692
ILE A 757
THR A 591
ALA A 580
1.56A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ILE A 450
ALA A 449
THR A 556
ALA A 558
1.75A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 102
1.48A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
VAL A 330
LEU A 271
ILE B 119
THR B 124
1.30A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 236
ALA A 125
THR A 123
ALA A 185
1.75A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 812
VAL A 605
THR A 586
ASP A 761
VAL A 588
1.58A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m71 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 124
ALA B 150
1.49A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
ALA A 706
THR A 710
ALA A  46
1.41A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 575
ALA A 580
THR A 582
ALA A 585
1.45A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
VAL A 693
LEU A 576
ILE A 579
ALA A 639
1.25A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ILE A 589
ALA A 688
THR A 687
ALA A 634
1.67A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 647
ARG A 654
THR A 531
ALA A 656
1.79A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 165
TYR A 787
LEU A 131
ILE A 171
VAL A 174
1.75A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 514
ALA B  86
THR B  84
ALA B  81
1.37A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m71 NSP8
(SARS-CoV-2)		5 / 11
TYR B 135
GLY B 144
VAL B 159
ILE B 132
VAL B 186
1.28A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
ALA D 102
1.65A11.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
VAL A 182
LEU A 131
ILE A 244
ALA A 176
1.34A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 624
ILE A 450
ALA A 449
ALA A 558
1.74A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
SER A 561
ILE A 562
THR A 531
ALA A 660
1.65A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 766
THR A 801
LEU A 805
GLY A 808
VAL A 763
1.75A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 569
ALA A 685
THR A 565
ALA A 512
1.44A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6m71 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 126
THR B 124
ALA B 150
1.65A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 11
THR B 299
VAL B 308
GLY B 601
THR B 599
ASP B 294
VAL B 597
1.54A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER C 596
ALA C 647
THR C 645
ALA C 653
1.40A17.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER C 555
ILE C 584
ALA C 575
THR C 573
1.44A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
TYR B 365
GLY B 381
VAL B 512
ILE B 434
VAL B 433
1.36A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
LEU B 984
VAL A 382
GLY A 381
THR A 430
ASP B 979
1.44A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
SER A  51
ALA A  55
THR A  57
ALA A  90
1.31A13.70
None
MES  A 203 (-3.3A)
CL  A 202 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
SER D  51
ALA D  55
THR D  57
ALA D  90
1.29A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
SER C  51
ALA C  55
THR C  57
ALA C  90
1.33A13.70
None
MES  C 204 (-3.3A)
CL  C 202 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
SER B  51
ALA B  55
THR B  57
ALA B  90
1.24A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		6 / 11
PHE C 400
TYR C 423
LEU C 425
VAL C 433
ILE C 402
VAL C 407
1.78A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
LEU A7052
GLY A7054
VAL A7057
ASP A6923
ILE A7079
1.78A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
VAL A7057
LEU A7073
ILE A7080
ALA A6960
1.68A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 NSP10
(SARS-CoV-2)		4 / 6
LEU B4345
ILE B4308
ALA B4307
THR B4368
1.66A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6969
ALA A7002
THR A6989
1.56A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w61 NSP10
(SARS-CoV-2)		5 / 11
LEU B4365
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
ILE A6926
THR A6880
ALA A6881
1.64A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 NSP10
(SARS-CoV-2)		4 / 6
VAL B4369
LEU B4345
ALA B4307
THR B4309
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w61 NSP10
(SARS-CoV-2)		5 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
VAL B4350
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
TYR A6950
GLY A6869
VAL A6894
ILE A6866
1.70A
None
None
SAM  A7104 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6831
ALA A6997
THR A6993
ALA A6843
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6924
ILE A6926
THR A6880
ALA A6905
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
VAL A6865
LEU A6848
ILE A6926
THR A6880
1.57A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
VAL A7057
ILE A7080
ALA A6960
ALA A6858
1.74A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6927
ILE A6967
THR A6949
ALA A6914
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6967
ALA A6966
ALA A6990
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6887
ALA A6905
THR A6880
ALA A6881
1.69A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
THR A6993
ALA A6808
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
ALA A7002
THR A6989
ALA A6808
1.53A17.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6964
ARG A7053
ALA A6858
THR A7055
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
PHE A 181
THR A 175
GLY A 146
ASP A 187
VAL A  86
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  53
ILE B  23
ALA B 154
ALA B 129
1.55A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  95
LEU B 109
ALA B  38
ALA B 124
1.77A16.67
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  53
ILE A  23
ALA A 154
ALA A 129
1.59A16.67
None
AMP  A 201 ( 4.0A)
AMP  A 201 ( 4.5A)
AMP  A 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  36
LEU B  43
ALA B  38
ALA B 112
1.46A16.67
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w6y NSP3
(SARS-CoV-2)		5 / 11
TYR A 113
LEU A 126
GLY A 130
ILE A 106
VAL A 100
1.58A
None
AMP  A 201 ( 4.4A)
AMP  A 201 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL A  95
LEU A 109
ALA A  38
ALA A 124
1.75A16.67
None
None
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w6y NSP3
(SARS-CoV-2)		5 / 11
TYR B 113
LEU B 126
GLY B 130
ILE B 106
VAL B 100
1.67A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL A  49
LEU A 153
ALA A  38
ALA A 129
1.72A16.67
AMP  A 201 ( 3.7A)
None
AMP  A 201 ( 3.9A)
AMP  A 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  35
ILE B  23
ALA B 124
ALA B  39
1.77A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL A  36
LEU A  43
ALA A  38
ALA A 112
1.49A16.67
None
None
AMP  A 201 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL A  35
ILE A  23
ALA A 124
ALA A  39
1.77A16.67
None
AMP  A 201 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  49
LEU B 153
ALA B  38
ALA B 129
1.67A16.67
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP10
(SARS-CoV-2)		5 / 11
LEU D4328
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.59A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
ILE C6926
THR C6880
ALA C6881
1.64A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
THR C6993
ALA C6808
1.54A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL A7057
LEU A7073
ILE A7080
ALA A6960
1.66A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A6964
ARG A7053
ALA A6858
THR A7055
1.51A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL A6865
LEU A6848
ILE A6926
THR A6880
1.57A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL C7057
ILE C7080
ALA C6960
ALA C6858
1.74A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
ALA A7002
THR A6989
ALA A6808
1.50A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL C7057
LEU C7073
ILE C7080
ALA C6960
1.68A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP10
(SARS-CoV-2)		6 / 11
TYR D4329
LEU D4365
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.60A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6924
ILE C6926
THR C6880
ALA C6905
1.23A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
ILE A6926
THR A6880
ALA A6881
1.63A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL C6865
LEU C6959
ILE C6925
ALA C6858
1.57A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C6964
ARG C7053
ALA C6858
THR C7055
1.75A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
ALA C7002
THR C6989
ALA C6808
1.49A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL A7057
ILE A7080
ALA A6960
ALA A6858
1.72A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP16
(SARS-CoV-2)		5 / 11
PHE A6954
TYR A6950
GLY A6869
VAL A6894
ILE A6866
1.70A17.15
None
FMT  A7109 ( 4.9A)
SAM  A7102 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER C6927
ILE C6967
THR C6949
ALA C6914
1.60A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
THR A6993
ALA A6808
1.55A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6978
ILE C6967
ALA C6966
ALA C6990
1.41A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
VAL B4369
LEU B4345
ALA B4307
THR B4309
1.21A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
VAL D4369
LEU D4345
ALA D4307
THR D4309
1.22A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6967
ALA A6966
ALA A6990
1.40A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
VAL D4274
LEU D4328
ILE D4334
ALA B4273
1.74A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP10
(SARS-CoV-2)		6 / 11
TYR D4329
LEU D4365
VAL D4361
GLY D4362
VAL D4350
ASP D4344
1.78A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
LEU B4345
ILE B4308
ALA B4307
THR B4368
1.68A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL C6865
LEU C6848
ILE C6926
THR C6880
1.58A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6887
ALA A6905
THR A6880
ALA A6881
1.67A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6978
ILE C6969
ALA C7002
THR C6989
1.55A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6w75 NSP16
(SARS-CoV-2)		4 / 6
SER A6927
ILE A6967
THR A6949
ALA A6914
1.60A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP10
(SARS-CoV-2)		6 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.63A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6969
ALA A7002
THR A6989
1.55A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6924
ILE A6926
THR A6880
ALA A6905
1.24A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
LEU D4345
ILE D4308
ALA D4307
THR D4368
1.68A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
VAL D4274
ILE B4334
ALA B4276
ALA B4273
1.72A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.59A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6w75 NSP16
(SARS-CoV-2)		5 / 11
PHE C6954
TYR C6950
GLY C6869
VAL C6894
ILE C6866
1.71A17.15
None
None
SAM  C7105 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP10
(SARS-CoV-2)		4 / 6
VAL B4274
LEU B4328
ILE B4334
ALA D4273
1.68A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6887
ALA C6905
THR C6880
ALA C6881
1.67A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 172
ILE B 151
ALA B 149
ALA B 131
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 117
ILE A 151
ALA A 149
THR A  90
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 113
ALA A  86
THR A  90
ALA A 145
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 282
ILE B 276
ALA B 261
THR B 259
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 172
ILE C 151
ALA C 149
ALA C 131
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 172
ILE A 151
ALA A 149
ALA A 131
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 282
ILE C 276
ALA C 261
THR C 259
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 113
ALA B  86
THR B  90
ALA B 145
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 117
ILE C 151
ALA C 149
THR C  90
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 282
ILE A 276
ALA A 261
THR A 259
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wcf NSP3
(SARS-CoV-2)		5 / 11
TYR A 113
LEU A 126
GLY A 130
ILE A 106
VAL A 100
1.65A
None
None
MES  A 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 6
VAL A   6
LEU A  55
ILE A  39
ALA A  48
ALA B 102
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE A  39
ALA A  48
THR A  46
ALA B 102
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wiq NSP8
(SARS-CoV-2)		5 / 11
TYR B 135
GLY B 144
VAL B 159
ILE B 132
VAL B 186
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 6
VAL A  53
LEU B 128
ALA B 150
ALA B 110
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wiq NSP8
(SARS-CoV-2)		4 / 6
VAL B 130
ILE B 156
ALA B 188
ALA B 152
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU D 291
ILE D 304
ALA D 305
ALA C 313
1.13A
None
None
CL  D 401 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU E 291
ILE E 304
ALA E 305
ALA F 313
1.15A
None
None
CL  E 401 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU F 291
ILE F 304
ALA F 305
ALA E 313
1.15A
None
None
CL  F 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER A 318
ALA A 313
THR B 263
ALA B 305
1.76A
None
None
None
CL  B 401 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A 291
ILE A 304
ALA A 305
ALA B 313
1.17A
None
None
CL  A 401 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 291
ILE C 304
ALA C 305
ALA D 313
1.18A
None
None
CL  C 401 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU B 291
ILE B 304
ALA B 305
ALA A 313
1.19A
None
None
CL  B 401 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt NSP10
(SARS-CoV-2)		6 / 11
TYR D4329
LEU D4365
VAL D4361
GLY D4362
VAL D4350
ASP D4344
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6927
ILE A6967
THR A6949
ALA A6914
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt NSP10
(SARS-CoV-2)		5 / 11
LEU D4328
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6924
ILE A6926
THR A6880
ALA A6905
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
TYR A6950
GLY A6869
VAL A6894
ILE A6866
1.69A
None
None
SAH  A7102 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6924
ILE C6926
THR C6880
ALA C6905
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt NSP10
(SARS-CoV-2)		4 / 6
VAL D4369
LEU D4345
ALA D4307
THR D4309
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6978
ILE C6967
ALA C6966
ALA C6990
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt NSP10
(SARS-CoV-2)		6 / 11
TYR D4329
LEU D4365
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
THR A6993
ALA A6808
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6964
ARG A7053
ALA A6858
THR A7055
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER C6927
ILE C6967
THR C6949
ALA C6914
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt NSP10
(SARS-CoV-2)		6 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6967
ALA A6966
ALA A6990
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wjt NSP10
(SARS-CoV-2)		4 / 6
VAL B4369
LEU B4345
ALA B4307
THR B4309
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE C6954
TYR C6950
GLY C6869
VAL C6894
ILE C6866
1.71A
None
None
SAH  C7102 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
THR C6993
ALA C6808
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER D  78
ILE D 146
THR D 141
ALA D 138
1.71A
None
MES  D 201 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER B  78
ILE B 146
THR B 141
ALA B 138
1.69A
None
MES  B 201 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER D  51
ALA D  55
THR D  57
ALA D  90
1.29A
None
None
ZN  A 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER B  51
ALA B  55
THR B  57
ALA B  90
1.29A
None
None
ZN  C 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER A  78
ILE A 146
THR A 141
ALA A 138
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER A  51
ALA A  55
THR A  57
ALA A  90
1.43A
None
MES  B 201 (-3.2A)
MES  B 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER A  51
ALA A  55
THR A  57
ALA A  90
1.47A
None
MES  B 201 (-3.2A)
MES  B 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
TYR C  87
THR C  54
LEU C 167
THR D  76
VAL C 158
1.47A
None
MES  D 201 (-4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER C  51
ALA C  55
THR C  57
ALA C  90
1.27A
None
MES  D 201 (-3.3A)
ZN  D 202 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
SER C  78
ILE C 146
THR C 141
ALA C 138
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP16
(SARS-CoV-2)		5 / 11
PHE A6954
TYR A6950
GLY A6869
VAL A6894
ILE A6866
1.70A
None
None
SFG  A7103 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A6927
ILE A6967
THR A6949
ALA A6914
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6967
ALA A6966
ALA A6990
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER A6964
ARG A7053
ALA A6858
THR A7055
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP10
(SARS-CoV-2)		5 / 11
LEU D4365
VAL D4361
GLY D4362
VAL D4350
ASP D4344
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP10
(SARS-CoV-2)		5 / 11
LEU D4328
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP16
(SARS-CoV-2)		5 / 11
PHE C6954
TYR C6950
GLY C6869
VAL C6894
ILE C6866
1.71A
None
None
SFG  C7103 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6978
ILE C6967
ALA C6966
ALA C6990
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
THR A6993
ALA A6808
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A6924
ILE A6926
THR A6880
ALA A6905
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
THR C6993
ALA C6808
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6924
ILE C6926
THR C6880
ALA C6905
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP10
(SARS-CoV-2)		6 / 11
TYR D4329
LEU D4365
VAL D4361
GLY D4362
ASP D4344
VAL D4350
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP10
(SARS-CoV-2)		4 / 6
VAL D4369
LEU D4345
ALA D4307
THR D4309
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP10
(SARS-CoV-2)		6 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C6964
ARG C7053
ALA C6858
THR C7055
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wkq NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wkq NSP16
(SARS-CoV-2)		4 / 6
SER C6927
ILE C6967
THR C6949
ALA C6914
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wkq NSP10
(SARS-CoV-2)		4 / 6
VAL B4369
LEU B4345
ALA B4307
THR B4309
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 300
VAL B 237
GLY B 254
ILE B 296
VAL B 295
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 207
SER A 198
ALA A 161
THR A 175
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 300
VAL A 237
GLY A 254
ILE A 296
VAL A 295
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 207
SER B 198
ALA B 161
THR B 175
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU A 300
VAL A 237
ASP A 297
ILE A 296
VAL A 295
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 11
LEU B 300
VAL B 237
ASP B 297
ILE B 296
VAL B 295
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 207
SER B 198
ALA B 161
THR B 175
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
TYR A 113
LEU A 126
GLY A 130
ILE A 106
VAL A 100
1.68A
None
None
APR  A 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
TYR B 113
LEU B 126
GLY B 130
ILE B 106
VAL B 100
1.69A
None
None
APR  B 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
TYR C 113
LEU C 126
GLY C 130
ILE C 106
VAL C 100
1.66A
None
APR  C 201 (-4.9A)
APR  C 201 (-3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
THR A6993
ALA A6808
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6978
ILE A6967
ALA A6966
ALA A6990
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wq3 NSP10
(SARS-CoV-2)		6 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
VAL B4350
ASP B4344
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6964
ARG A7053
ALA A6858
THR A7055
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
PHE A6954
TYR A6950
GLY A6869
VAL A6894
ILE A6866
1.69A
None
None
SAH  A7101 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
SER A6927
ILE A6967
THR A6949
ALA A6914
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wq3 NSP10
(SARS-CoV-2)		4 / 6
VAL B4369
LEU B4345
ALA B4307
THR B4309
1.20A
None
None
None
SO4  B4404 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6924
ILE A6926
THR A6880
ALA A6905
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wq3 NSP10
(SARS-CoV-2)		5 / 11
LEU B4328
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wq3 NSP10
(SARS-CoV-2)		6 / 11
TYR B4329
LEU B4365
VAL B4361
GLY B4362
ASP B4344
VAL B4350
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
VAL D 130
ILE D 156
ALA D 188
ALA D 152
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER A  57
ILE B 106
ALA B 110
ALA A  65
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE A  39
ALA A  48
THR A  46
ALA B 102
1.54A
None
None
None
EDO  B 302 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
VAL C  53
LEU D 128
ALA D 150
ALA D 110
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
VAL A  53
LEU B 128
ALA B 150
ALA B 110
1.33A
EDO  B 302 ( 4.8A)
None
EDO  B 302 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  57
ILE D 119
THR D 123
ALA D 152
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
VAL B 130
ILE B 156
ALA B 188
ALA B 152
1.17A
None
None
None
EDO  B 302 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 102
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
ALA D 102
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wqd NSP8
(SARS-CoV-2)		5 / 11
TYR B 135
GLY B 144
VAL B 159
ILE B 132
VAL B 186
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wqd NSP8
(SARS-CoV-2)		5 / 11
TYR D 135
GLY D 144
VAL D 159
ILE D 132
VAL D 186
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 6
VAL A   6
LEU A  55
ILE A  39
ALA A  48
ALA B 102
1.59A
None
None
None
None
EDO  B 302 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
SER A 111
ALA A 116
THR A 119
ALA A 261
1.74A
PO4  A 502 (-2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 282
ILE A 276
ALA A 261
THR A 259
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 172
ILE A 151
ALA A 149
ALA A 131
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 113
ALA A  86
THR A  90
ALA A 145
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xez NSP13
(SARS-CoV-2)		4 / 6
ILE E 493
ALA E 522
THR E 530
ALA E 509
1.29A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xez NSP13
(SARS-CoV-2)		4 / 6
ILE F 109
ALA F 110
THR F  37
ALA F  18
1.35A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xip NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  57
ILE D 119
THR D 123
ALA D 194
1.48A12.28
None
None
None
EDO  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xip NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 194
1.48A12.28
None
None
None
EDO  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xip NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER A  57
ILE B 119
THR B 123
ALA B 152
1.43A12.28
None
None
None
EDO  B 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xip NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE A  39
ALA A  48
THR A  46
ALA B 102
1.50A12.28
None
None
None
EDO  B 201 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6xip NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 102
1.49A12.28
None
None
None
EDO  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A   4
SER B 139
ARG A 298
ALA A   7
1.48A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.65A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 287
ILE A 281
ALA A 211
ALA A 206
1.48A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 271
ILE A 281
ALA A 211
ALA A 206
1.65A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
VAL A 296
LEU A 205
ALA A 210
THR A 257
1.74A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
VAL A 296
LEU A 250
ALA A 210
THR A 257
1.75A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.78A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.53A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
VAL B 130
ILE B 156
ALA B 188
ALA B 152
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
TYR B 135
GLY B 144
VAL B 159
ILE B 132
VAL B 186
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
VAL D 130
ILE D 156
ALA D 188
ALA D 152
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE A  39
ALA A  48
THR A  46
ALA B 102
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
VAL C  53
LEU D 128
ALA D 150
ALA D 110
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
VAL A  53
LEU B 128
ALA B 150
ALA B 110
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 102
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
TYR D 135
GLY D 144
VAL D 159
ILE D 132
VAL D 186
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 188
THR B 187
ALA B 126
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
ALA D 102
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 188
THR B 187
ALA B 126
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 6
VAL A   6
LEU A  55
ILE A  39
ALA A  48
ALA B 102
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
SER A  38
ILE A 106
THR A 101
ALA A  98
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
PHE A 392
THR A 430
GLY B 101
THR B 104
ILE C  34
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
TYR H  52
VAL E 407
VAL E 512
ILE E 434
VAL E 510
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 181
THR A 175
GLY A 146
ASP A 187
VAL A  86
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 11
PHE A 400
TYR A 423
LEU A 425
VAL A 433
ILE A 402
VAL A 407
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
ALA A 266
1.78A
None
None
None
IMD  A 402 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
PHE A 181
THR A 175
GLY A 146
ASP A 187
VAL A  86
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR B 113
LEU B 126
GLY B 130
ILE B 106
VAL B 100
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR E 113
LEU E 126
GLY E 130
ILE E 106
VAL E 100
1.68A
None
None
EPE  E 202 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR D 113
LEU D 126
GLY D 130
ILE D 106
VAL D 100
1.65A
None
None
EDO  D 205 ( 4.9A)
EDO  D 204 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR D 113
LEU D 126
GLY D 130
ILE D 106
VAL D 100
1.64A
None
APR  D 201 (-4.5A)
APR  D 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR B 113
LEU B 126
GLY B 130
ILE B 106
VAL B 100
1.64A
None
APR  B 201 (-4.7A)
APR  B 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR E 113
LEU E 126
GLY E 130
ILE E 106
VAL E 100
1.70A
None
APR  E 201 (-4.7A)
APR  E 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
ARG B 141
SER B 167
ALA A  52
ALA A  27
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR C 113
LEU C 126
GLY C 130
ILE C 106
VAL C 100
1.61A
None
None
MES  C 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
SER B 167
ALA A  56
THR A  57
ALA A  50
1.73A
None
None
None
MES  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
TYR B 113
LEU B 126
GLY B 130
ILE B 106
VAL B 100
1.64A
None
None
None
EDO  B 204 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
ILE B 137
ALA A  56
THR A  57
ALA A  50
1.59A
None
None
None
MES  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
ARG B 141
SER B 167
THR A  57
ALA A  27
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 6
ILE B 525
ALA B 522
THR B 530
ALA B 509
1.23A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 6
ILE A 525
ALA A 522
THR A 530
ALA A 509
1.18A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 6
ILE B 493
ALA B 522
THR B 530
ALA B 509
1.40A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 6
ILE A 493
ALA A 522
THR A 530
ALA A 509
1.37A24.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 514
ALA B  86
THR B  84
ALA B  81
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 126
THR B 124
ALA B 150
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 123
ALA B 150
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
ARG A 392
ALA A 400
THR A 402
ALA A 406
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7btf NSP12
(SARS-CoV-2)		5 / 11
PHE A 812
VAL A 605
THR A 586
ASP A 761
VAL A 588
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 124
ALA B 150
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 6
VAL C  53
LEU D 128
ALA D 150
ALA D 110
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
ILE A 589
ALA A 688
THR A 687
ALA A 634
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
SER A 397
ALA A 400
THR A 402
ALA A 406
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
VAL A 182
LEU A 131
ILE A 244
ALA A 176
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 6
SER C  57
ILE D 106
ALA D 110
ALA C  65
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
ALA A 706
THR A 710
ALA A  46
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP8
(SARS-CoV-2)		4 / 6
VAL D 130
ILE D 156
ALA D 188
ALA D 152
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
SER A 692
ILE A 757
THR A 591
ALA A 580
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
SER A 236
ALA A 125
THR A 123
ALA A 185
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
VAL A 693
LEU A 576
ILE A 579
ALA A 639
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 575
ALA A 580
THR A 582
ALA A 585
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
ARG A 624
ILE A 450
ALA A 449
ALA A 558
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 6
ILE C  39
ALA C  48
THR C  46
ALA D 102
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7btf NSP12
(SARS-CoV-2)		4 / 6
ARG A 569
ALA A 685
THR A 565
ALA A 512
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
VAL A 341
ALA A 383
THR B 124
ALA B 102
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
ALA D 102
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
ILE A 259
ALA A 260
THR A 224
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 11
VAL A  18
GLY A  29
VAL A  35
ASP A  33
VAL A  91
1.52A
DMS  A 403 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 11
LEU A  30
VAL A  18
GLY A  29
ASP A  33
VAL A  91
1.66A
None
DMS  A 403 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 6
VAL D 130
ILE D 156
ALA D 188
ALA D 152
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bv1 NSP8
(SARS-CoV-2)		5 / 11
TYR B 135
GLY B 144
VAL B 159
ILE B 132
VAL B 186
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
ALA A 706
THR A 710
ALA A  46
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 693
LEU A 576
ILE A 579
ALA A 639
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 514
ALA B  86
THR B  84
ALA B  81
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ILE B 120
THR A 324
ALA B 150
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 667
ALA A 558
THR A 556
ALA A 449
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ILE B 106
THR A 324
ALA B 150
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP7
(SARS-CoV-2)		4 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
VAL A 341
ALA A 383
THR B 124
ALA B 102
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 569
ALA A 685
THR A 565
ALA A 512
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 392
ALA A 400
THR A 402
ALA A 406
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
PHE A 812
VAL A 605
THR A 586
ASP A 761
VAL A 588
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
VAL A 182
LEU A 131
ILE A 244
ALA A 176
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
SER A 236
ALA A 125
THR A 123
ALA A 185
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
SER A 692
ILE A 757
THR A 591
ALA A 580
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv1 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 124
ALA B 150
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv1 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 123
ALA B 150
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
VAL A 330
LEU A 271
ILE B 119
THR B 124
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 589
ALA A 688
THR A 687
ALA A 634
1.76A
None
F86  P 102 ( 4.1A)
F86  P 102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 692
ILE A 757
THR A 591
ALA A 580
1.55A
None
None
None
A  T  13 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ILE B 120
THR A 324
ALA B 150
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ARG A 392
ALA A 400
THR A 402
ALA A 406
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ILE B 106
THR A 324
ALA B 150
1.42A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 514
ALA B  86
THR B  84
ALA B  81
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv2 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 123
ALA B 150
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 564
ALA A 685
THR A 687
ALA A 558
1.64A
None
A  T  11 ( 4.7A)
F86  P 102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
VAL A 341
ALA A 383
THR B 124
ALA B 102
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 271
ILE B 119
THR B 124
ALA B 102
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv2 NSP8
(SARS-CoV-2)		4 / 6
ARG B 190
ALA B 125
THR B 124
ALA B 150
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 450
ALA A 449
THR A 556
ALA A 558
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
SER A 564
ALA A 685
THR A 687
ALA A 558
1.54A
None
A  T  11 ( 4.7A)
F86  P 102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 862
GLY A 841
VAL A 848
ILE A 847
VAL A 844
1.59A
 U  P  17 ( 4.9A)
None
None
U  P  17 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP7
(SARS-CoV-2)		4 / 6
VAL C   6
LEU C  55
ILE C  39
ALA C  48
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
PHE A 812
VAL A 605
THR A 586
ASP A 761
VAL A 588
1.57A
None
None
None
MG  P 101 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
VAL A 182
LEU A 131
ILE A 244
ALA A 176
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
VAL A 667
ALA A 558
THR A 556
ALA A 449
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
VAL A 693
LEU A 576
ILE A 579
ALA A 639
1.24A
None