Ligand ID: MRC


Drugbank ID:
DB00410
(Mupirocin)


Indication:
For the treatment of Staphylococci nasal carriers.

Get human targets for MRC in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'MRC' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PRO A 168
GLY A 138
GLY A 174
HIS A 163
VAL A 114
1.70A15.38
None
None
None
GWS  A1001 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PRO A 168
GLY A 138
GLY A 174
HIS A 163
VAL A 114
1.70A15.38
None
None
None
GWS  A1001 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY E 446
ASN E 448
GLY E 496
ASP A  38
VAL E 445
1.52A13.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY F 447
ASN F 448
GLY F 496
ASP D  38
VAL F 445
1.76A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
GLY D 124
PRO B   9
SER B  10
GLY D 149
LEU D 177
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
GLY C 124
PRO A   9
SER A  10
GLY C 149
LEU C 177
1.71A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
PRO B 168
HIS B 163
HIS B 172
GLN B 189
LEU B  27
1.71A17.21
None
None
None
3WL  B 401 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 862
ASP C 867
HIS C1058
PHE C 823
VAL C 826
1.53A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER C 735
GLY B 648
GLN B 613
LEU B 650
ILE B 651
1.34A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 857
ASN C 317
GLY C 594
ASP C 614
VAL A 736
1.44A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO A 862
GLY A1059
HIS A1058
ASP A 867
VAL A1060
1.62A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
GLY A 526
PRO A 527
SER A 366
GLY A 545
ILE A 326
1.55A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO B 862
ASP B 867
HIS B1058
PHE B 823
VAL B 826
1.62A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO B 862
ASP B 867
HIS B1058
PHE B 823
VAL B 826
1.62A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
GLY B 147
HIS A  59
HIS B 145
SER B  51
LEU A  56
1.28A11.00
None
ZN  B 201 ( 3.3A)
ZN  B 201 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.50A16.14
None
SAM  A7102 (-3.4A)
SAM  A7102 (-3.6A)
ACT  A7104 ( 4.8A)
SAM  A7102 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.52A
None
SAM  A7104 (-3.6A)
SAM  A7104 (-3.3A)
EDO  A7102 ( 4.7A)
SAM  A7104 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.56A
None
SAM  A7104 (-3.6A)
SAM  A7104 (-3.3A)
EDO  A7102 ( 4.7A)
SAM  A7104 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
SER A6973
ASP A6897
PHE A6901
1.71A
None
SAM  A7104 (-3.3A)
EDO  A7102 ( 4.7A)
SAM  A7104 (-2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
GLY A6871
ASP A6897
1.62A
None
SAM  A7104 (-3.6A)
SAM  A7104 (-3.3A)
SAM  A7104 (-4.4A)
SAM  A7104 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.50A11.07
None
SAM  A7102 ( 3.4A)
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
ASN C6841
SER C6973
ASP C6897
PHE C6901
1.63A11.07
None
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
SER A6973
ASP A6897
PHE A6901
1.62A11.07
None
SAM  A7102 ( 3.4A)
None
SAM  A7102 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
GLY C6879
ASN C6841
SER C6973
ASP C6897
1.46A11.07
None
SAM  C7105 ( 3.4A)
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
GLY C6879
ASN C6841
SER C6973
ASP C6897
1.50A11.07
None
SAM  C7105 ( 3.4A)
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS C6867
ASN C6841
SER C6973
ASP C6897
PHE C6901
1.62A
None
SAH  C7102 (-3.7A)
None
SAH  C7102 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
GLY A6871
ASP A6897
PHE A6901
1.79A
None
SAH  A7102 (-3.6A)
SAH  A7102 (-4.4A)
SAH  A7102 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS C6867
GLY C6879
ASN C6841
SER C6973
ASP C6897
1.49A
None
SAH  C7102 (-3.5A)
SAH  C7102 (-3.7A)
None
SAH  C7102 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
SER A6973
ASP A6897
PHE A6901
1.60A
None
SAH  A7102 (-3.6A)
None
SAH  A7102 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.47A
None
SAH  A7102 (-3.5A)
SAH  A7102 (-3.6A)
None
SAH  A7102 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY B 147
HIS A  59
HIS B 145
SER B  51
LEU A  56
1.44A10.63
None
ZN  B 202 (-2.6A)
ZN  B 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY D 147
HIS C  59
HIS D 145
SER D  51
LEU C  56
1.46A10.63
None
ZN  D 202 (-3.2A)
ZN  D 202 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
GLY C6879
ASN C6841
SER C6973
ASP C6897
1.46A
None
SFG  C7103 ( 3.5A)
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
SER A6973
ASP A6897
PHE A6901
1.63A
None
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
ASN C6841
SER C6973
ASP C6897
PHE C6901
1.63A
None
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS C6867
GLY C6879
ASN C6841
SER C6973
ASP C6897
1.50A
None
SFG  C7103 ( 3.5A)
FMT  C7112 ( 3.3A)
None
SFG  C7103 ( 2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.49A
None
SFG  A7103 ( 3.5A)
FMT  A7104 ( 3.1A)
None
SFG  A7103 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6917
SER A6927
GLY A6911
ASP A6912
VAL A7092
1.60A16.14
SO4  A7105 (-3.5A)
None
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
ASN A6841
SER A6973
ASP A6897
PHE A6901
1.64A
None
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6867
GLY A6879
ASN A6841
SER A6973
ASP A6897
1.52A
None
SAH  A7101 (-3.5A)
SO4  A7109 ( 3.2A)
None
SAH  A7101 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
HIS A6917
SER A6927
GLY A6911
ASP A6912
VAL A7092
1.60A
SO4  A7105 (-3.5A)
None
None
SAH  A7101 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
GLY B 124
PRO A   9
SER A  10
GLY B 149
LEU B 177
1.66A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY E 526
ASN E 388
SER L  62
PHE E 392
VAL E 524
1.74A
None
None
MLI  B 303 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
GLY E 329
PRO E 330
GLY C  70
LEU C  79
ILE C  81
1.75A12.86
NAG  E 906 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY E 526
ASN E 388
SER L  62
PHE E 392
VAL E 524
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY A 526
ASN A 388
SER C  62
PHE A 392
VAL A 524
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  86
GLY C  85
ASN D 159
HIS C  91
VAL C  35
1.63A
None
None
None
EDO  C 207 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  85
HIS C  86
ASN D 159
HIS C  91
VAL C  35
1.73A
None
None
None
EDO  C 207 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  85
HIS C  86
ASN D 159
HIS C  91
VAL C  35
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
HIS C  86
GLY C  85
ASN D 159
HIS C  91
VAL C  35
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
GLY A 712
HIS A 133
GLY A  44
ASP A  36
LEU A 240
1.77A21.09
None