Ligand ID: LVY


Drugbank ID:
DB00480
(Lenalidomide)


Indication:
Lenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.

Get human targets for LVY in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LVY' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		6lzg ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
ASN B 439
PRO B 507
PHE B 497
TYR A  41
1.65A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		6lzg ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
ASN B 439
PRO B 507
PHE B 497
TYR A  41
1.64A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
ASN E 439
PRO E 507
PHE E 497
TYR B  41
1.71A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
ASN E 439
PRO E 507
PHE E 497
TYR B  41
1.71A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 217
GLU C 191
SER C  31
PHE C  59
GLY C 219
1.60A15.72
13.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO B 217
GLU B 191
SER B  31
PHE B  59
GLY B 219
1.57A15.72
13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_B_LVYB1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
PRO B 130
GLU B  70
HIS B  73
PHE B  79
ILE B  14
1.69A21.72
21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
PRO B 130
GLU B  70
HIS B  73
PHE B  79
ILE B  14
1.72A21.72
21.37
None