Ligand ID: LQQ


Drugbank ID:
DB09073
(Palbociclib)


Indication:
Palbociclib is indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. This indication is approved under accelerated approval based on progression-free survival (PFS). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Get human targets for LQQ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LQQ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.41A18.85
DMS  A 403 (-3.0A)
None
None
None
DMS  A 403 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 281
VAL A 296
PHE A 291
ASN A 214
ALA A 210
1.72A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.37A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.44A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.42A22.71
DMS  A 403 (-2.8A)
DMS  A 403 ( 4.9A)
None
None
DMS  A 403 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 170
VAL A 171
ALA A 173
PHE A 185
ALA A 193
1.70A22.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 524
ALA B 363
THR B 430
LEU B 513
ALA B 397
1.35A24.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 170
VAL A 171
ALA A 173
PHE A 185
ALA A 193
1.69A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.43A22.71
DMS  A 401 (-3.0A)
DMS  A 401 ( 4.8A)
None
None
DMS  A 401 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.43A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 170
VAL B 171
ALA B 173
PHE B 185
ALA B 193
1.67A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.36A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LYS C  97
VAL C  18
VAL C  36
LEU C  75
ALA C  70
1.48A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 124
VAL C 125
ALA C   7
PHE C   8
LEU A 115
1.74A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LYS B 269
VAL B 247
ASN B 228
LEU B 227
ASP B 229
1.50A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LYS A 269
VAL A 247
ASN A 228
LEU A 227
ASP A 229
1.55A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 200
VAL B 296
PHE B 291
THR B 243
ALA B 206
1.40A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 170
VAL D 171
ALA D 173
PHE D 185
ALA D 193
1.77A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 281
VAL D 296
PHE D 291
ASN D 214
ALA D 210
1.69A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 200
VAL D 296
PHE D 291
THR D 243
ALA D 206
1.41A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 124
VAL B 125
ALA B   7
PHE B   8
LEU D 115
1.73A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LYS B  97
VAL B  18
VAL B  36
LEU B  75
ALA B  70
1.42A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 200
VAL C 296
PHE C 291
THR C 243
ALA C 206
1.37A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 124
VAL D 125
ALA D   7
PHE D   8
LEU B 115
1.76A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.44A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 281
VAL A 296
PHE A 291
ASN A 214
ALA A 210
1.69A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.40A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
PHE A 753
VAL A 605
THR A 591
ALA A 762
1.56A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 664
GLY A 311
ALA A 672
THR A 604
ALA A 609
1.27A13.46
None
None
None
NAG  A1301 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 664
GLY C 311
ALA C 672
THR C 604
ALA C 609
1.34A13.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 664
GLY A 311
ALA A 672
THR A 604
ALA A 609
1.36A13.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A  86
VAL A  67
VAL A 142
THR A  99
ASP A 125
1.36A23.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w02 NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.27A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w02 NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.31A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 524
ALA C 363
THR C 430
LEU C 513
ALA C 397
1.41A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w4h NSP10
NSP16
(SARS-CoV-2)		6 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.77A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		6 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
VAL A6882
ASP A6895
THR A6908
LEU A6893
1.53A
SAM  A7104 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
VAL A6876
ASP A6895
THR A6908
ALA A6881
1.80A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.55A
EDO  A7102 (-3.2A)
None
EDO  A7102 (-4.6A)
KCX  A6935 ( 3.6A)
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6869
VAL B4295
ASP A6895
THR A6908
ALA A6881
1.80A19.61
SAM  A7104 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6871
VAL A6882
ASP A6895
THR A6908
ASP A6928
1.78A19.61
SAM  A7104 (-4.4A)
None
None
None
SAM  A7104 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 281
VAL A 296
PHE A 291
ASN A 214
ALA A 210
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.60A
None
None
AMP  A 201 ( 4.3A)
None
AMP  A 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE B  18
VAL B 147
PHE B 116
VAL B 144
ASN B 150
1.75A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.70A21.83
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  18
VAL A 147
PHE A 116
VAL A 144
ASN A 150
1.79A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.67A
None
None
AMP  A 201 ( 4.3A)
None
AMP  A 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  79
VAL B  96
ALA B  38
PHE B 132
THR B 146
1.76A
None
None
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ALA B4276
ASP D4335
ALA D4273
1.55A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LYS D4346
VAL C6876
VAL D4295
THR C6846
ALA C6877
1.59A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ASP D4335
ALA D4273
ASP D4275
1.63A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
ALA C6877
PHE C6901
THR D4311
ALA C6905
1.70A17.49
None
None
None
NA  C7101 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6882
ASP C6895
THR C6908
LEU C6893
1.50A19.61
SAM  C7105 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
THR B4364
LEU B4328
ALA B4276
ASP B4275
1.57A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ALA B4273
ASP B4275
1.70A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		6 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.78A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
VAL A6882
ASP A6895
THR A6908
LEU A6893
1.49A19.61
SAM  A7102 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A7088
VAL A7087
ASP A6906
ASN C7095
LEU A6892
1.71A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.48A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.70A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.47A19.61
FMT  A7108 ( 4.8A)
None
None
FMT  A7103 ( 4.4A)
SAM  A7102 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
THR B4364
LEU B4328
ALA B4276
ASP B4275
1.53A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ASP B4335
ALA B4273
ASP B4275
1.48A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.56A16.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
1.50A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6926
VAL C6859
THR C6880
LEU C6887
ASP C6923
1.70A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6876
VAL D4295
THR C6846
ALA C6877
ASP C6895
1.58A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 123
TYR A 136
VAL A 202
LEU A 178
ALA A 176
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE B 104
TYR B 112
ALA B 144
PHE B 147
ALA B 149
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY C  28
THR C   9
LEU C  36
ALA C  39
ASP C  40
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE C 104
TYR C 112
ALA C 144
PHE C 147
ALA C 149
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 104
TYR A 112
ALA A 144
PHE A 147
ALA A 149
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ILE A  23
VAL A  49
VAL A 155
LEU A 126
ALA A 129
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
VAL A 100
PHE A 132
ASP A 135
ALA A 129
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 304
THR A 350
LEU A 313
ALA A 338
ASP A 339
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 310
VAL A 304
PHE A 336
ASP A 339
ALA A 333
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 304
THR A 350
LEU A 313
ALA A 338
ASP A 339
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wey NSP3
(SARS-CoV-2)		5 / 12
ILE A 310
VAL A 304
PHE A 336
ASP A 339
ALA A 333
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wiq NSP7
(SARS-CoV-2)		5 / 12
VAL A  58
VAL A  66
VAL A  16
LEU A  20
ALA A  65
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL B 115
ALA B 110
VAL A  66
LEU A  59
ALA A  65
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ASP B4335
ALA B4273
ASP B4275
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY D4323
ALA C6877
PHE C6901
THR D4311
ALA C6905
1.69A
None
None
None
NA  C7101 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL C6876
VAL D4295
THR C6846
ALA C6877
ASP C6895
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
VAL A6882
ASP A6895
THR A6908
LEU A6893
1.50A
SAH  A7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.71A
None
None
None
NA  A7101 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
ALA D4276
ASP B4335
ALA B4273
ASP B4275
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
THR B4364
LEU B4328
ALA B4276
ASP B4275
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6946
PHE C6868
ASP C6931
THR C6934
ASP C6912
1.47A
None
None
None
FMT  C7104 (-4.2A)
SAH  C7102 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6882
ASP C6895
THR C6908
LEU C6893
1.51A
SAH  C7102 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.51A
None
None
None
FMT  A7103 (-4.6A)
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ALA D4279
VAL D4274
ASP B4282
ALA B4276
ASP B4275
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ALA B4276
ASP D4335
ALA D4273
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LYS D4346
VAL C6876
VAL D4295
THR C6846
ALA C6877
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ASP D4335
ALA D4273
ASP D4275
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
THR B4364
LEU B4328
ALA B4276
ASP B4275
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4323
ALA C6877
PHE C6901
THR D4311
ALA C6905
1.68A
None
None
None
NA  C7101 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
VAL C6882
ASP C6895
THR C6908
LEU C6893
1.50A
SFG  C7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6946
PHE C6868
ASP C6931
THR C6934
ASP C6912
1.58A
FMT  C7105 ( 2.9A)
None
None
FMT  C7104 ( 4.7A)
SFG  C7103 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.52A
None
None
None
FMT  A7105 ( 4.6A)
SFG  A7103 ( 3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
THR B4364
LEU B4328
ALA B4276
ASP B4275
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ALA B4276
ASP D4335
ALA D4273
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
VAL B4274
THR D4364
LEU D4328
ALA D4276
ASP D4275
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ASP B4335
ALA B4273
ASP B4275
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.71A
None
None
None
NA  A7101 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LYS D4346
VAL C6876
VAL D4295
THR C6846
ALA C6877
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
VAL A6882
ASP A6895
THR A6908
LEU A6893
1.50A
SFG  A7103 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6876
VAL D4295
THR C6846
ALA C6877
ASP C6895
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ILE B4334
VAL B4274
ASP D4335
ALA D4273
ASP D4275
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ALA B4273
ASP B4275
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 253
TYR A 238
VAL A 304
PHE A 303
ASP A 213
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A  86
VAL A  67
VAL A 142
VAL A  78
THR A  99
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 259
ASP B 297
THR B 196
LEU B 252
ALA B 256
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 102
VAL B   6
PHE B  16
THR B  48
ALA B  60
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 102
VAL A   6
PHE A  16
THR A  48
ALA A  60
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE B 259
ASP B 297
THR B 196
LEU B 252
ALA B 256
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE A 259
ASP A 297
THR A 196
LEU A 252
ALA A 256
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B  86
VAL B  67
VAL B 142
THR B  99
ASP B 125
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A 138
VAL A 122
ASP A 125
ALA A  82
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A  86
VAL A  67
VAL A 142
THR A  99
ASP A 125
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
PHE A 259
ASP A 297
THR A 196
LEU A 252
ALA A 256
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 157
VAL A  78
PHE A 123
THR A 322
LEU A  76
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 130
ALA B 138
VAL B 122
ASP B 125
ALA B  82
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 253
TYR B 238
VAL B 304
PHE B 303
ASP B 213
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 157
VAL B  78
PHE B 123
THR B 322
LEU B  76
1.44A
None
None
None
EDO  B 406 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 297
PHE A 294
LEU A 253
ASP A 295
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE C  23
VAL C  49
VAL C 155
LEU C 126
ALA C 129
1.59A
APR  C 201 (-3.9A)
APR  C 201 (-3.8A)
None
APR  C 201 (-4.9A)
APR  C 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY A 103
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LYS B4346
VAL A6876
VAL B4295
THR A6846
ALA A6877
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.54A
None
None
None
None
SAH  A7101 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
VAL A6882
ASP A6895
THR A6908
LEU A6893
1.51A
SAH  A7101 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6876
VAL B4295
THR A6846
ALA A6877
ASP A6895
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wqd NSP7
(SARS-CoV-2)		5 / 12
VAL A  58
VAL A  66
VAL A  16
LEU A  20
ALA A  65
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.36A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 281
VAL A 296
PHE A 291
ASN A 214
ALA A 210
1.71A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.37A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL C  58
VAL C  66
VAL C  16
LEU C  20
ALA C  65
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL B 115
ALA B 110
VAL A  66
LEU A  59
ALA A  65
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  33
VAL D  83
THR A   9
LEU A  40
ASP A  38
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL D 115
ALA D 110
VAL C  66
LEU C  59
ALA C  65
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 524
ALA A 363
THR A 430
LEU A 513
ALA A 397
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 382
VAL A 524
PHE A 515
ASP A 389
ASN A 388
1.61A
DMS  A 905 (-4.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 524
ALA A 363
THR A 430
LEU A 513
ALA A 397
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.41A
PEG  A 405 (-4.1A)
None
CL  A 406 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.32A
EDO  C 208 ( 4.7A)
None
None
EDO  C 208 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 100
THR E 146
LEU E 109
ALA E 134
ASP E 135
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 100
THR E 146
LEU E 109
ALA E 134
ASP E 135
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D 106
VAL D 100
PHE D 132
ASP D 135
ALA D 129
1.64A
EDO  D 204 (-4.2A)
None
EDO  D 205 ( 3.6A)
None
EDO  D 205 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.30A
None
None
EDO  D 204 ( 4.5A)
EDO  D 211 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.36A
EDO  C 208 ( 4.7A)
None
None
EDO  C 208 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E 106
VAL E 100
PHE E 132
ASP E 135
ALA E 129
1.64A
None
None
EPE  E 202 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.29A
None
None
EDO  D 204 ( 4.5A)
EDO  D 211 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.28A
None
None
None
EDO  A 204 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  49
ASP D 157
ASN C  87
ALA D  21
ASP D  22
1.43A
APR  D 201 (-3.7A)
None
None
None
APR  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E  23
VAL E  49
VAL E 155
LEU E 126
ALA E 129
1.64A
APR  E 201 (-4.1A)
APR  E 201 (-3.7A)
APR  E 201 ( 4.9A)
APR  E 201 (-4.7A)
APR  E 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D  23
VAL D  49
VAL D 155
LEU D 126
ALA D 129
1.61A
APR  D 201 (-3.9A)
APR  D 201 (-3.7A)
None
APR  D 201 (-4.5A)
APR  D 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.41A
None
None
None
EDO  A 204 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  79
VAL C  96
ALA C  38
PHE C 132
THR C 146
1.76A
None
None
APR  C 201 (-3.4A)
APR  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 100
THR E 146
LEU E 109
ALA E 134
ASP E 135
1.34A
None
None
None
None
EDO  B 202 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
VAL A  49
VAL A 155
LEU A 126
ALA A 129
1.65A
APR  A 201 (-3.9A)
APR  A 201 (-3.7A)
APR  A 201 ( 4.8A)
APR  A 201 (-4.8A)
APR  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
LYS A  28
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.59A
None
None
None
None
EDO  B 204 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.29A
None
None
None
EDO  B 204 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.33A
None
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A  23
VAL A  49
VAL A 155
LEU A 126
ALA A 129
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.73A
EDO  B 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
VAL B 100
PHE B 132
ASP B 135
ALA B 129
1.58A
EDO  B 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.27A
None
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
VAL C  49
VAL C 155
LEU C 126
ALA C 129
1.56A
EDO  C 206 (-4.1A)
None
EDO  C 206 ( 4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 12
GLY A 170
VAL A 171
ALA A 173
PHE A 185
ALA C   2
1.70A
None
None
None
None
02J  C   1 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 170
VAL A 171
ALA A 173
PHE A 185
ALA A 193
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 679
VAL A 557
ASP A 684
THR A 686
ALA A 558
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
PHE A 753
VAL A 605
THR A 591
ALA A 762
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LYS A  97
VAL A  18
VAL A  36
LEU A  75
ALA A  70
1.42A
DMS  A 403 (-3.0A)
DMS  A 403 ( 4.9A)
None
None
DMS  A 403 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 170
VAL A 171
ALA A 173
PHE A 185
ALA A 193
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A  96
ASP A  92
ASN A 198
ALA A 195
ASP A 194
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 679
VAL A 557
ASP A 684
THR A 686
ALA A 558
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
PHE A 753
VAL A 605
THR A 591
ALA A 762
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 880
THR A 817
LEU A 869
ALA A 866
ASP A 865
1.65A
None
None
None
None
U  P  18 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 670
ASP A 390
THR A 393
LEU A 388
ALA A 400
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 679
VAL A 557
ASP A 684
THR A 686
ALA A 558
1.54A
None
U  T  10 ( 4.6A)
None
None
None