Ligand ID: LEV


Drugbank ID:
DB09078
(Lenvatinib)


Indication:
Lenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.

Get human targets for LEV in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LEV' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A 177
VAL A 148
GLY A 120
CYH A  38
1.77A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.56A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 250
GLY A 251
ALA A 206
LEU A 282
CYH A 300
1.69A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.61A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 253
PHE A 294
ALA A 206
VAL A 202
GLY A 251
1.76A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 242
VAL A 202
PHE A 230
LEU A 262
1.69A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 253
GLY A 251
ALA A 206
VAL A 204
PHE A 230
1.65A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.69A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 149
VAL A 114
LEU A 141
GLY A 174
CYH A 145
1.78A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 253
GLY A 251
ALA A 206
VAL A 204
CYH A 265
1.51A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 294
ALA A 206
VAL A 202
TYR A 209
GLY A 251
1.76A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		3 / 3
LYS F 336
LEU F 368
ASP F 364
1.76A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C 149
ALA C   7
GLU A  14
LEU A 115
VAL A 125
1.22A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A 149
ALA A   7
GLU C  14
LEU C 115
VAL C 125
1.21A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.43A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B 149
ALA B   7
GLU D  14
LEU D 115
VAL D 125
1.16A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 282
GLY B 283
ALA B 210
VAL B 296
GLY B   2
1.44A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.47A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 253
GLY D 251
ALA D 206
VAL D 204
CYH D 265
1.43A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D 149
ALA D   7
GLU B  14
LEU B 115
VAL B 125
1.23A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 282
GLY B 283
ALA B 210
VAL B 296
GLY B   2
1.47A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D   7
LYS D   5
GLU D 288
GLY D 149
ALA D 129
1.41A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
VAL A 128
LEU A 186
VAL A 182
PHE A 287
1.30A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LYS A 849
LEU A 891
ASP A 418
1.55A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		6 / 12
GLY A 327
ALA A 379
VAL A 341
GLY A 345
CYH B 114
LEU A 271
1.27A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
GLY A 327
ALA A 379
LEU B 103
VAL A 341
GLY A 345
1.08A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 5
ILE A 333
VAL A 330
LEU B 117
ASP A 377
1.76A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 5
ILE B 106
VAL A 341
LEU B  95
ASP B  99
1.64A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 130
LEU A 247
CYH A 139
GLY A 137
PHE A 165
1.30A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m71 NSP12
(SARS-CoV-2)		3 / 3
TYR A 606
LEU A 819
ASP A 825
1.75A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6m71 NSP12
NSP8
(SARS-CoV-2)		3 / 3
TYR A 374
LEU B  95
ASP B  99
1.23A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LYS B 854
LEU B 861
ASP A 614
0.99A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ILE B 569
VAL C  42
LEU B 518
ASP B 571
1.60A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR B 269
LEU B  56
ASP B 290
1.28A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 650
GLY C 648
ALA C 609
GLU C 298
VAL C 608
1.28A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LYS A  90
ILE A  72
VAL A  67
LEU A 163
1.62A21.39
GOL  A 405 (-2.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
GLY B  48
ALA B  39
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
GLY B  48
ALA B  39
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  47
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
ALA B  50
GLY B  47
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		3 / 3
LYS A 163
LEU A 126
ASP A 135
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 650
GLY A 648
ALA A 609
GLU A 298
VAL A 608
1.15A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR A 269
LEU A  56
ASP A 290
1.20A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 650
GLY C 648
ALA C 609
GLU C 298
VAL C 608
1.16A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
TYR A 269
LEU A  56
ASP A 290
1.18A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LYS B 150
LEU B 143
ASP B 133
0.84A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.23A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.20A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w02 NSP3
(SARS-CoV-2)		3 / 3
LYS B 163
LEU B 126
ASP B 135
1.21A20.71
None
APR  B 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H  53
ALA C 435
VAL C 510
TYR C 508
ALA C 411
1.23A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w4h NSP16
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.45A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A17.38
None
None
None
None
SAM  A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.13A18.87
None
None
None
SAM  A7102 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A17.38
None
None
None
None
SAM  A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w4h NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.15A19.58
SAM  A7102 (-3.4A)
None
None
SAM  A7102 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6883
VAL A6865
GLY A6962
LEU A6848
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
PHE A7043
ALA A6843
VAL A6995
GLY A6837
1.64A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
GLY A6983
LEU A6924
GLY A7011
LEU A6855
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LYS A6844
ILE A6969
LEU A6883
ASP A6928
1.65A
EDO  A7103 (-3.6A)
None
None
SAM  A7104 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.14A
None
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
ALA A6877
ALA A6905
GLY B4347
1.68A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
VAL A6894
ALA A6870
GLY A6871
1.70A18.36
None
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7072
ALA A7056
VAL A7057
ALA A6858
ALA A6960
1.71A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6871
ALA A6905
ALA A6881
GLY A6879
ALA B4324
1.69A18.36
SAM  A7104 (-4.4A)
None
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A
None
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6843
LEU A7037
VAL A6995
GLY A6837
1.59A18.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
LEU A6852
GLY A6983
LEU A6924
1.75A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6893
VAL A6894
ALA A6905
ALA A6877
GLY A6879
1.67A18.36
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A
None
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.73A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
ALA A6870
GLY A6871
ALA A6905
1.52A18.36
None
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A7056
VAL A7057
ALA A6858
GLY A7076
ALA A6960
1.70A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL B4295
ALA A6877
ALA A6905
GLY B4347
1.76A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6871
ALA A6905
ALA A6881
GLY A6879
ALA B4324
1.72A18.36
SAM  A7104 (-4.4A)
None
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6893
VAL A6894
ALA A6905
ALA A6877
GLY A6879
1.68A18.36
None
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6875
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.72A18.36
None
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
ALA A6877
ALA A6905
GLY B4347
1.73A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
LEU A6855
GLY A6983
LEU A6924
1.55A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6875
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.72A18.36
None
None
None
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
PHE A7043
ALA A6843
VAL A6995
GLY A6837
1.60A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6871
VAL A6902
ALA B4324
ALA A6881
GLY A6879
1.41A
SAM  A7104 (-4.4A)
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.18A
SAM  A7104 (-3.6A)
None
None
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
ALA A6986
LEU A6855
LEU A6924
1.53A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
VAL B4295
ALA A6877
ALA A6905
GLY B4347
1.68A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TYR A6851
LEU A6848
ASP A6928
1.76A
None
None
SAM  A7104 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6869
PHE A6901
ALA A6905
ALA A6881
GLY A6879
1.79A18.36
SAM  A7104 (-3.6A)
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6887
ASP A6906
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.75A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.78A18.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
TYR B   9
LEU A  10
ASP A 162
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 164
GLU B  26
LEU B 123
CYH B 143
PHE B   6
1.53A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.57A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A  38
GLU A 104
ALA A  50
GLY A  47
1.79A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.38A
AMP  A 201 ( 3.5A)
None
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  47
1.65A20.65
AMP  A 201 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 123
VAL A  35
ALA A  27
VAL A  24
ALA A  21
1.60A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  47
ALA A  39
1.44A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  75
GLY B  79
VAL B  41
TYR B  68
ALA B  38
1.77A20.65
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.65A
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
None
MES  B 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  48
ALA A  39
1.34A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
AMP  A 201 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
PHE A 132
ALA A 112
TYR A 113
ALA A  39
1.59A20.65
None
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  48
1.61A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.24A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  48
ALA B  39
VAL B  95
GLY B 130
LEU B 123
1.48A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.57A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.66A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.24A
AMP  A 201 ( 3.5A)
None
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.28A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  48
1.59A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 123
VAL B  35
ALA B  27
VAL B  24
ALA B  21
1.58A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
GLU A  26
LEU A 123
CYH A 143
PHE A   6
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  47
ALA A  39
1.49A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 123
VAL A  35
ALA A  27
VAL A  24
ALA A  21
1.61A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.62A
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
None
MES  B 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
GLY A  97
VAL A  95
MET A  61
ALA A  50
1.76A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  48
ALA A  39
1.36A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
AMP  A 201 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  47
1.62A20.65
AMP  A 201 ( 3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 164
VAL B 155
LEU B 123
CYH B 143
PHE B   6
1.60A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B 130
VAL B  49
ALA B  50
GLY B  97
LEU B 123
1.69A21.33
MES  B 201 ( 3.4A)
None
MES  B 201 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  47
1.43A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.47A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.44A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
AMP  A 201 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  47
1.46A
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
GLY A  79
VAL A  41
TYR A  68
ALA A  50
1.54A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
VAL A 155
LEU A 123
CYH A 143
PHE A   6
1.60A21.33
None
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 109
PHE B 132
ALA B 112
TYR B 113
ALA B  39
1.65A20.65
None
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B 130
ALA B  38
GLU B 104
ALA B  50
GLY B  47
1.78A20.65
MES  B 201 ( 3.4A)
MES  B 201 ( 3.4A)
None
MES  B 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  75
GLY B  79
VAL B  41
TYR B  68
ALA B  50
1.54A20.65
None
None
None
None
MES  B 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
TYR A   9
LEU B  10
ASP B 162
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  48
ALA B  39
LEU B  93
VAL B  95
GLY B 130
1.68A21.33
None
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.69A20.65
AMP  A 201 ( 3.5A)
AMP  A 201 ( 3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 123
VAL B  35
ALA B  27
VAL B  24
ALA B  21
1.56A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LYS B 163
LEU B 126
ASP B 135
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 127
PHE B 132
ALA B 112
VAL B  77
ALA B  39
1.77A20.65
None
MES  B 201 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		3 / 3
TYR C6851
LEU C6848
ASP C6928
1.77A18.79
None
None
SAM  C7105 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL D4295
ALA C6877
ALA C6905
GLY D4347
1.70A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7042
ALA A6843
GLU A7001
ALA A6832
ALA A6997
1.74A18.79
None
None
FMT  A7104 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7072
ALA C7056
VAL C7057
ALA C6858
ALA C6960
1.70A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6883
VAL A6865
GLY A6962
LEU A6848
1.43A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7010
GLY C7011
LEU C6852
GLY C6983
LEU C6924
1.80A18.49
None
NA  C7103 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
ALA A6870
GLY A6871
ALA A6905
1.60A18.79
None
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6875
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.69A18.79
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
LEU A6855
GLY A6983
LEU A6924
1.53A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6981
GLY A6983
LEU A6924
GLY A7011
LEU A6855
1.40A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6869
PHE C6901
ALA C6905
ALA C6881
GLY C6879
1.78A18.79
SAM  C7105 ( 3.8A)
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6893
VAL A6894
ALA A6905
ALA A6877
GLY A6879
1.66A18.79
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.27A17.38
None
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7042
ALA C6843
GLU C7001
ALA C6832
ALA C6997
1.75A18.79
None
None
FMT  C7108 ( 3.9A)
FMT  C7111 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
LEU A6852
GLY A6983
LEU A6924
1.79A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6843
LEU C7037
VAL C6995
GLY C6837
1.62A18.87
None
None
None
None
FMT  D4404 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LYS C6844
ILE C6969
LEU C6883
ASP C6928
1.69A18.49
FMT  C7108 ( 4.0A)
None
None
SAM  C7105 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY C6871
ALA C6905
ALA C6881
GLY C6879
ALA D4324
1.73A18.79
SAM  C7105 ( 4.2A)
None
None
SAM  C7105 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.76A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
ALA A6877
ALA A6905
GLY B4347
1.74A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
GLY C6871
LEU C6834
1.14A18.87
None
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6875
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.69A18.79
None
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
PHE A7043
ALA A6843
VAL A6995
GLY A6837
1.61A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.15A18.49
SAM  A7102 ( 3.4A)
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7010
GLY C7011
LEU C6855
GLY C6983
LEU C6924
1.59A18.49
None
NA  C7103 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6893
VAL C6894
ALA C6905
ALA C6877
GLY C6879
1.68A18.79
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
PHE C7043
ALA C6843
VAL C6995
GLY C6837
1.57A17.38
None
None
None
None
FMT  D4404 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7010
GLY A7011
ALA A6986
LEU A6855
LEU A6924
1.51A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7078
GLY C6962
VAL C7057
ALA C7056
GLY C7076
1.71A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6883
ASP C6895
1.46A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
PHE C7043
ALA C6843
VAL C6995
GLY C6837
1.61A17.38
None
None
None
None
FMT  D4404 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		3 / 3
TYR A6851
LEU A6848
ASP A6928
1.78A18.79
None
None
SAM  A7102 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7010
GLY C7011
ALA C6986
LEU C6855
LEU C6924
1.54A18.49
None
NA  C7103 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.46A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL D4295
ALA C6877
ALA C6905
GLY D4347
1.79A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6892
VAL C6865
GLY C6890
PHE C7048
LEU C6852
1.50A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6883
VAL C6865
GLY C6962
LEU C6848
1.40A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6875
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.69A18.79
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7078
GLY C6962
VAL C7057
ALA C7056
GLY C7076
1.74A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
PHE A7043
ALA A6843
VAL A6995
GLY A6837
1.58A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY A6871
ALA A6905
ALA A6881
GLY A6879
ALA B4324
1.74A18.79
SAM  A7102 ( 4.2A)
None
None
SAM  A7102 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
ALA C6905
VAL C6894
GLY C6871
PHE C6954
1.15A18.49
SAM  C7105 ( 3.4A)
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
VAL A6894
ALA A6870
GLY A6871
1.61A18.79
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6911
VAL C6916
ALA C6870
GLY C6871
ALA C6905
1.62A18.79
 NA  C7104 ( 4.1A)
None
None
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6875
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.69A18.79
None
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL B4295
ALA A6877
ALA A6905
GLY B4347
1.76A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6893
VAL A6894
ALA A6905
ALA A6877
GLY A6879
1.67A18.79
None
None
None
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.27A17.38
None
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6887
ASP A6906
1.57A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6911
VAL C6916
VAL C6894
ALA C6870
GLY C6871
1.71A18.79
 NA  C7104 ( 4.1A)
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.27A17.38
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C7056
VAL C7057
ALA C6858
GLY C7076
ALA C6960
1.69A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6893
VAL C6894
ALA C6905
ALA C6877
GLY C6879
1.66A18.79
None
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6911
VAL C6916
VAL C6894
ALA C6870
GLY C6871
1.62A18.79
 NA  C7104 ( 4.1A)
None
None
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6887
ASP C6906
1.56A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
ALA C6877
ALA C6905
GLY D4347
1.76A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.72A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7078
GLY A6962
VAL A7057
ALA A7056
GLY A7076
1.71A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
GLY C6983
LEU C6924
GLY C7011
LEU C6855
1.44A18.49
None
None
None
NA  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
VAL C6876
ALA C6877
ALA C6905
GLY D4347
1.71A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
ALA A6870
GLY A6871
ALA A6905
1.54A18.79
None
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL A6876
ALA A6877
ALA A6905
GLY B4347
1.70A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LYS A6844
ILE A6969
LEU A6883
ASP A6928
1.69A18.49
FMT  A7104 ( 4.4A)
None
None
SAM  A7102 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6892
VAL A6865
GLY A6890
PHE A7048
LEU A6852
1.56A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7078
GLY C6962
VAL C7057
ALA C7056
GLY C7076
1.69A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6843
LEU A7037
VAL A6995
GLY A6837
1.63A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
VAL A6894
ALA A6870
GLY A6871
1.69A18.79
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6869
PHE C6901
ALA C6905
ALA C6881
GLY C6879
1.79A18.79
SAM  C7105 ( 3.8A)
None
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.27A17.38
None
None
None
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.12A18.87
None
None
None
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
VAL B4295
ALA A6877
ALA A6905
GLY B4347
1.66A17.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 253
ALA A 261
LEU A 118
GLY A 256
LEU A 290
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  87
GLY B  38
GLU A 161
VAL B 159
GLY B  81
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B  87
GLY B  38
GLU A 161
VAL B 159
GLY B  81
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  87
GLY C  38
GLU B 161
VAL C 159
GLY C  81
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  88
ALA A  43
VAL A  41
TYR A  31
ALA A  16
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wcf NSP3
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.65A
MES  A 201 (-3.2A)
MES  A 201 (-2.5A)
MES  A 201 (-3.6A)
None
MES  A 201 ( 3.0A)
MES  A 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wcf NSP3
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.62A
MES  A 201 (-3.2A)
MES  A 201 (-2.5A)
MES  A 201 (-3.6A)
None
MES  A 201 ( 3.0A)
MES  A 202 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  93
VAL A  36
VAL A 147
GLY A  79
LEU A 126
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		3 / 3
LYS A 163
LEU A 126
ASP A 135
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  48
ALA A  39
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  47
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
GLU A  26
LEU A 123
CYH A 143
PHE A   6
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
ALA A  50
GLY A  47
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  47
ALA A  39
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wen NSP3
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  36
GLY A  48
ALA A  39
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 357
VAL A 355
ALA A 328
VAL A 240
ALA A 316
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 357
VAL A 355
ALA A 328
VAL A 240
ALA A 316
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 334
PHE A 336
VAL A 240
GLY A 252
ALA A 243
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 334
PHE A 336
VAL A 240
ALA A 254
GLY A 251
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 331
VAL A 299
CYH A 296
GLY A 289
LEU A 357
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 292
GLY A 289
VAL A 239
ALA A 231
VAL A 234
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wey NSP3
(SARS-CoV-2)		5 / 12
GLY A 334
PHE A 336
VAL A 240
ALA A 254
GLY A 251
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.29A
None
None
None
None
SAH  C7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6887
ASP A6906
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.29A
None
None
None
None
SAH  C7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6883
VAL A6865
GLY A6962
LEU A6848
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TYR A6851
LEU A6848
ASP A6928
1.78A
None
None
SAH  A7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
GLY C6871
LEU C6834
1.13A
None
None
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6883
VAL C6865
GLY C6962
LEU C6848
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6887
ASP C6906
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LYS C6844
ILE C6969
LEU C6883
ASP C6928
1.68A
None
None
None
SAH  C7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6883
ASP C6895
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
GLY A6983
LEU A6924
GLY A7011
LEU A6855
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TYR C6851
LEU C6848
ASP C6928
1.78A
None
None
SAH  C7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.14A
None
None
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6879
ALA C6905
VAL C6894
GLY C6871
PHE C6954
1.19A
SAH  C7102 (-3.5A)
None
None
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.16A
SAH  A7102 (-3.5A)
None
None
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A
None
None
None
None
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6981
GLY C6983
LEU C6924
GLY C7011
LEU C6855
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LYS A6844
ILE A6969
LEU A6883
ASP A6928
1.67A
None
None
None
SAH  A7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A
None
None
None
None
SAH  A7102 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6887
ASP C6906
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP16
(SARS-CoV-2)		3 / 3
TYR A6851
LEU A6848
ASP A6928
1.79A
None
None
SFG  A7103 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.16A
SFG  A7103 ( 3.5A)
None
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.14A
None
None
None
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LYS C6844
ILE C6969
LEU C6883
ASP C6928
1.67A
FMT  C7112 ( 4.7A)
None
None
SFG  C7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.26A
None
None
None
None
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C6879
ALA C6905
VAL C6894
GLY C6871
PHE C6954
1.16A
SFG  C7103 ( 3.5A)
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.27A
None
None
None
None
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
ILE C7088
VAL C6865
LEU C6883
ASP C6895
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6981
GLY C6983
LEU C6924
GLY C7011
LEU C6855
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6883
VAL C6865
GLY C6962
LEU C6848
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP16
(SARS-CoV-2)		3 / 3
TYR C6851
LEU C6848
ASP C6928
1.79A
None
None
SFG  C7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6981
GLY A6983
LEU A6924
GLY A7011
LEU A6855
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6887
ASP A6906
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.27A
None
None
None
None
SFG  A7103 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6883
VAL A6865
GLY A6962
LEU A6848
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LYS A6844
ILE A6969
LEU A6883
ASP A6928
1.68A
FMT  A7104 ( 4.6A)
None
None
SFG  A7103 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
ALA C6870
GLY C6871
1.26A
None
None
None
None
SFG  C7103 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL D4295
ALA C6881
VAL C6882
GLY C6871
LEU C6834
1.15A
None
None
None
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B  43
PHE B  44
VAL B  32
ALA B   7
VAL B   6
1.41A
None
TRS  B 402 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ILE B 323
VAL B 295
LEU B 255
ASP B 297
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LYS B  90
ILE B  72
VAL B  67
LEU B 163
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 251
GLY B 254
VAL B 276
GLY B 248
PHE B 269
1.42A
None
None
None
U5P  B 401 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LYS B 150
LEU B 143
ASP B 133
0.77A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 251
GLY A 254
VAL A 276
GLY A 248
PHE A 269
1.41A
None
None
None
U5P  A 401 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A  43
PHE A  44
VAL A  32
ALA A   7
VAL A   6
1.44A
None
TRS  A 402 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A  43
PHE A  44
VAL A  32
ALA A  60
ALA A  55
1.45A
None
TRS  A 402 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B  43
PHE B  44
VAL B  32
ALA B   7
VAL B   6
1.44A
None
TRS  B 402 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B  43
PHE B  44
VAL B  32
ALA B  60
ALA B  55
1.44A
None
TRS  B 402 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LYS A  90
ILE A  72
VAL A  67
LEU A 163
1.68A
EDO  A 408 (-3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ILE A 323
VAL A 295
LEU A 255
ASP A 297
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A  43
PHE A  44
VAL A  32
ALA A   7
VAL A   6
1.41A
None
TRS  A 402 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
LYS A   5
GLU A 288
GLY A 149
ALA A 129
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 164
GLU C  26
LEU C 123
CYH C 143
PHE C   6
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  95
CYH C  92
GLY C  85
LEU C 153
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C  88
GLY C  85
VAL C  35
ALA C  27
VAL C  30
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.64A
APR  C 201 (-3.0A)
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
None
APR  C 201 (-3.5A)
APR  C 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.67A
APR  B 201 (-3.3A)
APR  B 201 (-3.6A)
APR  B 201 (-3.3A)
None
APR  B 201 (-3.3A)
APR  B 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.65A
APR  D 201 (-3.2A)
APR  D 201 (-3.5A)
APR  D 201 (-3.2A)
None
APR  D 201 ( 3.7A)
APR  D 201 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C  88
GLY C  85
VAL C  35
ALA C  27
VAL C  30
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.66A
APR  A 201 (-3.5A)
APR  A 201 (-3.1A)
APR  A 201 (-3.5A)
None
APR  A 201 (-3.4A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.66A
APR  C 201 (-3.0A)
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
None
APR  C 201 (-3.5A)
APR  C 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.65A
APR  B 201 (-3.3A)
APR  B 201 (-3.6A)
APR  B 201 (-3.3A)
None
APR  B 201 (-3.3A)
APR  B 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
TYR A 161
LEU A 160
ASP A 135
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.64A
APR  D 201 (-3.2A)
APR  D 201 (-3.5A)
APR  D 201 (-3.2A)
None
APR  D 201 ( 3.7A)
APR  D 201 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 164
GLU A  26
LEU A 123
CYH A 143
PHE A   6
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D  88
GLY D  85
VAL D  35
ALA D  27
VAL D  30
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.66A
APR  A 201 (-3.5A)
APR  A 201 (-3.1A)
APR  A 201 (-3.5A)
None
APR  A 201 (-3.4A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 127
VAL D  95
CYH D  92
GLY D  85
LEU D 153
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D  75
GLY D  79
VAL D  41
TYR D  68
ALA D  50
1.44A
None
None
None
None
APR  D 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LYS A6844
ILE A6969
LEU A6883
ASP A6928
1.64A
GTA  A7102 (-2.8A)
None
None
SAH  A7101 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.28A
None
None
None
None
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6883
VAL A6865
GLY A6962
LEU A6848
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6883
ASP A6895
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
GLY A6871
LEU A6834
1.16A
None
None
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TYR A6851
LEU A6848
ASP A6928
1.76A
None
None
SAH  A7101 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6871
VAL A6902
ALA B4324
ALA A6881
GLY A6879
1.37A
SAH  A7101 (-4.3A)
None
None
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6911
VAL A6916
ALA A6870
GLY A6871
ALA A6905
1.48A
None
None
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ILE A7088
VAL A6865
LEU A6887
ASP A6906
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6879
ALA A6905
VAL A6894
GLY A6871
PHE A6954
1.15A
SAH  A7101 (-3.5A)
None
None
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL B4295
ALA A6881
VAL A6882
ALA A6870
GLY A6871
1.27A
None
None
None
None
SAH  A7101 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6981
GLY A6983
LEU A6924
GLY A7011
LEU A6855
1.39A
None
None
None
None
8NK  A7103 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6xip NSP8
(SARS-CoV-2)		3 / 3
LYS B  79
LEU D 153
ASP D 143
1.17A18.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY B 149
ALA B   7
GLU A  14
LEU A 115
VAL A 125
1.22A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.70A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.62A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 253
PHE A 294
ALA A 206
VAL A 202
GLY A 251
1.77A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 294
ALA A 206
VAL A 202
TYR A 209
GLY A 251
1.76A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
LEU A 253
GLY A 251
ALA A 206
VAL A 204
CYH A 265
PHE A 230
1.64A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 215
VAL A 212
LEU A 250
CYH A 300
GLY A   2
1.75A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
LYS A   5
GLU A 288
GLY A 149
ALA A 129
1.50A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 143
LEU A 177
VAL A 148
GLY A 120
CYH A  38
1.75A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 250
GLY A 251
ALA A 206
LEU A 282
CYH A 300
1.70A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A 149
VAL A 114
LEU A 141
GLY A 174
CYH A 145
1.79A22.15
None
None
None
None
DMS  A 405 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 283
ALA A 210
VAL A 296
GLY A   2
1.56A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 206
LEU A 242
VAL A 202
PHE A 230
LEU A 262
1.68A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H  54
ALA E 435
VAL E 510
TYR E 508
ALA E 411
1.19A
None
None
None
DMS  E 902 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY B  54
ALA A 435
VAL A 510
TYR A 508
ALA A 411
1.26A
None
None
None
DMS  A 903 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H  54
ALA E 435
VAL E 510
TYR E 508
ALA E 411
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
TYR E 505
LEU B  18
ASP B  90
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY B  54
ALA A 435
VAL A 510
TYR A 508
ALA A 411
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		3 / 3
TYR A 505
LEU H  18
ASP H  90
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY H  54
ALA E 435
VAL E 510
TYR E 508
ALA E 411
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.60A
EDO  A 202 ( 4.4A)
EDO  A 202 (-3.9A)
EDO  A 202 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.69A
EDO  D 205 ( 4.9A)
EDO  D 205 ( 3.6A)
EDO  D 205 (-3.5A)
None
EDO  D 206 (-3.6A)
EDO  D 206 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.62A
EDO  A 202 ( 4.4A)
EDO  A 202 (-3.9A)
EDO  A 202 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS B 163
LEU B 126
ASP B 135
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D 130
PHE D 132
VAL D  95
ALA D  50
GLY D  48
1.31A
EDO  D 205 ( 4.9A)
EDO  D 205 ( 3.6A)
None
EDO  D 206 (-3.6A)
EDO  D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
VAL E  95
CYH E  92
GLY E  85
LEU E 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 130
PHE E 132
VAL E  95
ALA E  50
GLY E  48
1.34A
EPE  E 202 ( 4.5A)
EPE  E 202 (-3.2A)
None
EPE  E 202 (-3.1A)
EPE  E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  95
ALA B  50
GLY B  48
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  95
ALA C  50
GLY C  48
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS D 163
LEU D 126
ASP D 135
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D 130
PHE D 132
VAL D  95
ALA D  50
GLY D  48
1.34A
EDO  D 205 ( 4.9A)
EDO  D 205 ( 3.6A)
None
EDO  D 206 (-3.6A)
EDO  D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
GLY B  48
ALA B  39
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
GLU C 104
VAL C  96
ALA C  50
GLY C  48
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY E 130
PHE E 132
ALA E  38
VAL E  95
ALA E  50
GLY E  47
1.66A
EPE  E 202 ( 4.5A)
EPE  E 202 (-3.2A)
EPE  E 202 (-3.3A)
None
EPE  E 202 (-3.1A)
EPE  E 202 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.41A
EDO  A 202 ( 4.4A)
EDO  A 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A 130
PHE A 132
VAL A  95
ALA A  50
GLY A  48
1.36A
EDO  A 202 ( 4.4A)
EDO  A 202 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
GLU B 104
VAL B  96
ALA B  50
GLY B  48
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.66A
EDO  D 205 ( 4.9A)
EDO  D 205 ( 3.6A)
EDO  D 205 (-3.5A)
None
EDO  D 206 (-3.6A)
EDO  D 206 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 127
VAL D  95
CYH D  92
GLY D  85
LEU D 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 130
PHE E 132
VAL E  95
ALA E  50
GLY E  48
1.38A
EPE  E 202 ( 4.5A)
EPE  E 202 (-3.2A)
None
EPE  E 202 (-3.1A)
EPE  E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
GLU B 104
VAL B  96
ALA B  50
GLY B  48
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  95
ALA C  50
GLY C  47
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  95
ALA C  50
GLY C  48
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 153
VAL E 151
ALA E 124
VAL E  36
ALA E 112
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D 130
GLU D 104
VAL D  96
ALA D  50
GLY D  48
1.32A
EDO  D 205 ( 4.9A)
None
None
EDO  D 206 (-3.6A)
EDO  D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D 130
GLU D 104
VAL D  96
ALA D  50
GLY D  48
1.19A
EDO  D 205 ( 4.9A)
None
None
EDO  D 206 (-3.6A)
EDO  D 209 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.44A
EDO  A 202 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.34A
EDO  A 202 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 130
GLU E 104
VAL E  96
ALA E  50
GLY E  48
1.20A
EPE  E 202 ( 4.5A)
None
None
EPE  E 202 (-3.1A)
EPE  E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A 130
GLU A 104
VAL A  96
ALA A  50
GLY A  48
1.20A
EDO  A 202 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
ALA B  50
GLY B  47
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS A 163
LEU A 126
ASP A 135
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
GLY B  48
ALA B  39
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  36
GLY C  48
ALA C  39
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  36
ALA B  50
GLY B  47
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  95
ALA B  50
GLY B  47
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  95
CYH C  92
GLY C  85
LEU C 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  36
ALA C  50
GLY C  47
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
GLU C 104
VAL C  96
ALA C  50
GLY C  48
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY E 130
PHE E 132
ALA E  38
VAL E  95
ALA E  50
GLY E  47
1.63A
EPE  E 202 ( 4.5A)
EPE  E 202 (-3.2A)
EPE  E 202 (-3.3A)
None
EPE  E 202 (-3.1A)
EPE  E 202 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 130
GLU E 104
VAL E  96
ALA E  50
GLY E  48
1.32A
EPE  E 202 ( 4.5A)
None
None
EPE  E 202 (-3.1A)
EPE  E 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  95
ALA B  50
GLY B  48
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  88
GLY E  85
VAL E  35
ALA E  27
VAL E  30
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  88
GLY E  85
VAL E  35
ALA E  27
VAL E  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  36
ALA C  50
GLY C  47
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  36
GLY C  48
ALA C  39
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 153
VAL E 151
ALA E 124
VAL E  36
ALA E 112
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C 130
PHE C 132
VAL C  95
ALA C  50
GLY C  47
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS C 163
LEU C 126
ASP C 135
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 164
GLU E  26
LEU E 123
CYH E 143
PHE E   6
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.67A
APR  D 201 (-3.2A)
APR  D 201 (-3.3A)
APR  D 201 (-3.3A)
None
APR  D 201 (-3.6A)
APR  D 201 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.62A
APR  A 201 ( 3.2A)
APR  A 201 (-3.7A)
APR  A 201 (-3.4A)
None
APR  A 201 (-3.4A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 127
VAL D  95
CYH D  92
GLY D  85
LEU D 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.65A
APR  B 201 (-3.2A)
APR  B 201 (-3.5A)
APR  B 201 (-3.4A)
None
APR  B 201 (-3.5A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  88
GLY E  85
VAL E  35
ALA E  27
VAL E  30
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY D 130
PHE D 132
ALA D  38
VAL D  95
ALA D  50
GLY D  47
1.69A
APR  D 201 (-3.2A)
APR  D 201 (-3.3A)
APR  D 201 (-3.3A)
None
APR  D 201 (-3.6A)
APR  D 201 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY E 130
PHE E 132
ALA E  38
VAL E  95
ALA E  50
GLY E  47
1.67A
APR  E 201 (-3.2A)
APR  E 201 (-3.5A)
APR  E 201 (-3.3A)
None
APR  E 201 (-3.4A)
APR  E 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.65A
APR  C 201 (-3.2A)
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
None
APR  C 201 (-3.6A)
APR  C 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS D 163
LEU D 126
ASP D 135
1.15A
None
APR  D 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY E 130
PHE E 132
ALA E  38
VAL E  95
ALA E  50
GLY E  47
1.68A
APR  E 201 (-3.2A)
APR  E 201 (-3.5A)
APR  E 201 (-3.3A)
None
APR  E 201 (-3.4A)
APR  E 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 153
VAL E 151
ALA E 124
VAL E  36
ALA E 112
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 127
VAL E  95
CYH E  92
GLY E  85
LEU E 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.64A
APR  B 201 (-3.2A)
APR  B 201 (-3.5A)
APR  B 201 (-3.4A)
None
APR  B 201 (-3.5A)
APR  B 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS B 163
LEU B 126
ASP B 135
1.25A
None
APR  B 201 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS A 163
LEU A 126
ASP A 135
1.23A
None
APR  A 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.66A
APR  C 201 (-3.2A)
APR  C 201 (-3.5A)
APR  C 201 (-3.4A)
None
APR  C 201 (-3.6A)
APR  C 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS C 163
LEU C 126
ASP C 135
1.43A
None
APR  C 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.63A
APR  A 201 ( 3.2A)
APR  A 201 (-3.7A)
APR  A 201 (-3.4A)
None
APR  A 201 (-3.4A)
APR  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 153
VAL E 151
ALA E 124
VAL E  36
ALA E 112
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
VAL D 151
ALA D 124
VAL D  36
ALA D 112
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  95
CYH C  92
GLY C  85
LEU C 153
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  88
GLY A  85
VAL A  35
ALA A  27
VAL A  30
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.66A
MES  C 201 (-3.3A)
MES  C 201 (-3.6A)
MES  C 201 (-3.5A)
None
MES  C 201 ( 3.8A)
MES  C 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
GLU B 104
VAL B  96
ALA B  50
GLY B  48
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  95
ALA B  50
GLY B  48
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.64A
MES  A 201 (-3.1A)
MES  A 201 (-3.5A)
MES  A 201 (-3.5A)
None
MES  A 201 ( 3.7A)
MES  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY A 130
PHE A 132
ALA A  38
VAL A  95
ALA A  50
GLY A  47
1.67A
MES  A 201 (-3.1A)
MES  A 201 (-3.5A)
MES  A 201 (-3.5A)
None
MES  A 201 ( 3.7A)
MES  A 201 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LYS C 163
LEU C 126
ASP C 135
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
PHE B 132
VAL B  95
ALA B  50
GLY B  48
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 153
VAL B 151
ALA B 124
VAL B  36
ALA B 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 127
VAL A  95
CYH A  92
GLY A  85
LEU A 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
VAL B  95
CYH B  92
GLY B  85
LEU B 153
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
VAL C 151
ALA C 124
VAL C  36
ALA C 112
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  93
VAL B  36
VAL B 147
GLY B  79
LEU B 126
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY C 130
PHE C 132
ALA C  38
VAL C  95
ALA C  50
GLY C  47
1.65A
MES  C 201 (-3.3A)
MES  C 201 (-3.6A)
MES  C 201 (-3.5A)
None
MES  C 201 ( 3.8A)
MES  C 201 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
VAL A 151
ALA A 124
VAL A  36
ALA A 112
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B 130
GLU B 104
VAL B  96
ALA B  50
GLY B  48
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 127
VAL C  95
CYH C  92
GLY C  85
LEU C 153
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 164
GLU B  26
LEU B 123
CYH B 143
PHE B   6
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  88
GLY B  85
VAL B  35
ALA B  27
VAL B  30
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		6 / 12
GLY B 130
PHE B 132
ALA B  38
VAL B  95
ALA B  50
GLY B  47
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
VAL A 128
LEU A 186
VAL A 182
PHE A 287
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 401
GLY A 671
ALA A 382
LEU B 122
LEU A 389
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7btf NSP12
(SARS-CoV-2)		3 / 3
TYR A  69
LEU A  65
ASP A  63
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 130
LEU A 247
CYH A 139
GLY A 137
PHE A 165
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7btf NSP8
(SARS-CoV-2)		3 / 3
TYR D 135
LEU D 180
ASP D 163
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 12
GLY A 327
ALA A 379
VAL A 341
GLY A 345
CYH B 114
LEU A 271
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7btf NSP12
(SARS-CoV-2)		3 / 3
TYR A 788
LEU A 240
ASP A 208
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 12
GLY A 327
ALA A 379
LEU B 103
VAL A 341
GLY A 345
LEU A 271
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7btf NSP12
(SARS-CoV-2)		3 / 3
TYR A 289
LEU A 205
ASP A 221
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 130
LEU A 247
CYH A 139
GLY A 137
PHE A 165
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv1 NSP12
NSP8
(SARS-CoV-2)		6 / 12
GLY A 327
ALA A 379
VAL A 341
GLY A 345
CYH B 114
LEU A 271
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7bv1 NSP8
(SARS-CoV-2)		3 / 3
TYR D 138
LEU D 184
ASP D 163
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
TYR A 420
LEU A 838
ASP A 833
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
GLY A 327
ALA A 379
LEU B 103
VAL A 341
GLY A 345
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
TYR A 689
LEU A 638
ASP A 477
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
VAL A 128
LEU A 186
VAL A 182
PHE A 287
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
TYR A 420
LEU A 838
ASP A 833
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
GLY A 327
ALA A 379
LEU B 103
VAL A 341
GLY A 345
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
TYR A 689
LEU A 638
ASP A 477
1.40A
 U  T  12 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
VAL A 128
LEU A 186
VAL A 182
PHE A 287
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		6 / 12
GLY A 327
ALA A 379
VAL A 341
GLY A 345
CYH B 114
LEU A 271
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 5
ILE A 333
VAL A 330
LEU B 117
ASP A 377
1.79A
None