Ligand ID: LCR


Drugbank ID:
DB00341
(Cetirizine)
DB06282
(Levocetirizine)


Indication:
For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria;Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.

Get human targets for LCR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'LCR' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6m71 NSP12
(SARS-CoV-2)		5 / 9
LYS A 603
LEU A 614
LEU A 819
GLY A 808
LEU A 805
1.75A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU B  95
ASP A 377
LEU B  98
LEU B 103
ALA A 383
1.72A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 9
LYS C7012
LEU C6959
LEU C7073
GLY C6962
LEU C6961
1.75A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 9
LYS A7012
LEU A6959
LEU A7073
GLY A6962
LEU A6961
1.73A14.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 9
ASP A  50
LEU A  48
GLY A  17
LEU A  44
ALA A  28
1.67A13.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LYS C7012
LEU C6959
LEU C7073
GLY C6962
LEU C6961
1.73A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LYS A7012
LEU A6959
LEU A7073
GLY A6962
LEU A6961
1.72A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 9
LYS C7012
LEU C6959
LEU C7073
GLY C6962
LEU C6961
1.74A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		6wkq NSP16
(SARS-CoV-2)		5 / 9
LYS A7012
LEU A6959
LEU A7073
GLY A6962
LEU A6961
1.72A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		7btf NSP7
(SARS-CoV-2)		5 / 9
LEU C  20
ASP C  67
LEU C  60
LEU C  59
LEU C  13
1.65A8.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU B  95
ASP A 377
LEU B  98
LEU B 103
ALA A 383
1.57A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		7bv2 NSP7
(SARS-CoV-2)		5 / 9
LYS C   7
ASP C  38
LEU C  35
LEU C  55
LEU C  14
1.80A8.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 9
LYS A 603
LEU A 614
LEU A 819
GLY A 808
LEU A 805
1.77A20.60
None