Ligand ID: HSM


Drugbank ID:
DB05381
(Histamine)


Indication:
Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.

Get human targets for HSM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HSM' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 103
GLU A 178
GLN A  83
VAL A  86
1.67A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 7
ILE C 980
ARG C 983
ASP B 985
GLU B 988
1.66A24.29
None
None
ZN  B1302 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 5
VAL A 976
VAL C1164
ASP C1165
SER C 974
1.46A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 103
GLU A 178
GLN A  83
VAL A  86
1.59A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 103
GLU A 178
GLN A  83
VAL A  86
1.69A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 495
PHE E 497
ASP E 442
1.35A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 5
VAL F 510
TYR F 508
VAL F 407
ASP F 405
1.76A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ASP C  92
LEU C  89
LEU C  75
1.71A23.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
ASP C  92
LEU C  89
LEU C  75
1.65A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP D 145
LEU D 114
GLY D 115
1.13A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.74A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.73A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m71 NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.55A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 241
LEU A 240
1.50A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.55A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.49A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 708
GLY A  44
1.30A12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m71 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.73A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 5
VAL A 667
VAL A 560
ASP A 684
SER A 682
1.49A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m71 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.67A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.70A10.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.62A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.71A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		4 / 5
ASP A 879
GLU A 876
THR A 870
LEU A 869
1.76A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 5
VAL A 667
VAL A 560
ASP A 684
SER A 682
1.57A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.55A10.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.75A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 804
LEU A 819
LEU A 805
1.61A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		4 / 4
ASP A 717
LEU A 707
LEU A 723
LEU A 775
1.78A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.63A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		4 / 4
ASP A 465
LEU A 241
LEU A 245
LEU A 240
1.79A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.64A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		4 / 5
ASP A 465
LEU A 241
LEU A 245
LEU A 240
1.77A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.51A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		6m71 NSP12
(SARS-CoV-2)		4 / 6
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.51A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		4 / 5
SER C  15
SER C  10
VAL C  12
GLY A 413
1.70A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m71 NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.51A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 241
LEU A 240
1.50A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 804
LEU A 819
LEU A 805
1.54A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL B  47
TYR B 279
VAL B  42
ASP B  40
1.71A7.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER B 375
TYR B 508
VAL B 510
TRP B 436
1.64A7.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE B 285
TYR B  37
PHE B  55
ASP B  53
1.51A8.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B 994
LEU B 753
LEU B 752
1.22A8.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP A 614
SER A 596
VAL A 595
GLY A 593
1.40A12.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER B 375
TYR B 508
VAL B 510
TRP B 436
1.66A7.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ASP A 138
LEU A 141
LEU A 241
LEU A 244
1.53A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP A 294
GLU A 298
THR A 599
LEU A 296
1.54A8.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B 994
LEU B1001
GLY B 999
0.95A9.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B 994
LEU B 753
LEU B 752
1.23A9.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
GLU B1111
GLN B1106
VAL B 911
ASN B 914
1.57A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER B 309
VAL B 339
TYR B 231
ILE B 307
1.70A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 300
1.40A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
SER B 208
TYR B 226
ILE B 253
ASP B 301
1.55A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 300
1.42A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU A  43
HIS A  45
LEU A  83
HIS A  94
HIS A  86
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B  43
HIS B  45
LEU B  83
HIS B  94
HIS B  86
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6vxs NSP3
(SARS-CoV-2)		4 / 4
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.78A
SO4  B 204 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP A 294
GLU A 298
THR A 599
LEU A 296
1.51A8.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP B 389
SER B 530
VAL B 327
GLY B 545
1.21A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
GLU B1111
GLN B1106
VAL B 911
ASN B 914
1.41A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 285
TYR A  37
PHE A  55
ASP A  53
1.49A8.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP C 979
LEU B 390
GLY B 545
1.28A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
GLU A1111
GLN A1106
VAL A 911
ASN A 914
1.42A13.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
ASP C 294
GLU C 298
THR C 599
LEU C 296
1.52A8.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 994
LEU A 753
LEU A 752
1.39A9.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 285
TYR A  37
PHE A  55
ASP A  53
1.50A8.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A 994
LEU A 753
LEU A 752
1.37A8.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ASP C 979
LEU B 546
GLY B 545
1.03A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
ASP B 144
LEU B 113
GLY B 114
1.13A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 4
ASP A 301
LEU A 251
LEU A 298
LEU A 300
1.58A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 301
LEU A 251
LEU A 298
LEU A 300
1.61A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 301
GLU A 305
LEU A 298
LEU A 299
1.62A20.27
None
EDO  A 411 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w02 NSP3
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.07A23.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w02 NSP3
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.07A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6w02 NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.29A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6w02 NSP3
(SARS-CoV-2)		4 / 5
GLU A  25
THR A  57
LEU A  53
LEU A  88
1.58A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
VAL C 401
TYR C 508
VAL C 407
ASP C 405
1.63A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER C 383
TYR L  49
TYR L  91
ASP H 101
1.77A22.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
ILE C 402
TYR C 451
PHE C 497
ASP C 442
1.62A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
VAL C 510
TYR C 508
VAL C 407
ASP C 405
1.65A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
ILE C 402
TYR C 451
PHE C 497
ASP C 442
1.59A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
VAL C 401
TYR C 508
VAL C 407
ASP C 405
1.62A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w4h NSP16
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.28A21.95
SAM  A7102 (-3.7A)
None
SAM  A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6w4h NSP16
(SARS-CoV-2)		4 / 5
ASP A6897
SER A6896
SER A7090
VAL A6916
1.27A17.92
SAM  A7102 (-2.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6w4h NSP16
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.51A19.27
SAM  A7102 (-4.5A)
None
SAM  A7102 (-3.7A)
ACT  A7103 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.50A
SAM  A7104 (-4.6A)
None
SAM  A7104 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.51A
SAM  A7104 (-4.6A)
None
SAM  A7104 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ASP A6897
SER A6896
SER A7090
VAL A6916
1.27A
SAM  A7104 (-2.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.26A
SAM  A7104 (-3.8A)
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU A  43
HIS A  45
LEU A  83
HIS A  94
HIS A  86
1.28A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU B  43
HIS B  45
LEU B  83
HIS B  94
HIS B  86
1.34A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.26A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.32A18.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.28A21.16
SAM  A7102 ( 3.7A)
None
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.41A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP A6895
LEU A6892
LEU A6893
1.50A26.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP C6895
LEU C6892
LEU C6893
1.48A26.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.44A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.52A18.71
SAM  A7102 ( 4.5A)
None
SAM  A7102 ( 3.7A)
FMT  A7104 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.72A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.51A18.71
SAM  C7105 ( 4.5A)
None
SAM  C7105 ( 3.7A)
FMT  C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.68A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP C6928
LEU C6883
GLY C6879
1.28A21.16
SAM  C7105 ( 3.7A)
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.64A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.53A18.71
SAM  A7102 ( 4.5A)
None
SAM  A7102 ( 3.7A)
FMT  A7104 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6w75 NSP16
(SARS-CoV-2)		4 / 5
SER A6896
SER A7089
VAL A6916
GLY A6911
1.53A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.53A18.71
SAM  C7105 ( 4.5A)
None
SAM  C7105 ( 3.7A)
FMT  C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.53A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP C6895
LEU C6892
LEU C6893
1.50A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.69A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6w75 NSP16
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.50A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ASP A6895
LEU A6892
LEU A6893
1.51A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP B  61
LEU B  58
LEU B  64
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP B  40
LEU B  58
GLY B  32
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP B  61
LEU B  58
LEU B  64
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  76
LEU A  80
GLY A  81
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP C  76
LEU C  80
GLY C  81
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  61
LEU A  58
LEU A  64
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
ASP A  61
LEU A  58
LEU A  64
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6wcf NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wcf NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6wcf NSP3
(SARS-CoV-2)		5 / 9
LEU A  43
HIS A  45
LEU A  83
HIS A  94
HIS A  86
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wcf NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wen NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wen NSP3
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
GLU A  64
LEU A  43
HIS A  45
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wey NSP3
(SARS-CoV-2)		3 / 3
ASP A 309
LEU A 313
LEU A 312
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wey NSP3
(SARS-CoV-2)		4 / 5
VAL A 359
TYR A 365
VAL A 369
SER A 371
1.62A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wey NSP3
(SARS-CoV-2)		3 / 3
ASP A 309
LEU A 313
LEU A 312
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6wey NSP3
(SARS-CoV-2)		5 / 9
LEU A 287
HIS A 298
HIS A 290
LEU A 247
HIS A 249
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wey NSP3
(SARS-CoV-2)		4 / 5
VAL A 359
TYR A 365
VAL A 369
SER A 371
1.62A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6wey NSP3
(SARS-CoV-2)		4 / 4
VAL A 359
TYR A 365
VAL A 369
SER A 371
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.67A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.68A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.62A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wiq NSP7
(SARS-CoV-2)		3 / 3
ASP A  38
LEU A  14
LEU A  35
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wiq NSP7
(SARS-CoV-2)		3 / 3
ASP A  38
LEU A  14
LEU A  35
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.56A
SAH  C7102 (-4.6A)
None
SAH  C7102 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.54A
SAH  A7102 (-4.6A)
None
SAH  A7102 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.27A
SAH  A7102 (-3.7A)
None
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.77A19.70
None
FMT  C7107 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.71A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.51A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.55A
SAH  C7102 (-4.6A)
None
SAH  C7102 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP C6928
LEU C6883
GLY C6879
1.27A
SAH  C7102 (-3.7A)
None
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.53A19.70
FMT  C7107 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.74A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.73A19.70
None
FMT  C7107 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.55A
SAH  A7102 (-4.6A)
None
SAH  A7102 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.54A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.49A19.70
FMT  C7107 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP C 144
LEU C 113
GLY C 114
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP D 144
LEU D 113
GLY D 114
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP A 144
LEU A 113
GLY A 114
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
ASP B 144
LEU B 113
GLY B 114
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ASP C6928
LEU C6883
GLY C6879
1.27A
SFG  C7103 ( 3.7A)
None
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.54A
SFG  A7103 ( 4.6A)
None
SFG  A7103 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.50A19.70
 NA  A7102 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.51A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.53A
SFG  A7103 ( 4.6A)
None
SFG  A7103 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.27A
SFG  A7103 ( 3.6A)
None
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.69A19.70
None
NA  A7102 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.55A
SFG  C7103 ( 4.5A)
None
SFG  C7103 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL C6894
VAL A7092
ASP A7091
SER C7089
1.72A19.70
None
NA  A7102 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.75A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL A7092
VAL C6894
ASP C6895
SER C6896
1.47A19.70
 NA  A7102 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL A6894
VAL C7092
ASP C7091
SER A7089
1.73A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6wkq NSP16
(SARS-CoV-2)		4 / 5
VAL C7092
VAL A6894
ASP A6895
SER A6896
1.48A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 7
TYR C6845
PHE C7003
ASP C6928
GLU C7001
1.53A
SFG  C7103 ( 4.5A)
None
SFG  C7103 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 300
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 4
ASP B 301
LEU B 251
LEU B 298
LEU B 300
1.63A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP B 301
LEU B 298
LEU B 299
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP B 301
LEU B 298
LEU B 299
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 301
GLU A 305
LEU A 298
LEU A 299
1.63A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP B 301
LEU B 251
LEU B 298
LEU B 300
1.66A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP B 301
LEU B 298
LEU B 300
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 301
LEU A 251
LEU A 298
LEU A 300
1.64A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 299
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 4
ASP A 301
LEU A 251
LEU A 298
LEU A 300
1.61A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP A 301
GLU A 305
LEU A 298
LEU A 299
1.74A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 297
LEU A 255
GLY A 254
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 299
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP B 301
GLU B 305
LEU B 298
LEU B 299
1.71A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
ASP B 301
GLU B 305
LEU B 298
LEU B 299
1.61A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP B 301
LEU B 298
LEU B 300
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
ASP A 301
LEU A 298
LEU A 300
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.65A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B  43
HIS B  45
LEU B  83
HIS B  94
HIS B  86
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU C  83
HIS C  94
HIS C  86
GLU C  64
HIS C  45
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.70A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU C  83
HIS C  94
HIS C  86
LEU C  43
HIS C  45
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
0.99A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.00A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.67A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.05A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.72A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ASP A6928
LEU A6883
GLY A6879
1.27A
SAH  A7101 (-3.7A)
None
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
ASP A6897
SER A6896
SER A7090
VAL A6916
1.23A
SAH  A7101 (-2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.54A
SAH  A7101 (-4.5A)
None
SAH  A7101 (-3.7A)
GTA  A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
TYR A6845
PHE A7003
ASP A6928
GLU A7001
1.52A
SAH  A7101 (-4.5A)
None
SAH  A7101 (-3.7A)
GTA  A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wqd NSP7
(SARS-CoV-2)		3 / 3
ASP A  38
LEU A  14
LEU A  35
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wqd NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.74A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6wqd NSP7
(SARS-CoV-2)		3 / 3
ASP A  38
LEU A  14
LEU A  35
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.70A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6wqd NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.74A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
TYR B 209
VAL B 261
ASP B 263
SER B 267
1.77A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
ASP A  38
LEU A  14
LEU A  35
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.67A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.67A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.62A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.67A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.63A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 7
SER A  57
VAL B 130
TYR B 149
ILE B 106
1.67A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A  41
LEU A  73
LEU A  99
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		3 / 3
ASP A  41
LEU A  73
LEU A  99
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL A 510
TYR A 508
VAL A 407
ASP A 405
1.73A20.85
None
DMS  A 903 (-3.5A)
DMS  A 903 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL A 401
TYR A 508
VAL A 407
ASP A 405
1.69A20.85
None
DMS  A 903 (-3.5A)
DMS  A 903 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL E 401
TYR E 508
VAL E 407
ASP E 405
1.67A20.85
None
DMS  E 902 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 402
TYR A 451
PHE A 497
ASP A 442
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 375
TYR E 508
VAL E 510
TRP E 436
1.60A18.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER E 375
TYR E 508
VAL E 510
TRP E 436
1.48A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 375
TYR E 508
VAL E 510
TRP E 436
1.49A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 375
TYR E 508
VAL E 510
TRP E 436
1.47A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL E 510
TYR E 508
VAL E 407
ASP E 405
1.79A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 402
TYR A 451
PHE A 497
ASP A 442
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL E 401
TYR E 508
VAL E 407
ASP E 405
1.67A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE A 402
TYR A 451
PHE A 497
ASP A 442
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
VAL A 401
TYR A 508
VAL A 407
ASP A 405
1.67A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ILE E 402
TYR E 451
PHE E 497
ASP E 442
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 105
LEU E 109
LEU E 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 105
LEU E 109
LEU E 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  43
HIS C  45
LEU C  83
HIS C  94
HIS C  86
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  43
HIS A  45
LEU A  83
HIS A  94
HIS A  86
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  43
HIS B  45
LEU B  83
HIS B  94
HIS B  86
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  43
HIS D  45
LEU D  83
HIS D  94
HIS D  86
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU E  25
THR E  57
LEU E  53
LEU E  88
1.61A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL E 155
TYR E 161
VAL E 165
SER E 167
1.76A21.39
EDO  E 205 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL A 155
TYR A 161
VAL A 165
SER A 167
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.79A21.39
EDO  D 208 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  83
HIS E  94
HIS E  86
LEU E  43
HIS E  45
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU D  25
THR D  57
LEU D  53
LEU D  88
1.56A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.80A
EDO  D 208 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU A  25
THR A  57
LEU A  53
LEU A  88
1.59A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  43
HIS E  45
LEU E  83
HIS E  94
HIS E  86
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.74A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL E 155
TYR E 161
VAL E 165
SER E 167
1.76A
EDO  E 205 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.10A
None
EDO  D 204 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.09A
None
None
EDO  D 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU B  25
THR B  57
LEU B  53
LEU B  88
1.60A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.74A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL A 155
TYR A 161
VAL A 165
SER A 167
1.74A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  83
HIS D  94
HIS D  86
LEU D  43
HIS D  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.10A
None
EDO  D 204 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.08A
None
None
EDO  D 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.76A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
HIS C  94
HIS C  86
LEU C  43
HIS C  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  43
HIS D  45
LEU D  83
HIS D  94
HIS D  86
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.76A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.76A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  43
HIS E  45
LEU E  83
HIS E  94
HIS E  86
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL E 155
TYR E 161
VAL E 165
SER E 167
1.77A21.39
APR  E 201 ( 4.9A)
EDO  E 203 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D  83
HIS D  94
HIS D  86
LEU D  43
HIS D  45
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.79A21.39
APR  C 201 ( 4.9A)
EDO  C 203 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 105
LEU E 109
LEU E 108
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL E 155
TYR E 161
VAL E 165
SER E 167
1.77A
APR  E 201 ( 4.9A)
EDO  E 203 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  43
HIS B  45
LEU B  83
HIS B  94
HIS B  86
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU A  25
THR A  57
LEU A  53
LEU A  88
1.61A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU B  25
THR B  57
LEU B  53
LEU B  88
1.61A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP E 105
LEU E 109
LEU E 108
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.77A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU C  25
THR C  57
LEU C  53
LEU C  88
1.56A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E  83
HIS E  94
HIS E  86
LEU E  43
HIS E  45
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL D 155
TYR D 161
VAL D 165
SER D 167
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.08A
EDO  A 206 ( 4.6A)
None
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  43
HIS C  45
LEU C  83
HIS C  94
HIS C  86
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.79A21.39
APR  C 201 ( 4.9A)
EDO  C 203 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU D  25
THR D  57
LEU D  53
LEU D  88
1.59A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL E 155
TYR E 161
VAL E 165
SER E 167
1.77A21.39
APR  E 201 ( 4.9A)
EDO  E 203 (-4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP D 105
LEU D 109
LEU D 108
1.08A
EDO  A 206 ( 4.6A)
None
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU E  25
THR E  57
LEU E  53
LEU E  88
1.59A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  43
HIS A  45
LEU A  83
HIS A  94
HIS A  86
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
HIS C  94
HIS C  86
LEU C  43
HIS C  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
VAL B 155
TYR B 161
VAL B 165
SER B 167
1.77A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
VAL C 155
TYR C 161
VAL C 165
SER C 167
1.79A
APR  C 201 ( 4.9A)
EDO  C 203 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A  83
HIS A  94
HIS A  86
LEU A  43
HIS A  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU A  25
THR A  57
LEU A  53
LEU A  88
1.58A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  83
HIS C  94
HIS C  86
LEU C  43
HIS C  45
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.06A
None
None
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
GLU C  25
THR C  57
LEU C  53
LEU C  88
1.58A25.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP A 105
LEU A 109
LEU A 108
1.07A
None
None
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B  83
HIS B  94
HIS B  86
LEU B  43
HIS B  45
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP C 105
LEU C 109
LEU C 108
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C  43
HIS C  45
LEU C  83
HIS C  94
HIS C  86
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
ASP B 105
LEU B 109
LEU B 108
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.39A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		7btf NSP12
NSP7
(SARS-CoV-2)		4 / 5
SER C  15
SER C  10
VAL C  12
GLY A 413
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7btf NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		7btf NSP12
(SARS-CoV-2)		4 / 5
VAL A 667
VAL A 560
ASP A 684
SER A 682
1.55A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 241
LEU A 240
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 205
LEU A 207
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7btf NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 205
LEU A 207
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.44A10.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 708
GLY A  44
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		7btf NSP12
(SARS-CoV-2)		3 / 3
ASP A 804
LEU A 614
GLY A 808
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		7btf NSP12
(SARS-CoV-2)		4 / 5
ASP A 879
GLU A 876
THR A 870
LEU A 869
1.71A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		7btf NSP12
(SARS-CoV-2)		4 / 6
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.41A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.77A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.41A9.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
PHE A 103
GLU A 178
GLN A  83
VAL A  86
1.69A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
ASP A 717
LEU A 707
LEU A 723
LEU A 775
1.76A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.51A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 163
TYR A 787
PHE A 793
GLU A 796
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 208
LEU A 205
LEU A 207
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 304
LEU A 638
LEU A 636
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.50A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.69A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 374
TYR A 530
ILE A 536
ASP A 377
1.67A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 374
TYR A 530
ILE A 536
ASP A 377
1.70A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.69A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.50A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 374
TYR A 530
ILE A 536
ASP A 377
1.70A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 163
TYR A 787
PHE A 793
GLU A 796
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.49A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 7
SER C  57
VAL D 130
TYR D 149
ILE D 106
1.69A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 708
GLY A  44
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv1 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.54A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.50A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.59A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
ASP A 879
GLU A 876
THR A 870
LEU A 869
1.66A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 208
LEU A 205
LEU A 207
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.75A
POP  A1003 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.45A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
ASP A 465
LEU A 241
LEU A 245
LEU A 240
1.79A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.45A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.44A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
ASP A 879
GLU A 876
THR A 870
LEU A 869
1.56A12.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ARG A 553
TYR A 455
TYR A 458
ASP A 452
1.74A
POP  A1003 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 465
LEU A 241
LEU A 240
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv2 NSP12
NSP8
(SARS-CoV-2)		3 / 3
ASP A 390
LEU B 128
LEU A 388
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 205
LEU A 207
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A 804
LEU A 614
GLY A 808
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.42A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 787
TYR A 175
PHE A 134
GLU A 136
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
ASP A  36
LEU A 708
GLY A  44
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		7bv2 NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.42A9.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		7bv2 NSP7
(SARS-CoV-2)		3 / 3
ASP C  38
LEU C  14
LEU C  35
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 239
TYR A 732
ILE A 466
ASP A 465
1.54A10.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 289
VAL A 234
TYR A 238
ASP A 194
1.40A9.35
None