Ligand ID: GW6


Drugbank ID:
DB08906
(Fluticasone furoate)


Indication:
Fluticasone furoate nasal spray is indicated for the treatment of the symptoms of seasonal and perennial allergic rhinitis in patients aged 2 years and older.

Get human targets for GW6 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'GW6' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 205
ALA A 234
LEU A 272
ILE A 249
1.76A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 287
MET A 264
ALA A 266
ILE A 200
1.62A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 242
MET A 264
ALA A 260
LEU A 262
1.63A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 271
MET A 264
ALA A 266
TYR A 237
1.69A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
LEU F 962
ALA D 958
LEU D 959
GLN F 957
1.16A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C 160
LEU C  65
TYR C 113
ILE C 158
1.01A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  55
ALA C  48
GLN C  34
ILE D 119
1.54A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU C  55
ALA C  42
LEU C  40
GLN C  34
ILE D 119
1.75A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
ALA A 863
LEU A 862
TYR A 877
1.54A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
LEU A 731
GLN A 789
ILE A 244
1.24A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ALA A 625
GLN A 789
TYR A 788
ILE A 244
1.34A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 648
ALA A 639
LEU A 636
TYR A 653
1.56A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 317
GLY B 594
GLN B 613
LEU C 858
THR C 739
1.70A11.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 317
GLY B 594
GLN B 613
LEU C 858
THR C 739
1.69A11.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 962
ALA C 570
LEU A 966
GLN A 853
1.27A11.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU B 126
ALA B 112
LEU B 109
ILE B  23
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 798
GLN B 920
LEU B 916
LEU B1049
THR B 881
1.70A11.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 798
GLN C 920
LEU C 916
LEU C1049
THR C 881
1.67A11.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 159
LEU A  64
TYR A 112
ILE A 157
1.16A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
LEU C 513
LEU C 387
TYR C 380
ILE C 410
1.74A23.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w4h NSP16
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.27A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET A6818
ALA A7024
LEU A6820
ILE A7035
1.74A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
LEU A6961
GLN A6956
ILE A6951
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
MET B4297
LEU B4298
MET A7045
ILE A6926
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA A6858
LEU A6857
TYR A7009
ILE A6955
1.77A20.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 126
ALA B 112
LEU B 109
ILE B  23
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.49A
AMP  A 201 ( 4.4A)
None
None
AMP  A 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 123
ALA B  52
LEU B  53
ILE B  18
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 123
ALA A  52
LEU A  53
ILE A  18
1.65A20.00
None
AMP  A 201 ( 4.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
ALA A  50
LEU A  53
MET A  61
TYR A  68
1.75A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6959
MET C6982
LEU C6981
ILE C7079
1.30A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6959
LEU C6961
GLN C6956
ILE C6951
1.68A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7080
1.79A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
MET C6818
ALA C7024
LEU C6820
ILE C7035
1.74A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
MET D4297
LEU D4298
MET C7045
ILE C6926
1.51A16.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6959
LEU A6961
GLN A6956
ILE A6951
1.57A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C7004
MET C7022
ALA C7024
ILE C6951
1.48A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.30A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
MET A6818
ALA A7024
LEU A6820
ILE A7035
1.80A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6959
MET C6982
LEU C6981
ILE C7080
1.77A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 8
MET B4297
LEU B4298
MET A7045
ILE A6926
1.50A16.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU C 125
ALA C 135
LEU C 132
GLN C 121
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU B 172
ALA B 135
GLN B 121
ILE B 123
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 172
ALA A 135
GLN A 121
ILE A 123
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU C 185
ALA C 204
TYR C 310
ILE C 314
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 125
ALA A 135
LEU A 132
GLN A 121
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wcf NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wen NSP3
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wey NSP3
(SARS-CoV-2)		4 / 8
LEU A 330
ALA A 316
LEU A 313
ILE A 227
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  13
MET B  94
LEU B  95
GLN B  88
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU A  55
ALA A  42
LEU A  40
GLN A  34
ILE B 119
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
MET B4297
LEU B4298
MET A7045
ILE A6926
1.49A
None
FMT  B4403 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
MET D4297
LEU D4298
MET C7045
ILE C6926
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU C6959
MET C6982
LEU C6981
ILE C7079
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B 161
ALA B  55
LEU B  56
TYR B 112
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B  64
ALA B 173
LEU B 159
GLN B  70
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B  64
LEU B 161
TYR B 111
ILE B 130
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU A 161
ALA A  55
LEU A  56
TYR A 112
1.42A
None
MES  B 201 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C 161
ALA C  55
LEU C  56
TYR C 112
1.53A
None
MES  D 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C 159
LEU C  64
TYR C 112
ILE C 157
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU A 159
LEU A  64
TYR A 112
ILE A 157
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C  64
ALA C 173
LEU C 159
GLN C  70
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU D 161
ALA D  55
LEU D  56
TYR D 112
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU A  64
ALA A 173
LEU A 159
GLN A  70
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B 159
LEU B  64
TYR B 112
ILE B 157
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 8
MET D4297
LEU D4298
MET C7045
ILE C6926
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU C7004
MET C7022
ALA C7024
ILE C6951
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 8
MET B4297
LEU B4298
MET A7045
ILE A6926
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU C6959
MET C6982
LEU C6981
ILE C7079
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ALA B 256
LEU B 201
GLN B 197
ILE B 323
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU D 126
ALA D 112
LEU D 109
ILE D  23
1.52A
None
None
None
APR  D 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.50A
None
None
None
APR  A 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU C 126
ALA C 112
LEU C 109
ILE C  23
1.51A
APR  C 201 (-4.9A)
None
None
APR  C 201 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU B 126
ALA B 112
LEU B 109
ILE B  23
1.51A
None
None
None
APR  B 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
MET B4297
LEU B4298
MET A7045
ILE A6926
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6959
MET A6982
LEU A6981
ILE A7079
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  59
LEU A  20
GLN A  63
ILE B 106
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  13
MET D  94
LEU D  95
GLN D  88
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU C  55
ALA C  42
LEU C  40
GLN C  34
ILE D 119
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU A  55
ALA A  42
LEU A  40
GLN A  34
ILE B 119
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU A  13
MET B  94
LEU B  95
GLN B  88
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU B  95
ALA B 110
LEU A  60
GLN B  88
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU D  95
ALA D 110
LEU C  60
GLN D  88
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
LEU A 117
LEU A 172
MET A 169
ILE A 285
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
LEU A 125
ALA A 135
LEU A 132
GLN A 121
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 8
LEU A 172
ALA A 135
LEU A 150
GLN A 121
ILE A 123
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 287
MET A 264
ALA A 266
ILE A 200
1.62A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 242
MET A 264
ALA A 260
LEU A 262
1.65A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 271
MET A 264
ALA A 266
TYR A 237
1.69A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU C  13
MET D  94
LEU D  95
GLN D  88
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 8
LEU A  55
ALA A  42
LEU A  40
GLN A  34
ILE B 119
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU D  95
ALA D 110
LEU C  60
GLN D  88
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
LEU C  17
LEU D  91
GLN C  19
MET D  87
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 119
LEU A  24
TYR A  72
ILE A 117
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 126
ALA C 112
LEU C 109
ILE C  23
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 126
ALA B 112
LEU B 109
ILE B  23
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU E 126
ALA E 112
LEU E 109
ILE E  23
1.48A
None
None
None
EDO  E 205 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU A 126
ALA A 112
LEU A 109
ILE A  23
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU B 126
ALA B 112
LEU B 109
ILE B  23
1.48A
None
None
None
EDO  B 202 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
LEU C 126
ALA C 112
LEU C 109
ILE C  23
1.53A
None
None
None
EDO  C 206 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU C  55
ALA C  42
LEU C  40
GLN C  34
ILE D 119
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
LEU A 372
ALA A 526
LEU A 527
GLN B  73
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
ALA A 625
GLN A 789
TYR A 788
ILE A 244
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
MET A 380
ALA A 379
GLN A 661
ILE A 562
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 838
ALA A 863
LEU A 862
TYR A 877
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
ALA B 150
LEU B 122
TYR A 265
ILE A 266
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
LEU A 731
GLN A 789
ILE A 244
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 727
ALA A 702
TYR A 770
ILE A 715
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 749
ALA A 706
LEU A 707
ILE A 696
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
LEU A 241
LEU A 240
TRP A 290
MET A 463
TYR A 286
1.77A13.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
ALA B 150
LEU B 122
TYR A 265
ILE A 266
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
MET A 124
ALA A 125
TYR A 732
ILE A 466
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU C  55
ALA C  42
LEU C  40
GLN C  34
ILE D 119
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ALA A 625
GLN A 789
TYR A 788
ILE A 244
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
MET A 380
ALA A 379
GLN A 661
ILE A 562
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 8
LEU C  59
LEU C  20
GLN C  63
ILE D 106
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
LEU A 731
GLN A 789
ILE A 244
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
ALA B 181
LEU B 180
GLN B 158
ILE B 156
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
ALA B 181
LEU B 180
GLN B 158
ILE B 156
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
LEU B 117
ALA A 660
TYR A 273
ILE B 119
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
MET A 124
ALA A 125
TYR A 732
ILE A 466
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ALA A 625
GLN A 789
TYR A 788
ILE A 244
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP7
(SARS-CoV-2)		5 / 9
LEU C  17
LEU C  14
MET C  52
MET C  62
GLN C  63
1.59A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
LEU A 731
GLN A 789
ILE A 244
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 727
ALA A 702
TYR A 770
ILE A 715
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 749
ALA A 706
LEU A 707
ILE A 696
1.51A
None