Ligand ID: GJZ


Drugbank ID:
DB00752
(Tranylcypromine)


Indication:
For the treatment of major depressive episode without melancholia.

Get human targets for GJZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'GJZ' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.65A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.67A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.25A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.65A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.73A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.70A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.66A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.11A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.70A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.43A21.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.67A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.66A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.70A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.64A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.19A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B  89
PHE B  66
ILE B  43
THR B  25
1.67A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.32A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 205
ILE B 259
ALA B 260
THR B 224
1.25A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.58A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D 242
PHE D 230
ALA D 234
THR D 199
1.58A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D 220
PHE D 219
ALA D 211
THR D 257
1.68A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D  89
PHE D  66
ILE D  43
THR D  25
1.65A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D 205
ILE D 259
ALA D 260
THR D 224
1.49A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 220
PHE B 219
ALA B 211
THR B 257
1.50A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C 220
PHE C 219
ALA C 211
THR C 257
1.61A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C 242
PHE C 230
ALA C 234
THR C 199
1.63A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.24A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 242
PHE B 230
ALA B 234
THR B 199
1.56A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C  89
PHE C  66
ILE C  43
THR C  25
1.72A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.52A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.31A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
PHE B  66
ILE B  43
THR B  45
THR B  25
1.36A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.68A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.30A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.63A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.64A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 198
1.60A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP8
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 152
THR B 148
1.47A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ALA A 176
THR A 248
ALA A 250
THR A 246
1.77A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
ILE A 562
ALA A 502
THR A 538
1.64A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP8
(SARS-CoV-2)		4 / 6
PHE B 147
ILE B 156
ALA B 188
ALA B 191
1.63A19.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ALA A 585
THR A 582
ALA A 580
THR A 591
1.47A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 282
ALA A 250
THR A 246
THR A 319
1.71A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE A 714
ALA A 713
ALA B 893
THR B 887
0.88A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 546
ILE B 587
ALA B 575
THR B 572
1.25A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE C 714
ALA C 713
ALA A 893
THR A 887
0.88A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 546
ILE A 587
ALA A 575
THR A 572
1.14A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ILE C 714
ALA C 713
ALA A 893
THR A 887
0.90A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 546
ILE A 587
ALA A 575
THR A 572
1.10A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
ALA A6808
THR A6989
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6825
ILE A7035
ALA A6997
THR A6993
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A7035
ALA A6997
THR A6993
ALA A7002
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6838
ALA A6843
ALA A6832
THR A6833
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.36A
None
None
None
X77  A 401 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.70A
None
None
None
X77  A 401 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.36A
None
None
None
X77  A 401 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
ALA A6808
THR A6989
1.57A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
ALA C6808
THR C6989
1.59A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6825
ILE C7035
ALA C6997
THR C6993
1.45A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6825
ILE A7035
ALA A6997
THR A6993
1.45A16.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 258
ILE A 276
ALA A 261
THR A 119
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE C 258
ILE C 276
ALA C 261
THR C 119
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ILE B 276
ALA B 261
THR B 119
THR B 259
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE B 258
ILE B 276
ALA B 261
THR B 119
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 258
ILE A 276
ALA A 261
THR A 119
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE C 258
ILE C 276
ALA C 261
THR C 119
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A 304
ALA A 261
THR A 301
ALA A 246
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE B 258
ILE B 276
ALA B 261
THR B 119
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
PHE B 304
ALA B 261
THR B 301
ALA B 246
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wiq NSP8
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 150
THR B 148
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wiq NSP8
(SARS-CoV-2)		4 / 6
PHE B 147
ILE B 156
ALA B 188
ALA B 191
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wiq NSP8
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 152
THR B 148
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE D 286
ILE D 304
THR D 296
ALA D 264
1.51A
None
None
CL  D 401 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA E 305
THR E 296
ALA E 264
THR E 263
1.64A
 CL  E 401 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE A 286
ILE A 304
THR A 296
ALA A 264
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA A 305
THR A 296
ALA A 264
THR A 263
1.70A
 CL  A 401 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA D 305
THR D 296
ALA D 264
THR D 263
1.67A
 CL  D 401 ( 4.6A)
CL  D 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA B 311
THR A 296
ALA A 264
THR A 263
1.64A
 CL  A 401 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE F 286
ILE F 304
THR F 296
ALA F 264
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA D 311
THR C 296
ALA C 264
THR C 263
1.64A
 CL  C 401 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE B 286
ILE B 304
THR B 296
ALA B 264
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA E 311
THR F 296
ALA F 264
THR F 263
1.64A
 CL  F 401 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA F 305
THR F 296
ALA F 264
THR F 263
1.69A
 CL  F 401 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA F 311
THR E 296
ALA E 264
THR E 263
1.66A
 CL  E 401 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA A 311
THR B 296
ALA B 264
THR B 263
1.70A
 CL  B 401 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE E 286
ILE E 304
THR E 296
ALA E 264
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA C 311
THR D 296
ALA D 264
THR D 263
1.65A
 CL  D 401 ( 4.1A)
CL  D 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE C 286
ILE C 304
THR C 296
ALA C 264
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA C 305
THR C 296
ALA C 264
THR C 263
1.74A
 CL  C 401 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
ALA B 305
THR B 296
ALA B 264
THR B 263
1.67A
 CL  B 401 ( 4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
PHE C 315
ALA C 311
ALA B 267
THR D 296
1.79A
None
CL  D 401 ( 4.1A)
CL  D 401 ( 4.2A)
CL  D 401 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6825
ILE C7035
ALA C6997
THR C6993
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
ALA A6808
THR A6989
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
ALA C6808
THR C6989
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6825
ILE A7035
ALA A6997
THR A6993
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU D 104
ILE A 146
THR A 148
THR A 115
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU B 104
ILE C 146
THR C 148
THR C 115
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 104
ILE D 146
THR D 148
THR D 115
1.69A
None
MES  D 201 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A6825
ILE A7035
ALA A6997
THR A6993
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6825
ILE C7035
ALA C6997
THR C6993
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
ALA A6808
THR A6989
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ILE C6969
ALA C7002
ALA C6808
THR C6989
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 251
PHE A 303
ILE A 307
THR A 341
1.70A
None
None
None
U5P  A 401 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ILE A 100
ALA A  82
ALA A 138
THR A 113
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 134
ILE B 100
ALA B  82
THR B  84
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 134
ILE A 100
ALA A  82
THR A  84
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ILE B 100
ALA B  82
ALA B 138
THR B 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
PHE A  66
ILE A  43
THR A  45
THR A  25
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6825
ILE A7035
ALA A6997
THR A6993
1.33A
GTA  A7102 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ILE A6969
ALA A7002
ALA A6808
THR A6989
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ILE D 156
ALA D 188
ALA D 152
THR D 148
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ILE D 156
ALA D 188
ALA D 150
THR D 148
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 152
THR B 148
1.54A
None
None
EDO  B 302 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqd NSP8
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 150
THR B 148
1.69A
None
None
EDO  B 302 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PHE A 147
ALA A 144
THR A 102
ALA A 141
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
PHE A 304
ALA A 261
THR A 301
ALA A 246
1.70A
None
None
GOL  A 508 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6xez NSP13
(SARS-CoV-2)		4 / 6
ILE F 480
ALA F 487
THR F 549
THR F 552
1.13A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6xez NSP13
(SARS-CoV-2)		4 / 6
ILE F 480
ALA F 487
THR F 549
THR F 552
1.15A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6xez NSP13
(SARS-CoV-2)		4 / 6
PHE E 133
ILE E 109
ALA E 110
THR E 141
1.11A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B 205
ILE B 259
ALA B 260
THR B 224
1.10A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.26A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.65A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.65A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.72A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.66A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE D 156
ALA D 188
ALA D 152
THR D 148
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 152
THR B 148
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE B 156
ALA B 188
ALA B 150
THR B 148
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 6
ILE D 156
ALA D 188
ALA D 150
THR D 148
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
LEU A 390
PHE A 392
ILE C  34
THR B 104
1.63A
DMS  A 905 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
LEU A 387
PHE A 392
ILE C  34
THR B 104
1.66A
DMS  A 905 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ym0 HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 6
LEU E 387
PHE E 392
ILE L  34
THR H 104
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.25A
None
None
None
IMD  A 402 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.64A
None
None
None
PEG  A 404 (-3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.66A
None
None
None
PK8  A 401 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 242
PHE A 230
ALA A 234
THR A 199
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
ILE A 562
ALA A 502
THR A 538
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP8
(SARS-CoV-2)		4 / 6
ILE D 156
ALA D 188
ALA D 152
THR D 148
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ALA A 176
THR A 248
ALA A 250
THR A 246
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
ILE A 562
ALA A 502
THR A 538
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP8
(SARS-CoV-2)		4 / 6
PHE B 147
ILE B 156
ALA B 188
ALA B 191
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 630
PHE A 694
ALA A 625
THR A 462
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ALA A 585
THR A 582
ALA A 580
THR A 591
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A  48
ILE A  37
THR A 206
ALA A 125
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D 128
ILE D 156
THR D 146
THR D 148
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP8
(SARS-CoV-2)		4 / 6
PHE D 147
ILE D 156
ALA D 188
ALA D 191
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 758
ILE A 579
ALA A 580
THR A 582
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
ILE A 562
ALA A 502
THR A 538
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 282
ALA A 250
THR A 246
THR A 319
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
PHE A  66
ILE A  43
THR A  25
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ALA A 211
THR A 257
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 220
PHE A 219
ILE A 281
ALA A 211
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 205
ILE A 259
ALA A 260
THR A 224
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 579
ALA A 580
ALA A 685
THR A 686
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A 506
ILE A 562
ALA A 502
THR A 538
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
ILE A 562
ALA A 502
THR A 538
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ILE A 450
ALA A 449
THR A 556
ALA A 554
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
PHE A  48
ILE A  37
THR A 206
ALA A 125
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv2 NSP8
(SARS-CoV-2)		4 / 6
PHE B 147
ILE B 156
ALA B 188
ALA B 191
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 630
PHE A 694
ALA A 625
THR A 462
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 372
PHE A 506
ILE A 562
THR A 567
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
PHE A  48
ILE A  37
THR A 206
ALA A 125
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ILE A 450
ALA A 449
THR A 556
ALA A 554
1.57A
None