Ligand ID: FUN


Drugbank ID:
DB00695
(Furosemide)


Indication:
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.

Get human targets for FUN in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'FUN' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  57
ARG A  60
ILE A  43
1.16A8.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  57
ARG A  60
ILE A  43
1.19A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 11
SER B 940
ALA B 942
LEU C 938
SER B 939
LEU B 938
1.23A18.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
LEU E1186
ARG E1185
ILE E1183
1.00A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.40A8.33
None
DMS  A 404 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6m03 MAIN PROTEASE
(SARS-CoV-2)		5 / 11
PRO A 122
MET A  17
VAL A 148
PHE A 150
VAL A 114
1.80A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.45A8.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.46A8.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU B  58
ARG B  40
ILE B  59
1.40A8.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLN C 244
VAL C 247
LEU C 262
THR C 225
THR C 226
1.78A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU C  58
ARG C  40
ILE C  59
1.38A8.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.46A8.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 127
ARG A 181
ILE A 244
1.12A4.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 308
ARG A 305
ILE A 307
1.67A4.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 784
GLN A 724
LEU A 708
LEU A 707
SER A 778
1.54A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 772
ALA A 771
GLN A 724
LEU A 707
LEU A 775
1.71A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP7
(SARS-CoV-2)		5 / 11
SER C  61
SER C  57
LEU C  14
SER C  54
LEU C  55
1.62A12.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6m71 NSP8
(SARS-CoV-2)		5 / 11
PRO B 183
ILE B 185
VAL B 159
VAL B 186
ILE B 172
1.68A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
LEU A 131
LEU A 142
LYS A 143
LEU A 178
1.57A17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6m71 NSP12
(SARS-CoV-2)		5 / 12
HIS A 882
PHE A 428
VAL A 435
LEU A 869
THR A 870
1.56A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
PHE A 480
VAL A 587
THR A 687
THR A 686
1.58A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  98
LEU D  95
SER C  57
LEU C  56
1.60A12.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  61
LEU D  91
LEU D  95
SER C  57
LEU C  56
1.52A12.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
ARG A 249
ILE A 244
1.61A4.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 308
ARG A 640
ILE A 632
1.68A4.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP7
(SARS-CoV-2)		5 / 11
ALA C  65
LEU C  28
LEU C  17
LEU C  59
LEU C  55
1.60A12.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6m71 NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
VAL A 693
VAL A 587
THR A 687
THR A 686
1.66A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA D 110
LEU D  91
LEU C  13
LEU C  60
LEU C  17
1.69A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PRO B 897
MET B 900
ILE A 712
VAL A1094
VAL A1096
1.65A7.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 11
SER A 968
LEU A1004
SER A 967
LEU A 966
LYS A 964
LEU A 858
1.69A13.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6vxs NSP3
(SARS-CoV-2)		5 / 11
SER B 128
ALA B 129
LEU B 164
LEU B 126
LEU B  12
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6vxs NSP3
(SARS-CoV-2)		5 / 11
SER A 128
ALA A 129
LEU A 164
LEU A 126
LEU A  12
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU C 996
ARG C 995
ILE C 997
0.82A2.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PRO A 715
ARG A1107
ILE A 712
VAL A1096
VAL A1094
1.78A6.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 996
ARG B 995
ILE B 997
0.81A2.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ALA A 771
GLN C1010
LEU A1012
SER A 735
LEU A 767
1.45A13.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w4b NSP9
(SARS-CoV-2)		6 / 11
SER B  14
ALA B  29
LEU B 107
SER B  47
LEU B  46
LEU B 113
1.75A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.17A6.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A7081
ILE A6925
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER A6799
ALA A6802
SER A7038
ASN A6827
LEU A6825
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
LEU A6883
LEU A6924
LEU A6852
ASN A6853
LEU A7050
1.79A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER A6903
LEU A6887
SER A6907
LEU A6893
LEU A6924
1.79A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER A6903
ALA A6870
LEU A6924
LEU A6883
LEU A7050
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
SER B 139
LEU B 140
LEU B 169
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
LEU B 164
LYS B 163
LEU B 169
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
LEU A 164
LYS A 163
LEU A 169
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A7081
ILE A6925
1.34A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER A6903
ALA A6870
LEU A6924
LEU A6883
LEU A7050
1.54A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER C6927
ALA C6870
LEU C6887
SER C6896
LEU C6892
1.70A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU C6959
ARG C7081
ILE C6925
1.36A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU C7078
ARG C7077
ILE C7079
1.34A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER A6903
LEU A6887
SER A6907
LEU A6893
LEU A6924
1.78A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER C6999
SER C6998
ALA C6997
LEU C6848
ASN C6841
1.55A19.25
FMT  C7108 ( 2.7A)
None
None
None
SAM  C7105 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER C6903
LEU C6887
SER C6907
LEU C6893
LEU C6924
1.78A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 11
SER C6903
ALA C6870
LEU C6924
LEU C6883
LEU C7050
1.54A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.51A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 211
ARG A 166
ILE A 300
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU C 152
ARG C  82
ILE C 151
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU B 211
ARG B 166
ILE B 300
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		6 / 11
SER A  13
ALA A  28
LEU A  -8
LEU A 106
SER A  46
LEU A  45
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wen NSP3
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.54A
 CL  A 201 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wey NSP3
(SARS-CoV-2)		5 / 12
HIS A 323
VAL A 238
PHE A 210
VAL A 240
THR A 353
1.79A22.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wey NSP3
(SARS-CoV-2)		5 / 11
LEU A 214
LEU A 216
SER A 343
LEU A 344
LEU A 373
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  61
LEU B  91
LEU B  95
SER A  57
LEU A  56
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wiq NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL B 159
VAL B 131
THR B 137
THR B 141
1.76A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		3 / 3
LEU A  60
ARG B 111
ILE B 106
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  54
LEU B  98
LEU B  95
SER A  57
LEU A  56
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA B 110
LEU B  91
LEU A  13
LEU A  60
LEU A  17
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wiq NSP7
(SARS-CoV-2)		5 / 11
SER A  61
SER A  57
LEU A  14
SER A  54
LEU A  55
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER C6903
ALA C6870
LEU C6924
LEU C6883
LEU C7050
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU C6959
ARG C7081
ILE C6925
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A7081
ILE A6925
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU C7078
ARG C7077
ILE C7079
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER A6903
ALA A6870
LEU A6924
LEU A6883
LEU A7050
1.54A
None
None
None
None
FMT  A7107 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 145
GLN B  83
PHE B 110
LEU B 113
THR B 141
1.66A18.15
 ZN  B 202 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 145
GLN A  83
PHE A 110
LEU A 113
THR A 141
1.58A18.15
 ZN  A 201 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C  59
GLN D  83
HIS D 145
VAL C 158
THR C  57
1.70A18.15
 ZN  D 202 (-3.2A)
None
ZN  D 202 (-3.4A)
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
SER A  78
LEU D 161
LEU D 167
SER A  79
LEU D  64
1.69A
None
None
None
ZN  A 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 145
GLN C  83
PHE C 110
LEU C 113
THR C 141
1.67A18.15
 ZN  C 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
SER C  78
LEU B 161
LEU B 167
SER C  79
LEU B  64
1.65A
None
None
None
ZN  C 201 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
LEU C 167
LEU C  64
SER C 105
ASN D  77
LEU C 159
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 145
GLN D  83
PHE D 110
LEU D 113
THR D 141
1.69A18.15
 ZN  D 202 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU C7078
ARG C7077
ILE C7079
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 11
SER A6903
ALA A6870
LEU A6924
LEU A6883
LEU A7050
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A7081
ILE A6925
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 11
SER C6799
ALA C6802
SER C7038
ASN C6827
LEU C6825
1.58A
None
None
FMT  C7111 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU C6959
ARG C6864
ILE C6925
1.52A
None
FMT  C7106 ( 2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU C6959
ARG C7081
ILE C6925
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 11
SER C6903
ALA C6870
LEU C6924
LEU C6883
LEU C7050
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
SER B 139
LEU B 140
LEU B 169
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU D  10
LEU D  12
SER D 139
LEU D 140
LEU D 169
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU C  10
LEU C  12
SER C 139
LEU C 140
LEU C 169
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A7078
ARG A7077
ILE A7079
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A6864
ILE A6925
1.58A
None
SO4  A7106 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 11
SER A6903
ALA A6870
LEU A6924
LEU A6883
LEU A7050
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6959
ARG A7081
ILE A6925
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
LEU B 103
LEU B  95
SER A   4
LYS A   7
LEU A  13
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  61
LEU B  91
LEU B  95
SER A  57
LEU A  56
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  61
LEU D  91
LEU D  95
SER C  57
LEU C  56
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER B 151
LEU A  56
LEU A  60
ASN B 108
LEU A  71
1.27A
None
None
None
EDO  B 301 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
(SARS-CoV-2)		5 / 11
ALA C  65
LEU C  28
LEU C  17
LEU C  59
LEU C  55
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  98
LEU D  95
SER C  57
LEU C  56
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER A  54
LEU B  98
LEU B  95
SER A  57
LEU A  56
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER D 151
LEU C  56
LEU C  60
ASN D 108
LEU C  71
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA D 110
LEU D  91
LEU C  13
LEU C  60
LEU C  17
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
(SARS-CoV-2)		5 / 11
ALA A  65
LEU A  28
LEU A  17
LEU A  59
LEU A  55
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA B 110
LEU B  91
LEU A  13
LEU A  60
LEU A  17
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER B 151
LEU B  95
LEU A  56
ASN B 108
LEU A  71
1.54A
None
None
None
EDO  B 301 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wqd NSP8
(SARS-CoV-2)		5 / 12
VAL D 130
VAL D 159
VAL D 131
THR D 137
THR D 141
1.65A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6wqd NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL B 159
VAL B 131
THR B 137
THR B 141
1.68A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		3 / 3
LEU A 120
ARG A 140
ILE A 123
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6xez NSP13
(SARS-CoV-2)		5 / 11
SER E 289
ILE E 399
VAL E 372
VAL E 397
ILE E 304
1.34A11.98
 MG  E 706 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A  57
ARG A  60
ILE A  43
1.20A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER A  61
LEU B  91
LEU B  95
SER A  57
LEU A  56
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER C  61
LEU D  91
LEU D  95
SER C  57
LEU C  56
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ALA B 110
LEU B  91
LEU A  13
LEU A  60
LEU A  17
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER A  54
LEU B  98
LEU B  95
SER A  57
LEU A  56
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
ALA D 110
LEU D  91
LEU C  13
LEU C  60
LEU C  17
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL B 130
VAL B 159
VAL B 131
THR B 137
THR B 141
1.69A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER D 151
LEU C  56
LEU C  60
ASN D 108
LEU C  71
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER D 151
ALA D 150
LEU D  95
LEU C  56
LEU C  71
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  98
LEU D  95
SER C  57
LEU C  56
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
SER D 151
LEU D  95
LEU C  56
ASN D 108
LEU C  71
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL D 130
VAL D 159
VAL D 131
THR D 137
THR D 141
1.73A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
LEU A 119
LEU A  16
LEU A  24
LYS A  25
LEU A 127
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
SER B 139
LEU B 140
LEU B 169
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D  10
LEU D  12
SER D 139
LEU D 140
LEU D 169
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E  10
LEU E  12
SER E 139
LEU E 140
LEU E 169
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C  10
LEU C  12
SER C 139
LEU C 140
LEU C 169
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C  10
LEU C  12
SER C 139
LEU C 140
LEU C 169
1.66A
EDO  B 203 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E  10
LEU E  12
LEU E 164
LYS E 163
LEU E 169
1.51A
EDO  E 203 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E  10
LEU E  12
SER E 139
LEU E 140
LEU E 169
1.63A
EDO  E 203 ( 4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 164
LEU E 140
SER D   7
LEU E  12
LEU E 153
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
LEU A 164
LYS A 163
LEU A 169
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
SER B 139
LEU B 140
LEU B 169
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A  10
LEU A  12
SER A 139
LEU A 140
LEU A 169
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B  10
LEU B  12
LEU B 164
LYS B 163
LEU B 169
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C  10
LEU C  12
SER C 139
LEU C 140
LEU C 169
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.69A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7btf NSP8
(SARS-CoV-2)		5 / 11
ILE B 172
PRO B 183
ILE B 185
VAL B 159
VAL B 186
1.65A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 308
ARG A 305
ILE A 307
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 11
ILE A 333
ARG A 331
ILE B 107
VAL A 341
VAL A 330
1.77A8.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  61
LEU D  91
LEU D  95
SER C  57
LEU C  56
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
ARG A 249
ILE A 244
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA D 110
LEU D  91
LEU C  13
LEU C  60
LEU C  17
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
(SARS-CoV-2)		5 / 11
ALA C  65
LEU C  28
LEU C  17
LEU C  59
LEU C  55
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7btf NSP8
(SARS-CoV-2)		5 / 11
PRO B 183
ILE B 185
VAL B 159
VAL B 186
ILE B 172
1.64A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
LEU A 131
LEU A 142
LYS A 143
LEU A 178
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7btf NSP12
(SARS-CoV-2)		5 / 12
HIS A 882
PHE A 428
VAL A 435
LEU A 869
THR A 870
1.59A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		3 / 3
LEU C  60
ARG D 111
ILE D 106
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7btf NSP8
(SARS-CoV-2)		5 / 12
VAL D 130
VAL D 159
VAL D 131
THR D 137
THR D 141
1.78A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 330
VAL A 398
VAL B 115
THR B 123
THR B 124
1.73A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 784
GLN A 724
LEU A 708
LEU A 707
SER A 778
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  98
LEU D  95
SER C  57
LEU C  56
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 425
LEU A 838
LEU A 437
LYS A 417
ASN A 416
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 127
ARG A 181
ILE A 244
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 308
ARG A 640
ILE A 632
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.59A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		3 / 3
LEU A  58
ARG A  40
ILE A  59
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
VAL A 693
VAL A 587
THR A 687
THR A 686
1.53A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 11
ILE A 333
ARG A 331
ILE B 107
VAL A 341
VAL A 330
1.65A8.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  98
LEU D  95
SER C  57
LEU C  56
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 11
ARG A 331
ILE B 107
VAL A 341
VAL A 330
ILE A 333
1.67A8.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7bv1 NSP8
(SARS-CoV-2)		5 / 11
PRO B 183
ILE B 185
VAL B 159
VAL B 186
ILE B 172
1.54A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 11
SER C  54
LEU D  95
SER C  57
LEU C  56
ASN D 100
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 11
ILE A 333
ARG A 331
ILE B 107
VAL A 341
VAL A 330
1.68A8.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP7
(SARS-CoV-2)		5 / 11
SER C  61
SER C  57
LEU C  14
SER C  54
LEU C  55
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
HIS A 882
PHE A 428
VAL A 435
LEU A 869
THR A 870
1.58A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
PHE A 480
VAL A 587
THR A 687
THR A 686
1.56A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 475
PHE A 471
VAL A 704
VAL A 476
LEU A 749
1.80A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
ARG A 249
ILE A 244
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
LEU A 131
LEU A 142
LYS A 143
LEU A 178
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 127
ARG A 181
ILE A 244
1.10A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 772
ALA A 771
GLN A 724
LEU A 707
LEU A 775
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		7bv1 NSP8
(SARS-CoV-2)		5 / 11
ILE B 172
PRO B 183
ILE B 185
VAL B 159
VAL B 186
1.55A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 11
ALA D 110
LEU D  95
LEU D 103
LEU C  60
LEU C  13
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 127
ARG A 181
ILE A 244
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
PHE A 480
VAL A 587
THR A 687
THR A 686
1.66A13.20
None
None
None
F86  P 102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
ARG A 249
ILE A 244
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
HIS A 572
VAL A 693
VAL A 587
THR A 687
THR A 686
1.59A13.20
None
None
None
F86  P 102 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 682
SER A 681
LEU A 576
LEU A 638
ASN A 568
1.60A
 U  T  10 (-2.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 308
ARG A 305
ILE A 307
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
HIS A 882
PHE A 428
VAL A 435
LEU A 869
THR A 870
1.63A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
LEU A 247
LEU A 131
LEU A 142
LYS A 143
LEU A 178
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 330
VAL A 398
VAL B 115
THR B 123
THR B 124
1.75A13.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 784
GLN A 724
LEU A 708
LEU A 707
SER A 778
1.69A
None