Ligand ID: EDP


Drugbank ID:
DB00599
(Thiopental)


Indication:
For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.

Get human targets for EDP in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EDP' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 268
TYR A 209
ALA A 211
LEU A 205
1.77A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 368
SER B 371
TYR B 369
ALA B 372
1.39A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 6
LEU F 368
SER F 371
TYR F 369
ALA F 372
1.34A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C 115
SER C 113
TYR C 126
ALA C   7
1.76A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 754
THR A 586
THR A 604
SER A 607
1.61A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 501
THR A 540
SER A 681
THR A 565
1.42A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 371
TYR A 374
ALA A 376
LEU A 366
1.63A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 561
THR A 565
SER A 564
SER A 681
1.58A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 565
SER A 501
THR A 540
SER A 681
1.42A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 538
SER A 561
1.64A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 240
SER A 239
TYR A 237
LEU A 207
1.72A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
TYR A 728
ARG A 726
LEU A 731
1.59A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 561
THR A 565
SER A 564
1.58A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 565
SER A 681
THR A 540
THR A 538
1.53A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 682
THR A 540
SER A 501
THR A 556
1.60A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
THR A 538
SER A 564
THR A 540
1.52A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 707
TYR A 728
ALA A  46
LEU A 727
1.71A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 556
SER A 682
THR A 540
SER A 501
1.56A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
THR A 604
SER A 607
SER A 754
THR A 586
1.62A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
SER A 518
TYR A 515
ARG B  80
LEU A 514
1.58A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
THR A 540
SER A 501
THR A 556
1.49A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 731
TYR A 728
ARG A 467
LEU A 708
1.61A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 564
THR A 538
SER A 561
SER A 681
1.63A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER A1055
ALA A1056
ARG A 815
LEU A 878
1.39A9.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 368
SER A 371
TYR A 369
ALA A 372
1.17A9.13
NAG  A1307 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 368
SER A 371
TYR A 369
ALA A 372
1.18A9.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w4b NSP9
(SARS-CoV-2)		4 / 6
LEU B 107
SER B 106
ALA A 109
LEU B 113
1.23A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7042
SER A7038
TYR A7040
ALA A6802
1.79A24.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
TYR A6851
ALA A7002
LEU A6852
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
SER A 167
ARG A 141
LEU A  12
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B 140
SER B 139
ALA B 134
LEU B 153
1.78A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w75 NSP10
(SARS-CoV-2)		4 / 8
SER D4320
THR D4311
THR D4302
THR D4300
1.65A18.63
None
NA  C7101 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
SER A7071
ARG A7077
LEU A7010
1.68A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A7089
THR C6915
SER C7090
SER A6907
1.70A21.51
None
None
NA  C7104 ( 2.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
TYR C6851
ALA C7002
LEU C6852
1.70A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C7089
THR A6915
SER A7090
SER C6907
1.75A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A7072
SER A7074
ALA A6986
LEU A7078
1.76A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C7072
SER C7074
ALA C6986
LEU C7078
1.76A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C6907
SER C7089
THR A6915
SER A7090
1.71A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
TYR A6851
ALA A7002
LEU A6852
1.70A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6907
SER A7089
THR C6915
SER C7090
1.65A21.51
None
None
None
NA  C7104 ( 2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 101
ALA C 139
ARG C 140
LEU C 118
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 101
ALA A 139
ARG A 140
LEU A 118
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 120
ALA C 139
ARG C 140
LEU C 172
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 120
ALA B 139
ARG B 140
LEU B 172
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 150
TYR B 136
ALA B 144
LEU B 132
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU C 172
TYR C 136
ALA C 131
LEU C 120
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR A 168
THR A 115
SER A 262
THR A 119
1.41A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU B 101
ALA B 139
ARG B 140
LEU B 118
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR C 168
THR C 115
SER C 262
THR C 119
1.57A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 172
TYR A 136
ALA A 131
LEU A 120
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 150
TYR A 136
ALA A 144
LEU A 132
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
THR B 168
THR B 115
SER B 262
THR B 119
1.55A20.75
None
CL  B 502 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
SER A 167
ARG A 141
LEU A  12
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 344
SER A 343
ALA A 338
LEU A 357
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER E 310
THR F 265
THR F 296
SER E 312
1.40A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
THR A 332
THR A 325
SER A 327
THR A 329
1.43A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
THR F 332
THR F 325
SER F 327
THR F 329
1.44A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER D 310
THR C 265
THR C 296
SER D 312
1.40A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER A 310
THR B 265
THR B 296
SER A 312
1.39A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
THR C 332
THR C 325
SER C 327
THR C 329
1.40A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
THR E 332
THR E 325
SER E 327
THR E 329
1.41A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER C 310
THR D 265
THR D 296
SER C 312
1.40A16.72
None
None
CL  D 401 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER F 310
THR E 265
THR E 296
SER F 312
1.38A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER B 310
THR A 265
THR A 296
SER B 312
1.39A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
THR B 332
THR B 325
SER B 327
THR B 329
1.43A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C7072
SER C7074
ALA C6986
LEU C7078
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7072
SER A7074
ALA A6986
LEU A7078
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
TYR A7009
ALA A6960
LEU A7010
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
TYR A6851
ALA A7002
LEU A6852
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C6848
TYR C6851
ALA C7002
LEU C6852
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU D  56
ALA D  90
ARG D 107
LEU D  64
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU B  56
ALA B  90
ARG B 107
LEU B  64
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A  56
ALA A  90
ARG A 107
LEU A  64
1.58A
None
None
MES  B 201 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A6848
TYR A6851
ALA A7002
LEU A6852
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A7072
SER A7074
ALA A6986
LEU A7078
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C6848
TYR C6851
ALA C7002
LEU C6852
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C7072
SER C7074
ALA C6986
LEU C7078
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
SER A7071
ARG A7077
LEU A7010
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 190
SER A 155
TYR A 179
LEU A  76
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 190
SER B 155
TYR B 179
LEU B  76
1.71A
None
EDO  B 404 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A6848
TYR A6851
ALA A7002
LEU A6852
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
TYR A7009
ALA A6960
LEU A7010
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 115
SER A 113
TYR A 126
ALA A   7
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 120
ALA A 139
ARG A 140
LEU A 172
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 172
TYR A 136
ALA A 135
LEU A 120
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 101
ALA A 139
ARG A 140
LEU A 118
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
THR A 168
THR A 115
SER A 262
THR A 119
1.38A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
LEU A 172
TYR A 136
ALA A 131
LEU A 120
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 268
TYR A 209
ALA A 211
LEU A 205
1.78A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 119
SER A 136
TYR A 132
LEU A  16
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A  16
ALA A  50
ARG A  67
LEU A  24
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 368
SER A 371
TYR A 369
ALA A 372
1.77A
None
DMS  A 901 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 452
SER A 349
TYR A 495
ALA A 348
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER E 371
TYR E 369
ALA E 372
LEU E 368
1.66A
DMS  E 901 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 368
SER E 371
TYR E 369
ALA E 372
1.75A
None
DMS  E 901 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER A 371
TYR A 369
ALA A 372
LEU A 368
1.68A
DMS  A 901 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 452
SER A 349
TYR A 451
ALA A 352
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 495
ALA E 348
1.67A
None
None
None
DMS  E 905 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 451
ALA E 352
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER E 371
TYR E 369
ALA E 372
LEU E 368
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 451
ALA E 352
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 495
ALA E 348
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 452
SER A 349
TYR A 451
ALA A 352
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER A 371
TYR A 369
ALA A 372
LEU A 368
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 452
SER A 349
TYR A 495
ALA A 348
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
SER E 371
TYR E 369
ALA E 372
LEU E 368
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 495
ALA E 348
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 452
SER E 349
TYR E 451
ALA E 352
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 368
SER A 371
TYR A 369
ALA A 372
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 368
SER E 371
TYR E 369
ALA E 372
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 140
TYR C 113
ARG C 141
LEU C 126
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
TYR A 113
ARG A 141
LEU A 126
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
SER E 167
ARG E 141
LEU E  12
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 140
TYR D 113
ARG D 141
LEU D 126
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
SER E 167
ARG E 141
LEU E  12
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
TYR A 113
ARG A 141
LEU A 126
1.60A
None
None
EDO  A 206 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 140
SER A 139
ALA A 134
LEU A 153
1.77A
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 140
TYR C 113
ARG C 141
LEU C 126
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 371
TYR A 374
ALA A 376
LEU A 366
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 681
THR A 538
SER A 564
THR A 540
1.34A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 186
ALA A 253
ARG A 285
LEU A 245
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 731
TYR A 728
ARG A 467
LEU A 708
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 247
ALA A 250
ARG A 249
LEU A 131
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7btf NSP12
(SARS-CoV-2)		4 / 8
THR A 556
SER A 682
THR A 540
SER A 501
1.50A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 240
SER A 239
TYR A 237
LEU A 207
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
TYR A 728
ARG A 726
LEU A 731
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 564
THR A 538
SER A 561
SER A 681
1.39A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 538
SER A 561
1.41A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 682
THR A 540
SER A 501
THR A 556
1.52A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 731
TYR A 728
ARG A 467
LEU A 708
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 564
THR A 538
SER A 561
SER A 681
1.62A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
SER A 325
TYR A 273
ARG A 349
LEU A 329
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
THR A 538
SER A 564
THR A 540
1.41A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 501
THR A 540
SER A 681
THR A 565
1.55A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
THR A 565
SER A 501
THR A 540
SER A 681
1.58A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 636
SER A 635
ALA A 690
LEU A 655
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 501
THR A 565
THR A 538
THR A 540
1.58A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 371
TYR A 374
ALA A 376
LEU A 366
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 247
ALA A 250
ARG A 249
LEU A 131
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 240
SER A 239
TYR A 237
LEU A 207
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 186
ALA A 253
ARG A 285
LEU A 245
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 707
TYR A 728
ALA A  46
LEU A 727
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
TYR A 728
ARG A 726
LEU A 731
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 538
SER A 561
1.63A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 564
THR A 538
SER A 561
1.59A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
THR A 538
SER A 564
THR A 540
1.58A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 731
TYR A 728
ARG A 467
LEU A 708
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 186
ALA A 253
ARG A 285
LEU A 245
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
TYR A 728
ARG A 726
LEU A 708
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 681
SER A 561
THR A 565
SER A 564
1.57A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 564
THR A 538
SER A 561
SER A 681
1.58A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 727
TYR A 728
ARG A 726
LEU A 731
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 636
SER A 635
ALA A 690
LEU A 655
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 247
ALA A 250
ARG A 249
LEU A 131
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 240
SER A 236
TYR A 237
LEU A 207
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 240
SER A 239
TYR A 237
LEU A 207
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 371
TYR A 374
ALA A 376
LEU A 366
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 561
THR A 565
SER A 564
SER A 681
1.57A15.54
None