Ligand ID: DOL


Drugbank ID:
DB01764
(Dalfopristin)


Indication:
For the treatment of bacterial infections (usually in combination with quinupristin).

Get human targets for DOL in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DOL' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 307
HIS A 347
ASN A 297
PRO A 296
ASN A 356
1.72A12.46

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ILE A 466
LEU A 351
MET A 629
ASN A 297
VAL A 354
1.68A12.46

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ILE A 714
HIS A1101
PRO A1112
VAL A1137
TYR A1138
1.64A10.02
None
NAG  A1311 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z2P_B_DOLB2003_1
(VIRGINIAMYCIN B
LYASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ASN B 317
THR B 299
LYS B 638
GLY B 593
SER B 596
1.49A13.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 712
HIS A1101
PRO A1112
VAL A1137
TYR A1138
1.45A10.02
None
NAG  A1311 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.37A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.38A
None
SO4  B 204 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.42A
None
None
None
None
SO4  B 204 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.40A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A 200
ILE A 197
VAL C 512
TYR C 423
ASP C 398
1.36A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
TYR A 200
ILE A 197
VAL C 512
TYR C 423
ASP C 398
1.40A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 584
ASN C 544
LEU C 518
PRO C 579
ASP A 979
1.65A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ILE B 326
LEU B 546
PRO B 579
VAL C 976
ASP C 979
1.59A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
TYR C  87
ILE C 131
LEU C 167
PRO C  67
ASN D  77
1.70A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.48A24.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.43A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.41A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.40A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
TYR B 161
LEU A  10
LEU B 169
VAL A 165
ASP A 162
1.70A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.43A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.36A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wcf NSP3
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wen NSP3
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wey NSP3
(SARS-CoV-2)		5 / 11
LEU A 357
LEU A 364
ASN A 219
VAL A 351
TYR A 317
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
ASN A 219
VAL A 351
TYR A 317
LEU A 357
LEU A 364
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 357
LEU A 364
ASN A 219
VAL A 351
TYR A 317
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
TYR C  87
ILE C 131
LEU C 167
PRO C  67
ASN D  77
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
TYR A  87
ILE A 131
LEU A 167
PRO A  67
ASN B  77
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ASN D  15
VAL D 147
TYR D 113
LEU D 153
LEU D 160
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASN D 115
LEU D  93
LEU D  75
ASN A 159
VAL D  34
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
ASN C  15
VAL C 147
TYR C 113
LEU C 153
LEU C 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E 131
ASN E  37
LEU E  53
VAL E  24
ASP E  22
1.74A
EPE  E 202 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN C  15
VAL C 147
TYR C 113
LEU C 153
LEU C 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN D  15
VAL D 147
TYR D 113
LEU D 153
LEU D 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 153
LEU E 160
ASN E  15
VAL E 147
TYR E 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D 165
TYR D 161
TYR E 161
LEU D  10
LEU E  12
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 160
LEU E 140
ASN B  59
VAL B  63
ASP B  66
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A 131
ASN A  37
LEU A  53
VAL A  24
ASP A  22
1.76A
EDO  A 202 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ILE C  23
HIS C  91
MET C  61
ASN D  20
ASP D 162
1.64A
None
EDO  C 207 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN E  15
VAL E 147
TYR E 113
LEU E 153
LEU E 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
HIS C  91
MET C  61
ASN D  20
ASP D 162
1.70A
None
EDO  C 207 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ILE C  23
HIS C  91
MET C  61
ASN D  20
ASP D 162
1.62A
APR  C 201 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN C  15
VAL C 147
TYR C 113
LEU C 153
LEU C 160
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN E  15
VAL E 147
TYR E 113
LEU E 153
LEU E 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C  23
HIS C  91
MET C  61
ASN D  20
ASP D 162
1.67A
APR  C 201 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU E 153
LEU E 160
ASN E  15
VAL E 147
TYR E 113
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN D  15
VAL D 147
TYR D 113
LEU D 153
LEU D 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 153
LEU D 160
ASN D  15
VAL D 147
TYR D 113
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.35A
None
EDO  C 203 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 153
LEU C 160
ASN C  15
VAL C 147
TYR C 113
1.43A
None
EDO  C 203 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN A  15
VAL A 147
TYR A 113
LEU A 153
LEU A 160
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 131
ASN B  37
LEU B  53
LEU B 127
ASP B  22
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN B  15
VAL B 147
TYR B 113
LEU B 153
LEU B 160
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
ASN C  15
VAL C 147
TYR C 113
LEU C 153
LEU C 160
1.39A
None
None
None
None
EDO  C 203 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU A 153
LEU A 160
ASN A  15
VAL A 147
TYR A 113
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
LEU B 153
LEU B 160
ASN B  15
VAL B 147
TYR B 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ILE A 307
HIS A 347
ASN A 297
PRO A 296
ASN A 356
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ILE A 307
HIS A 347
ASN A 297
PRO A 296
ASN A 356
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 307
HIS A 347
ASN A 297
PRO A 296
ASN A 356
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
ILE A 466
LEU A 351
MET A 629
ASN A 297
VAL A 354
1.74A
None