Ligand ID: DGX


Drugbank ID:
DB00390
(Digoxin)


Indication:
For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

Get human targets for DGX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DGX' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
LEU F 981
VAL F 987
ARG D 983
1.69A19.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6lzg ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN A  76
GLU A  35
LEU A 100
ALA B 475
LEU B 455
1.27A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN A  76
GLU A  35
LEU A 100
ALA E 475
LEU E 455
1.26A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLN D  76
GLU D  35
LEU D 100
ALA F 475
LEU F 455
1.42A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 115
ALA B   7
VAL D 125
PHE D 150
CYH D 160
1.78A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 115
ALA D   7
VAL B 125
PHE B 150
CYH B 160
1.73A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH D 300
ALA B 116
ALA D   7
PHE D   3
HIS B 172
1.74A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 115
ALA A   7
VAL C 125
PHE C 150
CYH C 160
1.78A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH B 300
ALA D 116
ALA B   7
PHE B   3
HIS D 172
1.78A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH C 300
ALA A 116
ALA C   7
PHE C   3
HIS A 172
1.71A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
CYH C 300
ALA A 116
ALA C   7
PHE C   3
HIS A 172
1.79A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 115
ALA C   7
VAL A 125
PHE A 150
CYH A 160
1.70A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
LEU A 469
LEU A 308
VAL A 637
PHE A 480
1.79A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.62A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.58A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6m71 NSP8
(SARS-CoV-2)		5 / 12
GLN B 157
LEU B 189
PHE B 147
GLY B 144
LEU B 184
1.54A11.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
ALA A 639
ALA A 690
VAL A 693
LEU A 470
1.67A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLN A 292
LEU A 308
PHE A 283
ALA A 311
PHE A 313
1.73A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 261
VAL A 320
ARG A 183
1.79A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 282
VAL A 190
ARG A 285
1.57A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN C 779
ASP C 775
GLU B 661
GLY B 669
ALA B 668
1.41A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 924
ALA C 930
VAL C 722
PHE C1052
LEU C 806
1.53A11.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN C 779
ASP C 775
GLU B 661
GLY B 669
ALA B 668
1.42A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 924
ALA C 930
VAL C 722
PHE C1052
LEU C 806
1.53A11.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ASN B  87
VAL B  90
THR B 236
ILE B 235
1.61A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 293
VAL B  36
ARG B 273
1.25A11.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGJ_B_DGXB228_1
(IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN)
IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN))		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PRO A 230
ASN C 394
TYR A 200
TYR C 396
SER C 359
1.77A11.09
10.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 188
GLY A 141
ALA A 138
PHE A 135
LEU A 152
1.41A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 188
GLY A 141
ALA A 138
PHE A 135
LEU A 152
1.41A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA B 129
ALA B 112
VAL B  95
LEU B  53
LEU B 123
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA A 129
ALA A 112
VAL A  95
LEU A  53
LEU A 123
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 948
ALA C1022
MET C 731
VAL C 951
LEU C1012
1.55A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 924
ALA C 930
VAL C 722
PHE C1052
LEU C 806
1.59A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 948
ALA A1022
MET A 731
VAL A 951
LEU A1012
1.57A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 924
ALA C 930
VAL C 722
PHE C1052
LEU C 806
1.58A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 293
VAL B  36
ARG B 273
1.25A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASP C 389
LEU C 368
PHE C 515
ALA C 522
PHE C 392
1.79A9.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA A 109
ALA B 108
PHE B  91
LEU B  95
LEU B  98
1.61A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w4h NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.50A9.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w4h NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.50A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w4h NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.52A21.73
None
None
BDF  A7105 ( 3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w4h NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.50A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w61 NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
ALA A6960
ALA A6858
VAL A6859
LEU A6893
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLU A6971
LEU A6819
GLU A6821
ALA A6990
LEU A6825
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLN A6847
LEU A7042
LEU A6834
ALA A6832
CYH A6823
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.76A
None
None
AMP  A 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLU B  25
ASP B  22
LEU A 169
ALA B 124
LEU B  88
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLU A  25
ASP A  22
LEU B 169
ALA A 124
LEU A  88
1.78A
None
AMP  A 201 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN A6885
LEU A6893
LEU B4298
GLY A6879
LEU A6852
1.80A9.94
None
None
None
SAM  A7102 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.60A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLN A6847
LEU A7042
LEU A6834
ALA A6832
CYH A6823
1.78A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLU A6971
LEU A6819
GLU A6821
ALA A6990
LEU A6825
1.70A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
GLY C6963
ALA C6960
LEU C7070
ARG C7014
1.80A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLN C6847
LEU C7042
LEU C6834
ALA C6832
CYH C6823
1.68A20.58
None
None
None
FMT  C7111 ( 3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.56A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.63A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
GLN D4351
GLU D4319
PHE D4321
GLY D4323
ALA D4324
1.49A9.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.48A9.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6883
LEU C6887
CYH C7007
VAL C6859
LEU C7073
1.53A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.60A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
GLY C6963
ALA C6960
LEU C7070
ARG C7014
1.80A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w75 NSP10
(SARS-CoV-2)		5 / 12
LEU D4328
CYH B4332
ALA D4276
PHE D4272
LEU B4365
1.67A17.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.63A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLU B 161
LEU A 162
GLU A 161
ALA B 114
LEU B 152
1.53A
None
None
None
CL  B 502 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 118
LEU A 162
GLU A 161
ALA A 144
LEU A 172
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU B 199
VAL B 235
ARG B 183
1.54A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 118
LEU A 162
GLU A 161
ALA A 144
LEU A 172
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 118
LEU B 162
GLU B 161
ALA B 144
LEU B 172
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLU A 161
LEU C 162
GLU C 161
ALA A 114
LEU A 152
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP C 302
LEU C 211
LEU C 199
GLU C 203
GLY C 209
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP B 302
LEU B 211
LEU B 199
GLU B 203
GLY B 209
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 118
LEU B 162
GLU B 161
ALA B 144
LEU B 172
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP B 302
LEU B 211
LEU B 199
GLU B 203
GLY B 209
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP C 302
LEU C 211
LEU C 199
GLU C 203
GLY C 209
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 199
VAL A 235
ARG A 183
1.57A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
ALA A 154
ALA A  38
VAL A  95
PHE A 116
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 257
CYH A 347
ALA A 333
VAL A 240
PHE A 320
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 313
ALA A 328
ALA A 316
VAL A 300
LEU A 287
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 257
CYH A 347
ALA A 333
VAL A 240
PHE A 320
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 313
ALA A 328
ALA A 316
VAL A 300
LEU A 287
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA B 110
ALA B 150
VAL A  53
LEU A  17
LEU A  28
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt NSP10
(SARS-CoV-2)		5 / 12
LEU B4328
CYH D4332
ALA B4279
PHE B4272
LEU D4365
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C7052
GLY C7076
LEU C6959
ARG C7081
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt NSP10
(SARS-CoV-2)		5 / 12
GLN D4351
GLU D4319
PHE D4321
GLY D4323
ALA D4324
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C7078
ALA C6960
ALA C6858
VAL C6859
LEU C6893
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt NSP10
(SARS-CoV-2)		5 / 12
LEU D4328
CYH B4332
ALA D4276
PHE D4272
LEU B4365
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6855
LEU C7052
GLY C7076
LEU C6959
ARG C7081
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLN A6885
LEU A6893
LEU B4298
GLY A6879
LEU A6852
1.80A
None
None
FMT  B4403 (-4.7A)
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6883
LEU C6887
CYH C7007
VAL C6859
LEU C7073
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLN C6847
LEU C7042
LEU C6834
ALA C6832
CYH C6823
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
GLY C6963
ALA C6960
LEU C7070
ARG C7014
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C7078
ALA C6960
ALA C6858
VAL C6859
LEU C6893
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6883
LEU C6887
CYH C7007
VAL C6859
LEU C7073
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP10
(SARS-CoV-2)		5 / 12
LEU D4328
CYH B4332
ALA D4276
PHE D4272
LEU B4365
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN A6847
LEU A7042
LEU A6834
ALA A6832
CYH A6823
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN A6885
LEU A6893
LEU B4298
GLY A6879
LEU A6852
1.80A
None
None
None
SFG  A7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP10
(SARS-CoV-2)		5 / 12
GLN D4351
GLU D4319
PHE D4321
GLY D4323
ALA D4324
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6959
LEU C6909
ALA C6966
LEU C6887
ARG C6884
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLN A6885
LEU A6893
LEU B4298
GLY A6879
LEU A6852
1.80A
None
None
None
SFG  A7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP10
(SARS-CoV-2)		5 / 12
LEU B4328
CYH D4332
ALA B4279
PHE B4272
LEU D4365
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLN C6847
LEU C7042
LEU C6834
ALA C6832
CYH C6823
1.70A
None
None
None
FMT  C7111 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6855
GLY C6963
ALA C6960
LEU C7070
ARG C7014
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 252
GLU A 234
GLY A 254
ALA A 256
PHE A 214
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 188
GLY A 141
ALA A 138
PHE A 135
LEU A 152
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 252
GLU A 234
GLY A 254
ALA A 256
PHE A 214
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 252
GLU B 234
GLY B 254
ALA B 256
PHE B 214
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A 190
GLU A 146
PHE A 177
GLY A 157
LEU A  73
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN B 188
GLY B 141
ALA B 138
PHE B 135
LEU B 152
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN B 188
GLY B 141
ALA B 138
PHE B 135
LEU B 152
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 252
GLU B 234
GLY B 254
ALA B 256
PHE B 214
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 190
GLU B 146
PHE B 177
GLY B 157
LEU B  73
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 266
LEU B 300
GLU B 211
PHE B 204
GLU B 265
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLN A 188
GLY A 141
ALA A 138
PHE A 135
LEU A 152
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wq3 NSP10
(SARS-CoV-2)		5 / 12
GLN B4351
GLU B4319
PHE B4321
GLY B4323
ALA B4324
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
ALA A6960
ALA A6858
VAL A6859
LEU A6893
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLU A6971
LEU A6819
GLU A6821
ALA A6990
LEU A6825
1.70A
GTA  A7102 (-4.1A)
None
None
None
GTA  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6959
LEU A6909
ALA A6966
LEU A6887
ARG A6884
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
LEU A6887
CYH A7007
VAL A6859
LEU A7073
1.54A
None
None
8NK  A7103 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLN A6847
LEU A7042
LEU A6834
ALA A6832
CYH A6823
1.53A
None
None
None
None
GTA  A7102 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wqd NSP7
(SARS-CoV-2)		5 / 12
GLN C  19
LEU C  20
LEU C  17
VAL C  12
LEU A  55
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA B 110
ALA B 150
VAL A  53
LEU A  17
LEU A  28
1.64A
None
EDO  B 302 (-3.7A)
EDO  B 302 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU C  17
LEU C  28
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ASP A 302
LEU A 211
LEU A 199
GLU A 203
GLY A 209
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ASP A 302
LEU A 211
LEU A 199
GLU A 203
GLY A 209
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 103
LEU A  56
MET B  94
VAL A  12
LEU D  98
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU C  17
LEU C  28
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 103
LEU C  56
MET D  94
VAL C  12
LEU B  98
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
GLN B  88
LEU B  91
LEU B  95
ALA A  65
LEU B 117
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 110
ALA B 150
VAL A  53
LEU A  17
LEU A  28
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP E 389
LEU E 368
PHE E 515
ALA E 522
PHE E 392
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A 389
LEU A 368
PHE A 515
ALA A 522
PHE A 392
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 409
GLU E 406
LEU E 461
GLU E 465
PHE E 400
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 409
GLU A 406
LEU A 461
GLU A 465
PHE A 400
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP E 389
LEU E 368
PHE E 515
ALA E 522
PHE E 392
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 409
GLU E 406
LEU E 461
GLU E 465
PHE E 400
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN A 409
GLU A 406
LEU A 461
GLU A 465
PHE A 400
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLN E 409
GLU E 406
LEU E 461
GLU E 465
PHE E 400
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A 389
LEU A 368
PHE A 515
ALA A 522
PHE A 392
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP E 389
LEU E 368
PHE E 515
ALA E 522
PHE E 392
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  53
LEU E  88
ALA E 154
ALA E  27
LEU D 169
1.63A
None
None
EDO  E 205 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU B  43
LEU E 126
GLY B  46
ALA B  50
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E  53
CYH E 143
ALA E 129
VAL E  36
PHE E 116
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  53
CYH B 143
ALA B 129
VAL B  36
PHE B 116
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
ALA E 124
ALA E 112
VAL E  96
LEU E  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU B  43
LEU E 126
GLY B  46
ALA B  50
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  53
CYH C 143
ALA C 129
VAL C  36
PHE C 116
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  53
CYH C 143
ALA C 129
VAL C  36
PHE C 116
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.67A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.68A
EDO  D 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
ALA E 124
ALA E 112
VAL E  96
LEU E  83
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU B  43
LEU E 126
GLY B  46
ALA B  50
1.51A
None
None
APR  E 201 (-4.7A)
EDO  B 202 (-3.9A)
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU B  43
LEU E 126
GLY B  46
ALA B  50
1.52A
None
None
APR  E 201 (-4.7A)
EDO  B 202 (-3.9A)
APR  B 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
ALA E 124
ALA E 112
VAL E  96
LEU E  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 109
ALA D 124
ALA D 112
VAL D  96
LEU D  83
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
ALA E 124
ALA E 112
VAL E  96
LEU E  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 109
ALA C 124
ALA C 112
VAL C  96
LEU C  83
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  53
CYH B 143
ALA B 129
VAL B  36
PHE B 116
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  53
CYH B 143
ALA B 129
VAL B  36
PHE B 116
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 109
ALA A 124
ALA A 112
VAL A  96
LEU A  83
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 109
ALA B 124
ALA B 112
VAL B  96
LEU B  83
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A  53
CYH A 143
ALA A 129
VAL A  36
PHE A 116
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 663
LEU A 575
PHE A 571
ALA A 660
ARG A 651
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 838
LEU A 883
ALA A 423
VAL A 424
LEU D  98
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLN A 292
LEU A 308
PHE A 283
ALA A 311
PHE A 313
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 261
VAL A 320
ARG A 183
1.67A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU C  17
LEU C  28
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 723
VAL A 742
ARG A 726
1.78A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU D  91
PHE A 415
GLY A 413
PHE A 843
LEU A 437
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
ALA A 639
ALA A 690
VAL A 693
LEU A 470
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 282
VAL A 190
ARG A 285
1.63A13.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU D  91
LEU C  17
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLN C  34
LEU C  14
ALA A 443
VAL A 410
CYH A 669
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU D  91
LEU C  17
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 576
ALA A 639
ALA A 690
VAL A 693
LEU A 470
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 212
VAL A 147
ARG A 181
1.55A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 282
VAL A 190
ARG A 285
1.44A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 292
LEU A 308
PHE A 283
ALA A 311
PHE A 313
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLN C  34
LEU C  14
ALA A 443
VAL A 410
CYH A 669
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU D  91
PHE A 415
GLY A 413
PHE A 843
LEU A 437
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 261
VAL A 320
ARG A 183
1.68A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ALA D 150
VAL C  53
LEU C  17
LEU C  28
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 524
LEU A 527
CYH A 487
ALA A 490
ALA A 526
1.78A
None
None
ZN  A1002 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
LEU C  35
LEU C  55
ALA C  42
VAL C  11
PHE A 843
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 789
LEU A 469
LEU A 308
VAL A 637
PHE A 480
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 292
LEU A 308
PHE A 283
ALA A 311
PHE A 313
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 261
VAL A 320
ARG A 183
1.68A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLN A 524
LEU A 527
CYH A 487
ALA A 490
ALA A 526
1.79A
None
None
ZN  A1002 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 282
VAL A 190
ARG A 285
1.70A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 251
CYH A 151
ALA A 250
VAL A 182
LEU A 142
1.66A
None