Ligand ID: DCF


Drugbank ID:
DB00552
(Pentostatin)


Indication:
For the treatment of hairy cell leukaemia refractory to alpha interferon.

Get human targets for DCF in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'DCF' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.46A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.24A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.48A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 115
LEU A  32
PHE A 150
1.47A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.30A18.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  64
LEU A  58
LEU A  87
LEU A  27
1.67A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 5
LEU E1197
SER E 937
LEU E 938
GLY E 932
1.43A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D 977
LEU D1166
SER E 968
ALA E 972
ASP D1163
1.78A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.23A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.49A23.22
ALC  D   2 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.30A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m03 MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.45A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.53A23.16
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.28A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.51A23.16
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.74A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU D  32
LEU D  30
SER D  10
LEU D 115
1.32A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.45A23.04
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS C  64
LEU C  89
LEU C  87
LEU C  57
1.73A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS D  41
LEU D 177
TYR D  37
GLY D  29
1.44A23.04
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS C  41
LEU C 177
TYR C  37
GLY C  29
1.49A23.04
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU B 205
LEU B 220
PHE B 230
1.19A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS B  41
LEU B 177
TYR B  37
GLY B  29
1.45A23.04
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.77A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU D 115
LEU D  32
PHE D 150
1.40A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS C  41
LEU C 177
TYR C  37
GLY C  29
1.47A23.04
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU D  32
LEU D  30
SER D  10
LEU D 115
1.27A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.30A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU C  32
LEU C  30
SER C  10
LEU C 115
1.24A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU C 205
LEU C 220
PHE C 230
1.21A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS B  41
LEU B 177
TYR B  37
GLY B  29
1.47A23.04
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.23A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU A 205
LEU A 220
PHE A 230
1.18A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.47A23.04
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU B  32
LEU B  30
SER B  10
LEU B 115
1.30A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU D 205
LEU D 220
PHE D 230
1.23A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU C  32
LEU C  30
SER C  10
LEU C 115
1.29A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU C 115
LEU C  32
PHE C 150
1.39A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		3 / 3
LEU B 115
LEU B  32
PHE B 150
1.43A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
HIS D  41
LEU D 177
TYR D  37
GLY D  29
1.45A23.04
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.28A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU A 401
LEU B 117
PHE A 504
1.37A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU B  98
LEU B 103
LEU A 271
CYH B 114
1.77A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 775
1.48A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 749
1.66A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  98
LEU D  95
SER C  57
LEU C  60
1.79A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 862
PHE A 843
1.03A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 4
HIS C  36
LEU D  91
LEU C  59
LEU C  28
1.54A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 245
LEU A 207
PHE A 287
1.26A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.65A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 437
LEU A 838
LEU A 862
GLY A 839
1.75A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 883
PHE A 843
1.41A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 205
PHE A 287
0.69A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6m71 NSP12
(SARS-CoV-2)		4 / 4
HIS A 309
LEU A 316
LEU A 245
LEU A 207
1.33A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
HIS C 655
SER C 698
LEU C 699
GLY C 669
1.36A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B  73
LEU B 190
PHE B 123
0.81A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.31A
None
SO4  A 201 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6vxs NSP3
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
HIS B 655
SER B 698
LEU B 699
GLY B 669
1.40A14.47
NAG  B1310 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 533
LEU B 582
PHE B 543
1.00A15.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 533
LEU B 582
PHE B 543
0.90A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
HIS A 655
SER A 698
LEU A 699
GLY A 669
1.40A14.47
NAG  A1310 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASP B 574
LEU B 533
LEU B 552
ILE B 584
SER B 555
1.62A13.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 110
GLY A 147
HIS A 145
HIS D  59
ASP A  82
1.48A17.34
None
None
ZN  A 204 ( 3.3A)
ZN  A 204 ( 3.1A)
ZN  A 204 ( 2.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
ASP A 144
GLY A 147
HIS A 145
HIS D  59
ASP A  82
1.65A15.36
None
None
ZN  A 204 ( 3.3A)
ZN  A 204 ( 3.1A)
ZN  A 204 ( 2.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w02 NSP3
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.10A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w37 PROTEIN 7A
(SARS-CoV-2)		3 / 3
LEU A  62
LEU A  15
PHE A  48
1.17A12.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		3 / 3
LEU C 513
LEU C 425
PHE C 515
1.79A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		3 / 3
LEU C 368
LEU C 335
PHE C 342
0.85A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w4b NSP9
(SARS-CoV-2)		3 / 3
LEU B  89
LEU B  10
PHE B  91
1.09A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6959
SER A7074
LEU A7010
GLY A6963
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A7050
SER A6964
LEU A6924
CYH A7007
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A7070
LEU A7010
LEU A6981
GLY A7011
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6924
SER A7074
LEU A7073
GLY A6963
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6848
SER A6964
LEU A6924
CYH A7007
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 205
LEU A 220
PHE A 230
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.45A23.04
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.44A23.04
X77  A 401 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.69A
None
None
MES  B 201 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		4 / 5
LEU A 126
LEU A 164
SER B   7
LEU A 169
1.61A
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		4 / 5
LEU A 126
LEU A 164
SER B   7
LEU A 169
1.61A
AMP  A 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w6y NSP3
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.65A
None
None
MES  B 201 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A7050
SER A6964
LEU A6924
CYH A7007
1.62A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.46A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.56A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6959
SER A7074
LEU A7010
GLY A6963
1.61A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
LEU C7042
SER C6831
LEU C7037
1.60A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.66A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.42A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.46A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
LEU C7042
SER C6831
LEU C7037
1.68A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6848
SER C6964
LEU C6924
CYH C7007
1.61A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6959
SER C7074
LEU C7010
GLY C6963
1.60A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6848
SER A6964
LEU A6924
CYH A7007
1.61A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.43A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C7050
SER C6964
LEU C6924
CYH C7007
1.62A18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 4
HIS C 175
LEU C 125
LEU C 120
LEU C 113
1.51A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU C 125
LEU C 120
LEU C 113
CYH C 155
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 164
PHE A 304
ALA A 116
HIS A 275
ASP A 302
1.80A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 4
HIS B 272
LEU B 118
LEU B 117
LEU B 152
1.67A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A 175
LEU A 125
LEU A 120
LEU A 113
1.51A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A 125
LEU A 120
LEU A 113
CYH A 155
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU B 125
LEU B 120
LEU B 113
CYH B 155
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 4
HIS B 175
LEU B 125
LEU B 120
LEU B 113
1.62A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		3 / 3
LEU A 103
LEU A  -8
PHE A  90
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		3 / 3
LEU A  44
LEU A   9
PHE A  56
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		3 / 3
LEU A  88
LEU A  -8
PHE A  90
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		3 / 3
LEU A  45
LEU A   9
PHE A  75
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wcf NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wcf NSP3
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.70A
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wcf NSP3
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.64A
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wen NSP3
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wey NSP3
(SARS-CoV-2)		3 / 3
LEU A 331
LEU A 257
PHE A 320
1.24A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wey NSP3
(SARS-CoV-2)		4 / 5
LEU A 292
LEU A 257
SER A 269
LEU A 247
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wey NSP3
(SARS-CoV-2)		4 / 5
LEU A 368
LEU A 344
SER A 332
LEU A 313
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wey NSP3
(SARS-CoV-2)		3 / 3
LEU A 331
LEU A 279
PHE A 320
1.07A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wey NSP3
(SARS-CoV-2)		4 / 5
LEU A 368
LEU A 344
SER A 332
LEU A 313
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  91
LEU A  13
SER A  54
LEU A  35
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  91
LEU A  13
SER A  54
LEU A  35
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C7050
SER C6964
LEU C6924
CYH C7007
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A7070
LEU A7010
LEU A6981
GLY A7011
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6848
SER C6964
LEU C6924
CYH C7007
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.49A
FMT  B4403 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU D4298
LEU C7042
SER C6831
LEU C7037
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.61A
FMT  B4403 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6848
SER A6964
LEU A6924
CYH A7007
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A7050
SER A6964
LEU A6924
CYH A7007
1.61A
FMT  A7107 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6959
SER A7074
LEU A7010
GLY A6963
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6959
SER C7074
LEU C7010
GLY C6963
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE B 110
GLY B 147
HIS B 145
HIS A  59
ASP B  82
1.57A17.34
None
None
ZN  B 202 (-3.3A)
ZN  B 202 (-2.6A)
ZN  B 202 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B  59
ASP C 144
GLY C 147
HIS C 145
ASP C  82
1.52A15.63
 ZN  C 201 (-3.3A)
None
None
ZN  C 201 (-3.4A)
ZN  C 201 (-2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PHE D 110
GLY D 147
HIS D 145
HIS C  59
ASP D  82
1.71A17.34
None
None
ZN  D 202 (-3.4A)
ZN  D 202 (-3.2A)
ZN  D 202 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C7050
SER C6964
LEU C6924
CYH C7007
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
LEU C7042
SER C6831
LEU C7037
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6959
SER C7074
LEU C7010
GLY C6963
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6959
SER A7074
LEU A7010
GLY A6963
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A7050
SER A6964
LEU A6924
CYH A7007
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6848
SER A6964
LEU A6924
CYH A7007
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
LEU C7042
SER C6831
LEU C7037
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6848
SER C6964
LEU C6924
CYH C7007
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6893
LEU C6887
SER C6964
LEU C6857
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU B 201
LEU B 255
SER B 288
LEU B 246
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU A 215
LEU A 249
PHE A 204
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU A 201
LEU A 215
PHE A 264
1.24A
EDO  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 215
LEU B 249
PHE B 204
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 201
LEU B 215
PHE B 264
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 300
LEU B 255
PHE B 233
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU A 201
LEU A 255
SER A 288
LEU A 246
1.53A
EDO  A 405 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B  73
LEU B 190
PHE B 123
0.87A23.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU A 201
LEU A 255
SER A 288
LEU A 246
1.51A
EDO  A 405 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU A  73
LEU A 190
PHE A 123
0.90A23.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 5
LEU B 201
LEU B 255
SER B 288
LEU B 246
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.52A23.04
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.75A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		3 / 3
LEU A 115
LEU A  32
PHE A 150
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.68A
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.75A
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  53
PHE C 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.67A
None
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  75
PHE C 116
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU D  88
LEU D  53
SER D  65
LEU D  43
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.64A
None
None
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  53
PHE D 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  75
PHE D 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU C  88
LEU C  53
SER C  65
LEU C  43
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.69A
None
None
APR  B 201 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.67A
None
None
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  88
LEU A  53
SER A  65
LEU A  43
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.71A
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.77A
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU B  88
LEU B  53
SER B  65
LEU B  43
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A7050
SER A6964
LEU A6924
CYH A7007
1.66A
None
None
None
8NK  A7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6959
SER A7074
LEU A7010
GLY A6963
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
LEU A7042
SER A6831
LEU A7037
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6893
LEU A6887
SER A6964
LEU A6857
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6848
SER A6964
LEU A6924
CYH A7007
1.61A
None
None
None
8NK  A7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
LEU A6959
LEU A6852
PHE A6985
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  95
LEU B  91
SER C  10
LEU C  40
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  91
LEU A  13
SER A  54
LEU A  35
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  95
LEU B  91
SER C  10
LEU C  40
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
(SARS-CoV-2)		4 / 5
LEU C  13
LEU C  55
SER C  25
LEU C  28
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  95
LEU D  91
SER A  10
LEU A  40
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
(SARS-CoV-2)		4 / 5
LEU A  13
LEU A  55
SER A  25
LEU A  28
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  95
LEU D  91
SER A  10
LEU A  40
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU B  91
LEU A  13
SER A  54
LEU A  35
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
LEU A  58
LEU A  80
LEU A 150
GLY A  81
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
LEU A  58
LEU A  80
LEU A  87
GLY A  81
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 4
HIS A 175
LEU A 125
LEU A 120
LEU A 113
1.49A20.99
PO4  A 504 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 5
LEU A 125
LEU A 120
LEU A 113
CYH A 155
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6xez NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
LEU A 146
PHE A 165
1.35A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6xez NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 207
PHE A 287
1.20A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6xez NSP12
(SARS-CoV-2)		3 / 3
LEU A 245
LEU A 207
PHE A 287
1.31A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.26A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.30A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.47A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.45A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.24A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A 115
LEU A  32
PHE A 150
1.49A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU B  95
LEU B  91
SER C  10
LEU C  40
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU B  95
LEU B  91
SER C  10
LEU C  40
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU D  95
LEU D  91
SER A  10
LEU A  40
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU D  95
LEU D  91
SER A  10
LEU A  40
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU B  91
LEU A  13
SER A  54
LEU A  35
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU A  13
LEU A  55
SER A  25
LEU A  28
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU C  13
LEU C  55
SER C  25
LEU C  28
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A 513
LEU A 335
PHE A 342
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU E 368
LEU E 335
PHE E 342
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU E 368
LEU E 335
PHE E 342
1.08A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU E 513
LEU E 335
PHE E 342
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU E 368
LEU E 335
PHE E 342
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A 368
LEU A 335
PHE A 342
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.22A
EDO  A 202 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS A 119
LEU D 108
LEU D  93
GLY D  79
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU E 126
LEU E 160
SER E 166
ASP E 135
1.72A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  53
PHE C 116
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.63A
None
None
EDO  A 202 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.25A
EDO  A 202 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E  10
LEU E 169
SER D   5
GLY D   8
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D  10
LEU D 169
SER E   5
GLY E   8
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU E 140
LEU E 164
SER E 166
ASP E 135
1.73A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 126
LEU E 164
SER D   7
LEU E 169
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.64A
None
None
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.61A
None
None
EDO  A 202 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 169
LEU D  10
LEU E  12
GLY E   8
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 164
LEU E 140
SER E 128
LEU E 109
1.62A
None
None
EPE  E 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E 127
LEU E  75
PHE E 116
1.12A
None
EPE  E 203 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASP B  66
LEU E 126
LEU E 160
SER E 166
ASP E 135
1.70A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 126
LEU E 140
SER D   7
LEU E 169
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 164
LEU E 140
SER E 128
LEU E 109
1.64A
None
None
EPE  E 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS D 119
LEU A 108
LEU A  93
GLY A  79
1.61A
None
EDO  D 202 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  53
PHE D 116
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E  10
LEU E  12
SER D   5
GLY D   8
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  75
PHE C 116
1.11A
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 126
LEU E 164
SER D   7
LEU E 169
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 169
LEU E  10
LEU D  12
GLY D   8
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  75
PHE D 116
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.66A
None
None
None
EDO  D 204 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E 127
LEU E  53
PHE E 116
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D  10
LEU D 169
SER E   5
GLY E   8
1.71A
None
None
None
EDO  E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.62A
None
None
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.58A
None
None
APR  B 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  53
PHE D 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B  88
LEU B  53
SER B  65
LEU B  43
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D  88
LEU D  53
SER D  65
LEU D  43
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E 127
LEU E  75
PHE E 116
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.59A
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  53
PHE C 116
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.61A
None
None
APR  B 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  75
PHE C 116
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 164
LEU E 140
SER E 128
LEU E 109
1.62A
None
None
APR  E 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 169
LEU D  10
LEU E  12
GLY E   8
1.66A
None
None
None
EDO  E 203 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E  10
LEU E 169
SER D   5
GLY D   8
1.74A
EDO  E 203 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E  10
LEU E  12
SER D   5
GLY D   8
1.51A
EDO  E 203 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.64A
None
None
APR  C 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU E 164
LEU E 140
SER E 128
LEU E 109
1.64A
None
None
APR  E 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.59A
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E 127
LEU E  53
PHE E 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS A 119
LEU D 108
LEU D  93
GLY D  79
1.61A
None
EDO  A 206 (-4.6A)
None
EDO  D 203 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.62A
None
None
APR  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D 127
LEU D  75
PHE D 116
1.20A
None
EDO  D 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU D 164
LEU D 140
SER D 128
LEU D 109
1.62A
None
None
APR  D 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A  88
LEU A  53
SER A  65
LEU A  43
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B  88
LEU B  53
SER B  65
LEU B  43
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  53
PHE B 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B 127
LEU B  75
PHE B 116
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  53
PHE A 116
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU A 164
LEU A 140
SER A 128
LEU A 109
1.68A
None
None
MES  A 201 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A 127
LEU A  75
PHE A 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.68A
None
None
MES  C 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  75
PHE C 116
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 169
LEU C  12
SER C 139
LEU C 126
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS C 119
LEU A 108
LEU A  93
GLY A  78
1.73A
None
EDO  C 205 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS C 119
LEU A 108
LEU A  93
GLY A  79
1.62A
None
EDO  C 205 (-4.9A)
None
EDO  A 204 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU B 164
LEU B 140
SER B 128
LEU B 109
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C 127
LEU C  53
PHE C 116
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
LEU C 164
LEU C 140
SER C 128
LEU C 109
1.66A
None
None
MES  C 201 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 5
HIS A 119
LEU C 108
LEU C  93
GLY C  79
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.48A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		3 / 3
LEU A 205
LEU A 220
PHE A 230
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.49A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 470
LEU A 308
SER A 635
LEU A 655
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU A 401
LEU B 117
PHE A 504
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 862
PHE A 843
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 775
1.54A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 222
PHE A 192
HIS A  99
GLU A  83
ASP A 218
1.70A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7btf NSP7
(SARS-CoV-2)		4 / 5
LEU C  13
LEU C  55
SER C  25
LEU C  28
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 205
PHE A 287
0.86A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 437
LEU A 838
LEU A 862
GLY A 839
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 655
LEU A 636
LEU A 470
CYH A 310
1.28A
None
None
None
ZN  A1001 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 883
PHE A 843
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 245
LEU A 207
PHE A 287
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
LEU A 146
PHE A 165
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  98
LEU D  95
SER C  57
LEU C  60
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 749
1.70A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 222
PHE A 192
HIS A  99
GLU A  83
ASP A 218
1.71A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 222
PHE A 192
HIS A  99
GLU A  83
ASP A 218
1.65A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 222
PHE A 192
HIS A  99
GLU A  83
ASP A 218
1.66A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 207
PHE A 287
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  64
LEU A  89
LEU A  87
LEU A  57
1.77A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.47A23.04
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 4
HIS A  41
LEU A 177
TYR A  37
GLY A  29
1.49A23.04
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 5
LEU A  32
LEU A  30
SER A  10
LEU A 115
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 775
1.54A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 862
PHE A 843
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 655
LEU A 636
LEU A 470
CYH A 310
1.39A
None
None
None
ZN  A1001 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU A 401
LEU B 117
PHE A 504
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 636
SER A 647
LEU A 648
CYH A 646
1.74A
None
None
None
ZN  A1002 (-2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 245
LEU A 207
PHE A 287
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 5
LEU B  95
LEU B  98
SER A 343
LEU B 117
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
HIS A 295
LEU A 470
LEU A 308
LEU A 655
1.57A17.30
 ZN  A1001 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv1 NSP7
(SARS-CoV-2)		4 / 5
LEU C  13
LEU C  55
SER C  25
LEU C  28
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
HIS A 309
LEU A 316
SER A 236
LEU A 240
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 883
PHE A 843
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 207
PHE A 287
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 749
1.62A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU C  13
SER C  54
LEU C  35
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 470
LEU A 308
SER A 635
LEU A 655
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
LEU A 146
PHE A 165
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 437
LEU A 838
LEU A 862
GLY A 839
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 862
PHE A 843
1.04A
None
U  P  17 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 205
PHE A 287
0.89A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		3 / 3
LEU A 401
LEU B 117
PHE A 504
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
HIS A 309
LEU A 316
SER A 236
LEU A 240
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 655
LEU A 636
LEU A 470
CYH A 310
1.42A
None
None
None
ZN  A1001 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 470
LEU A 308
SER A 635
LEU A 655
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 437
LEU A 883
PHE A 843
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 437
LEU A 838
LEU A 862
GLY A 839
1.59A
None
None
U  P  17 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
HIS A 133
LEU A 731
LEU A 727
LEU A 775
1.56A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
HIS A 725
LEU A 707
SER A 236
LEU A 240
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 247
LEU A 146
PHE A 165
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		3 / 3
LEU A 186
LEU A 207
PHE A 287
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 727
LEU A 708
SER A 239
LEU A 240
1.62A
None