Ligand ID: D2V


Drugbank ID:
DB00153
(Ergocalciferol)


Indication:
For use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).

Get human targets for D2V in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'D2V' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.50A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.52A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 199
LEU A 287
PHE A 230
ALA A 206
ILE A 281
1.56A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		6 / 12
THR A 226
ASN A 228
VAL A 233
ALA A 234
ALA A 266
MET A 235
1.69A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
LEU E 948
GLU D1182
ILE D1183
0.99A14.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.52A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.54A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.56A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
THR A 199
LEU A 287
PHE A 230
ALA A 206
ILE A 281
1.59A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.53A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 116
VAL B 125
THR B 292
ILE B 106
MET B 130
1.48A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.45A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 116
VAL C 125
THR C 292
ILE C 106
MET C 130
1.56A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 116
VAL D 125
THR D 292
ILE D 106
MET D 130
1.54A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR D 199
LEU D 287
PHE D 230
ALA D 206
ILE D 281
1.59A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR C 199
LEU C 287
PHE C 230
ALA C 206
ILE C 281
1.60A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR B 226
ASN B 228
ALA B 234
ALA B 266
MET B 235
1.61A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 116
VAL C 125
THR C 292
ILE C 106
MET C 130
1.52A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 116
VAL D 125
THR D 292
ILE D 106
MET D 130
1.58A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.48A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 116
VAL B 125
THR B 292
ILE B 106
MET B 130
1.46A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.50A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.48A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASN A 228
VAL A 233
ALA A 234
ALA A 266
MET A 235
1.56A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.55A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL A 405
THR B 137
ILE B 172
THR B 141
1.58A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
PHE A 165
ALA A 176
THR A 462
ILE A 244
1.55A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ASN B 105
VAL B 115
ALA B 110
VAL A 341
THR A 324
1.47A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.54A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 568
VAL A 535
ALA A 660
ALA A 376
VAL A 373
1.36A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.49A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
THR A 567
VAL A 535
ALA A 660
VAL A 373
VAL A 299
1.49A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
ALA A 690
ALA A 639
THR A 586
ILE A 589
1.70A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.53A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
THR A 645
VAL A 595
THR A 299
ILE A 312
THR A 315
1.32A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 117
PHE B 133
THR B 114
ILE B 235
THR B 109
1.47A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B 650
GLU B 654
ILE B 693
0.84A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6vxs NSP3
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
THR B 645
VAL B 595
VAL B 620
THR B 299
ILE B 312
THR B 315
1.55A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A1063
GLU A 725
ILE A 726
0.98A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU C 699
GLU A 868
ILE A 870
0.96A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
THR A 645
VAL A 595
VAL A 620
THR A 299
ILE A 312
THR A 315
1.57A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 117
PHE C 133
THR C 114
ILE C 235
THR C 109
1.40A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 201
GLU B 265
ILE B 281
0.87A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w02 NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.36A17.95
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
PHE C 515
VAL C 395
ALA C 397
VAL C 382
THR C 523
1.70A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN C 388
PHE C 515
VAL C 382
VAL C 395
THR H 100
1.62A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
LEU C 368
PHE C 515
VAL C 382
VAL C 341
1.75A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.72A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN A6827
ALA A6832
VAL A6992
ILE A7035
THR A6993
1.76A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6995
ALA A6832
THR A6846
VAL A6842
ILE A6838
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6995
ALA A6832
ALA A6802
VAL A6842
ILE A6838
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6882
ALA A6881
ALA A6870
ILE A6838
MET B4297
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.66A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.38A
None
None
AMP  A 201 ( 3.9A)
AMP  A 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  93
ALA B  27
VAL B  30
THR B 149
VAL B 147
1.72A16.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 140
PHE B 116
ALA B 154
ALA B  38
VAL B  95
1.46A
None
None
None
MES  B 201 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  93
ALA A  27
VAL A  30
THR A 149
VAL A 147
1.69A16.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU B  88
GLU B  25
ILE B  23
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 140
PHE B 116
ALA B  38
VAL B  95
ILE B  18
1.52A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B   6
ALA B 124
ALA B  27
VAL B  30
VAL B 144
1.79A16.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.28A
None
None
MES  B 201 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6w6y NSP3
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.19A
None
None
AMP  A 201 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
LEU B4345
ALA B4276
VAL B4369
ILE B4308
THR B4368
1.78A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6857
ASN C7008
ALA C6960
THR C6891
VAL C6865
1.76A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C6995
ALA C6832
THR C6846
VAL C6842
ILE C6838
1.75A15.03
None
FMT  C7111 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6882
ALA C6881
ALA C6870
ILE C6838
MET D4297
1.65A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6808
ALA C6997
VAL C6995
ILE C7005
THR C6854
1.63A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6857
ASN A7008
ALA A6960
THR A6891
VAL A6865
1.79A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C6995
ALA C6832
ALA C6802
VAL C6842
ILE C6838
1.71A15.03
None
FMT  C7111 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A6995
ALA A6832
ALA A6802
VAL A6842
ILE A6838
1.75A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.74A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A6995
ALA A6832
THR A6846
VAL A6842
ILE A6838
1.77A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.63A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6991
ALA C6966
ALA C6990
THR C6846
VAL C6882
1.74A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6882
ALA A6881
ALA A6870
ILE A6838
MET B4297
1.63A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
LEU D4284
PHE B4272
ALA D4276
VAL B4274
THR D4292
1.80A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE C6991
ALA C6966
ALA C6990
THR C6846
VAL C6882
1.73A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w75 NSP10
(SARS-CoV-2)		5 / 12
LEU D4345
ALA D4276
VAL D4369
ILE D4308
THR D4368
1.77A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w75 NSP16
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.73A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR C 119
ALA C 139
VAL C  98
THR C  90
ILE C 151
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 119
ALA A 139
VAL A  98
THR A  90
ILE A 151
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
LEU C 178
GLU C 124
ILE C 123
0.92A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR C 119
ALA C 139
VAL C  98
ILE C 151
THR C  90
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR B 119
ALA B 139
VAL B  98
THR B  90
ILE B 151
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR B  10
ASN B  13
ALA B 131
ALA B  68
THR B  90
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR C 119
ALA C 139
VAL C  98
THR C  90
ILE C 151
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wcf NSP3
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
PHE A 116
ALA A  38
VAL A  95
ILE A  18
1.48A
None
None
MES  A 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.34A
None
None
MES  A 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
PHE A 116
ALA A 154
ALA A  38
VAL A  95
1.44A
None
None
None
MES  A 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wen NSP3
(SARS-CoV-2)		5 / 12
THR A  57
VAL A  36
ALA A  50
VAL A  49
VAL A 121
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wen NSP3
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 344
ALA A 328
ALA A 316
THR A 217
ILE A 222
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 368
ALA A 338
ALA A 242
VAL A 253
ILE A 341
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wey NSP3
(SARS-CoV-2)		3 / 3
LEU A 292
GLU A 229
ILE A 227
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wiq NSP8
(SARS-CoV-2)		5 / 12
LEU B 117
ASN B 118
ALA B 188
ALA B 150
VAL B 160
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 291
ALA B 308
ALA E 267
THR B 265
THR B 263
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 291
ALA A 311
ALA E 267
THR B 265
THR B 263
1.60A
None
CL  B 401 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6882
ALA A6881
ALA A6870
ILE A6838
MET B4297
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6808
ALA C6997
VAL C6995
ILE C7005
THR C6854
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL C6882
ALA C6881
ALA C6870
ILE C6838
MET D4297
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL C6995
ALA C6832
ALA C6802
VAL C6842
ILE C6838
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL C6995
ALA C6832
ALA C6802
VAL C6842
ILE C6838
1.72A
None
FMT  C7111 ( 3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6808
ALA C6997
VAL C6995
ILE C7005
THR C6854
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL C6882
ALA C6881
ALA C6870
ILE C6838
MET D4297
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
PHE C6991
ALA C6966
ALA C6990
THR C6846
VAL C6882
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
VAL A6882
ALA A6881
ALA A6870
ILE A6838
MET B4297
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 228
GLU B 234
ILE B 236
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU A 228
GLU A 234
ILE A 236
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU B 201
GLU B 265
ILE B 281
1.03A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		3 / 3
LEU A 201
GLU A 265
ILE A 281
1.07A
EDO  A 405 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.38A
None
None
APR  A 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 140
ALA D 124
ALA D 112
THR D  13
ILE D  18
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.38A
None
None
APR  B 201 (-3.3A)
APR  B 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 140
ALA C 124
ALA C 112
THR C  13
ILE C  18
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU D 164
ALA D 134
ALA D  38
VAL D  49
ILE D 137
1.37A
None
None
APR  D 201 (-3.2A)
APR  D 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.37A
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU C 164
ALA C 134
ALA C  38
VAL C  49
ILE C 137
1.39A
None
None
APR  C 201 (-3.4A)
APR  C 201 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
PHE A6991
ALA A6966
ALA A6990
THR A6846
VAL A6882
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
VAL A6882
ALA A6881
ALA A6870
ILE A6838
MET B4297
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
VAL A6995
ALA A6832
THR A6846
VAL A6842
ILE A6838
MET A6840
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6808
ALA A6997
VAL A6995
ILE A7005
THR A6854
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wqd NSP8
(SARS-CoV-2)		5 / 12
LEU B 117
ASN B 118
ALA B 188
ALA B 150
VAL B 160
1.25A
None
None
None
EDO  B 302 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wqd NSP8
(SARS-CoV-2)		5 / 12
LEU D 117
ASN D 118
ALA D 188
ALA D 150
VAL D 160
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
THR A   9
PHE A  49
VAL A  53
ALA A  48
ILE B 107
1.68A
None
None
EDO  B 302 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASN A 228
VAL A 233
ALA A 234
ALA A 266
MET A 235
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A 226
ASN A 228
ALA A 234
ALA A 266
MET A 235
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
THR A  18
PHE A  31
VAL A  57
VAL A   2
MET A  23
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
THR A  10
ASN A  13
ALA A 131
ALA A  68
THR A  90
1.71A
 CL  A 506 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6wrh NSP3
(SARS-CoV-2)		3 / 3
LEU A 178
GLU A 124
ILE A 123
0.63A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.51A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A 199
LEU A 287
PHE A 230
ALA A 206
ILE A 281
1.56A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.48A17.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B 117
ASN B 118
ALA B 188
ALA B 150
VAL B 160
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
THR C   9
PHE C  49
VAL C  53
ALA C  48
ILE D 107
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D 117
ASN D 118
ALA D 188
ALA D 150
VAL D 160
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
LEU D 184
GLU D 171
ILE D 166
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 515
VAL A 395
ALA A 397
VAL A 382
THR A 523
1.65A
None
None
None
DMS  A 905 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
PHE E 515
VAL E 382
VAL E 395
THR H 104
1.67A
None
None
DMS  L1601 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
VAL E 395
ALA E 397
VAL E 382
THR E 523
1.63A
None
None
None
DMS  L1601 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR H  31
LEU E 368
PHE E 515
VAL E 382
VAL E 341
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
VAL E 395
ALA E 397
VAL E 382
THR E 523
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
PHE E 515
VAL E 382
VAL E 395
THR H 104
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN E 388
PHE E 515
VAL E 382
VAL E 395
THR H 104
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE E 515
VAL E 395
ALA E 397
VAL E 382
THR E 523
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
ASN A 388
PHE A 515
VAL A 382
VAL A 395
THR B 104
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE A 515
VAL A 395
ALA A 397
VAL A 382
THR A 523
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E  88
GLU E  25
ILE E  23
1.21A
None
None
EDO  E 205 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  37
ALA B  52
ALA B 154
VAL B 155
VAL E 100
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B  88
GLU B  25
ILE B  23
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.37A
None
None
EDO  A 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 140
ALA E 124
ALA E 112
THR E  13
ILE E  18
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 164
ALA D 134
ALA D  38
VAL D  49
ILE D 137
1.41A
None
EDO  D 211 (-3.7A)
EDO  D 205 (-3.5A)
EDO  D 209 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 140
ALA D 124
ALA D 112
THR D  13
ILE D  18
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C  88
GLU C  25
ILE C  23
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 164
ALA E 134
ALA E  38
VAL E  49
ILE E 137
1.27A
None
None
EPE  E 202 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 164
ALA C 134
ALA C  38
VAL C  49
ILE C 137
1.37A
None
EDO  C 208 ( 3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 140
ALA C 124
ALA C 112
THR C  13
ILE C  18
1.40A
None
None
None
EDO  C 205 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D  88
GLU D  25
ILE D  23
1.18A
None
None
EDO  D 208 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU E  88
GLU E  25
ILE E  23
1.19A
None
None
APR  E 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 164
ALA E 134
ALA E  38
VAL E  49
ILE E 137
1.36A
None
None
APR  E 201 (-3.3A)
APR  E 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.37A
None
EDO  A 204 ( 3.9A)
APR  A 201 (-3.4A)
APR  A 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.20A
None
None
APR  A 201 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU D  88
GLU D  25
ILE D  23
1.18A
None
None
APR  D 201 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 140
ALA D 124
ALA D 112
THR D  13
ILE D  18
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C  88
GLU C  25
ILE C  23
1.16A
None
None
APR  C 201 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 140
ALA E 124
ALA E 112
THR E  13
ILE E  18
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.37A
None
None
APR  B 201 (-3.4A)
APR  B 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 140
ALA C 124
ALA C 112
THR C  13
ILE C  18
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU D 164
ALA D 134
ALA D  38
VAL D  49
ILE D 137
1.39A
None
None
APR  D 201 (-3.3A)
APR  D 201 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B  88
GLU B  25
ILE B  23
1.18A
None
None
APR  B 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 164
ALA C 134
ALA C  38
VAL C  49
ILE C 137
1.37A
None
None
APR  C 201 (-3.4A)
APR  C 201 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU B  88
GLU B  25
ILE B  23
1.21A
None
None
EDO  B 202 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 140
ALA B 124
ALA B 112
THR B  13
ILE B  18
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 164
ALA B 134
ALA B  38
VAL B  49
ILE B 137
1.37A
None
EDO  B 204 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 140
ALA C 124
ALA C 112
THR C  13
ILE C  18
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU A  88
GLU A  25
ILE A  23
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  12
ALA A  52
VAL A  24
VAL B 155
ILE B  18
1.47A
None
None
None
EDO  B 202 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 164
ALA A 134
ALA A  38
VAL A  49
ILE A 137
1.35A
None
EDO  A 205 (-4.0A)
MES  A 201 (-3.5A)
None
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C 164
ALA C 134
ALA C  38
VAL C  49
ILE C 137
1.40A
None
None
MES  C 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU A 140
ALA A 124
ALA A 112
THR A  13
ILE A  18
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		3 / 3
LEU C  88
GLU C  25
ILE C  23
1.18A
None
None
EDO  C 206 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
THR A 199
LEU A 287
PHE A 230
ALA A 206
ILE A 281
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
ALA C  65
VAL C  66
VAL C   6
THR C   9
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 340
VAL A 342
ALA A 379
VAL A 338
THR A 344
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 123
ALA A 399
VAL A 398
THR A 344
ILE B 107
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP8
(SARS-CoV-2)		5 / 12
LEU D 117
ASN D 118
ALA D 188
ALA D 150
VAL D 160
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
ALA B 188
VAL A 405
THR B 137
THR B 141
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 123
ALA A 399
VAL A 398
THR A 344
ILE B 107
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 567
VAL A 535
ALA A 660
VAL A 373
VAL A 299
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
ASN A 568
VAL A 535
ALA A 660
ALA A 376
VAL A 373
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL A 405
THR B 137
ILE B 172
THR B 141
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
ALA A 690
ALA A 639
THR A 586
ILE A 589
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
ALA B 188
ALA A 400
THR B 137
THR B 141
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
PHE A 165
ALA A 176
THR A 462
ILE A 244
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
ALA A 706
ALA A 699
THR A 769
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
ALA C  65
VAL C  66
VAL C   6
THR C   9
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
THR A 199
LEU A 287
PHE A 230
ALA A 206
ILE A 281
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 116
VAL A 125
THR A 292
ILE A 106
MET A 130
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASN A 568
VAL A 535
ALA A 660
ALA A 376
VAL A 373
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 123
ALA A 399
VAL A 398
THR A 344
ILE B 107
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
ALA A 690
ALA A 639
THR A 586
ILE A 589
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL A 405
THR B 137
ILE B 172
THR B 141
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 680
ALA A 685
ALA A 558
VAL A 557
ILE A 589
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
THR C   9
PHE C  49
VAL C  53
ALA C  48
ILE D 107
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 567
VAL A 535
ALA A 660
VAL A 373
VAL A 299
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
LEU C  35
VAL C  22
VAL C   6
ILE C  39
THR C   9
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
THR A 565
ASN A 568
ALA A 660
ALA A 376
VAL A 373
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ASN A 356
VAL A 341
ALA A 379
VAL A 335
VAL B 115
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		7bv1 NSP8
(SARS-CoV-2)		3 / 3
LEU D 128
GLU D 155
ILE D 156
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 124
ALA A 399
VAL A 398
ILE B 107
THR A 344
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
PHE A 165
ALA A 176
THR A 462
ILE A 244
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		7bv2 NSP8
(SARS-CoV-2)		3 / 3
LEU B 128
GLU B 155
ILE B 156
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 130
VAL A 405
THR B 137
ILE B 172
THR B 141
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 701
ALA A 762
ALA A 777
VAL A 776
THR A 586
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 123
ALA A 399
VAL A 398
THR A 344
ILE B 107
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 801
PHE A 753
VAL A 776
MET A 756
THR A 586
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 245
ALA A 185
VAL A 128
ILE A 244
MET A 124
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
THR A 567
ALA A 660
ALA A 376
VAL A 373
VAL A 299
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
THR B 124
ALA A 399
VAL A 398
THR A 344
ILE B 107
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 693
ALA A 690
ALA A 639
THR A 586
ILE A 589
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		6 / 12
THR A 567
VAL A 535
ALA A 660
ALA A 376
VAL A 373
VAL A 299
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 753
VAL A 776
VAL A 587
MET A 756
THR A 586
1.47A
None