Ligand ID: CYS


Drugbank ID:
DB00151
(L-Cysteine)


Indication:
For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen

Get human targets for CYS in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CYS' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ALA C1080
ASN A 914
HIS C1088
THR C1120
1.57A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6vxs NSP3
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ALA C1080
ASN A 914
HIS C1088
THR C1120
1.55A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ALA B1080
ASN C 914
HIS B1088
THR B1120
1.55A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w02 NSP3
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.71A20.15
APR  B 201 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w4h NSP16
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.45A20.58
None
None
None
ACT  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.45A16.26
None
None
None
KCX  A6935 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w6y NSP3
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.76A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ALA C7002
HIS C7023
ARG C7030
THR C6970
1.45A15.69
None
None
None
FMT  C7107 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.45A15.69
None
None
None
FMT  A7103 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
ALA C 107
ASN C 109
HIS C  89
THR C  90
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
ALA A 153
ASN A 156
ARG A  82
HIS A 175
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
ALA B 107
ASN B 109
HIS B  89
THR B  90
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
ALA A 107
ASN A 109
HIS A  89
THR A  90
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wcf NSP3
(SARS-CoV-2)		4 / 8
ALA A  52
HIS A  94
ASN A  37
THR A  57
1.76A
MES  A 202 (-4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wey NSP3
(SARS-CoV-2)		4 / 8
ALA A 256
HIS A 298
ASN A 241
THR A 261
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA C7002
HIS C7023
ARG C7030
THR C6970
1.46A
None
None
None
FMT  C7104 (-3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.44A
None
None
None
FMT  A7103 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.45A
None
None
None
FMT  A7105 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ALA C7002
HIS C7023
ARG C7030
THR C6970
1.45A
None
None
None
FMT  C7104 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ALA D  52
HIS D  94
ASN D  37
THR D  57
1.70A
APR  D 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.70A
APR  B 201 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ALA A  52
HIS A  94
ASN A  37
THR A  57
1.73A
APR  A 201 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ALA C  52
HIS C  94
ASN C  37
THR C  57
1.72A
APR  C 201 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA A7002
HIS A7023
ARG A7030
THR A6970
1.46A
None
None
None
GTA  A7102 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
ALA A 153
ASN A 156
ARG A  82
HIS A 175
1.38A
None
None
None
PO4  A 504 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA A  52
HIS A  94
ASN A  37
THR A  57
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA C  89
ASN D  20
HIS C  86
THR C  57
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA E  52
HIS E  94
ASN E  37
THR E  57
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA E  52
HIS E  94
ASN E  37
THR E  57
1.72A
APR  E 201 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA C  52
HIS C  94
ASN C  37
THR C  57
1.74A
APR  C 201 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA A  52
HIS A  94
ASN A  37
THR A  57
1.73A
APR  A 201 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA C  89
ASN D  20
HIS C  86
THR C  57
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA D  52
HIS D  94
ASN D  37
THR D  57
1.72A
EDO  D 204 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.75A
APR  B 201 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA C  52
HIS C  94
ASN C  37
THR C  57
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA A  52
HIS A  94
ASN A  37
THR A  57
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ALA B  52
HIS B  94
ASN B  37
THR B  57
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ALA A 634
ASN A 691
ARG A 631
HIS A 572
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ALA A 634
ASN A 691
ARG A 631
HIS A 572
1.75A
None