Ligand ID: COC


Drugbank ID:
DB00907
(Cocaine)


Indication:
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

Get human targets for COC in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'COC' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
LEU F 945
LEU F 938
SER D 937
GLU F1182
1.51A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
TYR B 113
TYR B  88
GLN B 161
ILE B  75
1.71A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
TYR A 286
LEU A 251
LEU A 241
1.67A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A 625
TYR A 458
TYR A 787
TYR A 175
1.48A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A  97
ARG A 116
TYR A 237
PHE A 192
1.54A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A 250
ARG A 183
TYR A 237
PHE A 287
1.42A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A 660
TYR A 346
TYR A 453
TYR A 456
1.49A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 237
LEU A 316
LEU A 241
GLU A 254
1.76A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP12
(SARS-CoV-2)		4 / 8
HIS A 347
TYR A 273
SER A 318
GLU A 278
1.56A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 316
LEU A 241
GLU A 254
1.67A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
CYH A 669
TYR A 674
THR A 556
GLN A 408
1.77A13.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 11
VAL B 131
ASP A 390
GLY A 446
PHE A 407
SER A 451
1.48A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 251
LEU A 241
GLU A 180
1.54A13.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6m71 NSP8
(SARS-CoV-2)		4 / 8
TYR B 138
LEU B 184
SER B 177
GLU B 171
1.72A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A  34
TYR A 129
TYR A 732
TYR A 728
1.76A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 11
PHE A 222
ALA A  95
VAL A 234
TYR A 238
GLY A 203
1.71A20.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6m71 NSP12
(SARS-CoV-2)		4 / 7
ALA A 130
TYR A 129
TYR A 788
PHE A  45
1.79A11.48

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR B 873
LEU B1034
SER B1030
GLU B 780
1.53A9.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE A 970
ALA C 570
TYR A 741
GLY B 757
GLY A 999
1.56A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR B 279
GLU B 224
TYR B  38
PRO B  39
1.52A11.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ALA B 520
TYR C  37
TYR C 204
PHE B 562
1.40A11.08
11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR B 873
LEU B1034
SER B1030
GLU B 780
1.54A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE B 275
ASP B  53
VAL B 193
TYR B  37
GLY B  35
1.72A18.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
PHE A 275
ASP A  53
VAL A 193
TYR A  37
GLY A  35
1.66A18.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 873
LEU A1034
SER A1030
GLU A 780
1.50A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
ALA C 520
TYR A  37
TYR A 204
PHE C 562
1.47A11.08
11.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 279
GLU A 224
TYR A  38
PRO A  39
1.62A11.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 6
TYR B 112
TYR B  87
GLN B 160
ILE B  74
1.71A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w37 PROTEIN 7A
(SARS-CoV-2)		4 / 8
HIS A   4
LEU A  16
LEU A   2
GLU A  18
1.80A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
ALA C 397
TYR C 365
TYR C 369
PHE C 342
1.76A24.20
22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w4h NSP16
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.48A21.38
21.97
None
None
None
ACT  A7103 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A6851
LEU A7004
LEU A6855
TRP A6987
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.49A20.80
21.17
None
None
None
KCX  A6935 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
TYR A7026
TYR A6813
GLN A6801
ILE A7035
1.70A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w75 NSP16
(SARS-CoV-2)		4 / 7
ALA C6990
TYR C7026
ARG C7030
TYR C6930
1.48A22.71
23.74
None
None
None
FMT  C7107 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w75 NSP16
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.46A22.71
23.74
None
None
None
FMT  A7103 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR C6851
LEU C7004
LEU C6855
TRP C6987
1.69A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TYR A6851
LEU A7004
LEU A6855
TRP A6987
1.76A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR C 251
LEU C 253
SER C 262
GLU C 263
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 310
LEU A 234
SER A 239
GLU A 238
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 154
LEU A  80
LEU A 150
GLU A  67
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR B 154
LEU B 117
LEU B 132
GLU B 143
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR B 310
LEU B 234
SER B 239
GLU B 238
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 154
TYR A  83
LEU A  87
GLU A 143
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
TYR C 296
TYR C 251
LEU C 253
SER C 262
GLU C 263
1.76A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR C 310
LEU C 234
SER C 239
GLU C 238
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
ALA B 139
ARG B 138
TYR B  72
TYR B 154
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ALA D 308
GLY C 321
PHE D 286
SER C 318
GLY D 284
1.71A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ALA B 308
GLY A 321
PHE B 286
SER A 318
GLY B 284
1.74A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ALA F 308
GLY E 321
PHE F 286
SER E 318
GLY F 284
1.74A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
ALA E 308
GLY F 321
PHE E 286
SER F 318
GLY E 284
1.74A10.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
TYR A7026
TYR A6813
GLN A6801
ILE A7035
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ALA C6990
TYR C7026
ARG C7030
TYR C6930
1.49A
None
None
None
FMT  C7104 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.48A
None
None
None
FMT  A7103 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TYR A6851
LEU A7004
LEU A6855
TRP A6987
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
HIS C 145
TYR C 112
LEU B 104
SER B 105
1.60A
 ZN  C 201 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		4 / 6
TYR A7026
TYR A6813
GLN A6801
ILE A7035
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wkq NSP16
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.46A
None
None
None
FMT  A7105 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TYR C6851
LEU C7004
LEU C6855
TRP C6987
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TYR A6851
LEU A7004
LEU A6855
TRP A6987
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wkq NSP16
(SARS-CoV-2)		4 / 7
ALA C6990
TYR C7026
ARG C7030
TYR C6930
1.48A
None
None
None
FMT  C7104 ( 4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
TYR B 325
TYR B 180
LEU B 143
LEU B  76
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
TYR A 325
TYR A 180
LEU A 143
LEU A  76
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ALA A6990
TYR A7026
ARG A7030
TYR A6930
1.48A
None
None
None
GTA  A7102 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 209
LEU A 287
LEU A 205
GLU A 270
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
ALA A  86
TYR A  83
TYR A 171
PHE A  79
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
ALA A 144
ARG A 138
TYR A  72
TYR A 154
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
ALA A 139
ARG A 138
TYR A  72
TYR A 154
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6xez NSP12
NSP13
(SARS-CoV-2)		4 / 8
TYR E  93
LEU E  92
LEU A 900
SER A 904
1.49A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
TYR B 149
LEU B 128
LEU B 153
GLU A  50
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  46
TYR A  71
SER A  11
GLY A 107
1.71A13.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 351
LEU A 455
LEU A 452
SER A 494
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE E 429
ASP E 398
ALA E 397
TYR E 423
GLY E 431
1.78A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 351
LEU A 455
LEU A 452
GLU A 484
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE A 429
ASP A 398
ALA A 397
TYR A 423
GLY A 431
1.79A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
PHE E 429
ASP E 398
ALA E 397
TYR E 423
GLY E 431
1.77A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 11
PHE E 486
ALA B  88
TYR E 489
GLY B 178
GLY E 485
1.77A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
PHE A 156
ASP A 157
VAL B 144
ASP B 145
PHE B 168
1.48A15.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
TYR A 209
LEU A 271
LEU A 205
GLU A 270
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A  34
TYR A 129
TYR A 732
TYR A 728
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 746
TYR A 748
SER A 754
GLU A 610
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
CYH A 669
TYR A 674
THR A 556
GLN A 408
1.76A13.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
HIS A 347
TYR A 273
SER A 318
GLU A 278
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A  97
ARG A 116
TYR A 237
PHE A 192
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 237
LEU A 187
LEU A 241
GLU A 180
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A  97
TYR A 217
ARG A 116
TYR A  69
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 237
LEU A 316
LEU A 241
GLU A 254
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A 250
ARG A 183
TYR A 237
PHE A 287
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 374
LEU A 366
SER A 367
GLU A 522
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 251
LEU A 241
GLU A 180
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
TYR A 286
LEU A 251
LEU A 241
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A 625
TYR A 458
TYR A 787
TYR A 175
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A 660
TYR A 346
TYR A 453
TYR A 456
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP8
(SARS-CoV-2)		4 / 8
TYR B 138
LEU B 184
SER B 177
GLU B 171
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP8
(SARS-CoV-2)		4 / 8
TYR D 138
LEU D 184
SER D 177
GLU D 171
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7btf NSP12
(SARS-CoV-2)		4 / 7
ALA A 130
TYR A 129
TYR A 788
PHE A  45
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 770
LEU A 749
LEU A 775
GLU A 744
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 316
LEU A 241
GLU A 254
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ALA A 660
TYR A 346
TYR A 453
TYR A 456
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 770
LEU A 749
LEU A 775
GLU A 744
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 251
LEU A 241
GLU A 180
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ALA A  34
TYR A 129
TYR A 732
TYR A 728
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 653
ARG A 533
TYR A 530
TYR A 374
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ALA A 625
TYR A 458
TYR A 787
TYR A 175
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ALA A 250
ARG A 183
TYR A 237
PHE A 287
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
TYR A 286
LEU A 251
LEU A 241
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ASP A 377
ALA A 376
TYR A 530
SER A 343
GLY A 345
1.55A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 347
TYR A 273
SER A 318
GLU A 278
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
HIS A 892
LEU A 895
LEU A 907
GLU A 857
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 316
LEU A 241
GLU A 254
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 237
LEU A 316
LEU A 241
GLU A 254
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ALA A 130
TYR A 129
TYR A 788
PHE A  45
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
PHE A 222
ALA A  95
VAL A 234
TYR A 238
GLY A 203
1.78A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
CYH A 669
TYR A 674
THR A 556
GLN A 408
1.78A13.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
TYR B 138
LEU B 184
SER B 177
GLU B 171
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ASP A 208
ALA A 125
VAL A 204
ASP A 221
GLY A  44
1.62A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 653
ARG A 533
TYR A 530
TYR A 374
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A 660
TYR A 346
TYR A 453
TYR A 456
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 770
LEU A 749
LEU A 775
GLU A 744
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
TYR A 286
LEU A 251
LEU A 241
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 251
LEU A 241
GLU A 180
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A  34
TYR A 129
TYR A 732
TYR A 728
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
HIS A 347
TYR A 273
SER A 318
GLU A 278
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 237
LEU A 316
LEU A 241
GLU A 254
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 238
LEU A 316
LEU A 241
GLU A 254
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
CYH A 669
TYR A 674
THR A 556
GLN A 408
1.72A13.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A 625
TYR A 458
TYR A 787
TYR A 175
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A 250
ARG A 183
TYR A 237
PHE A 287
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A  97
TYR A 217
ARG A 118
TYR A 149
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
HIS A 892
LEU A 895
LEU A 907
GLU A 857
1.66A
None
None
None
U  T  17 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
PHE A 222
ALA A  95
VAL A 234
TYR A 238
GLY A 203
1.79A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP8
(SARS-CoV-2)		4 / 8
TYR B 138
LEU B 184
SER B 177
GLU B 171
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
TYR A 867
TYR A 915
LEU A 829
GLU A 919
1.76A
None
U  T  16 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ALA A 130
TYR A 129
TYR A 788
PHE A  45
1.75A
None