Ligand ID: CIO


Drugbank ID:
DB03849
(Cilomilast)


Indication:
Investigated for use/treatment in chronic obstructive pulmonary disease (COPD).

Get human targets for CIO in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CIO' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.64A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D 959
ILE F1169
PHE F 970
SER D 968
GLN D 965
1.42A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU F 966
ASN D 969
ILE F 973
SER E 974
PHE E 970
1.67A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D 959
ILE F1169
PHE F 970
SER D 968
GLN D 965
1.37A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.77A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D 164
MET D  82
LEU D  58
THR D  21
PHE D  66
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS B 164
MET B  82
LEU B  58
THR B  21
PHE B  66
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.77A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C 164
MET C  82
LEU C  58
THR C  21
PHE C  66
1.70A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.65A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C  60
LEU C  57
THR B 166
ILE A  95
GLN B  71
1.48A16.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C  60
LEU C  57
THR B 166
ILE A  95
GLN B  71
1.50A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.68A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  87
THR A 540
ILE A 539
PHE A 504
PHE A 506
1.65A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m71 NSP12
(SARS-CoV-2)		5 / 12
HIS A 309
LEU A 351
ASN A 297
SER A 649
PHE A 652
1.63A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.73A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
HIS C1048
LEU C 916
THR C 719
ILE C 720
GLN C 926
1.67A14.71
None
None
None
None
NAG  C1309 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR B1047
ILE B 909
PHE B 906
MET B 902
GLN B1036
1.68A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR C1047
ILE C 909
PHE C 906
MET C 902
GLN C1036
1.72A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A1047
ILE A 909
PHE A 906
MET A 902
GLN A1036
1.65A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A1047
ILE A 909
PHE A 906
MET A 902
GLN A1036
1.69A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
HIS A1048
LEU A 916
THR A 719
ILE A 720
GLN A 926
1.53A13.65
None
None
None
None
NAG  A1312 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR A1047
ILE A 909
PHE A 906
MET A 902
GLN A1036
1.73A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
TYR C1047
ILE C 909
PHE C 906
MET C 902
GLN C1036
1.67A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
HIS B 145
HIS A  59
LEU B 113
THR B 148
ILE B 146
1.63A16.17
 ZN  B 201 ( 3.3A)
ZN  B 201 ( 3.3A)
None
None
ZN  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
HIS D  59
THR A 115
ILE A 146
SER A  51
PHE A 110
1.64A16.17
 ZN  A 204 ( 3.1A)
None
MES  A 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.71A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 145
HIS B  59
LEU C 113
THR C 148
ILE C 146
1.61A14.59
 ZN  C 201 (-3.4A)
ZN  C 201 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 145
HIS C  59
THR D 148
ILE D 146
PHE D 110
1.67A14.59
 ZN  D 202 (-3.4A)
ZN  D 202 (-3.2A)
None
MES  D 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 145
HIS C  59
LEU D 113
THR D 148
ILE D 146
1.55A14.59
 ZN  D 202 (-3.4A)
ZN  D 202 (-3.2A)
None
None
MES  D 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 145
HIS A  59
LEU B 113
THR B 148
ILE B 146
1.69A14.59
 ZN  B 202 (-3.3A)
ZN  B 202 (-2.6A)
None
None
MES  B 201 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 145
HIS C  59
LEU D 113
ILE D 146
SER D  51
1.74A14.59
 ZN  D 202 (-3.4A)
ZN  D 202 (-3.2A)
None
MES  D 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.73A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6y84 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.63A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.64A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.66A22.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.72A22.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.69A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
LEU A 372
ILE A 539
SER A 501
1.62A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  87
ILE A 539
PHE A 504
SER A 501
PHE A 506
1.64A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  87
LEU A 372
ILE A 539
SER A 501
PHE A 506
1.71A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
LEU A 372
ILE A 539
SER A 501
1.52A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  90
THR A 538
ILE A 539
PHE A 504
PHE A 506
1.71A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  87
LEU A 372
ILE A 539
SER A 501
PHE A 506
1.71A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
LEU A 372
ILE A 539
SER A 501
1.59A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  87
LEU A 372
ILE A 539
SER A 501
PHE A 506
1.73A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A 164
MET A  82
LEU A  58
THR A  21
PHE A  66
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  90
THR A 538
ILE A 539
PHE A 504
PHE A 506
1.63A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.70A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
THR A 540
ILE A 539
SER A 501
1.69A18.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
HIS A 381
MET B  87
LEU A 372
THR A 540
SER A 501
1.56A18.03
None
None
None
None
U  T   9 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
MET B  90
THR A 538
ILE A 539
PHE A 504
PHE A 506
1.72A19.15
None