Ligand ID: CED


Drugbank ID:
DB04133
(Degraded Cephaloridine)


Indication:

Get human targets for CED in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CED' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
SER F 967
ASN D 969
GLN D 965
SER F1170
GLY F1171
1.50A23.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6lzg ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER A  19
TYR A  83
GLY B 476
ALA B 475
TYR B 489
1.61A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
TYR D  83
GLU D  23
THR F 478
GLY F 476
ALA F 475
1.50A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA D 153
TYR A 112
ASN D 154
GLY A 121
ALA A 120
1.62A20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.44A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.51A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 892
SER B 884
GLU A1072
GLY B 891
TYR A1047
1.59A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 879
ASN B 703
ILE C 788
SER C 884
GLY C 880
1.68A11.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 703
SER B 884
THR B 887
GLY B 891
ALA B 892
1.45A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 703
SER B 884
THR B 887
GLY B 891
ALA B 892
1.39A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ALA A 653
TYR A 612
LYS A 640
GLY A 652
ALA A 609
1.72A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 703
SER B 884
THR B 887
GLY B 891
ALA B 892
1.41A11.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 879
ASN B 703
SER C 884
THR C 881
ALA C 876
1.72A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 879
ASN A 703
SER B 884
THR B 881
ALA B 876
1.75A11.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN C 703
SER A 884
THR A 887
GLY A 891
ALA A 892
1.71A11.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 879
ASN A 703
SER B 884
THR B 881
ALA B 876
1.71A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN C 703
SER A 884
THR A 887
GLY A 891
ALA A 892
1.66A12.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN C 703
SER A 884
THR A 887
GLY A 891
ALA A 892
1.73A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER B 884
ASN A 703
THR B 887
GLY B 891
ALA B 892
1.78A12.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6w02 NSP3
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.65A23.60
APR  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6w02 NSP3
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.72A23.60
APR  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
SER C 477
THR C 478
GLY C 476
ALA C 475
TYR C 489
1.74A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 11
ALA B  17
ASN B  28
THR B  19
GLY B  18
ALA B  23
1.70A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  17
ASN B  28
THR B  19
GLY B  18
ALA B  23
1.69A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  17
ASN B  28
THR B  19
GLY B  18
ALA B  23
1.66A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6w4h NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.80A20.27
None
SAM  A7102 ( 4.5A)
SAM  A7102 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.75A20.69
SAM  A7102 ( 4.5A)
SAM  A7102 (-4.5A)
SAM  A7102 (-3.6A)
SAM  A7102 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.71A
SAM  A7104 (-4.4A)
SAM  A7104 (-4.6A)
SAM  A7104 (-3.3A)
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.75A
None
SAM  A7104 (-4.4A)
SAM  A7104 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.71A
SAM  A7104 (-4.4A)
SAM  A7104 (-4.6A)
SAM  A7104 (-3.3A)
SAM  A7104 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.68A
MES  B 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.75A
MES  B 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.79A19.92
None
SAM  C7105 ( 4.4A)
SAM  C7105 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.76A19.69
SAM  A7102 ( 4.6A)
SAM  A7102 ( 4.5A)
SAM  A7102 ( 3.4A)
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.75A19.69
SAM  A7102 ( 4.6A)
SAM  A7102 ( 4.5A)
SAM  A7102 ( 3.4A)
SAM  A7102 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6872
TYR C6845
ASN C6841
GLY C6871
ALA C6870
1.74A19.69
SAM  C7105 ( 4.4A)
SAM  C7105 ( 4.5A)
SAM  C7105 ( 3.7A)
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6872
TYR C6845
ASN C6841
GLY C6871
ALA C6870
1.74A19.69
SAM  C7105 ( 4.4A)
SAM  C7105 ( 4.5A)
SAM  C7105 ( 3.7A)
SAM  C7105 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 136
GLU A 143
THR A 102
GLY A 142
ALA A 141
1.55A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN C 146
GLU C 143
THR C 102
GLY C 142
ALA C 141
1.68A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
TYR C 136
GLU C 143
THR C 102
GLY C 142
ALA C 141
1.53A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 114
SER B 103
ASN B 110
GLY B 287
TYR A 268
1.78A
 CL  B 502 ( 3.8A)
CL  B 502 ( 4.4A)
None
CL  B 502 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA B 114
SER B 103
ASN B 110
GLY B 287
TYR A 268
1.78A
 CL  B 502 ( 3.8A)
CL  B 502 ( 4.4A)
None
CL  B 502 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.73A
MES  A 201 ( 3.0A)
None
None
None
MES  A 201 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.67A
MES  A 201 ( 3.0A)
None
None
None
MES  A 201 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6wen NSP3
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 254
TYR A 272
SER A 269
ASN A 241
ALA A 243
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6wey NSP3
(SARS-CoV-2)		5 / 11
ALA A 254
TYR A 272
SER A 269
ASN A 241
ALA A 243
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6wiq NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.70A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wiq NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6wiq NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.67A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6wiq NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 313
SER E 312
TYR F 268
GLY E 316
ARG F 277
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6872
TYR C6845
ASN C6841
GLY C6871
ALA C6870
1.79A
SAH  C7102 (-4.7A)
SAH  C7102 (-4.6A)
SAH  C7102 (-3.7A)
SAH  C7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.77A
None
SAH  C7102 (-4.7A)
SAH  C7102 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.77A
SAH  A7102 ( 4.6A)
SAH  A7102 (-4.6A)
SAH  A7102 (-3.6A)
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.78A
SAH  A7102 ( 4.6A)
SAH  A7102 (-4.6A)
SAH  A7102 (-3.6A)
SAH  A7102 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.78A
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 156
ASN C 150
ASN C 154
LYS A 156
ALA B 155
1.72A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 156
ASN C 150
ASN C 154
LYS A 156
ALA B 155
1.72A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.77A
SFG  A7103 ( 4.5A)
SFG  A7103 ( 4.6A)
FMT  A7104 ( 3.1A)
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
ALA C6877
SER C6872
ASN C6841
GLY C6875
ARG D4331
1.79A
None
SFG  C7103 ( 4.5A)
FMT  C7112 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6872
TYR C6845
ASN C6841
GLY C6871
ALA C6870
1.76A
SFG  C7103 ( 4.5A)
SFG  C7103 ( 4.5A)
FMT  C7112 ( 3.3A)
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6872
TYR C6845
ASN C6841
GLY C6871
ALA C6870
1.76A
SFG  C7103 ( 4.5A)
SFG  C7103 ( 4.5A)
FMT  C7112 ( 3.3A)
SFG  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.76A
SFG  A7103 ( 4.5A)
SFG  A7103 ( 4.6A)
FMT  A7104 ( 3.1A)
SFG  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.71A
APR  D 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.66A
APR  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.73A
APR  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.67A
APR  B 201 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.64A
APR  D 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.64A
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.71A
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.74A
APR  B 201 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.74A
SO4  A7109 (-4.5A)
SAH  A7101 (-4.5A)
SO4  A7109 ( 3.2A)
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6872
TYR A6845
ASN A6841
GLY A6871
ALA A6870
1.75A
SO4  A7109 (-4.5A)
SAH  A7101 (-4.5A)
SO4  A7109 ( 3.2A)
SAH  A7101 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ALA A6877
SER A6872
ASN A6841
GLY A6875
ARG B4331
1.77A
None
SO4  A7109 (-4.5A)
SO4  A7109 ( 3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.55A20.00
None
None
EDO  B 301 (-3.9A)
EDO  B 302 ( 4.3A)
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.60A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.58A20.00
None
None
EDO  B 301 (-3.9A)
EDO  B 302 ( 4.3A)
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.55A20.00
None
None
EDO  B 301 (-3.9A)
EDO  B 302 ( 4.3A)
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.60A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.63A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER B 151
ASN B 109
ASN B 105
ALA B 152
ARG B 190
1.58A
None
None
EDO  B 301 (-3.9A)
EDO  B 302 ( 4.3A)
EDO  B 302 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		6wqd NSP8
(SARS-CoV-2)		5 / 12
SER D 151
TYR D 149
ASN D 105
ALA D 152
ARG D 190
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.59A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.62A17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
SER D 151
ASN D 109
ASN D 105
ALA D 152
ARG D 190
1.59A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 530
ASN A 334
ASN A 532
GLY A 526
ALA A 363
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 477
THR A 478
GLY A 476
ALA A 475
TYR A 489
1.57A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 477
THR E 478
GLY E 476
ALA E 475
TYR E 489
1.61A24.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER E 477
THR E 478
GLY E 476
ALA E 475
TYR E 489
1.61A24.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A 477
THR A 478
GLY A 476
ALA A 475
TYR A 489
1.61A24.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.77A
EDO  D 206 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.71A
EDO  D 206 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E  50
TYR E  68
SER E  65
ASN E  37
ALA E  39
1.68A
EPE  E 202 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E  50
TYR E  68
SER E  65
ASN E  37
ALA E  39
1.75A
EPE  E 202 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.78A
APR  D 201 (-3.6A)
EDO  D 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.71A
APR  B 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  50
TYR D  68
SER D  65
ASN D  37
ALA D  39
1.71A
APR  D 201 (-3.6A)
EDO  D 202 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.77A
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.67A
APR  C 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.70A
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.74A
APR  C 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA E  50
TYR E  68
SER E  65
ASN E  37
ALA E  39
1.75A
APR  E 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E  50
TYR E  68
SER E  65
ASN E  37
ALA E  39
1.68A
APR  E 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.78A
APR  B 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.69A
MES  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.77A
MES  C 201 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA A  50
TYR A  68
SER A  65
ASN A  37
ALA A  39
1.76A
MES  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
ALA B  50
TYR B  68
SER B  65
ASN B  37
ALA B  39
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  50
TYR C  68
SER C  65
ASN C  37
ALA C  39
1.70A
MES  C 201 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
GLY A 559
ALA A 558
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
HIS A 381
GLY A 385
ALA A 399
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
HIS A 381
GLY A 385
ALA A 399
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 399
1.77A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
LYS B  97
GLY A 385
ALA A 382
1.65A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
GLY A 559
ALA A 558
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
GLY A 559
ALA A 558
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 501
ASN A 507
ASN A 543
GLY A 559
ALA A 558
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 501
ASN A 507
ASN A 543
GLY A 559
ALA A 558
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		7bv2 NSP8
(SARS-CoV-2)		5 / 11
ALA B 102
ASN B 109
ASN B 105
THR B 123
ARG B 190
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.54A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.61A
None
U  T   9 ( 3.7A)
None
U  T  10 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
HIS A 381
GLY A 385
ALA A 399
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 383
SER A 384
HIS A 381
GLY A 385
ALA A 399
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 660
ASN A 534
SER A 343
ASN A 356
ASN A 657
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
TYR A 453
ASN A 543
THR A 540
GLY A 559
ALA A 558
1.69A
None
U  T   9 ( 3.7A)
None
U  T  10 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		7bv2 NSP8
(SARS-CoV-2)		5 / 10
ALA B 102
ASN B 109
ASN B 105
THR B 123
ARG B 190
1.79A20.65
None