Ligand ID: CDX


Drugbank ID:
DB00380
(Dexrazoxane)


Indication:
For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.

Get human targets for CDX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CDX' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5r7y 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.37A18.76
JFM  A1001 (-3.8A)
JFM  A1001 ( 3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.46A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.77A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.67A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.67A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.41A16.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.38A19.04
ALC  D   2 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.40A19.04
ALC  D   2 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.40A19.04
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.44A19.04
N0A  D   2 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.67A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.67A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS D  41
THR D  25
ASN D 119
GLN D  19
1.55A18.76
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR B  98
TYR B 101
TYR B  37
LEU B  30
1.69A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS B  41
THR B  25
ASN B 119
GLN B  19
1.48A18.76
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR C  98
TYR C 101
TYR C  37
LEU C  30
1.67A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS C  41
THR C  25
ASN C 119
GLN C  19
1.40A18.76
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR C  98
TYR C 101
TYR C  37
LEU C  30
1.68A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS D  41
THR D  25
ASN D 119
GLN D  19
1.59A18.76
3WL  D 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR B  98
TYR B 101
TYR B  37
LEU B  30
1.69A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR D  98
TYR D 101
TYR D  37
LEU D  30
1.71A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS B  41
THR B  25
ASN B 119
GLN B  19
1.43A18.76
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS C  41
THR C  25
ASN C 119
GLN C  19
1.43A18.76
3WL  C 401 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.47A18.76
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.40A18.76
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.70A18.76
3WL  A 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR D  98
TYR D 101
TYR D  37
LEU D  30
1.71A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS B  41
TYR B  54
ASN B  51
LEU B  57
1.73A18.76
3WL  B 401 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.70A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.70A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.49A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.46A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.79A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m71 NSP12
(SARS-CoV-2)		4 / 7
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.46A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m71 NSP12
(SARS-CoV-2)		5 / 7
HIS A 816
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.77A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6m71 NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.58A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6m71 NSP12
(SARS-CoV-2)		4 / 7
THR A 248
TYR A 175
ASN A 791
LEU A 172
1.53A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6vxs NSP3
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.64A
NHE  B 203 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6vxs NSP3
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.70A
NHE  A 202 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.54A
None
SAM  A7104 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.46A
None
SAM  A7104 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.67A
KCX  A6935 (-4.0A)
KCX  A6935 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.76A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6889
ASN A6862
TYR A6861
LEU A7052
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR A6889
ASN A6862
TYR A6861
LEU A7052
1.75A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.67A
KCX  A6935 (-4.0A)
KCX  A6935 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.54A
X77  A 401 (-3.2A)
X77  A 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.48A
X77  A 401 (-3.2A)
X77  A 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w6y NSP3
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ASN C7025
TYR C6813
LEU C6812
GLN C6816
1.71A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ASN C7025
TYR C6813
LEU C6812
GLN C6816
1.76A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.59A16.14
FMT  C7107 ( 4.3A)
FMT  C7107 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.54A16.14
None
SAM  C7105 ( 4.5A)
FMT  C7108 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.46A16.14
None
SAM  C7105 ( 4.5A)
FMT  C7108 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.44A16.14
None
SAM  A7102 ( 4.5A)
FMT  A7104 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.59A16.14
FMT  C7107 ( 4.3A)
FMT  C7107 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.63A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.68A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.53A16.14
None
SAM  A7102 ( 4.5A)
FMT  A7104 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.64A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w75 NSP16
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.59A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 158
ASN B 109
TYR B 112
LEU B 113
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  10
TYR A  56
TYR A  83
LEU A  80
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B  10
TYR B  56
TYR B  83
LEU B  80
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 311
TYR B 310
ASN B 186
LEU B 234
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 158
ASN C 109
TYR C 112
LEU C 113
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C  10
TYR C  56
TYR C  83
LEU C  80
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 158
ASN B 109
TYR B 112
LEU B 113
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 311
TYR A 310
ASN A 186
LEU A 234
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 158
ASN A 109
TYR A 112
LEU A 113
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B 311
TYR B 310
ASN B 186
LEU B 234
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 311
TYR C 310
ASN C 186
LEU C 234
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C  10
TYR C  56
TYR C  72
LEU C  80
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR B  10
TYR B  56
TYR B  83
LEU B  80
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A 158
ASN A 109
TYR A 112
LEU A 113
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C  10
TYR C  56
TYR C  72
LEU C  80
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  10
TYR A  56
TYR A  83
LEU A  80
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 158
ASN C 109
TYR C 112
LEU C 113
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C 311
TYR C 310
ASN C 186
LEU C 234
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
THR C  10
TYR C  56
TYR C  83
LEU C  80
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wcf NSP3
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wen NSP3
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wey NSP3
(SARS-CoV-2)		4 / 7
THR A 237
ASN A 354
TYR A 356
LEU A 327
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wiq NSP8
(SARS-CoV-2)		4 / 7
THR B 141
TYR B 138
ASN B 136
TYR B 135
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN C7025
TYR C6813
LEU C6812
GLN C6816
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.61A
FMT  C7104 (-4.3A)
FMT  C7104 (-3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.53A
None
SAH  C7102 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.53A
None
SAH  A7102 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.60A
FMT  C7104 (-4.3A)
FMT  C7104 (-3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.61A
FMT  A7103 (-4.2A)
FMT  A7103 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.45A
None
SAH  C7102 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.61A
FMT  A7103 (-4.2A)
FMT  A7103 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.44A
None
SAH  A7102 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.56A
FMT  A7105 ( 4.3A)
FMT  A7105 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ASN C7025
TYR C6813
LEU C6812
GLN C6816
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.58A
FMT  C7104 ( 4.2A)
FMT  C7104 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.46A
None
SFG  C7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS C6867
TYR C6845
ASN C6996
LEU C6848
1.54A
None
SFG  C7103 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.45A
None
SFG  A7103 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS C6972
THR C6970
TYR C6828
LEU C6825
1.58A
FMT  C7104 ( 4.2A)
FMT  C7104 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.53A
None
SFG  A7103 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
THR C6889
ASN C6862
TYR C6861
LEU C7052
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wkq NSP16
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.56A
FMT  A7105 ( 4.3A)
FMT  A7105 ( 3.0A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 179
ASN B  75
TYR B 325
LEU B 190
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR A 179
ASN A  75
TYR A 325
LEU A 190
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR A 179
ASN A  75
TYR A 325
LEU A 190
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
TYR B 179
ASN B  75
TYR B 325
LEU B 190
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.79A
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.42A
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.47A
U5G  A 401 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR D  33
ASN D 150
TYR D 152
LEU D 123
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR C  33
ASN C 150
TYR C 152
LEU C 123
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
ASN A7025
TYR A6813
LEU A6812
GLN A6816
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.48A
GTA  A7102 (-4.2A)
GTA  A7102 (-3.4A)
GTA  A7102 (-3.4A)
GTA  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6972
THR A6970
TYR A6828
LEU A6825
1.50A
GTA  A7102 (-4.2A)
GTA  A7102 (-3.4A)
GTA  A7102 (-3.4A)
GTA  A7102 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.53A
None
SAH  A7101 (-4.5A)
GTA  A7102 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
HIS A6867
TYR A6845
ASN A6996
LEU A6848
1.45A
None
SAH  A7101 (-4.5A)
GTA  A7102 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A  10
TYR A  56
TYR A  83
LEU A  80
1.43A
 CL  A 506 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A  10
TYR A  56
TYR A  83
LEU A  80
1.42A
 CL  A 506 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A 311
TYR A 310
ASN A 186
LEU A 234
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
THR A 311
TYR A 310
ASN A 186
LEU A 234
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A16.41
None
DMS  A 407 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A16.41
None
DMS  A 407 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.78A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.45A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.75A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.40A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR B   0
ASN A 370
TYR B  27
LEU L  53
1.57A
MLI  B 303 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yla HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR H  31
ASN E 388
TYR E 365
LEU E 368
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR H   0
ASN E 370
TYR H  27
LEU C  53
1.61A
MLI  B 303 (-4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yla HEAVY CHAIN
LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR B   0
ASN A 370
TYR B  27
LEU L  53
1.56A
MLI  B 303 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR H  31
ASN E 388
TYR E 365
LEU E 368
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
THR B  31
ASN A 388
TYR A 365
LEU A 368
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.54A
PK8  A 401 (-3.2A)
PK8  A 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.50A
PK8  A 401 (-3.2A)
PK8  A 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR D  33
ASN D 150
TYR D 152
LEU D 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR E  33
ASN E 150
TYR E 152
LEU E 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR C  33
ASN C 150
TYR C 152
LEU C 123
1.68A
EDO  C 207 ( 4.8A)
EDO  C 204 ( 4.5A)
EDO  C 203 (-4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR C  33
ASN C 150
TYR C 152
LEU C 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR D  33
ASN D 150
TYR D 152
LEU D 123
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR E  33
ASN E 150
TYR E 152
LEU E 123
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR A  33
ASN A 150
TYR A 152
LEU A 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR B  33
ASN B 150
TYR B 152
LEU B 123
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
THR C  33
ASN C 150
TYR C 152
LEU C 123
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
TYR A  54
ASN A  51
LEU A  57
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7btf NSP12
(SARS-CoV-2)		4 / 7
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7btf NSP12
(SARS-CoV-2)		4 / 7
THR A 248
TYR A 175
ASN A 791
LEU A 172
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7btf NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7btf NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
THR A  98
TYR A 101
TYR A  37
LEU A  30
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.39A
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 7
HIS A  41
THR A  25
ASN A 119
GLN A  19
1.44A
JRY  A 401 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bv1 NSP12
(SARS-CoV-2)		5 / 7
HIS A 816
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
THR A 148
TYR A 149
ASN A 177
LEU A 127
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bv1 NSP8
(SARS-CoV-2)		4 / 7
THR B 141
TYR B 138
ASN B 136
TYR B 135
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
THR A 148
TYR A 149
ASN A 177
LEU A 127
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
TYR A 831
ASN A 874
TYR A 877
LEU A 869
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
HIS A 816
TYR A 831
TYR A 877
LEU A 869
1.70A
None