Ligand ID: CBL


Drugbank ID:
DB00291
(Chlorambucil)


Indication:
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.

Get human targets for CBL in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CBL' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO B  74
VAL B  73
ARG B  69
TYR B 124
GLY B  86
1.51A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
PRO C  73
VAL C  72
ARG C  68
TYR C 123
GLY C  85
1.51A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6w02 NSP3
(SARS-CoV-2)		5 / 9
PHE B 132
PRO B  98
VAL B 100
GLY B 103
GLY B 133
1.73A21.97
APR  B 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6w6y NSP3
(SARS-CoV-2)		5 / 9
PHE B 132
PRO B  98
VAL B 100
GLY B 103
GLY B 133
1.78A
MES  B 201 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6wcf NSP3
(SARS-CoV-2)		5 / 9
PHE A 132
PRO A  98
VAL A 100
GLY A 103
GLY A 133
1.73A
MES  A 201 (-2.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO A  73
VAL A  72
ARG A  68
TYR A 123
GLY A  85
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO D  73
VAL D  72
ARG D  68
TYR D 123
GLY D  85
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 9
PRO B  73
VAL B  72
ARG B  68
TYR B 123
GLY B  85
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PHE C 132
PRO C  98
VAL C 100
GLY C 103
GLY C 133
1.74A
APR  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PHE A 132
PRO A  98
VAL A 100
GLY A 103
GLY A 133
1.78A
APR  A 201 (-3.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PHE B 132
PRO B  98
VAL B 100
GLY B 103
GLY B 133
1.71A
APR  B 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
PHE D 132
PRO D  98
VAL D 100
GLY D 103
GLY D 133
1.76A
APR  D 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
PRO A  33
VAL A  32
ARG A  28
TYR A  83
GLY A  45
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE D 132
PRO D  98
VAL D 100
GLY D 103
GLY D 133
1.78A
EDO  D 205 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE E 132
PRO E  98
VAL E 100
GLY E 103
GLY E 133
1.78A
EPE  E 202 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE A 132
PRO A  98
VAL A 100
GLY A 103
GLY A 133
1.79A
EDO  A 202 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE B 132
PRO B  98
VAL B 100
GLY B 103
GLY B 133
1.79A
APR  B 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE B 132
PRO B  98
VAL B 100
GLY B 103
GLY B 133
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
PHE C 132
PRO C  98
VAL C 100
GLY C 103
GLY C 133
1.78A
MES  C 201 (-3.6A)
None
None
None
None