Ligand ID: 9TP


Drugbank ID:
DB00444
(Teniposide)


Indication:
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia

Get human targets for 9TP in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '9TP' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		5r81 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A  94
LYS A  90
TYR A  37
LEU A 177
GLY A 179
1.35A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
ALA A 129
TYR A 239
LEU A 286
GLY A 275
1.78A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
ALA A 129
TYR A 239
LEU A 286
GLY A 275
1.79A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU E1186
ALA D1190
LEU D 945
GLY F 946
LYS F 947
1.55A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 262
ALA C 234
ILE C 259
LEU C 250
LEU C 253
1.77A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C  94
LYS C  90
TYR C  37
LEU C 177
GLY C 179
1.63A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
ALA A 129
TYR A 239
LEU A 286
GLY A 275
1.78A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 250
TYR A 175
ILE A 171
LEU A 131
LEU A 142
1.57A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 460
ALA A 250
TYR A 175
ILE A 171
LEU A 131
1.77A20.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 861
ALA A1015
TYR A1007
LEU A 959
GLY A 857
1.41A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 861
ALA A1015
TYR A1007
LEU A 959
GLY A 857
1.38A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 861
ALA C1015
TYR C1007
LEU C 959
GLY C 857
1.55A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 861
ALA C1015
TYR C1007
LEU C 959
GLY C 857
1.52A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B1063
HIS B1048
LEU B 877
LEU B1034
GLY B1035
1.57A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 861
ALA A1015
TYR A1007
LEU A 959
GLY A 857
1.53A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  27
ILE A  18
TYR A   9
LEU B  10
GLY B   8
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6883
ARG C6884
PRO C6888
ILE C6925
LEU C6892
1.68A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.79A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
ARG A6884
PRO A6888
ILE A6925
LEU A6892
1.66A13.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.75A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.74A12.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LYS A 254
ILE A 276
HIS A 275
TYR A 251
LEU A 211
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ALA C 149
TYR C  35
LEU C  80
LEU C  58
GLY C  32
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LYS C 254
ILE C 276
HIS C 275
TYR C 251
LEU C 211
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 353
ALA E 267
ILE A 320
LEU B 291
GLY B 284
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU B 353
ALA E 267
ILE A 320
LEU B 291
GLY B 284
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.76A
FMT  B4403 (-4.7A)
None
FMT  B4403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.78A
FMT  B4403 (-4.7A)
None
FMT  B4403 (-4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
PRO D  73
TYR D  86
ILE D 130
LEU D 113
GLY D 124
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU D4298
ALA C6877
HIS D4301
TYR D4349
GLY D4303
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wkq NSP10
NSP16
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A  94
LYS A  90
TYR A  37
LEU A 177
GLY A 179
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
LEU B4298
ALA A6877
HIS B4301
TYR B4349
GLY B4303
1.77A
None
None
None
None
SO4  B4403 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A  94
LYS A  90
TYR A  37
LEU A 177
GLY A 179
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 208
ALA A 129
TYR A 239
LEU A 286
GLY A 275
1.79A15.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PRO A  33
TYR A  46
ILE A  90
LEU A  73
GLY A  84
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PRO A 128
ALA A 133
ILE A  90
TYR A  47
GLY A  84
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
PRO A 128
ALA A 133
ILE A  90
TYR A  47
GLY A  84
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 169
LYS E 163
TYR E 161
LEU E 153
GLY E   8
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
ARG A 132
ALA A 250
ILE A 145
LEU A 207
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		7btf NSP8
(SARS-CoV-2)		5 / 12
LEU D 184
PRO D 133
ALA D 110
ILE D 156
GLY D 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ARG A  55
ALA A  16
ILE A 114
HIS A  75
LEU A 119
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LYS A  41
ILE A 715
LEU A 708
LEU A 707
GLY A 774
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 460
ALA A 250
TYR A 175
ILE A 171
LEU A 131
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 250
TYR A 175
ILE A 171
LEU A 131
LEU A 142
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 131
ARG A 132
ALA A 250
ILE A 145
LEU A 207
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 460
ALA A 250
TYR A 175
ILE A 171
LEU A 131
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 250
TYR A 175
ILE A 171
LEU A 131
LEU A 142
1.54A
None