Ligand ID: 6ZP


Drugbank ID:
DB08883
(Perampanel)


Indication:
Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.

Get human targets for 6ZP in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '6ZP' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.65A12.72
None
DMS  A 402 (-3.8A)
None
DMS  A 402 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR B 365
PHE B 374
SER B 399
SER B 371
1.39A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER B 438
ASP B 442
PHE B 497
ASN B 437
1.46A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 10
SER E 438
ASP E 442
TYR E 495
ASN E 450
PHE E 347
1.27A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 9
SER E 438
ASP E 442
TYR E 495
PHE E 347
SER E 375
1.51A14.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 9
SER F 438
ASP F 442
TYR F 495
PHE F 347
SER F 375
1.71A15.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER B 123
TYR B 126
SER D 301
SER D 113
1.72A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR C 239
PHE C 219
SER C 284
SER C 267
1.72A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER D 113
PHE D 305
SER D 158
SER B 123
1.46A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER C  10
TYR C 126
SER C 121
SER A 113
1.37A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PRO D   9
PHE D   8
SER D 301
SER D 113
1.70A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER B  10
TYR B 126
SER B 121
SER D 113
1.36A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
ASP D 295
PHE D 294
SER D 158
ASN D 151
1.79A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER C 113
PHE C 305
SER C 158
SER A 123
1.45A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR A 126
PHE C   8
SER C 301
SER C 113
1.74A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PRO A   9
SER A 158
ASN A 151
SER C 121
1.68A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR B 126
PHE D   8
SER D 301
SER D 113
1.76A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 7
ASP A 295
PHE A 294
SER A 158
ASN A 151
1.77A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
PRO C   9
PHE C   8
SER C 301
SER C 113
1.70A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER D  10
TYR D 126
SER D 121
SER B 113
1.61A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
SER A  10
TYR A 126
SER A 121
SER C 113
1.36A17.31

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 784
TYR A 129
SER A 778
ASN A 781
1.75A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		5 / 9
SER A 434
SER A 835
ASP A 833
PRO A 832
LEU A 869
1.54A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 564
PRO A 537
TYR A 346
SER A 681
1.39A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 7
SER A 835
ASP A 833
PRO A 832
SER A 433
1.75A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PHE A 326
ASN A 628
SER A 325
1.51A22.26

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 343
TYR A 273
PHE A 348
ASN A 356
1.43A22.26

None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ASP A 477
TYR A 746
PHE A 480
SER A 578
1.78A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER A 438
ASP A 442
TYR A 495
ASN A 450
PHE A 347
1.57A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER B1051
SER B1030
LEU B1024
PHE B1062
SER B1037
1.78A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
PHE A 497
ASN A 437
1.38A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 810
ASP A 808
PRO A 807
SER A 803
1.39A21.99
None
None
None
NAG  A1307 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
ASP A 442
PHE A 347
SER A 375
ASN A 437
1.26A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER C 438
ASP C 442
ASN C 450
PHE C 497
ASN C 439
1.78A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER C 555
SER A  45
TYR A  38
LEU C 560
PHE C 559
1.61A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR C 365
PHE C 374
SER C 399
SER C 371
1.29A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
TYR C 365
PHE C 374
SER C 399
SER C 371
1.64A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
SER C 438
ASP C 442
SER C 375
ASN C 437
1.59A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
SER C 438
ASP C 442
PHE C 497
ASN C 437
1.60A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
SER C 438
ASP C 442
TYR C 495
SER C 399
1.72A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
SER C 438
ASP C 442
PHE C 497
ASN C 437
1.48A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 9
SER C 438
ASP C 442
TYR C 495
PHE C 347
SER C 375
1.58A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 7
SER C 438
ASP C 442
TYR C 495
PHE C 347
1.56A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w4h NSP16
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.40A16.89
ACT  A7103 (-2.6A)
None
ACT  A7103 (-3.3A)
ACT  A7104 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6973
TYR A6979
SER A6999
SER A6927
1.63A11.57
EDO  A7102 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ASP A6931
PRO A6932
SER A6896
SER A6973
1.30A11.57
EDO  A7102 (-4.6A)
None
None
EDO  A7102 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w61 NSP10
(SARS-CoV-2)		4 / 7
PRO B4353
TYR B4379
PHE B4321
ASN B4358
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.38A11.57
None
None
None
EDO  A7102 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ASP A 295
PHE A 294
SER A 158
ASN A 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C6973
TYR C6979
SER C6999
SER C6927
1.65A11.75
None
None
FMT  C7108 ( 2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6973
TYR A6979
SER A6999
SER A6927
1.66A11.75
None
None
FMT  A7104 ( 2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ASP A6931
PRO A6932
SER A6896
SER A6973
1.45A11.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ASP C6931
PRO C6932
SER C6896
SER C6973
1.35A11.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP10
(SARS-CoV-2)		4 / 7
PRO D4353
TYR D4379
PHE D4321
ASN D4358
1.61A10.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.40A11.75
FMT  A7104 ( 2.9A)
None
FMT  A7104 ( 3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP10
(SARS-CoV-2)		4 / 7
PRO B4353
TYR B4379
PHE B4321
ASN B4358
1.56A10.38
None
None
None
NA  B4403 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C6999
TYR C7026
ASN C6996
SER C6973
1.39A11.75
FMT  C7108 ( 2.7A)
None
FMT  C7108 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ASP C6931
PRO C6932
ASN C6899
SER C6973
1.42A11.75
None
None
SAM  C7105 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
SER B 245
TYR B 273
PHE B 304
SER B 170
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
SER A 245
TYR A 273
PHE A 304
SER A 170
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
SER A 245
TYR A 273
PHE A 304
SER A 170
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 7
SER C 245
TYR C 273
PHE C 304
SER C 170
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wey NSP3
(SARS-CoV-2)		4 / 8
ASP A 349
TYR A 317
PHE A 372
ASN A 219
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER E 318
PHE F 314
SER E 312
SER F 318
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
SER B 318
PHE A 314
SER B 312
SER A 318
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.40A
FMT  A7104 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6973
TYR A6979
SER A6999
SER A6927
1.66A
None
None
FMT  A7104 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER C6999
TYR C7026
ASN C6996
SER C6973
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER C6973
TYR C6979
SER C6999
SER C6927
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wjt NSP10
(SARS-CoV-2)		4 / 7
PRO B4353
TYR B4379
PHE B4321
ASN B4358
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER D 105
TYR D 109
PHE D 171
SER A  79
1.59A
None
None
None
ZN  A 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER B 105
TYR B 109
PHE B 171
SER C  79
1.52A
None
None
None
ZN  C 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP10
(SARS-CoV-2)		4 / 7
PRO B4353
TYR B4379
PHE B4321
ASN B4358
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ASP C6931
PRO C6932
ASN C6899
SER C6973
1.58A
None
None
SFG  C7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER C6999
TYR C7026
ASN C6996
SER C6973
1.38A
FMT  C7110 ( 3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.41A
FMT  A7106 ( 3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
ASP C6931
PRO C6932
SER C6896
SER C6973
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6973
TYR A6979
SER A6999
SER A6927
1.65A
None
None
FMT  A7106 ( 3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER C6973
TYR C6979
SER C6999
SER C6927
1.64A
None
None
FMT  C7110 ( 3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wkq NSP10
(SARS-CoV-2)		4 / 7
PRO D4353
TYR D4379
PHE D4321
ASN D4358
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ASP B 324
TYR B 179
ASN B  74
SER B 198
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
ASP A 324
TYR A 179
ASN A  74
SER A 198
1.58A
None
None
EDO  A 406 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
ASP A 295
PHE A 294
SER A 158
ASN A 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ASP A 145
TYR A 113
PHE A 168
ASN A  15
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
ASP D 145
TYR D 113
PHE D 168
ASN D  15
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6973
TYR A6979
SER A6999
SER A6927
1.63A
None
None
GTA  A7102 (-2.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6999
TYR A7026
ASN A6996
SER A6973
1.40A
GTA  A7102 (-2.5A)
None
GTA  A7102 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 8
SER A 245
TYR A 273
PHE A 304
SER A 170
1.52A
None
GOL  A 508 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 7
SER A 245
TYR A 273
PHE A 304
SER A 170
1.59A
None
GOL  A 508 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
SER B  10
TYR B 126
SER B 121
SER A 113
1.32A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.69A12.34
None
DMS  A 403 (-3.8A)
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
TYR A 239
PHE A 219
SER A 284
SER A 267
1.52A12.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER E 438
ASP E 442
TYR E 495
ASN E 448
SER E 399
1.76A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 366
ASP A 364
PRO A 527
SER L  62
1.72A
None
None
None
MLI  B 303 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER E 438
ASP E 442
TYR E 495
PHE E 347
SER E 375
1.64A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 530
PRO A 527
TYR A 365
ASN A 334
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
TYR A 495
PHE A 347
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
SER A 375
ASN A 437
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
TYR E 495
SER E 399
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
TYR E 495
PHE E 347
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 365
PHE E 374
SER E 399
SER E 371
1.44A
None
DMS  E 901 (-4.4A)
None
DMS  E 901 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
PHE A 497
ASN A 437
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER A 438
ASP A 442
TYR A 495
PHE A 347
SER A 375
1.63A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
SER E 375
ASN E 437
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
TYR A 495
SER A 399
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 365
PHE A 374
SER A 399
SER A 371
1.51A
None
DMS  A 901 (-4.3A)
None
DMS  A 901 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
PHE A 497
ASN A 437
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER E 366
ASP E 364
PRO E 527
SER C  62
1.72A
None
None
None
MLI  B 303 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 365
PHE E 374
SER E 399
SER E 371
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER E 438
ASP E 442
TYR E 495
PHE E 347
SER E 375
1.59A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER E 438
ASP E 442
TYR E 495
ASN E 448
SER E 399
1.77A14.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
TYR E 495
SER E 399
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
TYR E 495
PHE E 347
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
SER E 375
ASN E 437
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 375
SER E 438
ASN E 437
SER E 371
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
ASP A 295
PHE A 294
SER A 158
ASN A 151
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor IGG H CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
TYR H 149
PHE A 486
SER H 176
SER H 119
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
PHE A 497
ASN A 437
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
PHE A 497
ASN A 437
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
TYR A 495
SER A 399
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER E 438
ASP E 442
TYR E 495
PHE E 347
SER E 375
1.64A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR E 365
PHE E 374
SER E 399
SER E 371
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
SER A 438
ASP A 442
TYR A 495
PHE A 347
SER A 375
1.65A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER A 438
ASP A 442
TYR A 495
ASN A 448
SER A 399
1.76A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 365
PHE A 374
SER A 399
SER A 371
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
SER E 375
ASN E 437
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER E 438
ASP E 442
TYR E 495
ASN E 448
SER E 399
1.75A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
TYR E 495
SER E 399
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
PHE E 497
ASN E 437
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
TYR A 495
PHE A 347
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER E 438
ASP E 442
TYR E 495
PHE E 347
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
SER A 375
ASN A 437
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
TYR A 239
PHE A 219
SER A 284
SER A 267
1.57A
PEG  A 404 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PRO A   9
PHE A   8
SER A 301
SER A 113
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP D 145
TYR D 113
PHE D 168
ASN D  15
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP E 145
TYR E 113
PHE E 168
ASN E  15
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP E  14
TYR E  17
PHE D   6
ASN D 150
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP A 145
TYR A 113
PHE A 168
ASN A  15
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP C 145
TYR C 113
PHE C 168
ASN C  15
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 9
SER A 434
SER A 835
ASP A 833
PRO A 832
LEU A 869
1.42A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 235
TYR A  38
ASN A 734
SER A 239
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		4 / 7
SER A 564
PRO A 537
TYR A 346
SER A 681
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 10
SER A 318
PHE A 317
TYR A 294
ASN A 297
PHE A 275
1.80A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PHE A 326
ASN A 628
SER A 325
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PHE A 326
ASN A 628
SER A 325
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 564
PRO A 537
TYR A 346
SER A 681
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
SER A 434
SER A 835
ASP A 833
PRO A 832
LEU A 869
1.57A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv1 NSP12
NSP7
NSP8
(SARS-CoV-2)		4 / 8
SER B 164
ASP B 163
ASN A 404
SER C  24
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 343
TYR A 273
PHE A 348
ASN A 356
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 343
TYR A 273
PHE A 348
ASN A 356
1.07A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 564
PRO A 537
TYR A 346
SER A 681
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 784
TYR A 129
SER A 778
ASN A 781
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
SER A 564
PRO A 537
TYR A 346
SER A 681
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 664
PHE A 326
ASN A 628
SER A 325
1.60A
None