Ligand ID: 6J3


Drugbank ID:
DB09218
(Clonixin)


Indication:
Used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.

Get human targets for 6J3 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '6J3' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 286
ALA B 285
LEU B 287
THR B 280
1.70A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.72A17.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.56A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.62A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.42A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP7
(SARS-CoV-2)		4 / 6
LYS C  43
LEU C  41
LEU C  40
SER C  10
1.73A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.43A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.57A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 103
ALA B 125
LEU B  98
SER A 384
1.61A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.79A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.64A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.41A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 650
ALA A 609
LEU A 611
SER A 596
0.94A8.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU B 650
ALA B 609
LEU B 611
SER B 596
0.78A7.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU C 650
ALA C 609
LEU C 611
SER C 596
0.77A7.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.64A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.66A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.67A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6w75 NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.65A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 6
LEU A 103
ALA A 107
SER A 105
THR A 109
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 6
LEU A 103
ALA A 107
SER A 105
THR A 109
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 159
ALA C  55
SER D  78
THR C  57
1.77A
None
MES  D 201 (-3.3A)
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 159
ALA C  55
SER D  78
THR C  57
1.77A
None
MES  D 201 (-3.3A)
None
ZN  D 202 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C  56
ALA C 173
SER D  78
THR D  76
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C  56
ALA C 173
SER D  78
THR D  76
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A 161
ALA A 173
LEU A 159
THR B  76
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A 161
ALA A 173
LEU A 159
THR B  76
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 161
ALA C 173
LEU C 159
THR D  76
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A  56
ALA A 173
SER B  78
THR B  76
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU C 161
ALA C 173
LEU C 159
THR D  76
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 6
LEU A  56
ALA A 173
SER B  78
THR B  76
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU C7073
ALA C6858
LEU C7078
THR C7055
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wkq NSP16
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 249
LEU B 246
SER B 288
THR B 282
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 249
LEU B 246
SER B 289
THR B 286
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 249
LEU A 246
SER A 289
THR A 286
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 249
LEU A 246
SER A 288
THR A 282
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 249
LEU B 246
SER B 289
THR B 286
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A 249
LEU A 246
SER A 288
THR A 282
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B 249
LEU B 246
SER B 288
THR B 282
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7072
THR A7055
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7072
THR A7055
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
LEU A7073
ALA A6858
LEU A7078
THR A7055
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.71A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LYS A 137
ALA A 129
SER A 113
THR A 111
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU E 517
ALA E 522
LEU E 518
THR E 523
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 517
ALA A 522
LEU A 518
THR A 523
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 517
ALA A 522
LEU A 518
THR A 523
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 286
ALA A 285
LEU A 287
THR A 280
1.70A
PEG  A 404 ( 3.6A)
None
PEG  A 404 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 103
ALA B 125
LEU B  98
SER A 384
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU B 103
ALA B 125
LEU B  98
SER A 384
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
LEU A 575
SER A 578
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 673
ALA A 400
SER A 384
THR A 402
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7btf NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LYS A 391
LEU A 389
LEU A 388
SER A 672
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 575
ALA A 639
LEU A 638
SER A 635
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LYS A 641
LEU A 575
LEU A 638
SER A 635
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LYS A 391
LEU A 389
LEU A 388
SER A 672
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.77A
None
A  T  13 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 152
LEU B 128
THR B 148
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 576
ALA A 580
SER A 578
THR A 582
1.74A
None
A  T  13 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 150
LEU B 128
THR B 148
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 251
ALA A 250
LEU A 316
THR A 248
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 245
ALA A 250
LEU A 316
THR A 252
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
LEU A 131
ALA A 130
LEU A 127
THR A 141
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 6
LEU A 387
ALA B 150
LEU B 128
THR B 148
1.67A
None