Ligand ID: 68P


Drugbank ID:
DB00215
(Citalopram)
DB01175
(Escitalopram)


Indication:
For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label]. ;Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.

Get human targets for 68P in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '68P' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.62A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.43A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.72A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 191
GLY A 174
PHE A 185
GLY A 170
VAL A 171
1.57A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.73A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.69A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
PHE A 140
GLY A 149
VAL A 114
1.76A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.60A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 191
GLY A 174
PHE A 185
GLY A 170
VAL A 171
1.62A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.71A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
TYR A 182
GLY A 146
LEU A 167
GLY A 179
VAL A  86
1.79A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.74A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.41A20.25
None
None
DMS  A 401 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.59A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.25
None
None
None
DMS  A 401 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.44A20.25
None
None
DMS  A 401 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.59A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.80A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.77A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.44A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 173
TYR D 182
LEU D 167
GLY D 149
VAL D 114
1.41A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.76A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B 173
TYR B 182
LEU B 167
GLY B 149
VAL B 114
1.43A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.77A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA C 173
TYR C 182
PHE C 140
LEU C 167
GLY C 149
VAL C 114
1.77A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.74A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 216
ALA A 206
GLY A   2
PHE A   3
GLY A 302
1.63A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASP B 216
ALA B 206
GLY B   2
PHE B   3
GLY B 302
1.62A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA B 173
TYR B 182
PHE B 140
LEU B 167
GLY B 149
VAL B 114
1.77A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
TYR C 182
LEU C 167
GLY C 149
VAL C 114
1.41A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C 173
TYR C 182
LEU C 167
GLY C 149
VAL C 114
1.43A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 173
TYR D 182
LEU D 167
GLY D 149
VAL D 114
1.38A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D 173
TYR D 182
LEU D 167
GLY D 149
VAL D 114
1.37A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.77A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.63A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.34A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 440
GLY A 413
LEU A 544
1.27A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.33A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.27A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ILE A 562
TYR A 516
GLY A 683
SER A 501
GLY A 503
1.49A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 440
GLY A 413
LEU A 544
1.36A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6m71 NSP12
(SARS-CoV-2)		6 / 12
ASP A 684
ILE A 562
ALA A 512
TYR A 516
PHE A 506
GLY A 503
1.76A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN B 564
PHE B 543
GLU B 583
LEU B 552
ILE B 587
1.69A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
GLY B 908
GLY B1035
LEU B1034
GLY A 910
1.04A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
GLY B 908
GLY B1035
LEU B1034
GLY A 910
1.07A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B 890
GLY B 908
GLY B1035
LEU B1034
GLY A 910
1.14A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
TYR A  68
ASP A  67
ALA B  39
GLY A  73
LEU B  43
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN B 564
PHE B 543
GLU B 583
LEU B 552
ILE B 587
1.69A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
GLN C 564
PHE C 543
GLU C 583
LEU C 552
ILE C 587
1.66A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
TYR L  27
PHE C 429
SER H  99
GLY C 381
GLY C 413
1.77A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 495
ASP C 405
ALA C 419
PHE C 400
VAL C 510
1.69A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 495
ASP C 405
ILE C 410
PHE C 400
VAL C 510
1.64A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 495
ASP C 405
ALA C 419
PHE C 400
VAL C 510
1.67A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ASP C 405
ILE C 410
ALA C 411
PHE C 400
VAL C 510
1.70A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
TYR C 495
ASP C 405
ALA C 419
PHE C 400
VAL C 510
1.74A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.65A16.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.55A
None
None
None
SAM  A7104 (-4.4A)
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ASP A6895
GLY A6879
GLY A6875
GLY B4322
VAL B4295
1.60A
None
SAM  A7104 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.52A
None
None
None
SAM  A7104 (-4.4A)
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
TYR B4349
ALA A6843
TYR A6845
LEU B4298
GLY A6871
1.79A11.52
None
None
SAM  A7104 (-4.6A)
None
SAM  A7104 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6977
ILE A6955
GLY A6953
GLY A7006
VAL A6965
1.78A16.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 112
TYR A 113
GLY A 130
PHE A 132
VAL A  49
1.72A14.65
None
None
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.57A
None
None
None
AMP  A 201 ( 3.6A)
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  18
ALA A 154
TYR A 161
LEU A 123
GLY B   8
1.76A14.65
None
AMP  A 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 112
TYR A 113
GLY A 130
PHE A 132
VAL A  49
1.78A14.65
None
None
AMP  A 201 ( 3.5A)
AMP  A 201 ( 4.3A)
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.54A
None
None
None
AMP  A 201 ( 3.6A)
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  18
ALA A 154
TYR A 161
LEU A 123
GLY B   8
1.76A14.65
None
AMP  A 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.56A
None
None
None
AMP  A 201 ( 3.6A)
AMP  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
TYR A 161
SER A   7
LEU A 123
GLY B   8
1.45A
AMP  A 201 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ILE A  18
ALA A 154
PHE A 168
GLY B   8
GLY A   8
1.77A14.65
None
AMP  A 201 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.59A15.40
None
None
None
NA  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.48A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7026
ILE C7035
PHE C6991
GLY C6806
VAL C6807
1.65A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7040
ALA C6843
PHE C7043
SER C7038
LEU C6834
1.79A15.40
FMT  C7111 ( 4.3A)
None
None
FMT  C7111 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.60A15.40
None
None
None
NA  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP C6912
ILE C6951
GLY C6946
PHE C6948
GLY C6953
1.76A15.40
SAM  C7105 ( 3.5A)
None
FMT  C7115 ( 3.0A)
FMT  C7115 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP C6912
ILE C6951
GLY C6946
PHE C6948
GLY C6953
1.73A15.40
SAM  C7105 ( 3.5A)
None
FMT  C7115 ( 3.0A)
FMT  C7115 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR B4349
ALA A6843
TYR A6845
LEU B4298
GLY A6871
1.78A11.33
None
None
SAM  A7102 ( 4.5A)
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.51A15.40
 NA  C7103 ( 4.8A)
None
NA  C7103 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.41A15.40
None
None
None
SAM  A7102 ( 3.8A)
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6912
ILE A6951
GLY A6946
PHE A6948
GLY A6953
1.73A15.40
SAM  A7102 ( 3.5A)
None
FMT  A7108 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP C6977
ILE C6955
GLY C6953
GLY C7006
VAL C6965
1.73A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR D4349
ALA C6843
TYR C6845
LEU D4298
GLY C6871
1.78A11.33
None
None
SAM  C7105 ( 4.5A)
None
SAM  C7105 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.60A15.40
None
None
None
NA  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6912
ILE A6951
GLY A6946
PHE A6948
GLY A6953
1.73A15.40
SAM  A7102 ( 3.5A)
None
FMT  A7108 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.45A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7026
ILE C7035
PHE C6991
GLY C6806
VAL C6807
1.64A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.39A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7040
ALA A6843
PHE A7043
SER A7038
LEU A6834
1.74A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
TYR B4349
ALA A6843
TYR A6845
LEU B4298
GLY A6871
1.80A11.33
None
None
SAM  A7102 ( 4.5A)
None
SAM  A7102 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.58A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.45A15.40
None
None
None
SAM  A7102 ( 3.8A)
SAM  A7102 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP C6912
ILE C6951
GLY C6946
PHE C6948
GLY C6953
1.78A15.40
SAM  C7105 ( 3.5A)
None
FMT  C7115 ( 3.0A)
FMT  C7115 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.51A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.44A15.40
 NA  C7103 ( 4.8A)
None
NA  C7103 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6963
PHE C6985
GLY C7011
VAL C6965
1.40A15.40
None
None
None
NA  C7103 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASP A6977
ILE A6955
GLY A6953
GLY A7006
VAL A6965
1.74A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.48A15.40
 NA  C7103 ( 4.8A)
None
NA  C7103 ( 4.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.65A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w75 NSP16
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.64A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
ALA C 261
PHE C 258
GLU C 252
LEU C 282
ILE C 276
1.68A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  78
LEU A  75
GLY A 133
VAL A 100
1.28A
MES  A 201 ( 4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  78
LEU A  75
GLY A 133
VAL A 100
1.29A
MES  A 201 ( 4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wen NSP3
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 338
GLY A 301
LEU A 313
GLY A 252
VAL A 253
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 338
GLY A 301
LEU A 313
GLY A 252
VAL A 253
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 338
GLY A 301
LEU A 313
GLY A 252
VAL A 253
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE A  68
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE A  68
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE A  68
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.43A
None
None
None
SAH  A7102 (-3.9A)
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6963
PHE C6985
GLY C7011
VAL C6965
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.38A
None
None
None
SAH  A7102 (-3.9A)
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP C6873
GLY C6875
PHE C6901
LEU C6898
GLY C6879
1.42A
None
None
None
SAH  C7102 (-4.2A)
SAH  C7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE B 131
PHE B 110
PHE B  66
GLY B  85
VAL B 133
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE A 131
PHE A 110
PHE A  66
GLY A  85
VAL A 133
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE D 131
PHE D 110
PHE D  66
GLY D  85
VAL D 133
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE C 131
PHE C 110
PHE C  66
GLY C  85
VAL C 133
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE B 131
PHE B 110
PHE B  66
GLY B  85
VAL B 133
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP C6873
GLY C6875
PHE C6901
LEU C6898
GLY C6879
1.42A
None
None
None
SFG  C7103 ( 3.9A)
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.46A
None
None
None
SFG  A7103 ( 3.9A)
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6963
PHE C6985
GLY C7011
VAL C6965
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.42A
None
None
None
SFG  A7103 ( 3.9A)
SFG  A7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6955
GLY C6962
PHE C6985
GLY C7011
VAL C6965
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
TYR C7009
ILE C7080
GLY C7011
GLY C6962
GLY C7063
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASP C6873
GLY C6875
PHE C6901
LEU C6898
GLY C6879
1.46A
None
None
None
SFG  C7103 ( 3.9A)
SFG  C7103 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 236
ALA A 232
PHE A 214
PHE A 303
GLY A 254
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP B 301
ILE B 253
PHE B 303
PHE B 214
VAL B 237
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP A 301
ILE A 253
PHE A 303
PHE A 214
VAL A 237
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP B 301
ILE B 253
PHE B 303
PHE B 214
VAL B 237
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP B  79
ILE B 100
ALA B 109
PHE B 123
GLY B 141
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP A  79
ILE A 100
ALA A 109
PHE A 123
GLY A 141
1.32A
EDO  A 406 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 236
ALA B 232
PHE B 214
PHE B 303
GLY B 254
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 306
TYR A 194
PHE A 342
LEU A 251
VAL A 319
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 306
TYR B 194
PHE B 342
LEU B 251
VAL B 319
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 306
TYR A 194
PHE A 342
LEU A 251
VAL A 319
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ASP A 301
ILE A 253
PHE A 303
PHE A 214
VAL A 237
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 236
PHE B 214
PHE B 303
LEU B 332
GLY B 254
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B 236
PHE B 214
PHE B 303
LEU B 332
GLY B 254
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 236
PHE A 214
PHE A 303
LEU A 332
GLY A 254
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 306
TYR A 194
PHE A 342
LEU A 251
VAL A 319
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A 236
PHE A 214
PHE A 303
LEU A 332
GLY A 254
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.79A
None
None
None
U5G  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.77A
None
None
None
U5G  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.44A
None
None
U5G  A 401 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.62A
None
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.60A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.62A
None
None
None
APR  B 201 (-3.4A)
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.59A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE D 106
GLY D  97
SER D 111
GLY D 103
VAL D 100
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE C 106
GLY C  97
SER C 111
GLY C 103
VAL C 100
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.61A
None
None
None
APR  D 201 (-3.5A)
APR  D 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.62A
None
None
None
APR  A 201 (-3.5A)
APR  A 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.59A
None
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7026
ILE A7035
PHE A6991
GLY A6806
VAL A6807
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.49A
SO4  A7109 (-3.3A)
None
None
SAH  A7101 (-4.3A)
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6963
PHE A6985
GLY A7011
VAL A6965
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
TYR A7009
ILE A7080
GLY A7011
GLY A6962
GLY A7063
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6955
GLY A6962
PHE A6985
GLY A7011
VAL A6965
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASP A6873
GLY A6875
PHE A6901
LEU A6898
GLY A6879
1.53A
SO4  A7109 (-3.3A)
None
None
SAH  A7101 (-4.3A)
SAH  A7101 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU C  13
GLY D 113
VAL D 115
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASP B 112
PHE B  92
LEU B 103
GLY A  64
VAL A  66
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.73A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.62A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.74A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.73A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
PHE A 140
GLY A 149
VAL A 114
1.77A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.71A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.45A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 161
GLY A 170
LEU A 167
GLY A 146
1.73A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.60A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
TYR A 182
GLY A 146
LEU A 167
GLY A 179
VAL A  86
1.78A14.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU C  13
GLY D 113
VAL D 115
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU C  13
GLY D 113
VAL D 115
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU C  13
GLY D 113
VAL D 115
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP B 112
PHE B  92
LEU B 103
GLY A  64
VAL A  66
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU A  13
GLY B 113
VAL B 115
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU B  91
GLY B 113
VAL B 115
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU B  95
GLY B 113
VAL B 115
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP D 112
PHE D  92
LEU D 103
GLY C  64
VAL C  66
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP B 112
PHE B  92
LEU B 103
GLY A  64
VAL A  66
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP C  67
GLY C  64
LEU D  91
GLY D 113
VAL D 115
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU A  13
GLY B 113
VAL B 115
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP A  67
GLY A  64
LEU A  13
GLY B 113
VAL B 115
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ASP B 112
PHE B  92
LEU B 103
GLY A  64
VAL A  66
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
ALA A 173
TYR A 182
PHE A 140
LEU A 167
GLY A 149
VAL A 114
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.51A
None
EDO  A 202 ( 4.9A)
EDO  D 202 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.55A
EDO  D 211 (-3.7A)
None
EDO  D 204 ( 4.5A)
EDO  D 209 ( 4.7A)
EDO  D 209 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.50A
None
None
None
EPE  E 202 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.54A
EDO  D 211 (-3.7A)
None
EDO  D 204 ( 4.5A)
EDO  D 209 ( 4.7A)
EDO  D 209 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.53A
None
None
None
EPE  E 202 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.51A
None
EDO  A 202 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.54A
EDO  C 208 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D 106
GLY D  97
SER D 111
GLY D 103
VAL D 100
1.50A
EDO  D 204 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E 106
GLY E  97
SER E 111
GLY E 103
VAL E 100
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.50A
EDO  C 208 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.51A
EDO  D 211 (-3.7A)
None
EDO  D 204 ( 4.5A)
EDO  D 209 ( 4.7A)
EDO  D 209 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.52A
None
None
None
EPE  E 202 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.53A
None
EDO  A 202 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C 106
GLY C  97
SER C 111
GLY C 103
VAL C 100
1.56A
EDO  C 208 ( 4.2A)
None
None
None
EDO  C 208 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.53A
EDO  C 208 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.54A
None
EDO  A 202 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.61A
None
None
None
APR  E 201 (-3.4A)
APR  E 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.53A
EDO  A 204 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.51A
None
None
None
APR  B 201 (-3.5A)
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.56A
EDO  A 204 ( 3.9A)
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.54A
None
None
None
APR  B 201 (-3.5A)
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.57A
None
None
None
APR  E 201 (-3.4A)
APR  E 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE D 106
GLY D  97
SER D 111
GLY D 103
VAL D 100
1.48A
None
None
EDO  A 206 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.58A
None
None
None
EDO  D 204 ( 3.4A)
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.59A
None
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.60A
None
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.53A
EDO  A 204 ( 3.9A)
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.60A
None
None
None
EDO  D 204 ( 3.4A)
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.57A
None
None
None
APR  C 201 (-3.5A)
APR  C 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 134
GLY D  97
LEU D 109
GLY D  48
VAL D  49
1.57A
None
None
None
EDO  D 204 ( 3.4A)
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.53A
None
None
None
APR  B 201 (-3.5A)
APR  B 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE E 106
GLY E  97
SER E 111
GLY E 103
VAL E 100
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.55A
EDO  A 204 ( 3.9A)
None
None
APR  A 201 (-3.4A)
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C 106
GLY C  97
SER C 111
GLY C 103
VAL C 100
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 134
GLY E  97
LEU E 109
GLY E  48
VAL E  49
1.59A
None
None
None
APR  E 201 (-3.4A)
APR  E 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE B 106
GLY B  97
SER B 111
GLY B 103
VAL B 100
1.55A
EDO  B 204 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.56A
EDO  B 204 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.57A
EDO  B 204 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.50A
EDO  A 205 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.54A
EDO  A 205 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 134
GLY B  97
LEU B 109
GLY B  48
VAL B  49
1.54A
EDO  B 204 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 134
GLY C  97
LEU C 109
GLY C  48
VAL C  49
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE C 106
GLY C  97
SER C 111
GLY C 103
VAL C 100
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 134
GLY A  97
LEU A 109
GLY A  48
VAL A  49
1.53A
EDO  A 205 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ILE A 106
GLY A  97
SER A 111
GLY A 103
VAL A 100
1.59A
EDO  A 205 ( 4.3A)
None
EDO  C 205 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		5 / 12
TYR B 306
ASP B 374
PHE B 291
LEU B 391
VAL B 272
1.41A23.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		5 / 12
TYR A 306
ASP A 374
PHE A 291
LEU A 391
VAL A 272
1.41A23.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A  97
TYR A  87
GLY A  13
SER A 115
LEU A 119
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 440
GLY A 413
LEU A 544
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 843
GLY A 413
LEU A 544
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 440
GLY A 413
LEU A 544
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 843
GLY A 413
LEU A 544
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7btf NSP12
(SARS-CoV-2)		5 / 9
ALA A 863
PHE A 881
PRO A 918
LEU A 885
ILE A 888
1.51A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.46A
None
None
DMS  A 405 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A 173
TYR A 182
LEU A 167
GLY A 149
VAL A 114
1.48A
None
None
DMS  A 405 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  11
PHE A 150
LEU A 177
GLY A 124
VAL A 125
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASP A 421
PHE A 428
SER A 425
GLY A 427
GLY A 839
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 413
PHE A 843
GLY A 839
LEU A 838
VAL C  11
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
TYR A 546
ALA A 554
PHE A 440
GLY A 413
LEU A 544
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ILE A 562
TYR A 516
GLY A 683
SER A 501
GLY A 503
1.32A
None
None
U  T  10 ( 3.1A)
U  T   9 ( 2.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 413
PHE A 843
GLY A 839
LEU A 838
VAL C  11
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ASP A 418
PHE A 843
GLY A 841
LEU A 838
VAL C  11
1.35A
None