Ligand ID: 486


Drugbank ID:
DB00834
(Mifepristone)


Indication:
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.

Get human targets for 486 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '486' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		5r7y 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.46A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		5r80 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  71
GLN A  19
VAL A  18
TRP A  31
LEU A  67
1.48A19.22
DMS  A1005 (-3.8A)
None
None
None
DMS  A1003 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		5r83 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.63A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
VAL A  36
LEU A  67
1.67A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		5r84 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.51A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A 165
GLY A 146
LEU A  87
MET A  49
CYH A  44
1.64A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
GLU A  55
LEU A  58
MET A 165
MET A  82
1.78A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.68A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.64A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.70A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.77A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.48A20.95
None
K1Y  A 404 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.52A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6lvn SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU D  26
VAL D  22
LEU B  26
GLU B  15
ILE B  16
1.27A10.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		6 / 12
LEU E 938
LEU F1197
GLN F 935
ILE F 934
ILE E 934
ALA E 930
1.78A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.66A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.72A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.71A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.73A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.45A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.52A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ASN A  72
GLY A  71
GLN A  19
VAL A  18
LEU A  67
1.69A19.47
None
DMS  A 403 (-3.8A)
None
DMS  A 403 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.75A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  71
GLN A  69
VAL A  18
TRP A  31
LEU A  67
1.78A19.47
DMS  A 403 (-3.8A)
None
DMS  A 403 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
LEU E 390
GLY E 526
VAL E 362
PHE E 392
LEU E 513
1.65A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.41A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.74A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.72A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.65A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.53A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.74A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  27
ASN B  28
GLY B 146
LEU B  89
MET B  17
1.59A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET A   6
GLY C 138
VAL C 171
PHE A   3
LEU C 141
1.80A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.52A21.45
None
None
None
3WL  A 401 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET C  82
GLY C  79
VAL C  77
CYH C  44
CYH C  38
1.53A21.45
None
None
None
3WL  C 401 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D 208
LEU D 253
PHE D 219
LEU D 220
CYH D 265
1.68A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.73A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  27
GLY D 146
VAL D 148
LEU D  87
CYH D  22
1.75A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 208
LEU C 253
PHE C 219
LEU C 220
CYH C 265
1.71A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  27
GLY C 146
VAL C 148
LEU C  87
CYH C  22
1.71A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 208
LEU B 253
PHE B 219
LEU B 220
CYH B 265
1.64A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET C   6
GLY A 138
VAL A 171
PHE C   3
LEU A 141
1.76A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  27
ASN C  28
GLY C  29
LEU C  89
LEU C  67
1.73A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B  71
GLN B  69
VAL B  18
TRP B  31
LEU B  67
1.79A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  27
GLY B 146
VAL B 148
LEU B  87
CYH B  22
1.70A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.71A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  27
GLY C 146
VAL C 148
LEU C  87
CYH C  22
1.71A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.61A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C  27
ASN C  28
GLY C 146
LEU C  89
MET C  17
1.61A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 282
VAL B 204
MET B 264
LEU B 220
MET B 276
1.76A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  27
GLY B 146
VAL B 148
LEU B  87
CYH B  22
1.70A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  27
ASN D  28
GLY D  29
LEU D  89
LEU D  67
1.65A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  27
ASN D  28
GLY D 146
LEU D  89
MET D  17
1.59A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET D  82
GLY D  79
VAL D  77
CYH D  44
CYH D  38
1.54A21.45
None
None
None
3WL  D 401 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  27
GLY D 146
VAL D 148
LEU D  87
CYH D  22
1.76A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 253
PHE A 219
LEU A 220
CYH A 265
1.65A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET D   6
GLY B 138
VAL B 171
PHE D   3
LEU B 141
1.76A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B  27
ASN B  28
GLY B  29
LEU B  89
LEU B  67
1.69A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.74A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET B  82
GLY B  79
VAL B  77
CYH B  44
CYH B  38
1.53A21.45
None
None
None
3WL  B 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.74A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.72A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.57A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.47A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.56A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.66A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.44A14.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 241
LEU A 240
MET A 463
TYR A 286
1.54A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
VAL B 115
ILE B 120
ILE B 106
ALA B 102
1.55A14.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 351
LEU A 329
GLY A 327
PHE A 652
VAL A 675
1.73A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  91
VAL C  22
TRP C  29
LEU C  56
MET C  52
1.63A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 198
LEU A  90
GLY A 200
VAL A 202
LEU A 205
1.61A12.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP7
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.74A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
VAL A 398
LEU A 329
ILE A 539
ALA A 376
1.66A14.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.57A12.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 178
GLY A 179
LEU A 212
MET A 124
LEU A 241
1.79A14.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 568
GLN A 570
MET A 519
LEU A 372
ILE A 536
1.79A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
LEU A 544
GLN A 541
GLU A 665
ILE A 539
1.73A14.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
VAL B 115
ILE B 119
ILE B 106
ALA B 102
1.76A14.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 330
LEU B  95
ILE B 120
ILE B 106
ALA B 102
1.56A14.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 801
GLY B 799
GLN B 920
PHE B 898
MET B1050
1.79A11.10
NAG  B1309 (-1.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
LYS A 557
GLN A 563
ILE B 285
LEU B  48
1.61A12.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER C 967
ALA B 570
LEU C 962
ILE C 742
PHE A 759
1.23A12.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A  56
GLY A  35
VAL A  36
LEU A 293
ARG A 273
1.59A10.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 368
1.50A11.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
GLY A 526
VAL A 362
PHE A 515
LEU A 368
1.47A11.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 387
ASN B 388
GLY B 526
VAL B 362
LEU B 513
1.57A10.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 9
THR A 941
LEU A 938
ALA A 944
LEU A 948
THR A 724
1.58A11.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 368
1.39A11.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B1063
VAL B 722
ILE B 934
GLN B 935
ILE B 818
1.32A11.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vxs NSP3
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 387
GLY B 526
VAL B 362
PHE B 515
LEU B 368
1.53A11.66
None
None
None
None
NAG  B1307 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER B 967
ALA A 570
LEU B 962
ILE B 742
PHE C 759
1.05A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 513
1.50A10.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 546
ASN B 542
GLY B 548
LEU B 585
ILE B 326
1.48A11.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C1063
VAL C 722
ILE C 934
GLN C 935
ILE C 818
1.25A10.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 801
GLY B 799
GLN B 920
PHE B 898
MET B1050
1.65A11.66
NAG  B1314 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET C1050
LEU C1049
GLY C 908
LEU C 916
GLN C 901
1.69A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET C1050
LEU C1049
GLY C 908
LEU C 916
GLN C 901
1.72A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 861
GLY B 594
GLY B 593
GLN B 314
VAL B 595
1.61A10.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A1063
ILE A 931
GLN A 935
GLU A 819
ILE A 818
1.22A10.89
None
None
NAG  A1314 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER B 967
ALA A 570
LEU B 962
ILE B 742
PHE C 759
1.10A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN A 801
GLY A 799
GLN A 920
PHE A 898
MET A1050
1.66A11.66
NAG  A1314 (-1.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 546
ASN A 542
GLY A 548
LEU A 585
ILE A 326
1.42A11.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 861
GLY B 594
GLY B 593
GLN B 314
VAL B 595
1.59A10.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w02 NSP3
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.63A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 387
GLY C 526
VAL C 362
PHE C 515
LEU C 368
1.64A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w4b NSP9
(SARS-CoV-2)		5 / 12
LEU A  95
VAL A 103
GLN A  12
ILE A  92
ALA A  55
1.30A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w4b NSP9
(SARS-CoV-2)		5 / 12
LEU A  43
ASN A  99
GLY A 101
GLY B 101
LEU A  89
1.61A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.47A22.48
None
BDF  A7105 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6927
ALA A6966
TYR A6845
LEU A6883
PHE A6901
1.64A22.06
None
None
SAM  A7102 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU A6857
ALA A6966
GLN A6847
TYR A6851
LEU A6855
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
VAL A6882
GLN A6847
ILE A6926
ALA A6966
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A6852
ILE A6967
ILE A6969
ALA A7002
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7010
LEU A7078
GLY A7076
LEU A6959
CYH A7007
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
GLY A6963
GLY A6962
ARG A7053
CYH A6849
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
LEU A6961
GLY A6962
GLY A6963
LEU A7070
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6924
GLY A6963
GLY A6962
ARG A7053
CYH A6849
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7078
LEU A6961
GLY A6962
GLY A6963
LEU A7070
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A7010
ILE A6955
ILE A6967
ALA A6966
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 253
PHE A 219
LEU A 220
CYH A 265
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.66A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.65A
X77  A 401 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 7
LEU A 205
ASN A 203
GLU A 288
LEU A 282
1.67A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.50A21.45
X77  A 401 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.64A
X77  A 401 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.63A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.58A21.45
None
None
None
X77  A 401 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 122
VAL A 151
LEU A 140
GLU A 114
ALA A 112
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  12
LEU A  10
GLY B   8
LEU A 164
CYH A 143
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  12
LEU A  10
GLY B   8
LEU A 164
CYH A 143
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU B  12
LEU B  10
GLY A   8
LEU B 164
CYH B 143
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w6y NSP3
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6978
LEU C7010
ILE C6955
ILE C6967
ALA C6966
1.53A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6883
VAL C6882
GLN C6847
ILE C6926
ALA C6966
1.66A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASN C7008
LEU C6855
GLY C7006
VAL C6965
LEU C7050
1.49A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C7060
ILE C7065
GLU C7082
ILE C7080
ALA C6960
1.74A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6812
GLN C6816
MET C6815
MET C6982
ILE C7017
1.70A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A7010
ILE A6955
ILE A6967
ALA A6966
1.54A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.48A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A7060
ILE A7065
GLU A7082
ILE A7080
ALA A6960
1.77A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
VAL A6882
GLN A6847
ILE A6926
ALA A6966
1.66A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A6852
ILE A6967
ILE A6969
ALA A7002
1.80A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 120
GLY A 142
PHE A 127
LEU A 132
CYH A 148
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 162
GLY C 160
VAL C 159
TRP C  93
LEU B 162
1.58A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
THR A 119
LEU A 120
LEU A 178
GLN A 174
PHE A 173
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 125
GLN A 133
LEU A 132
PHE A 127
MET A 169
1.58A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY B 160
VAL B 159
TRP B  93
LEU A 162
CYH A 270
1.69A
None
None
None
None
ZN  A 401 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 120
GLY B 142
PHE B 127
LEU B 132
CYH B 148
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
THR B 119
LEU B 120
LEU B 178
GLN B 174
PHE B 173
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C  87
ASN C  88
GLY C  38
VAL C  41
LEU C  80
1.77A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER B 239
ALA B 204
TYR B 213
LEU B 234
LYS B 217
1.71A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  87
ASN A  88
GLY A  38
VAL A  41
LEU A  80
1.74A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
THR C 119
LEU C 120
LEU C 178
GLN C 174
PHE C 173
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 5
LEU B 117
LEU B 113
MET B 169
GLN B 122
1.60A21.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 9
THR A 102
LEU A 117
ALA A 139
LEU A 150
PHE A 147
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 120
GLY C 142
PHE C 127
LEU C 132
CYH C 148
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 290
VAL C  98
LEU C 117
GLN C 121
ILE C 285
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 162
GLY A 160
VAL A 159
TRP A  93
LEU C 162
1.49A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A   4
GLY A  -2
GLY A   0
LEU A  97
MET A 101
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A   4
GLY A  -2
GLY A   0
LEU A  97
MET A 101
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  94
VAL A 102
GLN A  11
ILE A  91
ALA A  54
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
LEU A  94
VAL A 102
LEU A  29
GLN A  11
ILE A  91
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wcf NSP3
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A 122
VAL A 151
LEU A 140
GLU A 114
ALA A 112
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wen NSP3
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wey NSP3
(SARS-CoV-2)		5 / 9
LEU A 331
ALA A 328
LEU A 297
GLN A 322
PHE A 320
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wey NSP3
(SARS-CoV-2)		5 / 12
LEU A 326
VAL A 355
LEU A 344
GLU A 318
ALA A 316
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  91
VAL A  22
TRP A  29
LEU A  56
MET A  52
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wiq NSP8
(SARS-CoV-2)		5 / 12
LEU B 184
VAL B 159
LEU B 189
GLN B 157
ILE B 132
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 316
VAL D 270
ARG C 319
LEU D 353
ILE D 304
1.79A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6978
LEU C7010
ILE C6955
ILE C6967
ALA C6966
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A7010
ILE A6955
ILE A6967
ALA A6966
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C7060
ILE C7065
GLU C7082
ILE C7080
ALA C6960
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6883
VAL C6882
GLN C6847
ILE C6926
ALA C6966
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A6852
ILE A6967
ILE A6969
ALA A7002
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
VAL A6882
GLN A6847
ILE A6926
ALA A6966
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6812
GLN C6816
MET C6815
MET C6982
ILE C7017
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 9
LEU C6857
ALA C6966
GLN C6847
TYR C6851
LEU C6855
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.48A
None
None
None
None
FMT  A7107 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN C7008
LEU C6855
GLY C7006
VAL C6965
LEU C7050
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A7010
ILE A6955
ILE A6967
ALA A6966
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C7060
ILE C7065
GLU C7082
ILE C7080
ALA C6960
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6883
VAL A6882
GLN A6847
ILE A6926
ALA A6966
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A7060
ILE A7065
GLU A7082
ILE A7080
ALA A6960
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 9
LEU C6857
ALA C6966
GLN C6847
TYR C6851
LEU C6855
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASN C7008
LEU C6855
GLY C7006
VAL C6965
LEU C7050
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6812
GLN C6816
MET C6815
MET C6982
ILE C7017
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6978
LEU C7010
ILE C6955
ILE C6967
ALA C6966
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6883
VAL C6882
GLN C6847
ILE C6926
ALA C6966
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU B 120
VAL B 122
GLN B 131
ILE B 100
ILE B 108
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
LEU A  76
VAL A 142
GLN A 131
ILE A 144
ALA A 161
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.66A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 253
PHE A 219
LEU A 220
CYH A 265
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.75A
U5G  A 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.54A21.45
U5G  A 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.73A19.50
U5G  A 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASN A  72
GLY A  71
GLN A  19
VAL A  18
LEU A  67
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.76A
U5G  A 401 ( 4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.50A21.45
None
None
None
U5G  A 401 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7010
LEU A7078
GLY A7076
LEU A6959
CYH A7007
1.70A
None
None
None
None
8NK  A7103 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6978
LEU A7010
ILE A6955
ILE A6967
ALA A6966
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN A7008
LEU A6855
GLY A7006
VAL A6965
LEU A7050
1.49A
None
8NK  A7103 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6883
VAL A6882
GLN A6847
ILE A6926
ALA A6966
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU C  17
LEU C  59
MET D  87
GLN C  18
1.57A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU A  17
LEU A  59
MET B  87
GLN A  18
1.62A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wqd NSP8
(SARS-CoV-2)		5 / 12
LEU D 184
VAL D 159
LEU D 189
GLN D 157
ILE D 132
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
(SARS-CoV-2)		4 / 5
LEU A  14
LEU A  55
MET A  62
GLN A  18
1.68A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  95
MET D  87
MET D  90
LEU C  20
VAL A  12
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  13
MET D  87
GLN A  18
1.77A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  91
VAL A  22
TRP A  29
LEU A  56
MET A  52
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU B  95
MET B  87
MET B  90
LEU A  20
VAL C  12
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.71A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU A  14
LEU A  13
MET B  87
GLN C  18
1.77A17.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  91
VAL C  22
TRP C  29
LEU C  56
MET C  52
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.71A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.53A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
VAL A  36
LEU A  67
1.67A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.51A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.56A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.68A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 9
THR A 102
LEU A 117
ALA A 139
LEU A 150
PHE A 147
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A  87
ASN A  88
GLY A  38
VAL A  41
LEU A  80
1.77A23.88
None
GOL  A 507 (-4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 9
THR A 119
LEU A 120
LEU A 178
GLN A 174
PHE A 173
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 120
GLY A 142
PHE A 127
LEU A 132
CYH A 148
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		6y2f REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
LEU A  87
LEU A  67
MET A 162
TYR A  37
1.59A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.52A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.53A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  72
GLY A  71
GLN A  69
VAL A  18
TRP A  31
1.50A21.05
None
DMS  A 406 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.67A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
MET A 165
GLY A 146
LEU A  87
MET A  49
CYH A  44
1.63A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.70A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.77A19.29
None
None
None
None
DMS  A 402 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.48A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B  95
MET B  87
MET B  90
LEU A  20
VAL C  12
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.72A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU A  17
LEU A  59
MET B  87
GLN A  18
1.62A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU C  17
LEU C  59
MET D  87
GLN C  18
1.61A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU B  91
VAL A  22
TRP A  29
LEU A  56
MET A  52
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU A  14
LEU A  35
MET A  62
GLN A  18
1.77A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU A  14
LEU A  55
MET A  62
GLN A  18
1.74A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D  91
VAL C  22
TRP C  29
LEU C  56
MET C  52
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  13
MET D  87
GLN A  18
1.78A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU D  95
MET D  87
MET D  90
LEU C  20
VAL A  12
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
THR A  14
LEU A 119
ALA A  15
GLN A  18
TYR A 132
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 9
THR A  14
LEU A 119
ALA A  15
LEU A  24
TYR A 132
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
LEU A 390
GLU A 516
LEU A 518
TYR C  55
1.59A19.85
DMS  A 905 (-4.9A)
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
GLY A 526
VAL A 362
PHE A 515
LEU A 368
1.52A23.08
DMS  A 905 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 368
1.67A22.18
DMS  A 905 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
LEU A 390
GLY A 526
VAL A 362
1.71A
DMS  A 905 ( 4.2A)
None
DMS  A 905 (-4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
ASN E 388
GLY E 526
VAL E 362
LEU E 513
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 513
1.79A
DMS  A 905 ( 4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
GLY E 526
VAL E 362
PHE E 515
LEU E 368
1.42A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
ASN E 388
GLY E 526
VAL E 362
LEU E 513
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
GLY E 526
VAL E 362
PHE E 515
LEU E 368
1.49A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.47A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.54A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.76A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  72
GLY A  71
GLN A  69
VAL A  18
TRP A  31
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  71
GLN A  19
VAL A  18
TRP A  31
LEU A  67
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.69A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.51A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
GLY A 526
VAL A 362
PHE A 515
LEU A 368
1.42A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
ASN E 388
GLY E 526
VAL E 362
LEU E 513
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
ASN A 388
GLY A 526
VAL A 362
LEU A 513
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU E 387
GLY E 526
VAL E 362
PHE E 515
LEU E 368
1.43A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.64A
PK8  A 401 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.56A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.57A21.45
PK8  A 401 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.74A21.41
PK8  A 401 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.64A
PK8  A 401 ( 3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.45A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.71A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  78
GLY D  79
VAL D  77
ARG A 148
CYH D 143
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 127
ALA E 124
LEU E  93
GLN E 118
PHE E 116
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU C  88
VAL C  35
LEU C 127
ILE C  23
ALA C  52
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D 127
ALA D 124
LEU D  93
GLN D 118
PHE D 116
1.61A
None
None
None
EDO  D 201 ( 4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.63A
EDO  A 202 ( 4.8A)
None
None
EDO  D 201 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  78
GLY A  79
VAL A  77
ARG D 148
CYH A 143
1.79A
None
None
None
EDO  D 202 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 127
ALA C 124
LEU C  93
GLN C 118
PHE C 116
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN A 117
LEU D 108
GLY D  78
GLY D  79
VAL D  95
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  78
GLY D  79
VAL D  77
ARG A 148
CYH D 143
1.75A
None
EDO  D 203 (-3.1A)
None
EDO  A 206 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU E 127
ALA E 124
LEU E  93
GLN E 118
PHE E 116
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  78
GLY D  79
VAL D  77
ARG A 148
CYH D 143
1.79A
None
EDO  D 203 (-3.1A)
None
EDO  A 206 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 127
ALA C 124
LEU C  93
GLN C 118
PHE C 116
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.62A
None
None
None
EDO  D 203 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU D 127
ALA D 124
LEU D  93
GLN D 118
PHE D 116
1.60A
None
None
None
EDO  A 207 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  78
GLY A  79
VAL A  77
ARG D 148
CYH A 143
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY D  78
GLY D  79
VAL D  77
ARG A 148
CYH D 143
1.79A20.00
None
EDO  D 203 (-3.1A)
None
EDO  A 206 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN A 117
LEU D 108
GLY D  78
GLY D  79
VAL D  95
1.49A
None
EDO  A 206 (-4.6A)
None
EDO  D 203 (-3.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU A 127
ALA A 124
LEU A  93
GLN A 118
PHE A 116
1.64A
None
None
None
EDO  A 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  78
VAL B  41
LEU B 127
GLN B 118
LEU B  93
1.78A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU C 127
ALA C 124
LEU C  93
GLN C 118
PHE C 116
1.62A
None
None
None
EDO  A 204 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY A  78
GLY A  79
VAL A  77
ARG C 148
CYH A 143
1.78A
None
EDO  A 204 (-3.6A)
None
EDO  C 205 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  78
GLY C  79
VAL C  77
ARG A 148
CYH C 143
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
LEU B 127
ALA B 124
LEU B  93
GLN B 118
PHE B 116
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 253
PHE A 219
LEU A 220
CYH A 265
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.52A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.65A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.66A
PJE  C   5 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.68A19.50
PJE  C   5 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.59A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.66A
PJE  C   5 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 7
LEU A 205
ASN A 203
GLU A 288
LEU A 282
1.66A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.54A21.45
PJE  C   5 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
VAL B 115
ILE B 120
ILE B 106
ALA B 102
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 241
LEU A 240
MET A 463
TYR A 286
1.55A13.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7btf NSP7
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.73A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7btf NSP8
(SARS-CoV-2)		5 / 12
LEU D 184
VAL D 159
LEU D 189
GLN D 157
ILE D 156
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 401
LEU B  91
MET A 666
MET B  90
1.76A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 361
ASN A 360
GLU A 370
LEU A 366
1.62A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 401
LEU A 387
MET B  94
MET B 129
1.79A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 351
LEU A 329
GLY A 327
PHE A 652
VAL A 675
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 351
ILE A 307
GLU A 658
ILE A 632
ALA A 634
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 7
LEU A 630
GLU A 658
LEU A 638
TYR A 619
1.68A14.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 10
LEU C  17
MET C  52
LEU C  60
MET D  90
LEU D  91
1.68A16.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D  91
VAL C  22
TRP C  29
LEU C  56
MET C  52
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
VAL A 398
LEU A 329
ILE A 539
ALA A 376
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7btf NSP8
(SARS-CoV-2)		5 / 12
LEU D 184
VAL D 159
LEU D 189
GLN D 157
ILE D 132
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
MET A  82
GLY A  79
VAL A  77
CYH A  44
CYH A  38
1.43A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A 146
LEU A  89
MET A  17
1.56A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
GLY A 146
VAL A 148
LEU A  87
CYH A  22
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A  27
ASN A  28
GLY A  29
LEU A  89
LEU A  67
1.78A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 208
LEU A 253
PHE A 219
LEU A 220
CYH A 265
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
GLY A 215
LEU A 220
PHE A 219
MET A 264
1.71A21.45
DMS  A 404 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 282
VAL A 204
MET A 264
LEU A 220
MET A 276
1.65A21.45
DMS  A 404 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 241
LEU A 240
MET A 463
TYR A 286
1.56A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLN A 541
MET A 668
ILE A 539
MET A 380
ALA A 399
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU D 122
VAL C  53
LEU D  98
GLU C  47
ALA C  42
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 351
LEU A 329
GLY A 327
PHE A 652
VAL A 675
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 7
LEU A 401
LEU B  91
MET A 666
MET B  90
1.72A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP7
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.60A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU C  17
LEU C  59
MET D  87
GLN C  18
1.74A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.44A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
LEU A 727
GLU A 474
LEU A 470
TYR A  38
1.55A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 5
LEU D  91
LEU D  95
MET C  62
GLN C  19
1.67A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
LEU A 544
GLN A 541
GLU A 665
ILE A 539
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
VAL A 398
LEU A 329
ILE A 539
ALA A 376
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv1 NSP12
(SARS-CoV-2)		5 / 9
THR A 206
LEU A 205
LEU A  90
GLN A 224
PHE A 222
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 413
VAL A 844
ARG A 555
PHE A 442
CYH C   8
1.45A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 397
ALA A 399
TYR B 149
LEU B 128
ILE B 185
1.59A15.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 271
VAL B 115
ILE B 120
ILE B 106
ALA B 102
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
GLN A 541
MET A 666
GLU A 665
ILE A 539
1.69A
None
U  T   8 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 241
LEU A 240
MET A 463
TYR A 286
1.58A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
LEU A 544
GLN A 541
GLU A 665
ILE A 539
1.55A
None
None
U  T   8 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
LEU A 544
GLN A 408
GLU A 665
ILE A 539
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 413
VAL A 844
ARG A 555
PHE A 442
LEU A 437
1.74A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 469
LEU A 470
MET A 242
GLN A 789
1.80A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 351
LEU A 329
GLY A 327
PHE A 652
VAL A 675
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 630
MET A 755
TYR A 746
MET A 633
1.79A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 205
GLY A 203
VAL A 202
LEU A  90
PHE A 192
1.79A13.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 469
ASN A 312
GLU A 350
TYR A 788
1.73A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 673
VAL A 398
LEU A 329
ILE A 539
ALA A 376
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP7
(SARS-CoV-2)		4 / 5
LEU C  14
LEU C  55
MET C  62
GLN C  18
1.45A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
LEU A 361
ASN A 360
GLU A 370
LEU A 366
1.38A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.69A
None