Ligand ID: 27R


Drugbank ID:
DB00963
(Bromfenac)


Indication:
For the treatment of postoperative inflammation in patients who have undergone cataract extraction.

Get human targets for 27R in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '27R' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		6m71 NSP12
(SARS-CoV-2)		4 / 5
TYR A 294
THR A 276
PRO A 296
VAL A 353
1.67A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR C 674
THR C 599
PRO C 600
VAL C 308
1.70A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
TYR A 674
THR A 599
PRO A 600
VAL A 308
1.70A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		7btf NSP12
(SARS-CoV-2)		4 / 5
TYR A 294
THR A 276
PRO A 296
VAL A 353
1.62A17.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
TYR A 294
THR A 276
PRO A 296
VAL A 353
1.61A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
TYR A 294
THR A 276
PRO A 296
VAL A 353
1.65A17.06
None