Ligand ID: Y70


Drugbank ID:
DB08910
(Pomalidomide)


Indication:
Pomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy.

Get human targets for Y70 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'Y70' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 7
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.74A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		1x7q HLA, A-11
NUCLEOCAPSID PEPTIDE
(Homo
sapiens)		4 / 8
ASN A  66
PRO C   4
PHE C   3
TYR A 171
1.73A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
TRP B  94
PHE B  96
THR C 201
TRP B 107
1.67A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS A 337
GLU A 233
HIS A 234
PHE A 302
GLY A 229
1.72A22.50
5.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
HIS A  69
TRP A 124
PHE A 156
THR A  93
1.64A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
HIS A  69
TRP A 124
PHE A 156
THR A  93
1.61A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 7
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.65A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.67A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
ASN S 473
PRO S 462
PHE S 460
TYR A 442
1.61A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 7
HIS A  69
TRP A 124
PHE A 156
THR A  93
1.64A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_B_Y70B502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		3sci ACE2
(Homo
sapiens)		5 / 12
PRO B 284
GLU B 433
PHE B 428
GLN B 287
GLY B 286
1.78A21.30
5.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		3sci ACE2
(Homo
sapiens)		5 / 12
ASN B 437
GLU B 433
PHE B 428
GLN B 287
GLY B 286
1.61A21.30
5.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ASN A  78
PRO A  79
PHE A  76
PHE A  69
1.64A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
ASN C  78
PRO C  79
PHE C  76
PHE C  69
1.68A8.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
MET A1032
PHE A 870
TRP A 868
TYR C1029
1.42A8.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO A1094
PHE A1057
PHE A1085
TRP A1084
1.66A8.08
PRO  A1094 ( 1.1A)
PHE  A1057 ( 1.3A)
PHE  A1085 ( 1.3A)
TRP  A1084 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.70A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
ASN B1090
PRO B1051
TRP A 868
TYR A 886
1.75A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO A1094
PHE A1057
PHE A1085
TRP A1084
1.48A8.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASN C  78
PRO C  79
PHE C  76
PHE C  69
1.73A8.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASN A 135
PRO A 136
PHE A  76
TYR A 252
1.60A8.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASN D  33
GLU D  35
HIS D  34
PHE B 460
GLN D  76
1.71A21.46
5.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.68A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
ASN A 527
PRO A 526
PHE A 529
TRP A 534
1.77A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
MET A1032
PHE A 870
TRP A 868
TYR B1029
1.33A7.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6nur NSP12
(SARSr-CoV)		4 / 8
ASN A 703
PHE A 753
TRP A 617
TYR A 619
1.73A8.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 8
ASN B 118
PRO A 328
PHE A 396
TYR A 453
1.79A16.41
None