Ligand ID: VOG


Drugbank ID:
DB04878
(Voglibose)


Indication:
For the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.

Get human targets for VOG in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'VOG' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP C 727
ASP C 719
MET C 722
ARG A 306
PHE A 305
1.76A20.47
ASP  C 727 ( 0.5A)
ASP  C 719 ( 0.6A)
MET  C 722 ( 0.0A)
ARG  A 306 ( 0.6A)
PHE  A 305 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASP C 727
ASP C 719
MET C 722
ARG A 306
PHE A 305
1.80A20.38
ASP  C 727 ( 0.5A)
ASP  C 719 ( 0.6A)
MET  C 722 ( 0.0A)
ARG  A 306 ( 0.6A)
PHE  A 305 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP C 727
ASP C 719
MET C 722
ARG B 306
PHE B 305
1.68A20.53
None