Ligand ID: VLB


Drugbank ID:
DB00570
(Vinblastine)


Indication:
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Get human targets for VLB in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'VLB' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
LYS A 102
ASP A 176
TYR A  37
LEU A  32
1.74A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		4 / 5
VAL F 933
ASN F 937
VAL D1157
ILE D1160
1.66A12.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 5
PRO B   5
VAL B  27
VAL B  37
ILE B  35
1.19A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
PRO B   5
LYS B   6
VAL B  27
VAL B  37
ILE B  35
1.38A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 7
PRO B   5
VAL B  27
VAL B  37
ILE B  35
1.02A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LYS A 102
ASP A 176
TYR A  37
LEU A  32
1.72A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.34A21.66
22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		2a5i 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 9
LYS A  90
VAL A  91
ASP A  92
PHE A  66
THR A  21
1.77A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.27A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 5
PRO B 214
VAL B 185
ASN B 213
ILE B 303
1.62A18.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 7
PRO A 307
ILE A 200
VAL A 337
ILE A 205
1.24A17.95
None
None
GOL  A1010 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
LEU C 282
PRO C 280
VAL C 259
ILE C 223
GLY C 285
1.23A17.95
GOL  C1011 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  31
TYR F 475
PRO F 462
LEU F 443
1.43A22.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU F  22
VAL E  16
ILE E  46
PHE E  92
ILE E  20
1.39A11.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU A  22
VAL B  16
ILE B  46
PHE B  92
ILE B  20
1.40A10.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 12
ILE H  34
ALA H  93
PHE H  29
GLY H  55
ILE H  56
1.34A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		4 / 5
PRO L 114
ASN L 113
VAL L 204
ILE L 137
1.58A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
LEU C 101
PRO C  99
VAL C  78
ILE C  42
GLY C 104
1.21A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 7
PRO B 126
ILE B  19
VAL B 156
ILE B  24
1.18A17.52
None
None
APR  B 477 ( 4.9A)
APR  B 477 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		4 / 5
PRO C  33
VAL C   4
ASN C  32
ILE C 122
1.53A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ASP B  63
TYR A  28
THR A  55
TYR A  36
1.36A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
PRO A  47
VAL A  22
VAL A   8
ILE A   6
1.60A22.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU C 291
ALA C 142
PHE C  96
GLY C 288
ILE C 286
1.40A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2fxp SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
VAL C  20
ASN C  22
VAL B  20
ILE A  23
1.42A10.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU D  31
ASN D  10
ALA J  20
VAL D 108
GLY D 109
1.35A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		4 / 6
ASP D 105
TYR D  95
TYR D 168
LEU D  45
1.79A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LYS A 390
VAL A 389
ASP A 429
THR A 363
1.42A16.07
 CL  A 246 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		2gri NSP3
(SARSr)		4 / 7
PRO A   2
ASN A  21
VAL A  13
ILE A   3
1.07A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2h2z REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A  30
VAL A 114
ILE A 136
ALA A 129
GLY A 146
1.40A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr)		4 / 7
PRO A  50
VAL A  51
ASN A  52
ILE A  26
1.09A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2idy NSP3
(SARSr-CoV)		4 / 5
PRO A   2
ASN A  21
VAL A  13
ILE A   3
1.57A16.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		4 / 8
VAL A  52
ASP A  57
THR A  30
LEU A  36
1.43A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2kaf NSP3
(SARSr-CoV)		4 / 8
VAL A  10
TYR A  16
TYR A  21
LEU A  33
1.35A10.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2kaf NSP3
(SARSr)		4 / 8
VAL A  10
TYR A  21
TYR A  16
LEU A  33
1.31A10.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2kqw NSP3
(SARSr-CoV)		4 / 8
VAL A 141
TYR A 152
TYR A 147
LEU A 164
1.43A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
LEU B  30
VAL B 114
ILE B 136
ALA B 129
GLY B 146
1.37A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.33A20.73
21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU A 331
LYS A 319
VAL A 320
ILE A 322
ALA A 325
1.39A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
VAL C  84
ASN C  62
VAL C 101
ILE C  79
1.48A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.28A21.41
21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 6
LYS B 102
ASP B 176
TYR B  37
LEU B  32
1.72A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.29A20.75
21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
VAL A  77
ASP A  92
THR A  21
LEU A  87
1.29A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
THR E 105
PRO E  50
ASN E  52
ILE E  26
ILE A  27
1.25A22.94
21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
PRO F  50
VAL F  51
ASN F  52
ILE F  26
1.07A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
PRO B 270
VAL C  40
ILE C  38
ALA B  94
VAL C  35
ILE C  42
1.76A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 5
PRO F  50
VAL F  51
ASN F  52
ILE C  27
1.56A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 8
LYS D 276
VAL D 294
TYR D 278
THR D 281
LEU D 254
1.79A23.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
VAL B  77
ASP B  92
THR B  21
LEU B  87
1.42A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.29A20.59
21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		2wct NSP3
(SARSr-CoV)		6 / 12
VAL C 611
ASP B 447
PRO B 460
ILE B 417
VAL B 458
ILE B 459
1.61A20.27
19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		2wct NSP3
(SARSr-CoV)		4 / 6
LYS A 545
ASP A 575
TYR A 564
LEU A 537
1.80A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
VAL A 197
ASN A 198
VAL A  35
ILE A  36
1.60A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
VAL A 197
ASN A 198
VAL A  35
ILE A  36
1.60A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LYS B 102
ASP B 176
TYR B  37
LEU B  32
1.77A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.31A21.51
22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 6
ASP S 463
TYR A 475
PRO A 462
LEU A 443
1.61A16.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
LEU C 181
LYS C 149
ILE C 117
PHE C 118
VAL C 132
1.34A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3bgf F26G19 FAB
(Mus
musculus)		4 / 6
ASP C  55
PRO B  98
TYR C  91
LEU B 100
1.58A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3bgf SPIKE PROTEIN S1
(SARSr-CoV)		4 / 8
ASP A 463
TYR S 475
PRO S 462
LEU S 443
1.33A16.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
VAL A 581
ASP A 225
PRO A 583
LEU A 585
1.43A22.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PRO A 451
ILE A 513
VAL A 226
ILE A 233
1.14A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
ASP B 543
PRO B 538
TYR B 587
LEU B 439
1.77A21.88
NDG  B 618 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PRO A 415
LYS A 416
ILE A 421
VAL A 293
ILE A 291
1.30A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LYS A 102
ASP A 176
TYR A  37
LEU A  32
1.77A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.26A20.86
21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		3e9s NSP3
(SARSr-CoV)		4 / 5
PRO A  47
VAL A  22
VAL A   8
ILE A   6
1.63A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3e9s NSP3
(SARSr-CoV)		4 / 8
ASP A 215
TYR A 208
THR A 232
LEU A 186
1.39A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		3e9s NSP3
(SARSr-CoV)		5 / 12
LEU A 291
ALA A 142
PHE A  96
GLY A 288
ILE A 286
1.35A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.28A21.51
22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.28A18.32
22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL C 204
PRO A 293
ILE A 259
VAL C 212
ILE C 213
1.22A12.65
12.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.33A18.91
22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.26A21.53
21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.29A20.99
21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3i6g HLA, A-2
(Homo
sapiens)		4 / 8
VAL D 249
THR D 228
TYR D 257
LEU D 201
1.28A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		3i6g BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 7
PRO B   5
VAL B  27
VAL B  37
ILE B  35
0.93A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		3i6g BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 5
PRO B   5
VAL B  27
VAL B  37
ILE B  35
1.11A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		3i6k BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
PRO F   5
LYS F   6
VAL F  27
VAL F  37
ILE F  35
1.02A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
LYS D 102
THR D 175
TYR D  37
LEU D  30
1.32A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL C 204
PRO A 293
ILE A 259
VAL C 212
ILE C 213
1.23A21.29
21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 204
PRO B 293
ILE B 259
VAL B 212
ILE B 213
1.32A21.29
21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
VAL A  77
ASP A  92
THR A  21
LEU A  87
1.39A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.26A20.22
21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
VAL A 197
ASN A 198
VAL A  35
ILE A  36
1.62A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3sci ACE2
(Homo
sapiens)		4 / 8
LYS A 541
PRO A 590
TYR A 587
LEU A 439
1.34A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LYS B  31
TYR F 475
PRO F 462
LEU F 443
1.62A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
PRO A 451
ILE A 513
VAL A 226
ILE A 233
1.19A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PRO B 415
LYS B 416
ILE B 421
VAL B 293
ILE B 291
1.26A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 6
LYS A 577
TYR A 215
PRO A 565
TYR A 217
1.70A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
LYS A 541
PRO A 590
TYR A 587
LEU A 439
1.43A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.32A20.77
21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.29A21.13
20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
VAL B  77
ASP B  92
THR B  21
LEU B  87
1.37A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		4m0w UBIQUITIN
(bos
taurus)		4 / 8
LYS B  27
VAL B  26
ASP B  32
LEU B  56
0.69A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		4m0w UBIQUITIN
(Bos
taurus)		5 / 12
LYS B   6
VAL B   5
ILE B   3
VAL B  26
ILE B  30
1.39A10.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 5
PRO A 317
VAL A 318
VAL A 189
ILE A 315
1.44A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
ASP A 287
PHE A 305
THR A 302
TYR A 297
LEU A 254
1.43A21.54
NHE  A 403 (-2.9A)
None
None
None
GOL  A 406 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.35A20.75
21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 8
ASP B 215
TYR B 208
THR B 232
LEU B 186
1.41A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
LEU A 291
ALA A 142
PHE A  96
GLY A 288
ILE A 286
1.33A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 9
ASP A 287
PHE A 305
THR A 302
TYR A 297
LEU A 254
1.37A21.84
None
None
P85  A 902 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 7
PRO D 293
VAL D 296
ASN D 297
ILE D 300
0.74A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 7
PRO B 293
VAL B 296
ASN B 297
ILE B 300
0.52A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 7
PRO C 293
VAL C 296
ASN C 297
ILE C 300
0.37A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		4wme MERS-COV 3CL
PROTEASE
(MERS-CoV)		4 / 7
PRO A 293
VAL A 296
ASN A 297
ILE A 300
0.43A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 204
PRO A 293
ILE A 259
VAL A 212
ILE A 213
1.29A21.62
22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LYS A 102
ASP A 176
TYR A  37
LEU A  32
1.77A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LYS B 376
ASP B 379
TYR B 351
LEU B 366
1.39A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
VAL B 389
ASN B 388
VAL B 398
ILE B 332
1.33A22.36
SAH  B 605 (-4.7A)
G3A  B 606 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
LYS B 376
ASP B 379
TYR B 351
LEU B 366
1.42A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 8
LYS B 376
ASP B 379
TYR B 351
LEU B 366
1.36A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
VAL D 389
ASN D 388
VAL D 398
ILE D 332
1.18A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
LYS B 376
ASP B 379
TYR B 351
LEU B 366
1.38A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		5e6j UBIQUITIN
(synthetic
construct)		5 / 12
LYS E   6
VAL E   5
ILE E   3
VAL E  26
ILE E  30
1.39A10.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		4 / 7
VAL C  26
ILE C  30
VAL C   5
ILE C   3
1.18A10.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5e6j POLYUBIQUITIN-B
(synthetic
construct)		4 / 8
LYS C  27
VAL C  26
ASP C  32
LEU C  56
0.89A11.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5e6j UBIQUITIN
(synthetic
construct)		4 / 8
LYS E  27
VAL E  26
ASP E  32
LEU E  56
0.85A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5f22 NSP8
(SARSr-CoV)		4 / 5
PRO B 188
VAL B 137
VAL B 164
ILE B 190
1.65A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 6
LYS D 376
ASP D 379
TYR D 351
LEU D 366
1.21A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 8
LYS B 376
ASP B 379
TYR B 351
LEU B 366
1.13A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
VAL C 389
ASN C 388
VAL C 398
ILE C 332
1.20A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 291
ALA B 142
PHE B  96
GLY B 288
ILE B 286
1.36A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
ASP D 215
TYR D 208
THR D 232
LEU D 186
1.42A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ASP B 287
PHE B 305
THR B 302
TYR B 297
LEU B 254
1.42A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL A 114
ILE A 116
PHE A 220
ILE A 226
1.08A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 5
PRO B 136
ASN B  78
VAL B 102
ILE B 152
1.57A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
VAL C 382
ASN C 381
ILE C 345
VAL C 510
1.16A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
LYS B1021
TYR B 794
PRO B1131
LEU B 894
1.69A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU B 847
VAL B 711
ALA B1002
VAL B 763
ILE B 852
1.40A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ILE A 970
ALA A 956
PHE C 778
GLY C1170
ILE C1180
1.20A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		5x5f S PROTEIN
(MERS-CoV)		4 / 5
PRO B 476
VAL B 575
ASN B 475
ILE B 428
1.49A15.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		5x5f S PROTEIN
(MERS-CoV)		4 / 8
VAL A 356
TYR A 663
TYR A 351
LEU A 347
1.32A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
ASP A 191
PRO A 259
TYR A  41
LEU A 257
1.76A16.93
ASP  A 191 ( 0.5A)
PRO  A 259 ( 1.1A)
TYR  A  41 ( 1.3A)
LEU  A 257 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 9
ASP A 287
PHE A 305
THR A 302
TYR A 297
LEU A 254
1.45A21.70
None
None
GOL  A 409 (-3.5A)
None
GOL  A 408 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LYS B  94
ASP B 171
TYR B 200
LEU B 182
1.73A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 696
ALA C 695
PHE C1077
GLY C 892
ILE C 891
1.41A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6acg ACE2
(Homo
sapiens)		4 / 7
PRO D 451
ILE D 513
VAL D 226
ILE D 233
1.11A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
TYR B 598
PHE B 305
THR B 616
PRO B 617
TYR B 622
1.79A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 596
THR B 616
PRO B 617
TYR B 622
VAL B 601
1.32A16.50
17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
PRO A 136
ASN A  78
VAL A 102
ILE A 152
1.43A17.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6acj ACE2
(Homo
sapiens)		5 / 12
PRO D 415
LYS D 416
ILE D 421
VAL D 293
ILE D 291
1.37A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
TYR B 689
THR A 773
PRO A 774
LEU A 776
1.23A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
ILE A 116
PHE A 103
VAL A 196
ILE A 219
1.14A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
ASP A 684
THR B 775
PRO B 774
LEU B 788
1.29A16.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C 123
ASN C 122
ALA C 167
GLY C 100
ILE C 116
1.34A15.93
None
NAG  C1302 (-3.1A)
NAG  C1303 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
PRO C 136
ASN C  78
VAL C 102
ILE C 152
1.50A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
VAL A 186
ASP A  85
TYR A  88
TYR A  41
LEU A 216
1.77A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
ASP A  85
TYR A  88
TYR A  41
LEU A 216
1.55A17.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
VAL B 510
PHE B 501
VAL B 382
ILE B 345
1.00A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
TYR A  41
THR A 261
TYR A  53
LEU A 264
1.12A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		4 / 6
LYS D  31
TYR B 475
PRO B 462
LEU B 443
1.68A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6iex BETA-2-MICROGLOBULIN
(Homo
sapiens)		4 / 8
ASP B  98
THR B  73
PRO B  72
LEU B  23
1.37A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
TYR A  74
PHE A  22
THR A  10
TYR A 118
LEU A  78
1.79A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6jyt HELICASE
(SARSr-CoV)		4 / 8
VAL B  49
TYR B  48
THR B  61
LEU B  41
1.33A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6jyt HELICASE
(SARSr-CoV)		4 / 6
LYS B  76
TYR B  64
TYR B  70
LEU B  83
1.78A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
LEU A 526
ILE A 488
ALA A 487
VAL A 521
ILE A 525
1.34A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
PRO A 579
VAL A 582
ASN A 580
ILE A 187
1.56A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
VAL C 402
ILE C 401
VAL C 393
ILE C 325
1.03A21.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6m1d ACE2
(Homo
sapiens)		4 / 8
VAL D 491
ASP D 499
TYR D 613
THR D 686
1.40A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6m1d ACE2
(Homo
sapiens)		4 / 6
ASP B 206
TYR B 516
TYR B 521
LEU B 520
1.28A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
VAL C1076
ILE C1086
VAL C1078
ILE C 694
1.22A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
VAL B 711
ASN B 759
VAL B 763
ILE B 852
1.53A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
LYS B 768
VAL B 767
THR B 869
LEU B1016
1.29A16.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
LEU B 847
VAL B 711
ASN B 759
ALA B1002
VAL B 763
ILE B 852
1.63A16.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 7
VAL L  83
ILE L  80
VAL L 109
ILE L 111
1.12A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6nur NSP12
(SARSr)		4 / 8
LYS A 188
THR A 206
TYR A 238
LEU A 241
1.01A18.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		6nus NSP12
(SARSr-CoV)		4 / 6
ASP A 284
PRO A 232
TYR A 238
LEU A 205
1.53A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6vw1 ACE2
(Homo
sapiens)		4 / 7
PRO A 451
ILE A 513
VAL A 226
ILE A 233
1.11A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6vw1 ACE2
(Homo
sapiens)		5 / 12
VAL A 209
ASN A 210
LYS A  94
VAL A 212
GLY A 214
1.41A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
VAL L 104
TYR L  86
THR L  74
LEU L  78
1.67A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ASP L   9
THR L  97
TYR L  87
LEU H  45
1.58A17.14
SO4  L 303 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
LYS L 145
VAL L 196
PRO L 204
LEU L 201
1.65A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
PRO H  52
ASN H  76
ILE H  75
ILE H  51
1.61A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
VAL L 104
TYR L  86
THR L  20
LEU L  78
1.62A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TYR L  49
THR H 100
PRO H 100
LEU L  46
1.51A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
VAL H 184
PRO H 126
TYR H 194
LEU H 189
1.75A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
LYS H  83
VAL H 111
THR H 108
LEU H  18
1.72A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
TYR L  36
THR H 100
PRO H 100
ILE L   2
VAL L  27
1.68A15.51
16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L 187
LYS L 155
ILE L 123
PHE L 124
VAL L 138
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
LEU H 128
PRO H 127
VAL H 215
ILE H 199
GLY H 143
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR C  55
THR B 104
PRO B 105
LEU C  52
1.41A
DMS  A 905 (-4.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU L 187
LYS L 155
ILE L 123
PHE L 124
VAL L 138
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L  55
THR H 104
PRO H 105
LEU L  52
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU L 187
LYS L 155
ILE L 123
PHE L 124
VAL L 138
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
LEU H 128
PRO H 127
VAL H 215
ILE H 199
GLY H 143
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
LEU B 128
PRO B 127
VAL B 215
ILE B 199
GLY B 143
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
LEU C 187
LYS C 155
ILE C 123
PHE C 124
VAL C 138
1.52A
None