Ligand ID: TZN


Drugbank ID:
DB01162
(Terazosin)


Indication:
For the treatment of symptomatic BPH and mild to moderate hypertension.

Get human targets for TZN in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TZN' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY B 104
LEU B 103
PHE B  75
LEU B 112
VAL B 110
0.98A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY B 104
LEU B 103
PHE B  75
LEU B 112
VAL B 110
1.00A16.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 138
GLY B   2
THR B 285
GLY A 170
VAL A 171
1.31A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 12
GLY A 100
PHE A  90
LEU A  42
LEU A 106
GLY A 104
1.16A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 12
GLY A 100
PHE A  90
LEU A  42
LEU A 106
GLY A 104
1.24A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		6 / 12
GLY C 229
GLY C 228
MET C 243
LEU C 235
GLY C 230
VAL C 231
1.58A17.68
GOL  C1009 (-4.0A)
GOL  C1009 (-3.4A)
None
None
GOL  C1005 ( 3.7A)
GOL  C1005 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLY B 230
ALA B 234
GLY B 229
GLY B 233
THR C 195
1.18A18.18
None
None
GOL  B1004 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2ajf ACE2
(Homo
sapiens)		5 / 12
ALA A 264
THR A 276
PHE A 452
GLY A 486
VAL A 485
1.23A23.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY B 146
GLY B  29
THR B  35
PHE B  66
LEU B  87
VAL B  42
1.79A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY B 146
GLY B  29
THR B  35
PHE B  66
LEU B  87
VAL B  42
1.76A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 137
THR H 193
LEU H 138
LEU H 159
GLY H 162
VAL H 163
1.60A17.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 137
THR H 193
LEU H 138
LEU H 159
GLY H 162
VAL H 163
1.64A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		6 / 12
GLY B  48
GLY B  47
MET B  62
LEU B  54
GLY B  49
VAL B  50
1.62A15.27
APR  B 477 (-3.6A)
APR  B 477 (-3.7A)
None
None
APR  B 477 (-3.5A)
APR  B 477 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ALA C  51
GLY C  47
GLY C  48
PHE C 133
GLY B 104
1.27A16.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY C  29
GLY C  33
PHE C  32
THR C  11
VAL C  42
1.24A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2ga6 ORF1A POLYPROTEIN
(SARSr-CoV)		6 / 12
GLY X 121
ALA X  54
GLY X  52
THR X 101
PHE X 110
GLY X 127
1.78A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
GLY A 116
GLY A   1
GLY A   1
LEU A 112
VAL A   3
1.30A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
GLY A  71
GLY A  71
GLY A  71
LEU A  66
VAL A  74
1.17A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
GLY A 116
GLY A 116
THR A  68
LEU A  66
GLY A 116
1.21A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
GLY A 368
ALA A 371
LEU A 374
PHE A 364
LEU A 499
GLY A 418
1.77A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY A 246
GLY A 238
GLY A 247
MET A 251
LEU A 254
1.34A23.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
THR A 190
PHE A 185
LEU A 167
GLY A 170
VAL A 171
1.28A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
THR A 190
PHE A 185
LEU A 167
GLY A 170
VAL A 171
1.29A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
GLY B 174
ALA B 173
THR D   1
LEU B 167
VAL B 186
1.29A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2qc2 3C-LIKE PROTEINASE
(-)		6 / 12
GLY B 146
GLY B  29
THR B  35
PHE B  66
LEU B  87
VAL B  42
1.77A18.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A 190
PHE A 185
LEU A 167
GLY A 170
VAL A 171
1.33A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLY B 246
GLY B 238
GLY B 247
MET B 251
LEU B 254
1.21A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLY B 246
GLY B 238
GLY B 247
MET B 251
LEU B 254
1.22A23.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		2wct NSP3
(SARSr-CoV)		5 / 12
ALA D 620
GLY D 609
PHE B 406
GLY D 614
VAL D 611
1.34A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY B 146
GLY B  29
THR B  35
PHE B  66
LEU B  87
VAL B  42
1.77A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
GLY H  42
GLY H  44
LEU H  45
PHE H  91
VAL H  89
1.26A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 264
THR A 276
PHE A 452
GLY A 486
VAL A 485
1.21A23.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 264
THR B 276
LEU B 267
GLY B 486
VAL B 485
1.25A23.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY A 146
GLY A  29
THR A  35
PHE A  66
LEU A  87
VAL A  42
1.79A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3e9s NSP3
(SARSr-CoV)		5 / 12
GLY A  29
GLY A  33
PHE A  32
THR A  11
VAL A  42
1.22A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY A 143
PHE A 150
MET A  17
LEU A 115
GLY A 124
VAL A 125
1.79A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 146
GLY A  29
THR A  35
LEU A  87
VAL A  42
1.30A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY A 146
GLY A  29
THR A  35
PHE A  66
LEU A  87
VAL A  42
1.69A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLY A  29
GLY A  33
PHE A  32
THR A  11
VAL A  42
1.28A23.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLY A  29
GLY A  33
PHE A  32
THR A  11
VAL A  42
1.16A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3scj ACE2
(Homo
sapiens)		5 / 12
ALA B 264
THR B 276
PHE B 452
GLY B 486
VAL B 485
1.20A23.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
THR B 593
LEU B 595
PHE B 588
LEU B 236
VAL B 447
1.30A23.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 264
THR A 276
PHE A 452
GLY A 486
VAL A 485
1.22A23.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
GLY B 146
GLY B  29
THR B  35
PHE B  66
LEU B  87
VAL B  42
1.73A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLY A  29
GLY A  33
PHE A  32
THR A  11
VAL A  42
1.24A22.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY D  29
GLY D  33
PHE D  32
THR D  11
VAL D  42
1.23A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY D  29
GLY D  33
PHE D  32
THR D  11
VAL D  42
1.22A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 926
PHE A 805
LEU A 804
GLY A1041
VAL A1042
1.18A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA A 926
PHE A 805
LEU A 804
GLY A1041
VAL A1042
1.25A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 350
GLY B 512
PHE B 316
PHE B 379
LEU B 377
1.20A16.33
ALA  B 350 ( 0.0A)
GLY  B 512 ( 0.0A)
PHE  B 316 ( 1.3A)
PHE  B 379 ( 1.3A)
LEU  B 377 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 350
GLY B 512
PHE B 316
PHE B 379
LEU B 377
1.22A16.32
ALA  B 350 ( 0.0A)
GLY  B 512 ( 0.0A)
PHE  B 316 ( 1.3A)
PHE  B 379 ( 1.3A)
LEU  B 377 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLY A  29
GLY A  33
PHE A  32
THR A  11
VAL A  42
1.26A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 350
GLY A 512
PHE A 316
PHE A 379
LEU A 377
1.28A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 350
GLY A 512
PHE A 316
PHE A 379
LEU A 377
1.28A16.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY A 871
GLY A 867
THR C 693
LEU A 876
GLY A 862
1.28A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLY B 873
ALA B 875
GLY B 871
LEU B 859
VAL B 767
1.29A16.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6cs2 ACE2
(Homo
sapiens)		5 / 12
ALA D 264
THR D 276
PHE D 452
GLY D 486
VAL D 485
1.23A23.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6cs2 ACE2
(Homo
sapiens)		6 / 12
ALA D 264
THR D 276
LEU D 267
PHE D 452
GLY D 486
VAL D 485
1.41A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6lzg ACE2
(Homo
sapiens)		5 / 12
ALA A 264
THR A 276
LEU A 267
GLY A 486
VAL A 485
1.23A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6m0j ACE2
(Homo
sapiens)		5 / 12
ALA A 264
THR A 276
LEU A 267
GLY A 486
VAL A 485
1.23A23.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY A 438
GLY A 285
GLY A 284
PHE A 277
GLY A 434
1.22A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY C  68
ALA C  69
GLY C  67
GLY C  66
LEU C  61
1.24A20.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 151
THR H 207
LEU H 152
LEU H 173
GLY H 176
VAL H 177
1.67A18.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 151
THR H 207
LEU H 152
LEU H 173
GLY H 176
VAL H 177
1.63A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6nur NSP12
(SARSr-CoV)		6 / 12
GLY A 839
ALA A 840
GLY A 841
PHE A 859
LEU A 862
VAL A 844
1.56A18.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ALA H  93
GLY H  95
GLY H  94
THR H  77
LEU H   4
1.64A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ALA H  93
GLY H  95
GLY H  94
THR H  77
GLY H  97
1.55A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		6 / 12
ALA H 137
THR H 193
LEU H 138
LEU H 159
GLY H 162
VAL H 163
1.71A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		6 / 12
ALA H 137
THR H 193
LEU H 138
LEU H 159
GLY H 162
VAL H 163
1.64A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLY H  35
GLY H  95
GLY H  94
LEU H   4
PHE H  29
1.61A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
ALA L  34
THR L  69
LEU L  33
LEU L   4
GLY L  99
1.61A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY H  95
GLY H  94
LEU L  46
PHE L  98
GLY H  35
1.46A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY L 200
ALA L 112
THR L 164
LEU L 136
VAL L 196
1.77A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLY H  35
GLY H  95
GLY H  94
LEU H   4
PHE H  29
1.51A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ALA H  93
GLY H  95
GLY H  94
THR H  77
LEU H   4
1.56A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY L 200
ALA L 112
THR L 164
LEU L 136
VAL L 196
1.76A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
GLY B  28
GLY B  26
PHE L  68
LEU L  53
GLY L  63
VAL L  64
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA B 141
THR B 197
LEU B 142
LEU B 163
GLY B 166
VAL B 167
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
GLY H  28
GLY H  26
PHE C  68
LEU C  53
GLY C  63
VAL C  64
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA B 141
THR B 197
LEU B 142
LEU B 163
GLY B 166
VAL B 167
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
GLY B  28
GLY B  26
PHE L  68
LEU L  53
GLY L  63
VAL L  64
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		6 / 12
GLY H  28
GLY H  26
PHE C  68
LEU C  53
GLY C  63
VAL C  64
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
GLY H  35
LEU H   4
PHE H  29
MET H   2
GLY H  99
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6ym0 HEAVY CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 12
ALA B 141
THR B 197
LEU B 142
LEU B 163
GLY B 166
VAL B 167
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 12
ALA B 141
THR B 197
LEU B 142
LEU B 163
GLY B 166
VAL B 167
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		6yor IGG H CHAIN
(Homo
sapiens)		6 / 12
ALA H 141
THR H 197
LEU H 142
LEU H 163
GLY H 166
VAL H 167
1.74A
None