Ligand ID: TOR


Drugbank ID:
DB00273
(Topiramate)


Indication:
Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia® is indicated for the treatment and management of obesity.

Get human targets for TOR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TOR' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.52A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.53A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
ASN A 221
ALA A 267
GLN A 273
VAL A 233
THR A 225
1.43A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.43A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.40A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1uk4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN B 942
ALA B 938
GLN F 931
VAL F1158
VAL E 933
1.51A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.74A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.46A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.52A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.50A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.48A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ASN C 222
ALA C 221
GLN C 244
HIS C 227
HIS C 276
1.50A25.27
GOL  C1009 (-3.8A)
GOL  C1009 (-4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
SER D 247
HIS D 276
VAL D 231
LEU D 270
HIS D 268
1.33A23.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.53A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.51A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 221
ALA B 267
GLN B 273
VAL B 233
THR B 225
1.48A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN B 221
ALA B 267
GLN B 273
VAL B 233
THR B 225
1.44A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASN B  41
ALA B  40
GLN B  63
HIS B  46
HIS B  95
1.46A23.93
APR  B 477 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
SER A  66
HIS A  95
VAL A  50
LEU A  89
HIS A  87
1.35A23.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
HIS B 172
VAL B 117
LEU B 174
THR B 171
1.53A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
GLU C  68
HIS C  18
THR C  64
1.05A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
GLU H  60
HIS H  48
THR H  51
1.22A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 144
PHE A 181
HIS A 163
HIS A 172
LEU A 167
1.77A21.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 234
ASN A 231
VAL A 247
LEU A 262
THR A 225
1.45A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2kaf NSP3
(SARSr)		3 / 3
GLU A  49
HIS A  51
THR A  43
1.34A22.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 234
ASN A 231
VAL A 247
LEU A 262
THR A 225
1.45A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.53A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.51A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.50A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASN B  74
PHE B 329
VAL B 294
LEU B 297
THR B 195
1.41A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.49A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.51A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.52A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.50A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.53A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 11
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.42A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.50A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
ASN B 231
ALA B 234
VAL B 247
LEU B 262
THR B 225
1.51A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
GLN A 244
VAL A 247
VAL A 261
THR A 225
THR A 226
1.42A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.51A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.51A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.52A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.52A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.52A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.48A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 221
ALA B 267
GLN B 273
VAL B 233
THR B 225
1.50A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.50A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER B  67
PHE A 250
GLN A  87
HIS B  48
LEU A 244
1.55A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER B  67
PHE A 250
GLN A  87
HIS B  48
LEU A 244
1.57A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.46A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.49A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER B 204
VAL B 121
VAL B 144
LEU B 154
THR B 153
1.50A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 409
GLN B 442
VAL B 447
LEU B 584
THR B 519
1.70A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 221
ALA B 267
GLN B 273
VAL B 233
THR B 225
1.41A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.46A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.45A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.48A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3e9s NSP3
(SARSr-CoV)		3 / 3
GLU A  68
HIS A  18
THR A  64
1.13A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3e9s NSP3
(SARSr-CoV)		5 / 12
PHE A 148
HIS A 172
VAL A 117
LEU A 174
THR A 171
1.54A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.51A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.48A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.53A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.52A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.50A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ebn REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.49A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
ALA A 234
VAL A 247
LEU A 262
THR A 225
1.43A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.51A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN A 244
VAL A 247
LEU A 262
THR A 225
THR A 226
1.47A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.49A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.48A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.50A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
ALA A 234
VAL A 247
LEU A 262
THR A 225
1.50A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3i6l HLA, A-24
(Homo
sapiens)		3 / 3
GLU D 264
HIS D 263
THR D 182
1.38A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.53A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.50A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 221
ALA B 267
GLN B 273
VAL B 233
THR B 225
1.44A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN B 244
VAL B 247
LEU B 262
THR B 225
THR B 226
1.51A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 234
ASN B 231
VAL B 247
LEU B 262
THR B 225
1.44A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.47A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.49A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.48A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		5 / 12
SER B  67
PHE A 250
GLN A  87
HIS B  48
LEU A 244
1.51A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A 264
HIS A 263
THR A 182
1.41A22.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.52A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 234
ASN A 231
VAL A 247
LEU A 262
THR A 225
1.50A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.51A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN B 231
HIS B 246
VAL B 261
LEU B 205
THR B 201
1.50A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		3 / 3
GLU A  68
HIS A  18
THR A  64
1.07A19.53
None
GOL  A 405 (-3.9A)
GOL  A 405 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
HIS A 172
VAL A 117
LEU A 174
THR A 171
1.54A21.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.52A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASN A 231
HIS A 246
VAL A 261
LEU A 205
THR A 201
1.50A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
PHE B 148
HIS B 172
VAL B 117
LEU B 174
THR B 171
1.60A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		3 / 3
GLU A  68
HIS A  18
THR A  64
1.06A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4wy3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ASN A 221
ALA A 267
GLN A 273
VAL A 233
THR A 225
1.47A23.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		5c8s NSP10
(SARSr-CoV)		3 / 3
GLU C  66
HIS C  48
THR C 101
1.26A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5e6j POLYUBIQUITIN-B
REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV;
synthetic
construct)		5 / 12
ALA D 130
HIS D 176
VAL F  70
LEU D  76
THR D  75
1.30A19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE D 148
HIS D 172
VAL D 117
LEU D 174
THR D 171
1.58A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
GLU D  68
HIS D  18
THR D  64
1.09A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
HIS B 172
VAL B 117
LEU B 174
THR B 171
1.56A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS B1030
PHE B 909
LEU B1045
THR B 705
HIS B1046
1.67A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
ALA A1130
VAL A1103
VAL A1107
LEU A 951
THR A 948
1.29A11.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU C 843
THR C 716
THR C 841
1.38A12.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASN A 304
GLN A 301
LEU C 843
THR C 716
THR C 841
1.42A12.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU C 843
THR C 716
THR C 841
1.40A12.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS B1030
PHE B 909
LEU B1045
THR B 705
HIS B1046
1.70A12.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6ack ACE2
(Homo
sapiens)		5 / 12
HIS D 378
PHE D 314
LEU D 370
THR D 371
HIS D 374
1.58A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.37A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.34A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS C1030
PHE C 909
LEU C1045
THR C 705
HIS C1046
1.76A12.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.36A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.29A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.25A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A 304
GLN A 301
LEU B 843
THR B 716
THR B 841
1.27A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
HIS B1030
PHE B 909
LEU B1045
THR B 705
HIS B1046
1.74A12.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6cs2 ACE2
(Homo
sapiens)		5 / 12
HIS D 378
PHE D 314
LEU D 370
THR D 371
HIS D 374
1.66A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
HIS A1030
PHE A 909
LEU A1045
THR A 705
HIS A1046
1.74A12.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6vw1 ACE2
(Homo
sapiens)		5 / 12
SER B 409
GLN B 442
VAL B 447
LEU B 584
THR B 519
1.64A19.23
None