Ligand ID: TAC


Drugbank ID:
DB00759
(Tetracycline)


Indication:
Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.

Get human targets for TAC in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'TAC' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.61A10.68
19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.59A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU E 941
LEU D 930
VAL D 934
LEU F 941
VAL F 933
1.57A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		4 / 7
THR A  94
SER A  92
PRO B  32
LEU B  64
1.41A11.34
20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		1x7q HLA, A-11
(Homo
sapiens)		5 / 12
TYR A 159
ILE A  52
TYR A   7
TYR A  59
GLU A  63
1.44A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		1x7q BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 11
SER B  28
PHE B  62
HIS B  31
ILE B  35
SER B  33
1.78A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.58A10.75
19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B1098
SER B1094
ASP B1033
VAL B1091
1.66A10.75
18.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU H  30
PHE I   9
GLN I  17
GLN I  15
ILE K  13
1.78A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.60A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.61A10.71
18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
(SARSr-CoV)		5 / 12
PRO F 121
ILE F 125
PHE F 152
TYR F 154
TYR F 143
1.45A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.59A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.63A10.56
18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.58A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
LEU G 353
LEU G 340
LEU G 292
ILE G 338
ILE G 358
1.47A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 7
SER E  72
SER E  56
VAL F  93
LEU F  53
1.47A16.88
14.11
None
None
None
D10  F1099 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 177
ASP H 144
PRO H 119
VAL H 150
1.64A15.24
19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		2dd8 IGG LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
THR S 363
SER L  93
SER L  94
LEU S 412
1.18A12.50
20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		4 / 6
SER L 138
ASP L 139
PRO L 114
VAL L 197
1.59A11.83
21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 205
PRO H 202
VAL H  11
LEU H 175
1.36A15.24
19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
THR Q 111
PRO Q 107
VAL Q  42
LEU Q  14
1.19A16.89
17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 421
PHE C 379
ARG C 342
VAL C 328
ILE C 345
1.65A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
SER A 273
ASN A  74
PRO A 343
VAL A 275
ILE A 322
1.75A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
SER A 273
ASN A  74
PRO A 343
VAL A 275
ILE A 322
1.73A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A  51
ILE A  27
TYR A  32
GLU A  41
ILE A  42
1.75A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 11
SER A 273
ASN A  74
PRO A 343
VAL A 275
ILE A 322
1.79A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 603
LEU A 596
ILE A 560
VAL A 574
ILE A 573
1.37A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2kqv NSP3
(SARSr-CoV)		5 / 11
LEU A  81
LEU A  74
ILE A  38
VAL A  52
ILE A  51
1.28A24.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.60A10.71
18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.59A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
THR C 120
SER A 315
ASP C  78
LEU C 189
1.30A10.12
23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
LEU B 245
LEU B 254
ILE B 269
VAL B 275
ILE B 295
1.55A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.60A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.54A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL C  51
ILE C  27
TYR C  32
GLU C  41
ILE C  42
1.73A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
SER E 273
ASN E  74
PRO E 343
VAL E 275
ILE E 322
1.51A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
SER E 273
ASN E  74
PRO E 343
VAL E 275
ILE E 322
1.48A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
SER D 273
ASN D  74
PRO D 343
VAL D 275
ILE D 322
1.56A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
LEU A 603
LEU A 596
ILE A 560
VAL A 574
ILE A 573
1.25A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.63A10.79
19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.59A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2w2g NSP3
(SARSr-CoV)		4 / 6
SER A 637
ASP A 639
SER A 636
VAL A 635
1.56A12.33
21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2w2g NSP3
(SARSr-CoV)		5 / 11
LEU A 603
LEU A 596
ILE A 560
VAL A 574
ILE A 573
1.31A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.76A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.79A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.77A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.76A23.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.75A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.77A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2zu5 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.57A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3bgf F26G19 FAB
(Mus
musculus)		4 / 7
THR H 184
SER L 116
VAL L 133
LEU H 154
1.34A10.48
21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		3bgf F26G19 FAB
(Mus
musculus)		4 / 5
THR B 167
SER B 180
PRO B 169
SER C 176
1.76A10.48
21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TYR B  34
TYR F 442
ILE F 397
TYR F 481
TYR F 408
1.76A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.55A22.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.60A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.63A10.40
19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ASP B 155
PRO B  99
VAL B  13
LEU B 177
1.42A10.40
19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.48A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.63A10.68
19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.64A10.68
18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.56A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3i6g BETA-2-MICROGLOBULIN
HLA, A-2
(Homo
sapiens)		4 / 7
THR A  94
SER A  92
PRO B  32
LEU B  64
1.31A10.12
20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		3i6l BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 11
SER E  28
PHE E  62
HIS E  31
ILE E  35
SER E  33
1.75A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		4 / 7
THR D  94
SER D  92
PRO E  32
LEU E  64
1.38A10.53
22.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.62A10.75
19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.79A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.78A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ASN A 196
PHE A 193
PRO A  12
GLN A   3
ILE A 237
1.77A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
SER B  19
ASP F 463
PRO F 462
LEU B  79
1.30A5.43
19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3snd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
ASP A 155
PRO A  99
VAL A  13
LEU A 177
1.49A10.75
19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU B  30
VAL B  13
CYH B 160
VAL B 157
ILE B 152
1.58A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.65A10.71
19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.59A21.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR A  98
SER A  94
ASP A  33
VAL A  91
1.63A10.75
18.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 7
SER B  61
ASP B  62
VAL B  58
LEU B  21
1.31A8.03
21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		4 / 6
THR B 302
ASP B 303
SER B 116
VAL B 117
1.66A8.03
21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
LEU B 124
SER B 241
PHE B 305
ARG B 167
VAL B 206
1.76A19.44
None
None
None
DMS  A 903 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
VAL A 304
TYR A 306
TYR A 214
TYR A 252
TYR A 208
1.78A22.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 7
ASP A 262
PRO A 261
VAL A 255
LEU A 290
1.41A11.64
21.49
None
None
PO4  A 404 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
THR B  98
SER B  94
ASP B  33
VAL B  91
1.62A10.75
19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		4twy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A  30
VAL A  13
CYH A 160
VAL A 157
ILE A 152
1.58A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
LEU D 383
LEU D 442
VAL D 316
ILE D 502
VAL D 312
1.55A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5c8s NSP10
(SARSr-CoV)		4 / 7
THR C 111
PRO C 107
VAL C  42
LEU C  14
1.42A18.46
17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU B 366
HIS B 373
SER B 369
PHE B 377
VAL B 389
1.75A17.06
None
None
None
None
SAH  B 605 (-4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU B 366
HIS B 373
SER B 369
PHE B 377
VAL B 389
1.74A17.06
None
None
None
None
SAM  B 605 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
PRO D 443
TYR D 494
TYR D 446
ILE D 474
TYR D 447
1.74A18.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL D 304
TYR D 306
TYR D 214
TYR D 252
TYR D 208
1.78A22.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
THR A 302
ASP A 303
SER A 116
VAL A 117
1.61A7.67
21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
LEU C 366
HIS C 373
SER C 369
PHE C 377
VAL C 389
1.65A17.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
VAL B 304
TYR B 306
TYR B 214
TYR B 252
TYR B 208
1.74A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 6
THR B 302
ASP B 303
SER B 116
VAL B 117
1.65A8.03
21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
SER A 268
PHE A 281
PRO A 145
VAL A 118
ILE A 256
1.59A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
SER A 268
PHE A 281
PRO A 145
VAL A 118
ILE A 256
1.58A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5x4r S PROTEIN
(MERS-CoV)		6 / 12
PRO A 145
VAL A 118
TYR A 293
ILE A 143
TYR A  87
ILE A 295
1.72A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
SER A 268
PHE A 281
PRO A 145
VAL A 118
ILE A 256
1.61A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR A 256
ILE A 234
TYR A 252
PHE A 103
ILE A  87
1.77A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
TYR A 256
ILE A 234
TYR A 252
PHE A 103
ILE A  87
1.75A12.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
SER B 268
PHE B 281
PRO B 145
VAL B 118
ILE B 256
1.61A9.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
SER B 299
PRO B 297
SER B  88
VAL B  86
1.64A3.77
13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		5x59 S PROTEIN
(MERS-CoV)		4 / 5
SER C 365
ASP A 805
PRO C 658
SER C 656
1.79A3.77
13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 6
THR A 760
ASP A 757
PRO A 845
VAL A 842
1.42A3.69
13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU A 132
ASN A 129
VAL A 114
ILE A 226
SER A 105
1.77A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
THR A 760
ASP A 757
PRO A 845
LEU A 930
1.33A3.69
13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
LEU B 224
LEU B 194
ILE B 152
VAL B 124
ILE B 125
1.60A9.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
SER C 268
PHE C 281
PRO C 145
VAL C 118
ILE C 256
1.58A9.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5x5c S PROTEIN
(MERS-CoV)		5 / 12
VAL B 631
TYR B 641
TYR B 642
ILE C 333
PHE C 279
1.71A11.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
LEU B 347
HIS C 836
LEU C 840
LEU B 344
ILE B 662
1.26A9.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
SER A 268
PHE A 281
PRO A 145
VAL A 118
ILE A 256
1.59A9.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5x5f S PROTEIN
(MERS-CoV)		4 / 7
THR C 961
SER C 975
VAL C1124
LEU C 951
1.48A3.77
13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 504
SER B 380
ARG B 315
PRO B 565
GLN B 550
1.36A10.92
LEU  B 504 ( 0.6A)
SER  B 380 ( 0.0A)
ARG  B 315 ( 0.6A)
PRO  B 565 ( 1.1A)
GLN  B 550 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
THR A 302
ASP A 303
SER A 116
LEU A 163
1.41A7.67
19.84
GOL  A 408 (-3.6A)
None
NA  A 403 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A 304
TYR A 306
TYR A 214
TYR A 252
TYR A 208
1.78A22.81
None
GOL  A 407 (-4.8A)
None
GOL  A 407 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 6
THR A 302
ASP A 303
SER A 116
VAL A 117
1.65A7.67
19.84
GOL  A 409 (-3.5A)
None
NA  A 404 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
THR B 760
ASP B 757
PRO B 845
VAL B 842
1.57A3.64
13.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B 196
ILE B 228
PHE B 161
ILE B 125
TYR B 163
1.45A12.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B1045
SER B1033
PHE B 909
GLN B1036
VAL B 860
1.65A10.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A 303
ASN C 746
VAL A 581
GLN A 301
SER C 717
1.70A10.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A 303
ASN C 746
VAL A 581
GLN A 301
SER C 717
1.68A10.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6ack ACE2
(Homo
sapiens)		5 / 12
ASN D 397
TYR D 217
TYR D 207
ILE D 233
ILE D 513
1.70A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
LEU B1031
VAL B1047
LEU B 788
ILE B 905
ILE B 913
1.56A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
THR B 567
PRO B 565
SER B 516
LEU B 538
1.48A3.69
13.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
TYR B 256
ILE B 234
TYR B 252
PHE B 103
ILE B  87
1.71A13.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
SER A 303
ASN B 746
VAL A 581
GLN A 301
SER B 717
1.66A10.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
SER B 541
ASP B 572
PRO B 540
SER B 542
1.38A3.69
13.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
LEU C 224
LEU C 194
ILE C 152
VAL C 124
ILE C 125
1.55A10.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 788
ASN C 783
PHE C 784
GLN C 786
ILE C 913
1.61A10.48
None
NAG  C1316 (-1.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
SER B 541
ASP B 572
PRO B 540
SER B 542
1.39A3.69
13.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
PRO C1061
VAL C1076
TYR A 886
ILE C1114
TYR A 899
1.45A13.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
SER B 785
ASN B 783
PHE B 784
GLN B 786
ILE B 913
1.60A10.86
None
NAG  B1316 (-1.8A)
None
NAG  B1316 (-3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
THR A 567
PRO A 565
SER A 516
LEU A 538
1.24A3.69
13.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A  94
SER A  92
PRO B  32
LEU B  64
1.34A9.87
20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6m17 ACE2
(Homo
sapiens)		5 / 11
VAL B 647
LEU B 725
ILE B 694
VAL B 700
ILE B 704
1.53A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
LEU A  88
VAL A 505
LEU A  11
ILE A 518
VAL A 511
1.56A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
SER A 291
PRO A  33
SER A 288
LEU A 458
1.43A4.79
18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6m1d ACE2
(Homo
sapiens)		4 / 7
SER D 646
SER D 645
VAL D 670
LEU D 675
1.36A3.90
16.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
THR C 185
SER C 188
ASP C 189
VAL C 582
1.59A4.79
18.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6m1d ACE2
(Homo
sapiens)		5 / 12
HIS D 373
SER D 409
PHE D 314
PRO D 415
SER D 545
1.78A13.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL A 393
PHE A 253
GLU A 391
ILE A 325
TYR A 322
1.77A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		6m1d ACE2
(Homo
sapiens)		5 / 11
HIS D 373
SER D 409
PHE D 314
PRO D 415
SER D 545
1.79A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  61
HIS A  65
GLN A 274
VAL A 275
ILE A 545
1.59A15.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C1045
SER C1033
PHE C 909
GLN C1036
VAL C 860
1.66A10.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
THR A 760
ASP A 757
PRO A 845
VAL A 842
1.48A3.65
13.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 191
ASP H 158
PRO H 133
VAL H 164
1.58A13.73
20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6nur NSP12
NSP8
(SARSr-CoV)		4 / 7
SER B 164
ASP B 163
VAL A 405
LEU A 544
1.33A10.34
20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6nur NSP12
(SARSr-CoV)		4 / 6
THR A 556
SER A 682
SER A 681
VAL A 560
1.54A5.20
17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		6nus NSP12
(SARSr-CoV)		5 / 12
TYR A 122
ILE A 171
TYR A 175
ILE A 145
TYR A 149
1.67A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6nus NSP12
NSP8
(SARSr-CoV)		4 / 7
ASP A 377
PRO A 328
VAL A 675
LEU B 122
1.44A5.20
17.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
VAL H 207
SER H 120
ASP H 144
PRO H 119
1.77A17.16
17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
SER H 120
ASP H 144
PRO H 119
VAL H 207
1.77A17.36
17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
SER H 203
PRO H 119
VAL H 150
LEU H 170
1.48A17.36
17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H 177
ASP H 144
PRO H 119
VAL H 150
1.75A17.36
17.16
GOL  L 301 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
VAL H 150
LEU H 170
SER H 203
PRO H 119
1.53A17.16
17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
VAL H 150
SER H 177
ASP H 144
PRO H 119
1.76A17.16
17.36
None
GOL  L 301 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
VAL H 150
SER H 177
ASP H 144
PRO H 119
1.75A17.16
17.36
None
GOL  L 301 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
SER H 120
ASP H 144
PRO H 119
VAL H 207
1.76A17.36
17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
SER H 177
ASP H 144
PRO H 119
VAL H 150
1.77A17.36
17.16
GOL  L 301 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 11
LEU H 159
LEU H 189
ASN H 155
VAL H 211
ILE H 195
1.77A18.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 155
SER B  21
SER B   7
VAL B   5
1.72A
MLI  H 305 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H  11
LEU H 179
THR H 209
PRO H 206
1.41A
None
MLI  H 301 ( 4.9A)
None
DMS  H 303 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER B 124
ASP B 148
PRO B 123
VAL B 211
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO H 171
SER H 181
VAL H 173
LEU L 142
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL B 154
LEU B 174
SER B 207
PRO B 123
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B 181
ASP B 148
PRO B 123
VAL B 154
1.68A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 181
ASP H 148
PRO H 123
VAL H 154
1.73A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 211
SER H 124
ASP H 148
PRO H 123
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
VAL H 154
SER H 181
ASP H 148
PRO H 123
1.72A21.05
18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER H 207
PRO H 123
VAL H 154
LEU H 174
1.43A
None
None
None
MLI  H 304 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
VAL B 154
SER B 181
ASP B 148
PRO B 123
1.65A21.05
18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
LEU B 163
LEU B 193
ASN B 159
VAL B 215
ILE B 199
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER B   7
VAL B   5
THR H 155
SER B  21
1.75A
None
None
MLI  H 305 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 179
THR H 116
PRO H 206
1.37A
None
MLI  H 301 ( 4.9A)
None
DMS  H 303 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
THR H 155
SER B  21
SER B   7
VAL B   5
1.74A18.18
21.05
MLI  H 305 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B 124
ASP B 148
PRO B 123
VAL B 211
1.75A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL B 211
SER B 124
ASP B 148
PRO B 123
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR B 116
PRO B 206
VAL B 154
LEU B 174
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR B 116
PRO B 206
VAL B 154
LEU B 179
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
LEU H 163
LEU H 193
ASN H 159
VAL H 215
ILE H 199
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 174
SER H 207
PRO H 123
1.47A
None
MLI  H 304 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL B 154
LEU B 179
THR B 116
PRO B 206
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
SER H 181
VAL H 173
LEU L 142
PRO H 171
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER B 207
PRO B 123
VAL B 154
LEU B 174
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER B   7
VAL B   5
THR H 155
SER B  21
1.70A21.05
18.18
None
None
MLI  H 305 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 116
PRO H 206
VAL H 154
LEU H 179
1.39A
None
DMS  H 303 ( 4.7A)
None
MLI  H 301 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 209
PRO H 206
VAL H  11
LEU H 179
1.46A
None
DMS  H 303 ( 4.7A)
None
MLI  H 301 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.77A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 174
SER H 207
PRO H 123
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 211
SER H 124
ASP H 148
PRO H 123
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 181
ASP H 148
PRO H 123
VAL H 154
1.70A17.61
20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 116
PRO H 206
VAL H 154
LEU H 179
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 6
THR L 103
SER H  61
PRO L 101
SER H  63
1.41A10.33
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER H 207
PRO H 123
VAL H 154
LEU H 174
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.73A17.61
20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
THR H 116
PRO H 206
VAL H 154
LEU H 174
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 179
THR H 116
PRO H 206
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
LEU H 163
LEU H 193
ASN H 159
VAL H 215
ILE H 199
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
VAL H 211
SER H 124
ASP H 148
PRO H 123
1.80A20.64
17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
VAL H 154
SER H 181
ASP H 148
PRO H 123
1.70A20.64
17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H 181
ASP H 148
PRO H 123
VAL H 154
1.73A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
SER B 181
VAL B 173
LEU C 142
PRO B 171
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
VAL H 211
SER H 124
ASP H 148
PRO H 123
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR H 116
PRO H 206
VAL H 154
LEU H 174
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B 124
ASP B 148
PRO B 123
VAL B 211
1.78A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO B 171
SER B 181
VAL B 173
LEU C 142
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
LEU B 163
LEU B 193
ASN B 159
VAL B 215
ILE B 199
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.76A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
VAL H 154
SER H 181
ASP H 148
PRO H 123
1.73A21.05
18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
SER H 124
ASP H 148
PRO H 123
VAL H 211
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR H 116
PRO H 206
VAL H 154
LEU H 179
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
LEU H 163
LEU H 193
ASN H 159
VAL H 215
ILE H 199
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR B 116
PRO B 206
VAL B 154
LEU B 179
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
THR B 116
PRO B 206
VAL B 154
LEU B 174
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
VAL B 154
SER B 181
ASP B 148
PRO B 123
1.73A21.05
18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
SER B 207
PRO B 123
VAL B 154
LEU B 174
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
SER H 181
VAL H 173
LEU L 142
PRO H 171
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO H 171
SER H 181
VAL H 173
LEU L 142
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
SER H 207
PRO H 123
VAL H 154
LEU H 174
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
VAL B 154
LEU B 174
SER B 207
PRO B 123
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 179
THR H 116
PRO H 206
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
SER B 181
ASP B 148
PRO B 123
VAL B 154
1.74A18.18
21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
VAL H 154
LEU H 174
SER H 207
PRO H 123
1.47A
None