Ligand ID: T1C


Drugbank ID:
DB00560
(Tigecycline)


Indication:
For the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes and Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.

Get human targets for T1C in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'T1C' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
ASN A  53
GLN A  61
ASN A 118
GLY A  57
SER A  56
1.59A24.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A 172
PHE A 140
THR A 135
LEU A 177
SER A 147
1.65A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.55A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.39A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
SER B  33
ARG A  75
PRO A  20
THR A  10
LEU A  81
1.57A20.23
None
SO4  A4002 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B1306
MET A  17
ASN A 119
GLY A  71
GLY A 124
1.73A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B1306
MET A  17
ASN A 119
GLY A  71
GLY A 124
1.72A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 11
ARG B 279
PHE B 219
ASN B 277
GLY B 283
ASN B 214
1.54A22.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLN D 210
ASN D 240
ALA D 232
GLY D 233
ASN D 219
1.36A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 11
GLN B 320
PRO B 280
ALA B 284
GLY B 285
GLU D 286
1.39A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
GLN B 320
PRO B 280
ALA B 284
GLY B 285
GLU D 286
1.20A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.48A23.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
HIS A 290
GLN A 122
PHE A  96
GLY A 143
GLY A 288
1.51A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
THR A  68
ASN A  69
HIS A  70
GLY A  71
GLY A  90
1.49A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
THR A  68
ASN A  69
HIS A  70
GLY A  71
ALA A  65
1.39A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
THR A  68
ASN A  69
HIS A  70
GLY A   1
ASN A 115
1.46A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASN D  57
ARG C 495
PRO C 493
GLN C 492
THR C 487
1.76A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr)		5 / 12
ASN A   8
HIS A  14
GLY A  13
ALA A  54
ASN A  45
1.44A25.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		2og3 NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		5 / 11
ASN A  76
GLN A  84
GLY A  80
SER A  79
GLY A 115
1.76A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.54A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.51A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.48A24.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ARG B 135
ASN B 136
GLY B 140
GLY B 125
GLU B 145
1.73A26.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASN F   8
HIS F  14
GLY F  13
ALA F  54
ASN F  45
1.51A25.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
ARG B   4
GLN B 127
THR B 292
LEU A 141
SER A 123
1.78A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
HIS A 378
GLY A 405
GLY A 561
GLU A 564
ASN A 572
1.32A22.77
 ZN  A 901 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
PHE B 327
ASN B 322
GLY B 326
SER B 331
GLY B 377
1.67A20.49
None
NDG  B 618 ( 3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.47A23.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.38A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.48A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A   4
ASN B 142
HIS B 172
GLY B 170
GLU B 240
1.71A23.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.53A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.55A22.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3i6k HLA, A-2
(Homo
sapiens)		5 / 12
GLN E 180
HIS E   3
PRO A 267
ALA A 184
GLY A 265
1.43A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3scj ACE2
(Homo
sapiens)		5 / 12
HIS A 378
GLY A 405
GLY A 561
GLU A 564
ASN A 572
1.13A22.77
 ZN  A 901 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
PHE F 460
HIS F 445
THR B  20
GLN B  24
SER F 461
1.70A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
PHE B 327
ASN B 322
GLY B 326
SER B 331
GLY B 377
1.67A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
HIS B 378
GLN B 524
ARG B 518
PHE B 523
GLY B 405
1.80A23.09
 ZN  B 901 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
PHE B 525
ASN B 556
ALA B 576
GLY B 575
ASN B 580
1.57A23.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3sn8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.50A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3snc 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG A 279
PHE A 219
ASN A 277
GLY A 283
ASN A 214
1.37A23.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		3vb3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B 169
HIS B 172
GLY B 138
ALA A 211
GLY A 215
1.49A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ARG B 279
PHE B 219
ASN B 277
GLY B 283
ASN B 214
1.40A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
GLN A 213
ASN A 267
GLY A 248
GLY A 271
GLU A 273
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
GLN A 213
ASN A 267
GLY A 248
GLY A 271
GLU A 273
1.58A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B 169
HIS B 172
GLY B 138
ALA A 211
GLY A 215
1.34A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 11
GLN D 175
ARG D 184
PRO C 130
GLY C 128
ASN C 151
1.57A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 12
SER C  91
HIS C 149
ARG C 127
THR C 145
LEU C 135
1.72A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
PHE D  57
ASN D  16
HIS D  18
PRO D  60
GLU D  68
1.73A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 939
THR C 943
GLN A 744
LEU A 994
SER A 750
1.67A10.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ASP C 727
ARG B 306
PHE B 305
ASN C 721
GLY B 580
1.57A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
ARG A 269
GLY A 275
ALA A 124
GLY A 121
ASN A 125
1.35A21.53
None
None
NAG  A 502 (-3.9A)
None
NAG  A 502 (-1.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
GLN B1088
PHE B 888
GLY B 892
PRO B1051
GLY B1028
1.78A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
GLN A 902
PHE A 880
ASN C 691
GLY A 781
MET A1032
1.69A16.61
None
None
NAG  C1302 ( 2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASN A  78
GLY A 100
GLY A 104
GLU C 452
ASN A 189
1.49A16.61
None
None
None
NAG  A1310 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ASN B 637
GLY B 615
ALA C 930
GLY C 931
GLN C 927
1.27A14.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
HIS A  81
ALA A 124
GLY A 121
GLU A 249
ASN A 125
1.53A14.86
None
NAG  A1402 (-4.7A)
None
None
NAG  A1402 (-2.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
ARG B 269
GLY B 275
ALA B 124
GLY B 121
ASN B 125
1.35A15.62
None
None
NAG  B1402 (-4.7A)
None
NAG  B1402 (-2.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
GLN C 902
PHE C 880
ASN B 691
GLY C 780
MET C1032
1.73A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
GLN A 883
PHE A 870
GLY A 867
ALA A 857
MET A 770
1.55A17.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
GLN C 902
PHE C 880
ASN B 691
GLY C 780
MET C1032
1.73A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLN C 786
PHE C 779
ALA C 866
GLY C 867
GLN C 877
1.18A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE A 741
GLN C 987
THR C 991
GLN C 992
LEU C 941
1.64A10.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
GLN C 902
PHE C 880
ASN B 691
GLY C 780
MET C1032
1.73A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
GLN B 466
MET B 452
ASN B 501
GLY B 462
SER B 460
1.66A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
GLN A  72
PHE A  75
ASN A 114
GLY A  73
GLY A 340
1.67A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASP A 727
ASN A 746
GLY B 580
SER A 717
GLY A 726
1.61A17.16
ASP  A 727 ( 0.5A)
ASN  A 746 ( 0.6A)
GLY  B 580 ( 0.0A)
SER  A 717 ( 0.0A)
GLY  A 726 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN B 599
GLY B 580
ALA A 748
GLY A 751
GLN A 744
1.38A17.16
GLN  B 599 ( 0.6A)
GLY  B 580 ( 0.0A)
ALA  A 748 ( 0.0A)
GLY  A 751 ( 0.0A)
GLN  A 744 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
ASN A 951
GLN c  10
GLN A 947
LEU C 941
SER C 949
1.72A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN A 902
PHE A 880
ASN B 691
GLY A 780
MET A1032
1.47A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLN B 902
PHE B 880
ASN C 691
GLY B 780
MET B1032
1.46A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN A 902
PHE A 880
ASN B 691
GLY A 780
MET A1032
1.47A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN A 902
PHE A 880
ASN B 691
GLY A 780
MET A1032
1.47A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLN B 902
PHE B 880
ASN C 691
GLY B 780
MET B1032
1.42A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 902
PHE A 880
ASN B 691
GLY A 780
MET A1032
1.43A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE A 741
GLN B 987
THR B 991
GLN B 992
LEU B 941
1.35A10.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6acg ACE2
(Homo
sapiens)		5 / 10
HIS D 374
PHE D 400
ASN D 394
GLY D 561
GLY D 405
1.69A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6acj ACE2
(Homo
sapiens)		5 / 11
PHE D 327
ASN D 322
SER D 331
GLY D 377
MET D 360
1.43A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 599
GLY A 580
ALA C 748
GLY C 751
GLN C 744
1.26A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASP A1023
ASN A1090
GLY A 892
PRO A1051
GLY A1028
1.63A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.58A16.75
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.59A16.83
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASP A 976
GLN C 984
ARG C 977
PHE C 952
SER C 985
1.58A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.59A16.75
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.58A16.75
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN C 902
PHE C 880
ASN B 691
GLY C 780
MET C1032
1.54A16.25
None
None
NAG  B1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.57A16.25
None
None
NAG  A1304 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN A 599
GLY A 580
ALA B 748
GLY B 751
GLN B 744
1.41A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN A  78
GLY A 100
GLY A 104
GLU C 452
ASN A 189
1.29A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ASP A 976
GLN C 984
ARG C 977
PHE C 952
SER C 985
1.67A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 740
PHE B 741
THR A 943
GLN A 947
LEU A 983
1.54A10.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.40A16.25
None
None
NAG  A1309 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.41A16.75
None
None
NAG  A1309 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6cs2 ACE2
(Homo
sapiens)		5 / 11
PHE D 327
ASN D 322
GLY D 326
SER D 331
GLY D 377
1.65A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.41A16.83
None
None
NAG  A1309 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.40A16.75
None
None
NAG  A1309 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 902
PHE B 880
ASN A 691
GLY B 780
MET B1032
1.40A16.75
None
None
NAG  A1309 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6jyt HELICASE
(SARSr-CoV)		5 / 11
ASP B 207
ASN B 516
ARG B 173
SER B 486
GLY B 206
1.71A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6lzg ACE2
(Homo
sapiens)		5 / 11
PHE A 327
ASN A 322
GLY A 326
SER A 331
GLY A 377
1.57A20.66
None
NAG  A 703 (-1.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6m18 ACE2
(Homo
sapiens)		5 / 11
PHE D 327
ASN D 322
GLY D 326
SER D 331
GLY D 377
1.75A18.47
None
NAG  D 907 (-1.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6m18 ACE2
(Homo
sapiens)		5 / 12
HIS D 378
GLY D 405
GLY D 561
GLU D 564
ASN D 572
1.26A18.72
 ZN  D 914 ( 4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
ASN C  54
PHE C  74
GLY C 311
SER C 314
GLY C 272
1.71A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.22A16.71
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER B 740
PHE B 741
THR C 943
GLN C 947
LEU C 983
1.44A10.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.21A16.71
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.22A16.79
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.22A16.71
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.27A16.37
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLN C 902
PHE C 880
ASN A 691
GLY C 780
MET C1032
1.35A16.37
None
None
NAG  A1323 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN C 599
GLY C 580
ALA B 748
GLY B 751
GLN B 744
1.36A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 136
PHE H 136
GLN H 185
THR L 185
SER L 132
1.58A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 12
PHE A 440
HIS A 439
GLY A 839
ALA C  42
GLU C  47
1.55A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		6nur NSP12
(SARSr-CoV)		5 / 11
ASN A 507
GLN A 541
GLY A 559
SER A 501
PRO A 505
1.76A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER E 477
ASN E 487
PRO A  84
GLN A  24
LEU A  29
1.79A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6vw1 ACE2
(Homo
sapiens)		5 / 12
PHE B 525
ASN B 556
ALA B 576
GLY B 575
ASN B 580
1.47A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
THR L  20
GLN L   6
ALA L  51
GLY L  64
ASN L  31
1.47A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L 131
PHE H 122
GLN H 171
THR L 180
SER L 127
1.53A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
THR L   5
PHE L  98
GLY H  44
ALA L  34
MET H 100
1.79A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLN H  39
PHE L  98
GLY H  44
PRO L  44
GLU L  55
1.59A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 137
PHE H 126
GLN H 175
THR L 186
SER L 133
1.58A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
THR C  20
GLN C   6
ALA C  57
GLY C  70
ASN C  37
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN H  39
PHE L 104
GLY H  44
PRO L  50
GLU L  61
1.66A19.34
1PE  L1603 (-3.4A)
None
1PE  L1603 ( 4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN B  39
PHE C 104
GLY B  44
PRO C  50
GLU C  61
1.63A19.34
1PE  C 301 ( 4.1A)
None
1PE  C 301 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
GLN B  39
PHE C 104
GLY B  44
PRO C  50
GLU C  61
1.72A
1PE  C 301 ( 4.1A)
None
1PE  C 301 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
GLN B  39
PHE C 104
GLY B  44
PRO C  50
GLU C  61
1.71A19.34
1PE  C 301 ( 4.1A)
None
1PE  C 301 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
GLN H  39
PHE L 104
GLY H  44
PRO L  50
GLU L  61
1.73A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
GLN H  39
PHE L 104
GLY H  44
PRO L  50
GLU L  61
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
GLN H  39
PHE L 104
GLY H  44
PRO L  50
GLU L  61
1.69A18.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 137
PHE H 126
GLN H 175
THR L 186
SER L 133
1.58A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 137
PHE B 126
GLN B 175
THR C 186
SER C 133
1.57A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLN H  39
PHE L 104
GLY H  44
PRO L  50
GLU L  61
1.65A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
GLN B  39
PHE C 104
GLY B  44
PRO C  50
GLU C  61
1.64A19.34
None