Ligand ID: SWF


Drugbank ID:
DB00682
(Warfarin)


Indication:
For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.

Get human targets for SWF in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SWF' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
PHE B  90
LEU B  45
LEU B   9
SER A 105
ALA B 107
1.49A11.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A1171
LEU A1174
LEU A 920
SER B 919
ILE B 916
1.42A11.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1wyy E2 GLYCOPROTEIN
(SARSr-CoV)		6 / 11
ALA B 940
LEU B 941
LEU B 944
LEU B 948
SER B 949
ILE B1150
1.71A13.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
LEU A 205
LEU A 250
LEU A 253
ILE A 259
ALA A 260
1.49A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
PHE B1230
ALA B1266
LEU B1268
LEU B1287
ILE B1281
1.46A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A  40
LEU A  41
LEU E  44
ILE D   5
ALA C  40
1.35A6.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 11
LEU F 100
LEU B  61
LEU B  64
ILE B  73
ALA F 115
1.48A15.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		2ajf ACE2
(Homo
sapiens)		6 / 12
LEU A  39
ALA A  36
PHE A 390
THR A  78
LEU A 100
LEU A  79
1.56A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		2ajf ACE2
(Homo
sapiens)		6 / 12
LEU A  39
ALA A  36
PHE A 390
THR A  78
LEU A 100
LEU A  79
1.53A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 940
LEU A 941
LEU C 944
ILE E1154
ALA B 940
1.36A5.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2dd8 IGG HEAVY CHAIN
IGG LIGHT CHAIN
(Homo
sapiens)		5 / 11
ALA H 168
LEU L 136
SER L 138
ILE L 137
ALA L 175
1.17A17.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
ALA B 145
PHE B  96
LEU B 114
LEU B 173
1.46A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
ALA B 145
PHE B  96
LEU B 114
LEU B 173
1.37A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 11
LEU A   5
LEU A  35
HIS A  34
LEU A  77
ILE A  60
1.00A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TRP C 423
ALA E 371
LEU E 374
LEU C 355
ILE C 345
1.51A15.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 345
PHE C 325
ASN C 347
THR C 320
LEU C 322
1.40A16.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2hsx LEADER PROTEIN
P65 HOMOLOG
NSP1
(SARSr-CoV)		6 / 11
PHE A  20
ALA A  31
LEU A  77
LEU A  96
LEU A  42
SER A   6
1.70A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2kqv NSP3
(SARSr-CoV)		5 / 11
ALA A 107
LEU A  81
LEU A 105
SER A  69
ILE A  70
1.50A15.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
PHE C 302
LEU C 298
PHE C 221
LEU C 227
LEU C 331
1.49A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
PHE C 302
LEU C 298
PHE C 221
LEU C 227
LEU C 331
1.41A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
ALA F   6
LEU F   2
LEU C   2
SER C  25
ILE C  26
1.41A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		2wct NSP3
(SARSr-CoV)		5 / 11
ALA C 415
LEU C 421
LEU C 437
SER C 451
ILE C 454
1.50A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU E 472
ALA E 471
LEU A  79
ASN E 473
LEU E 443
1.37A15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 100
ALA A  99
LEU A  29
LEU A 392
PHE A 390
1.42A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
LEU B  39
ALA B  36
PHE B 390
THR B  78
LEU B 100
LEU B  79
1.64A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		3e9s NSP3
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.35A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		3e9s NSP3
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.44A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ARG A 222
PHE A 219
LEU A 268
ALA A 267
THR A 257
1.52A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.49A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE B 148
PHE B  96
LEU B  88
LEU B 114
LEU B 173
1.26A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 100
ALA B  99
LEU B  29
LEU B 392
PHE B 390
1.38A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		6 / 12
LEU A  39
ALA A  36
PHE A 390
THR A  78
LEU A 100
LEU A  79
1.72A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.53A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 12
PHE A 148
ALA A 146
PHE A  96
LEU A  88
LEU A 114
LEU A 173
1.77A21.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 12
ILE A 149
PHE A 148
ALA A 150
LEU A 169
LEU A 120
1.41A21.07
PO4  A 402 (-4.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ARG B 278
PHE B 111
ALA B 274
LEU B 170
PHE B 183
1.54A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU D 321
ALA D 320
PHE D 445
LEU D 442
LEU D 439
1.53A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ALA D 132
LEU D 133
HIS D 176
LEU D 173
ALA D 154
1.50A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.50A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.42A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ARG A 278
PHE A 111
ALA A 274
LEU A 170
PHE A 183
1.49A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
ALA B 145
PHE B  96
LEU B 114
LEU B 173
1.39A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
PHE B 148
ALA B 145
PHE B  96
LEU B 114
LEU B 173
1.48A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 12
PHE A  26
LEU A  27
PHE A  20
LEU B  21
PHE B  26
1.50A9.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5x4r S PROTEIN
(MERS-CoV)		6 / 12
ALA A 146
PHE A 147
LEU A 180
LEU A 149
LEU A 187
PHE A 183
1.56A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 11
ALA A 282
LEU A 265
LEU A 284
LEU A 169
ILE A 290
1.49A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
ALA A 146
PHE A 147
LEU A 149
LEU A 187
PHE A 183
1.50A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ALA A 146
PHE A 147
LEU A 149
LEU A 187
PHE A 183
1.51A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU A 944
LEU A 986
THR B 991
LEU A 994
LEU B 994
1.34A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE B 905
PHE B 909
ALA B 906
ASN B 910
PHE B 784
1.52A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5x5c S PROTEIN
(MERS-CoV)		6 / 12
ALA B 146
PHE B 147
LEU B 180
LEU B 149
LEU B 187
PHE B 183
1.57A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
ALA A 282
LEU A 265
LEU A 284
LEU A 169
ILE A 290
1.48A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
PHE C1044
LEU C 930
SER C 712
ILE C1000
ALA C1004
1.50A17.22
PHE  C1044 ( 1.3A)
LEU  C 930 ( 0.6A)
SER  C 712 ( 0.0A)
ILE  C1000 ( 0.7A)
ALA  C1004 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.49A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
PHE A 148
ALA A 145
PHE A  96
LEU A 114
LEU A 173
1.41A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 11
ALA A 940
LEU A 941
LEU B 944
ILE b  11
ALA C 940
1.43A9.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ARG C  99
ILE C 234
ALA C 233
ASN C  78
THR C 247
1.42A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 971
ARG A 977
LEU A 959
SER A 957
ALA A 954
1.37A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6acg ACE2
(Homo
sapiens)		5 / 12
ILE D 446
LEU D 240
ALA D 443
LEU D 585
PHE D 592
1.52A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6ack ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C 472
ALA C 471
LEU D  79
ASN C 473
LEU C 443
1.21A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6ack ACE2
(Homo
sapiens)		5 / 11
ALA D  80
LEU D  29
LEU D 100
LEU D 391
ALA D  36
1.38A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 804
ALA A1037
PHE A 764
LEU A 859
LEU A 788
1.55A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA C 926
LEU C 927
LEU C 920
LEU C 803
SER C 798
1.42A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE C 752
LEU C 745
ASN C 746
THR C 841
LEU C 843
1.51A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 745
LEU C 986
ASN C 746
THR C 841
LEU C 843
1.40A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6cs2 ACE2
(Homo
sapiens)		5 / 11
ALA D 443
LEU D 440
LEU D 444
LEU D 278
SER D 280
1.36A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6cs2 ACE2
(Homo
sapiens)		6 / 12
LEU D  39
ALA D  36
PHE D 390
THR D  78
LEU D 100
LEU D  79
1.77A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6m0j ACE2
(Homo
sapiens)		6 / 12
LEU A  39
ALA A  36
PHE A 390
THR A  78
LEU A 100
LEU A  79
1.55A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6m17 ACE2
(Homo
sapiens)		5 / 12
LEU D  39
ALA D  36
THR D  78
LEU D 100
LEU D  79
1.51A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6m18 ACE2
(Homo
sapiens)		6 / 12
LEU B  39
ALA B  36
PHE B 390
THR B  78
LEU B 100
LEU B  79
1.53A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ILE A 497
PHE A 283
LEU A 281
ALA A 498
PHE A 277
1.49A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU C 475
THR C 131
LEU C 201
LEU C 127
PHE C 473
1.41A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE A 752
LEU A 745
ASN A 746
THR A 841
LEU A 843
1.55A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ARG A 553
LEU C 959
PHE A 558
LEU C 978
LEU A 503
1.41A16.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ALA A 926
LEU A 927
LEU A 920
LEU A 803
SER A 798
1.35A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6nur NSP12
(SARSr-CoV)		5 / 11
ALA A 130
LEU A 131
LEU A 142
LEU A 146
ILE A 171
1.30A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 11
ALA L  51
LEU L  33
LEU L   4
SER L  26
ILE L   2
1.77A13.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 11
ALA L  57
LEU L  39
LEU L   4
SER L  26
ILE L   2
1.79A
None