Ligand ID: STZ


Drugbank ID:
DB00428
(Streptozocin)


Indication:
For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Get human targets for STZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'STZ' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ASP C  62
THR C  11
VAL C  58
VAL C   8
TYR C  28
1.79A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ASP D 106
TYR D  27
VAL D  13
ASN D  10
ASN D  40
1.63A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		2xyq NSP10
(SARSr-CoV)		5 / 11
ASP B 106
TYR B  27
VAL B  13
ASN B  10
ASN B  40
1.69A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 11
TYR A  84
THR A  80
VAL C   8
VAL A  95
TYR A 116
1.67A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		5c8u NSP10
(SARSr-CoV)		5 / 11
ASP C 106
TYR C  27
VAL C  13
ASN C  10
VAL C   7
1.49A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
ASP A  62
THR A  11
VAL A  58
VAL A   8
TYR A  28
1.78A17.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
ASP O 106
TYR O  27
VAL O  13
ASN O  10
VAL O   7
1.60A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
ASP C 402
THR C 428
ASN C 388
TYR C 392
ASN C 386
1.68A19.57
None