Ligand ID: SRE


Drugbank ID:
DB01104
(Sertraline)


Indication:
For the management of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD) with or without agoraphobia, premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD) [FDA Label].

Get human targets for SRE in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'SRE' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 9
ASP B 216
VAL B 296
ALA B 206
GLY B   2
PHE B   3
1.53A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
PRO B   6
VAL B   7
ALA B   8
GLY A 100
SER B 105
1.57A13.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
LEU A  42
GLN A  11
ALA A  43
PHE A  90
LEU A 103
THR A 109
1.78A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
PRO B   6
VAL B   7
ALA B   8
GLY A 100
SER B 105
1.56A12.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ILE B1281
ALA B1260
LEU B1208
LEU B1271
LEU B1268
1.45A21.20
19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.41A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.55A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1271
LEU B1272
ALA B1234
LEU B1205
THR B1226
1.44A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2ajf ACE2
(Homo
sapiens)		5 / 10
VAL A 244
LEU A 278
LEU A 267
TYR A 237
LEU A 444
1.33A18.95
13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2bx3 MAIN PROTEINASE
(SARS-COV
Sin2774)		5 / 9
ASP A 216
VAL A 296
ALA A 206
GLY A   2
PHE A   3
1.50A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2bx4 3C-LIKE PROTEINASE
(SARS-COV
Sin2774)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.68A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU D  47
LEU D  49
ARG D  48
ALA D  12
LEU D  82
1.59A11.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA S 422
PHE S 325
GLY S 326
PHE S 329
SER S 358
1.67A17.21
None
None
NAG  S1330 (-3.0A)
NAG  S1330 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA S 422
PHE S 325
GLY S 326
PHE S 329
SER S 358
1.66A17.21
None
None
NAG  S1330 (-3.0A)
NAG  S1330 (-4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.61A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ALA A 210
ILE A 213
GLY A 302
SER A   1
GLY A   2
1.61A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
PRO B  99
VAL B  97
ALA B 113
GLY B 131
PHE B 133
1.69A16.42
None
None
None
APR  B 477 (-3.4A)
APR  B 477 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
PRO B  99
VAL B  97
ALA B 113
GLY B 131
PHE B 133
1.71A17.54
None
None
None
APR  B 477 (-3.4A)
APR  B 477 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.34A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ARG C 141
ALA C 136
LEU C 121
LEU C 174
LEU C 173
1.25A23.31
18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU E 499
PHE E 325
PHE E 364
LEU C 377
ASP C 376
1.58A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA C 422
PHE C 325
GLY C 326
PHE C 329
SER C 358
1.62A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 9
ASP B 182
ALA B 157
GLY B 196
SER B 163
GLY B 200
1.49A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA C 422
PHE C 325
GLY C 326
PHE C 329
SER C 358
1.61A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 9
ASP B 182
ALA B 157
GLY B 196
SER B 163
GLY B 200
1.49A19.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
ASP C 480
ALA D 166
GLY D 200
PHE D 203
SER D 224
1.57A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 9
ASP C 480
ALA D 166
GLY D 200
PHE D 203
SER D 224
1.67A14.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2gri NSP3
(SARSr)		5 / 10
ARG A  31
VAL A  32
LEU A  73
LEU A  72
LEU A  66
1.13A16.22
18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2gri NSP3
(SARSr)		5 / 10
ILE A  78
VAL A  62
ALA A  61
LEU A  80
LEU A  28
1.24A16.22
18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ASP B 289
ALA A 312
ILE B 305
GLY B 296
GLY A 317
1.43A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
ASP B 289
ALA A 312
ILE B 305
GLY B 296
GLY A 317
1.44A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
TYR A 334
PHE A 315
ALA A 309
PHE B 316
LEU B 332
1.56A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2kys NSP7
(SARSr-CoV)		5 / 10
ILE A  41
VAL A  18
ALA A  67
LEU A  73
LEU A  37
1.21A17.26
18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP A 300
ALA A 255
ILE A 252
PHE A 302
SER A 207
1.75A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP A 300
ALA A 255
ILE A 252
PHE A 302
SER A 207
1.75A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP B 106
PRO B  50
VAL B  53
ALA B  54
SER B  97
1.69A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
LEU A 205
LEU A 242
ALA A 234
PHE A 230
LEU A 272
1.51A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
PRO A   9
VAL A 125
ALA A   7
GLY A 149
PHE A 150
1.72A22.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ALA E 283
GLY E 246
PHE E 240
SER F 171
GLY E 286
1.78A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP E 282
VAL F 162
ALA F 160
GLY E 243
GLY F 169
1.77A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ASP E 282
VAL F 162
ALA F 160
GLY E 243
GLY F 169
1.67A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 9
ALA E 283
GLY E 246
PHE E 240
SER F 171
GLY E 286
1.78A21.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2wct NSP3
(SARSr-CoV)		5 / 9
PRO B 588
VAL B 589
ALA B 590
GLY B 614
GLY C 465
1.49A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3atw 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 289
PRO B 241
ALA B 234
TYR B 239
GLY B 109
1.69A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA F 422
PHE F 325
GLY F 326
PHE F 329
SER F 358
1.62A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0h SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA F 422
PHE F 325
GLY F 326
PHE F 329
SER F 358
1.61A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 440
LEU B 591
TYR B 279
PHE B 588
THR B 414
1.45A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
TYR A 237
ALA A 264
PHE A 274
GLY A 448
GLY A 486
1.80A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
ARG A 245
VAL A 244
LEU A 248
TYR A 237
LEU A 278
1.33A19.46
13.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.73A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.77A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3e9s NSP3
(SARSr-CoV)		5 / 10
ARG A 141
ALA A 136
LEU A 121
LEU A 174
LEU A 173
1.13A23.12
18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 205
LEU A 242
PHE A 230
LEU A 272
THR A 198
1.49A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
ILE A 259
VAL A 296
ALA A 291
LEU A 253
LEU A 250
1.40A21.20
17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.70A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.75A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 216
ALA B 140
GLY A 283
PHE A   3
GLY A   2
1.64A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 216
ALA B 140
GLY A 283
PHE A   3
GLY A   2
1.71A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.70A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.64A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3i6g HLA, A-2
(Homo
sapiens)		5 / 9
ASP D 183
ALA D 205
GLY D 239
PHE D 241
SER D 207
1.73A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU D 268
LEU D 272
ALA D 234
LEU D 242
THR D 226
1.40A21.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
PRO A   9
ALA A   7
GLY A 302
SER B 139
GLY B 124
1.54A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 440
LEU B 591
TYR B 279
PHE B 588
THR B 414
1.46A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
ARG B 245
VAL B 244
LEU B 248
TYR B 237
LEU B 278
1.35A19.40
14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 205
LEU A 242
PHE A 230
LEU A 272
THR A 198
1.55A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.63A21.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.71A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.24A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 289
PRO A 241
ALA A 234
TYR A 239
GLY A 109
1.79A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 9
PRO B  60
VAL B  12
ALA B  69
TYR B  73
GLY B  82
1.78A22.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4mm3 PAPAIN-LIKE
PROTEINASE
(SARSr-CoV)		5 / 12
LEU B 151
GLN B 175
ALA B 177
PHE B 128
LEU B 121
1.27A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 10
ALA A 154
LEU A 113
TYR A 155
LEU A 170
LEU A 169
1.45A20.99
20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 289
PRO B 241
ALA B 234
TYR B 239
GLY B 109
1.61A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP B 289
PRO B 241
ALA B 234
TYR B 239
GLY B 109
1.79A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
LEU D 383
TYR D 351
ALA D 396
PHE D 384
THR D 378
1.54A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.27A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
VAL D 117
ALA D 120
LEU D 173
LEU D 174
LEU D 133
1.46A22.25
19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 12
LEU A  65
PHE B  97
ALA A  70
LEU A  25
THR B  94
1.53A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 10
VAL A  21
LEU A  18
LEU B 100
LEU A  65
LEU A  64
1.33A18.58
20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
LEU A 442
TYR A 494
PHE A 444
PHE A 514
LEU A 519
1.50A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ILE D  87
VAL D 421
ALA D 425
LEU D 411
LEU D 174
1.42A20.80
15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ARG D 141
ALA D 136
LEU D 121
LEU D 174
LEU D 173
1.19A23.31
18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
PRO D  60
VAL D  12
ALA D  69
TYR D  72
PHE D  57
1.73A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 151
GLN D 175
ALA D 177
PHE D 128
LEU D 121
1.28A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 9
ASP B 230
PRO B 248
GLY A  89
SER B 222
GLY B 210
1.64A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP C 757
ALA C1037
ILE C 852
SER C 712
GLY C1041
1.38A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP C 757
ALA C1037
ILE C 852
SER C 712
GLY C1041
1.38A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU A 986
LEU A 944
GLN B 744
ALA A 940
THR B 991
1.48A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
TYR C 689
ALA A 906
PHE A1034
PHE A 880
GLY A 780
1.63A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 9
TYR C 689
ALA A 906
PHE A1034
PHE A 880
GLY A 780
1.63A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
VAL C 374
ALA C 597
GLY C 615
PHE C 617
GLY C 372
1.59A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5x5c S PROTEIN
(MERS-CoV)		5 / 9
VAL C 374
ALA C 597
GLY C 615
PHE C 617
GLY C 372
1.54A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 9
TYR C1142
ILE C1123
GLY C1120
SER C 787
GLY C 789
1.35A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
LEU B 894
TYR B1135
PHE B1012
ALA B 889
LEU B 873
1.55A16.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5x5f S PROTEIN
(MERS-CoV)		5 / 9
TYR C1142
ILE C1123
GLY C1120
SER C 787
GLY C 789
1.35A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE C 724
ALA C 971
LEU C 959
LEU C 978
LEU C 735
1.41A13.79
8.11
ILE  C 724 ( 0.6A)
ALA  C 971 ( 0.0A)
LEU  C 959 ( 0.6A)
LEU  C 978 ( 0.6A)
LEU  C 735 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU A 151
GLN A 175
ALA A 177
PHE A 128
LEU A 121
1.26A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE A 724
ALA A 971
LEU A 959
LEU A 978
LEU A 735
1.42A13.98
8.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP A 757
VAL A 763
ALA A1007
SER A 712
GLY A1041
1.66A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP A 600
VAL A 606
ALA A 609
GLY A 580
SER A 577
1.76A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA B 237
GLY B  77
PHE B  76
SER B 248
GLY B 246
1.47A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ALA B 237
GLY B  77
PHE B  76
SER B 248
GLY B 246
1.47A19.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6ack ACE2
(Homo
sapiens)		5 / 10
VAL D 244
LEU D 278
LEU D 267
TYR D 237
LEU D 444
1.29A18.88
14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6ack ACE2
(Homo
sapiens)		5 / 12
LEU D 440
LEU D 591
TYR D 279
PHE D 588
THR D 414
1.36A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 898
GLN A 904
TYR A 899
ALA A 906
PHE A 782
1.43A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
TYR C 689
ALA A 866
ILE A 878
GLY A 780
SER C 690
1.60A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
TYR B 689
ALA C 866
ILE C 878
GLY C 780
SER B 690
1.60A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU A 986
LEU A 944
GLN B 744
ALA A 940
THR B 991
1.57A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
ILE A 724
ALA A 971
LEU A 959
LEU A 978
LEU A 735
1.43A14.33
11.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU C 986
LEU C 944
GLN A 744
ALA C 940
THR A 991
1.54A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP B 351
ALA B 371
GLY B 326
PHE B 329
SER B 353
1.41A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP B 757
ALA B1037
ILE B 852
SER B 712
GLY B1041
1.52A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP C 376
VAL C 510
ALA C 350
GLY C 531
GLY C 512
1.54A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
ASP B 757
ALA B1037
ILE B 852
SER B 712
GLY B1041
1.52A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6cs2 ACE2
(Homo
sapiens)		5 / 12
LEU D  79
PHE D  72
ALA D  80
PHE D  28
LEU D  29
1.60A21.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6cs2 ACE2
(Homo
sapiens)		5 / 10
VAL D 244
LEU D 278
LEU D 267
TYR D 237
LEU D 444
1.38A18.70
13.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 160
LEU A 130
TYR A 159
ALA A 153
LEU C   8
1.51A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
PRO C 493
ALA C 590
TYR C 488
SER C 487
GLY C 490
1.77A26.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
LEU A  52
ARG A  57
TYR A 129
PHE A 277
LEU A 482
ASP A 486
1.19A26.91
None
None
LEU  A 707 ( 3.9A)
LEU  A 707 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6m17 ACE2
(Homo
sapiens)		5 / 10
VAL D 244
LEU D 278
LEU D 267
TYR D 237
LEU D 444
1.40A17.44
11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
PRO A 493
ALA A 590
TYR A 488
SER A 487
GLY A 490
1.72A27.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 9
ASP D 509
VAL D 184
TYR D 183
GLY D 200
PHE D 464
1.72A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 12
LEU B 359
ALA B 348
LEU B 351
ASP B 350
THR B 324
1.58A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6m1d ACE2
(Homo
sapiens)		5 / 9
ASP D 509
VAL D 184
TYR D 183
GLY D 200
PHE D 464
1.73A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP A 376
VAL A 314
GLY A 512
PHE A 316
GLY A 531
1.51A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
ILE A 724
ALA A 971
LEU A 959
LEU A 978
LEU A 735
1.34A13.93
10.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
ASP A 376
VAL A 314
GLY A 512
PHE A 316
GLY A 531
1.54A17.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 986
LEU A 944
GLN C 744
ALA A 940
THR C 991
1.56A17.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		6 / 10
ILE H  70
ALA H  92
LEU H  48
TYR H  95
LEU H  79
LEU H  20
1.59A22.26
20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6nur NSP12
(SARSr-CoV)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.53A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		6nur NSP12
(SARSr-CoV)		5 / 9
ASP A 717
VAL A 776
ALA A 771
TYR A 770
GLY A 774
1.56A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 10
VAL C  16
LEU C  13
LEU D  95
LEU C  60
LEU C  59
1.46A17.26
18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6nus NSP12
(SARSr-CoV)		5 / 12
LEU A 638
ARG A 640
ALA A 639
LEU A 655
ASP A 304
1.60A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		6vw1 ACE2
(Homo
sapiens)		5 / 12
LEU B 440
LEU B 591
TYR B 279
PHE B 588
THR B 414
1.45A21.48
None