Ligand ID: RPB


Drugbank ID:
DB12332
(Rucaparib)


Indication:
Indicated as monotherapy for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. Select patients for therapy based on an FDA-approved companion diagnostic for rucaparib.

Get human targets for RPB in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RPB' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 8
GLY B 146
TYR B 118
ALA B 116
SER B 147
1.42A21.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		1uk2 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B 163
GLY B 146
ALA B 116
SER B 147
1.31A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
GLN B 110
GLY B 174
LYS B 180
TYR B 182
GLU B 178
1.75A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B1134
GLY B1183
ALA B1173
TYR B1182
1.41A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.42A22.19
None
None
AZP  A 307 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.43A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.41A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
GLN C 304
GLY D 317
TYR C 299
ALA C 265
SER D 313
1.67A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
GLY C 488
TYR C 484
ALA D  33
TYR C 491
1.37A21.46
 CL  C  20 ( 4.9A)
None
None
CL  C  20 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2gri NSP3
(SARSr)		4 / 8
GLY A  18
ALA A   1
LYS A   1
TYR A  19
1.34A15.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 8
HIS B 134
GLY B 183
ALA B 173
TYR B 182
1.40A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 8
HIS A 163
GLY A 146
ALA A 116
SER A 147
1.40A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.44A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.38A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.44A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
HIS C  14
GLY C  13
ALA C  59
GLU C  56
1.30A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 8
GLY B 146
TYR B 118
ALA B 116
SER B 147
1.38A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B 134
GLY B 183
ALA B 173
TYR B 182
1.39A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 11
GLY E 482
TYR E 442
TYR A  34
LYS E 390
TYR E 481
1.47A18.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
HIS A 378
GLY A 377
ALA A 403
TYR A 381
1.38A17.61
 ZN  A 901 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.41A23.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.43A23.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY B 146
TYR B 118
ALA B 116
SER B 147
1.36A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
GLY A 146
TYR A 118
ALA A 116
SER A 147
1.33A22.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
HIS A 163
GLY A 146
LYS A 142
SER A 144
TYR A 118
1.75A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS A 134
GLY A 183
ALA A 173
TYR A 182
1.44A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS A 163
GLY A 146
ALA A 116
SER A 147
1.44A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B 163
GLY B 146
ALA B 116
SER B 147
1.43A23.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
GLY F 403
TYR F 442
TYR F 408
GLU B  30
1.39A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
HIS B 378
GLY B 377
ALA B 403
TYR B 381
1.38A17.61
 ZN  B 901 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 8
HIS B 134
GLY B 183
ALA B 173
TYR B 182
1.44A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5tl7 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
HIS B  74
TYR B  72
TYR B  73
GLU B 135
1.44A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5x5c S PROTEIN
(MERS-CoV)		4 / 8
GLY B 610
TYR B 577
SER B 439
TYR B 438
1.41A10.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
GLN A  72
GLU B 823
GLY A1045
ALA A1049
SER A1048
1.73A14.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6acg ACE2
(Homo
sapiens)		4 / 8
HIS D 378
GLY D 377
ALA D 403
TYR D 381
1.35A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
GLY C 177
TYR C 200
ALA C 249
SER C 176
GLU C  93
1.63A15.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLY B 255
TYR B 197
ALA B  90
TYR B  88
GLU B 184
1.71A15.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
HIS B  33
GLY B  68
ALA B  91
GLU B  93
1.21A11.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A 252
ALA A 199
SER A 251
GLU A 198
1.43A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6jyt HELICASE
(SARSr-CoV)		4 / 8
HIS A  39
GLY A  17
ALA B  18
LYS B  40
1.41A17.94
 ZN  A 703 (-3.1A)
None
ZN  B 703 (-2.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 191
ALA L 189
SER L 187
GLU L 192
1.41A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6vw1 ACE2
(Homo
sapiens)		4 / 8
HIS A 378
GLY A 377
ALA A 403
TYR A 381
1.38A17.67
 ZN  A 704 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6vw1 ACE2
(Homo
sapiens)		5 / 11
GLN B 388
HIS B 378
GLY B 377
ALA B 403
TYR B 381
1.79A21.36
None
ZN  B 703 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6vw1 SARS-COV-2 CHIMERIC
RBD
(SARSr)		4 / 8
GLY E 496
TYR E 451
SER E 494
TYR E 495
1.36A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
GLY L 128
TYR L 186
ALA L 184
GLU L 187
1.60A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TYR L 186
ALA L 184
SER L 182
GLU L 187
1.69A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
GLY L 200
TYR L 140
ALA L 144
GLU L 143
1.51A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
ALA L 184
LYS L 183
SER L 182
GLU L 187
1.71A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6xhn 3C-LIKE PROTEINASE
(SARSr)		4 / 8
HIS B 134
GLY B 183
ALA B 173
TYR B 182
1.46A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLY C 134
TYR C 192
ALA C 190
GLU C 193
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLY C 206
TYR C 146
ALA C 150
GLU C 149
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLY L 206
TYR L 146
ALA L 150
GLU L 149
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR C 192
ALA C 190
SER C 188
GLU C 193
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
ALA L 190
SER L 188
GLU L 193
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
GLY L 206
TYR L 146
ALA L 150
GLU L 149
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
ALA L 190
SER L 188
GLU L 193
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR L 192
ALA L 190
SER L 188
GLU L 193
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
TYR C 192
ALA C 190
SER C 188
GLU C 193
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLY C 206
TYR C 146
ALA C 150
GLU C 149
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 8
GLY L 206
TYR L 146
ALA L 150
GLU L 149
1.42A
None