Ligand ID: RIV


Drugbank ID:
DB06228
(Rivaroxaban)


Indication:
Rivaroxaban is indicated for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hips replacements and total knee replacement surgery; prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); to reduce risk of recurrent DVT and/or PE. Due to a lack of safety studies, it is not recommended for use in those under 18 years old. Its use is also not recommended in those with severe renal impairment (<30mL/min).

Get human targets for RIV in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'RIV' AND SARS-RELATED PROTEINS ONLY

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
TYR A  65
PHE A  31
ASP A  60
ALA A 116
GLY A  92
1.43A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
TYR A  65
PHE A  31
ASP A  60
ALA A 116
GLY A  92
1.46A19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP B 216
ALA B 211
GLN B 299
GLY B   2
GLY B 283
1.58A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 11
TYR B  67
PHE B  22
GLY A 237
GLY A 239
TYR B  26
1.42A18.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		1x7q BETA-2-MICROGLOBULIN
HLA, A-11
(Homo
sapiens)		5 / 12
TYR B  67
PHE B  22
GLY A 237
GLY A 239
TYR B  26
1.38A18.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		2amq 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE A   8
SER B 139
CYH A 300
GLY A 302
TYR B 118
1.56A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ASP H  95
GLY H  99
GLY H 100
GLY S 488
TYR S 491
1.47A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASP H  95
GLY H  99
GLY H 100
GLY S 488
TYR S 491
1.51A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR S 481
GLN S 396
GLY S 391
GLY S 490
TYR S 491
1.25A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2ghw SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR C 481
GLN C 396
GLY C 391
GLY C 490
TYR C 491
1.36A17.96
None
None
None
CL  C  20 ( 4.2A)
CL  C  20 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 11
ALA A   0
GLN A 299
GLY A   2
GLY B 138
GLY B 170
1.51A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		5 / 12
TYR B 126
ALA A   0
SER B 144
GLY A   2
GLY B 170
1.53A19.94
None
None
WR1  B 602 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
PHE A   8
SER B 139
CYH A 300
GLY A 302
TYR B 118
1.61A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 11
TYR A 161
ALA A  41
GLN C   6
GLY A 146
GLY A 143
1.50A19.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ALA A  83
VAL B  42
GLY B  70
GLY B  94
GLY B  69
1.47A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 11
ALA A  83
VAL B  42
GLY B  70
GLY B  94
GLY B  69
1.48A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE A   8
SER B 139
CYH A 300
GLY A 302
TYR B 118
1.42A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
TYR B 126
ALA B 140
GLY B 138
GLY B 170
GLY A   2
1.53A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
TYR B 126
ALA B 140
GLY B 138
GLY B 170
GLY A   2
1.50A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		5 / 11
TYR E  67
PHE E  22
GLY D 237
GLY D 239
TYR E  26
1.32A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		3i6l BETA-2-MICROGLOBULIN
HLA, A-24
(Homo
sapiens)		5 / 12
TYR E  67
PHE E  22
GLY D 237
GLY D 239
TYR E  26
1.29A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE A   8
SER B 139
CYH A 300
GLY A 302
TYR B 118
1.59A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		3vb6 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE B   8
SER A 139
CYH B 300
GLY B 302
TYR A 118
1.46A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
SER A 116
VAL A 166
GLY B  76
GLY A 272
GLY A 164
1.51A22.05
 NA  A 402 (-2.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER B 116
VAL B 166
GLY A  75
GLY B 272
GLY B 164
1.59A22.05
None
None
GLZ  A  76 ( 2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
TYR D 197
ALA D 138
VAL D 136
TRP D 159
GLY D  93
1.59A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
PHE D 436
ALA D 320
GLN D 313
VAL D 381
TYR D 511
1.54A19.00
None
None
SAM  D 605 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
TYR D 197
ALA D 138
VAL D 136
TRP D 159
GLY D  93
1.58A17.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5e6j REPLICASE
POLYPROTEIN 1AB
UBIQUITIN
(SARSr-CoV;
synthetic
construct)		5 / 12
SER A 116
VAL A 166
GLY B  75
GLY A 272
GLY A 164
1.56A22.05
None
None
AYE  B  76 ( 2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5tl6 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER D 116
VAL D 166
GLY C 156
GLY D 272
GLY D 164
1.56A22.05
None
None
AYE  C 157 ( 2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
PHE C1126
ALA C 968
GLN B 772
GLY C 953
GLY C 959
1.41A10.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ALA C 875
TRP C 868
GLY C 867
GLY C 862
GLY C 871
1.41A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA C 875
TRP C 868
GLY C 867
GLY C 862
GLY C 871
1.41A11.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR C1049
ASP C1023
GLY C1028
GLY C1026
GLY B 871
1.43A10.91
TYR  C1049 ( 1.3A)
ASP  C1023 ( 0.5A)
GLY  C1028 ( 0.0A)
GLY  C1026 ( 0.0A)
GLY  B 871 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B  90
SER B 211
GLY B  68
GLY B 255
TYR B  88
1.45A10.99
ALA  B  90 ( 0.0A)
SER  B 211 ( 0.0A)
GLY  B  68 ( 0.0A)
GLY  B 255 ( 0.0A)
TYR  B  88 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
TYR C1049
ASP C1023
GLY C1028
GLY C1026
GLY B 871
1.43A10.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
TYR B  88
PHE B 185
GLN B 201
GLY B 199
TYR B  42
1.30A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ALA A 872
GLN A 766
VAL C1022
GLY C1026
GLY C1028
1.58A10.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA A 872
SER A1012
VAL C1022
GLY C1026
GLY C1028
1.44A11.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP B1023
SER B1019
GLY B1026
GLY B1028
TYR B1029
1.34A11.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
GLN B 766
VAL B1015
GLY B 871
GLY B 873
GLY B 867
1.33A11.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
TYR A 177
PHE A 400
ALA A 392
GLY A 397
GLY A 395
1.52A16.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
PHE A  48
SER A 290
GLY A 285
GLY A 284
TYR A 292
1.41A16.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
PHE B 629
SER B 582
VAL B 581
GLY B 638
TYR B 598
1.51A10.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
TYR H  59
PHE H  63
ALA H  78
SER H  70
GLY H  35
1.68A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
ALA H  79
GLN H   6
TRP H  47
GLY H  35
GLY H  98
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR B  60
PHE B  64
ALA B  79
SER B  71
GLY B  35
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 11
ALA B  79
GLN B   6
TRP B  47
GLY B  35
GLY B  98
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H  60
PHE H  64
ALA H  79
SER H  71
GLY H  35
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
TYR H  60
PHE H  64
ALA H  79
SER H  71
GLY H  35
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
TYR L  42
GLN L  96
VAL H  37
GLY L 105
GLY H  44
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 11
ALA H  79
GLN H   6
TRP H  47
GLY H  35
GLY H  98
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
ALA B  79
GLN B   6
TRP B  47
GLY B  35
GLY B  98
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR B  60
PHE B  64
ALA B  79
SER B  71
GLY B  35
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
TYR H  60
PHE H  64
ALA H  79
SER H  71
GLY H  35
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOF_H_RIVH301_1
(COAGULATION FACTOR X)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 11
ALA H  79
GLN H   6
TRP H  47
GLY H  35
GLY H  98
1.76A
None